Details for: FZD9

Gene ID: 8326

Symbol: FZD9

Ensembl ID: ENSG00000188763

Description: frizzled class receptor 9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.3991
    Cell Significance Index: 44.8100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3021
    Cell Significance Index: 247.8000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7401
    Cell Significance Index: 668.2100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6560
    Cell Significance Index: 13.9700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4661
    Cell Significance Index: 50.7000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.4546
    Cell Significance Index: 6.4600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4437
    Cell Significance Index: 72.1700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3503
    Cell Significance Index: 21.0300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.2773
    Cell Significance Index: 4.5700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2687
    Cell Significance Index: 18.5800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2284
    Cell Significance Index: 22.5900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1071
    Cell Significance Index: 2.8700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0174
    Cell Significance Index: 0.7900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0157
    Cell Significance Index: 0.5500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0118
    Cell Significance Index: 0.3400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0105
    Cell Significance Index: 0.4900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0090
    Cell Significance Index: 3.9900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0070
    Cell Significance Index: 0.9000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0034
    Cell Significance Index: 0.4400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0005
    Cell Significance Index: 0.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0005
    Cell Significance Index: -0.2800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0024
    Cell Significance Index: -0.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0027
    Cell Significance Index: -5.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0062
    Cell Significance Index: -1.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0064
    Cell Significance Index: -4.8300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0065
    Cell Significance Index: -9.9700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0074
    Cell Significance Index: -4.7200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0083
    Cell Significance Index: -6.1200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0107
    Cell Significance Index: -6.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0132
    Cell Significance Index: -2.6500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0136
    Cell Significance Index: -6.1900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0136
    Cell Significance Index: -1.5900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0193
    Cell Significance Index: -5.5400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0211
    Cell Significance Index: -3.6100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0242
    Cell Significance Index: -4.3600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0291
    Cell Significance Index: -6.1300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0316
    Cell Significance Index: -3.6200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0351
    Cell Significance Index: -4.3100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0365
    Cell Significance Index: -1.5900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0374
    Cell Significance Index: -5.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0378
    Cell Significance Index: -5.1900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0421
    Cell Significance Index: -1.1800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0480
    Cell Significance Index: -4.9000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0494
    Cell Significance Index: -3.0300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0503
    Cell Significance Index: -5.2400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0541
    Cell Significance Index: -2.8100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0576
    Cell Significance Index: -1.4800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0619
    Cell Significance Index: -2.9100
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.0647
    Cell Significance Index: -0.3800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0650
    Cell Significance Index: -1.7700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0665
    Cell Significance Index: -1.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0701
    Cell Significance Index: -4.7200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0720
    Cell Significance Index: -1.5600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0741
    Cell Significance Index: -3.8600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0745
    Cell Significance Index: -1.5600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0803
    Cell Significance Index: -5.1800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0845
    Cell Significance Index: -9.9600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0905
    Cell Significance Index: -5.5700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0920
    Cell Significance Index: -5.1600
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0974
    Cell Significance Index: -1.0100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0992
    Cell Significance Index: -5.2100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1107
    Cell Significance Index: -8.2500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1180
    Cell Significance Index: -4.1000
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1291
    Cell Significance Index: -1.8100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1334
    Cell Significance Index: -2.0100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1347
    Cell Significance Index: -4.7200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1365
    Cell Significance Index: -3.4100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1408
    Cell Significance Index: -3.5100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1422
    Cell Significance Index: -6.2900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1455
    Cell Significance Index: -5.5100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1494
    Cell Significance Index: -4.4000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1549
    Cell Significance Index: -4.4200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1555
    Cell Significance Index: -5.0900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1625
    Cell Significance Index: -5.1800
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1650
    Cell Significance Index: -2.2900
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.1681
    Cell Significance Index: -1.3900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1704
    Cell Significance Index: -4.4800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1763
    Cell Significance Index: -3.0400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1764
    Cell Significance Index: -4.4000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1794
    Cell Significance Index: -1.9500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1795
    Cell Significance Index: -2.8800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1809
    Cell Significance Index: -2.5900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1839
    Cell Significance Index: -3.5900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1844
    Cell Significance Index: -6.7700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1849
    Cell Significance Index: -2.6600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1904
    Cell Significance Index: -2.4900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1906
    Cell Significance Index: -2.6000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1931
    Cell Significance Index: -4.9200
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1938
    Cell Significance Index: -1.1500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1941
    Cell Significance Index: -4.1500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1990
    Cell Significance Index: -4.0500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2043
    Cell Significance Index: -5.2200
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.2055
    Cell Significance Index: -1.8600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2062
    Cell Significance Index: -4.1400
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.2073
    Cell Significance Index: -2.4500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2118
    Cell Significance Index: -5.1300
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.2140
    Cell Significance Index: -2.2200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2144
    Cell Significance Index: -4.5500
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.2147
    Cell Significance Index: -2.4000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2148
    Cell Significance Index: -4.6400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** FZD9 is a type of GPCR that belongs to the Frizzled family, which is characterized by the presence of a seven-transmembrane domain structure. The receptor is activated by Wnt proteins, which bind to the extracellular domain of FZD9, triggering a cascade of downstream signaling events. FZD9 is a negative regulator of the canonical Wnt signaling pathway, meaning that it inhibits the activity of the β-catenin/TCF complex, which is a key effector molecule in this pathway. Additionally, FZD9 is involved in the regulation of various other signaling pathways, including the non-canonical Wnt signaling pathway and the p53 tumor suppressor pathway. **Pathways and Functions** FZD9 is involved in several signaling pathways, including: 1. **Canonical Wnt signaling pathway**: FZD9 acts as a negative regulator of this pathway, inhibiting the activity of the β-catenin/TCF complex, which is essential for cell proliferation, differentiation, and survival. 2. **Non-canonical Wnt signaling pathway**: FZD9 is involved in the regulation of this pathway, which is implicated in cell migration, differentiation, and survival. 3. **p53 tumor suppressor pathway**: FZD9 is involved in the regulation of this pathway, which is essential for preventing cancer progression. 4. **Cell cycle regulation**: FZD9 is involved in the regulation of the cell cycle, particularly in the G2/M phase, where it inhibits the activity of cyclin-dependent kinases. 5. **Apoptosis regulation**: FZD9 is involved in the regulation of apoptosis, particularly in the regulation of mitochondrial outer membrane permeabilization and the release of cytochrome c. **Clinical Significance** FZD9 has been implicated in various diseases, including: 1. **Cancer**: FZD9 is often overexpressed in various types of cancer, including colorectal cancer, breast cancer, and lung cancer, where it can promote tumor progression and metastasis. 2. **Neurological disorders**: FZD9 is implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis, where it can regulate cellular processes such as cell proliferation, differentiation, and survival. 3. **Bone metabolism**: FZD9 is involved in the regulation of bone metabolism, particularly in the regulation of osteoblast differentiation and bone mineralization. 4. **Gastrointestinal disorders**: FZD9 is implicated in various gastrointestinal disorders, including inflammatory bowel disease, where it can regulate cellular processes such as cell proliferation, differentiation, and survival. In conclusion, FZD9 is a critical regulator of various cellular processes, including development, differentiation, and signaling pathways. Its dysregulation has been implicated in various diseases, making it a potential target for therapeutic intervention. Further research is needed to fully understand the role of FZD9 in human health and disease.

Genular Protein ID: 2000368263

Symbol: FZD9_HUMAN

Name: Frizzled-9

UniProtKB Accession Codes:

O00144

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 GO 39 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9147651

Title: A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23.

PubMed ID: 9147651

DOI: 10.1093/hmg/6.3.465

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 9707618

Title: A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.

PubMed ID: 9707618

DOI: 10.1073/pnas.95.17.10164

PubMed ID: 27509850

Title: A human neurodevelopmental model for Williams syndrome.

PubMed ID: 27509850

DOI: 10.1038/nature19067

Sequence Information:

  • Length: 591
  • Mass: 64466
  • Checksum: 0D3784A78DF0B2E5
  • Sequence:
    • MAVAPLRGAL LLWQLLAAGG AALEIGRFDP ERGRGAAPCQ AVEIPMCRGI GYNLTRMPNL 
LGHTSQGEAA AELAEFAPLV QYGCHSHLRF FLCSLYAPMC TDQVSTPIPA CRPMCEQARL 
RCAPIMEQFN FGWPDSLDCA RLPTRNDPHA LCMEAPENAT AGPAEPHKGL GMLPVAPRPA 
RPPGDLGPGA GGSGTCENPE KFQYVEKSRS CAPRCGPGVE VFWSRRDKDF ALVWMAVWSA 
LCFFSTAFTV LTFLLEPHRF QYPERPIIFL SMCYNVYSLA FLIRAVAGAQ SVACDQEAGA 
LYVIQEGLEN TGCTLVFLLL YYFGMASSLW WVVLTLTWFL AAGKKWGHEA IEAHGSYFHM 
AAWGLPALKT IVILTLRKVA GDELTGLCYV ASTDAAALTG FVLVPLSGYL VLGSSFLLTG 
FVALFHIRKI MKTGGTNTEK LEKLMVKIGV FSILYTVPAT CVIVCYVYER LNMDFWRLRA 
TEQPCAAAAG PGGRRDCSLP GGSVPTVAVF MLKIFMSLVV GITSGVWVWS SKTFQTWQSL 
CYRKIAAGRA RAKACRAPGS YGRGTHCHYK APTVVLHMTK TDPSLENPTH L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.