H2AC15 | ENSG00000275221 | NCBI 8330

Details for: H2AC15

Gene ID: 8330

Symbol: H2AC15

Ensembl ID: ENSG00000275221

Description: H2A clustered histone 15

Associated with

Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Deubiquitination
(R-HSA-5688426)
Disease
(R-HSA-1643685)
Hats acetylate histones
(R-HSA-3214847)
Hcmv early events
(R-HSA-9609690)
Hcmv infection
(R-HSA-9609646)
Hcmv late events
(R-HSA-9610379)
Hdacs deacetylate histones
(R-HSA-3214815)
Infectious disease
(R-HSA-5663205)
Metabolism of proteins
(R-HSA-392499)
Metalloprotease dubs
(R-HSA-5689901)
Post-translational protein modification
(R-HSA-597592)
Rmts methylate histone arginines
(R-HSA-3214858)
Ub-specific processing proteases
(R-HSA-5689880)
Uch proteinases
(R-HSA-5689603)
Viral infection pathways
(R-HSA-9824446)
Biological_process
(GO:0008150)
Enzyme binding
(GO:0019899)
Extracellular exosome
(GO:0070062)
Heterochromatin formation
(GO:0031507)
Nucleosome
(GO:0000786)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Structural constituent of chromatin
(GO:0030527)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 1.1300
Cell Significance Index: 11.3300
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 0.8854
Cell Significance Index: 9.4200
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 0.7228
Cell Significance Index: -2.2200
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.6334
Cell Significance Index: 13.4900
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.5537
Cell Significance Index: 105.3700
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.4862
Cell Significance Index: 31.3700
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.4804
Cell Significance Index: 6.8800
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.4381
Cell Significance Index: 26.3000
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.4061
Cell Significance Index: 11.7000
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.3229
Cell Significance Index: 35.1200
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 0.3135
Cell Significance Index: 3.2500
Cell Name: sensory neuron (CL0000101)
Fold Change: 0.3096
Cell Significance Index: 1.7600
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.3030
Cell Significance Index: 3.8800
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 0.2882
Cell Significance Index: 2.2400
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2500
Cell Significance Index: 24.7300
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2197
Cell Significance Index: 4.7600
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1986
Cell Significance Index: 32.3100
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1783
Cell Significance Index: 8.0800
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1701
Cell Significance Index: 153.5800
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.1664
Cell Significance Index: 4.4500
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1453
Cell Significance Index: 10.0500
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.1355
Cell Significance Index: 15.9800
Cell Name: type I NK T cell (CL0000921)
Fold Change: 0.1318
Cell Significance Index: 1.2900
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0957
Cell Significance Index: 4.9700
Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.0813
Cell Significance Index: 1.1400
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.0725
Cell Significance Index: 0.7500
Cell Name: paneth cell (CL0000510)
Fold Change: 0.0604
Cell Significance Index: 0.6300
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0558
Cell Significance Index: 1.9600
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.0538
Cell Significance Index: 0.8100
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0496
Cell Significance Index: 1.2400
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.0437
Cell Significance Index: 1.4000
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.0339
Cell Significance Index: 0.2100
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.0221
Cell Significance Index: 0.3100
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0190
Cell Significance Index: 1.2000
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0174
Cell Significance Index: 2.3900
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0135
Cell Significance Index: 5.9500
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0113
Cell Significance Index: 2.2400
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0032
Cell Significance Index: 0.5800
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0003
Cell Significance Index: -0.1700
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0007
Cell Significance Index: -0.4100
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0007
Cell Significance Index: -0.5500
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0011
Cell Significance Index: -2.0400
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0018
Cell Significance Index: -3.2900
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0018
Cell Significance Index: -2.7100
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0018
Cell Significance Index: -2.5000
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0025
Cell Significance Index: -0.5300
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0035
Cell Significance Index: -0.1800
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0039
Cell Significance Index: -2.4700
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0042
Cell Significance Index: -0.1800
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0044
Cell Significance Index: -0.3100
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0052
Cell Significance Index: -3.9300
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0057
Cell Significance Index: -4.1700
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0060
Cell Significance Index: -2.1500
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0062
Cell Significance Index: -0.7900
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0067
Cell Significance Index: -1.1400
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0069
Cell Significance Index: -1.3800
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0074
Cell Significance Index: -3.3700
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0104
Cell Significance Index: -0.8000
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0172
Cell Significance Index: -0.3600
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0183
Cell Significance Index: -2.1000
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0194
Cell Significance Index: -2.8200
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0231
Cell Significance Index: -1.4200
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0235
Cell Significance Index: -1.3200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0241
Cell Significance Index: -2.9700
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0249
Cell Significance Index: -0.7000
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0327
Cell Significance Index: -0.8400
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0338
Cell Significance Index: -4.3700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0360
Cell Significance Index: -1.6800
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0365
Cell Significance Index: -3.8000
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0378
Cell Significance Index: -3.8700
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0394
Cell Significance Index: -1.8500
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0429
Cell Significance Index: -2.2600
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: -0.0453
Cell Significance Index: -0.5700
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0487
Cell Significance Index: -1.0100
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0513
Cell Significance Index: -1.3500
Cell Name: PP cell (CL0000696)
Fold Change: -0.0571
Cell Significance Index: -0.5800
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0580
Cell Significance Index: -4.3200
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0705
Cell Significance Index: -1.1800
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0710
Cell Significance Index: -3.1400
Cell Name: peg cell (CL4033014)
Fold Change: -0.0736
Cell Significance Index: -1.7000
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0745
Cell Significance Index: -2.8200
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0820
Cell Significance Index: -2.1900
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.0874
Cell Significance Index: -0.9500
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: -0.0901
Cell Significance Index: -1.2500
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0957
Cell Significance Index: -1.6400
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0973
Cell Significance Index: -3.4100
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0996
Cell Significance Index: -3.2600
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.1009
Cell Significance Index: -1.3200
Cell Name: radial glial cell (CL0000681)
Fold Change: -0.1028
Cell Significance Index: -0.6100
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1084
Cell Significance Index: -2.7700
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.1092
Cell Significance Index: -3.1300
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1096
Cell Significance Index: -3.4900
Cell Name: proerythroblast (CL0000547)
Fold Change: -0.1117
Cell Significance Index: -1.6000
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.1131
Cell Significance Index: -1.2800
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.1161
Cell Significance Index: -1.7400
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.1188
Cell Significance Index: -1.3500
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.1199
Cell Significance Index: -2.9100
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.1215
Cell Significance Index: -3.5800
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1236
Cell Significance Index: -4.3000
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: -0.1252
Cell Significance Index: -0.9100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** H2AC15 is a ubiquitously expressed histone variant, found in all human tissues, with highest expression levels in epithelial cells, such as colon goblet cells, intestinal epithelial cells, and respiratory basal cells. Its expression is also significant in immune cells, including neutrophil progenitor cells, CD8-positive alpha-beta cytokine-secreting effector T cells, and intestinal crypt stem cells. Notably, H2AC15 is associated with specific cell types, including BEST4+ intestinal epithelial cells and tuft cells of the colon. **Pathways and Functions:** H2AC15 is involved in various chromatin-modifying pathways, including histone acetylation, deacetylation, and methylation. It interacts with histone acetyltransferases (HATs) and histone deacetylases (HDACs), influencing chromatin structure and gene expression. Additionally, H2AC15 is implicated in the regulation of protein binding, heterodimerization, and post-translational modification. Its role in deubiquitination and ubiquitin-specific processing proteases suggests that H2AC15 may also modulate protein degradation and turnover. **Clinical Significance:** The dysregulation of H2AC15 has been linked to various diseases, including infectious diseases, such as cytomegalovirus (HCMV) infection, which affects chromatin organization and gene expression. H2AC15 has also been implicated in cancer, where its expression is altered in various types of tumors. Furthermore, its role in immune regulation suggests that H2AC15 may be involved in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. The identification of H2AC15 as a potential biomarker for disease diagnosis and treatment is an area of ongoing research. **Infectious Disease Pathways:** H2AC15 has been implicated in HCMV early and late events, suggesting that it plays a crucial role in the regulation of chromatin structure and gene expression during viral infection. The interaction between H2AC15 and HCMV proteins, such as the viral protein Vmw139, may influence the host cell's response to infection, potentially contributing to the development of HCMV-related diseases. **Clinical Implications:** The study of H2AC15 has significant clinical implications for the diagnosis and treatment of infectious diseases, such as HCMV infection. Understanding the role of H2AC15 in chromatin organization and gene expression may lead to the development of novel therapeutic strategies, including the targeting of histone-modifying enzymes and the manipulation of chromatin structure to modulate the host cell's response to viral infection. In conclusion, H2AC15 is a multifunctional histone variant that plays a crucial role in immune regulation, cellular differentiation, and disease pathology. Further research is needed to fully elucidate the mechanisms by which H2AC15 influences chromatin structure and gene expression, as well as its clinical significance in various diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.