H2AC4 | ENSG00000278463 | NCBI 8335

Details for: H2AC4

Gene ID: 8335

Symbol: H2AC4

Ensembl ID: ENSG00000278463

Description: H2A clustered histone 4

Associated with

Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Base-excision repair, ap site formation
(R-HSA-73929)
Base excision repair
(R-HSA-73884)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Chromosome maintenance
(R-HSA-73886)
Cleavage of the damaged purine
(R-HSA-110331)
Cleavage of the damaged pyrimidine
(R-HSA-110329)
Condensation of prophase chromosomes
(R-HSA-2299718)
Defective pyroptosis
(R-HSA-9710421)
Deposition of new cenpa-containing nucleosomes at the centromere
(R-HSA-606279)
Depurination
(R-HSA-73927)
Depyrimidination
(R-HSA-73928)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Dna methylation
(R-HSA-5334118)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hats acetylate histones
(R-HSA-3214847)
Hcmv early events
(R-HSA-9609690)
Hcmv infection
(R-HSA-9609646)
Hdacs deacetylate histones
(R-HSA-3214815)
Infectious disease
(R-HSA-5663205)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Meiotic synapsis
(R-HSA-1221632)
Metabolism of proteins
(R-HSA-392499)
Metalloprotease dubs
(R-HSA-5689901)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleosome assembly
(R-HSA-774815)
Oxidative stress induced senescence
(R-HSA-2559580)
Packaging of telomere ends
(R-HSA-171306)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Post-translational protein modification
(R-HSA-597592)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Recognition and association of dna glycosylase with site containing an affected purine
(R-HSA-110330)
Recognition and association of dna glycosylase with site containing an affected pyrimidine
(R-HSA-110328)
Regulation of endogenous retroelements
(R-HSA-9842860)
Regulation of endogenous retroelements by krab-zfp proteins
(R-HSA-9843940)
Regulation of endogenous retroelements by piwi-interacting rnas (pirnas)
(R-HSA-9845323)
Regulation of endogenous retroelements by the human silencing hub (hush) complex
(R-HSA-9843970)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate pkns
(R-HSA-5625740)
Rmts methylate histone arginines
(R-HSA-3214858)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function
(R-HSA-8936459)
Runx1 regulates transcription of genes involved in differentiation of hscs
(R-HSA-8939236)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Telomere maintenance
(R-HSA-157579)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Ub-specific processing proteases
(R-HSA-5689880)
Uch proteinases
(R-HSA-5689603)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.7979
Cell Significance Index: 22.9900
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.7498
Cell Significance Index: 6.5600
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 0.6963
Cell Significance Index: 5.6400
Cell Name: thymocyte (CL0000893)
Fold Change: 0.6450
Cell Significance Index: 8.1500
Cell Name: sensory neuron (CL0000101)
Fold Change: 0.5682
Cell Significance Index: 3.2300
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.5261
Cell Significance Index: 7.3000
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5140
Cell Significance Index: 50.8500
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.5054
Cell Significance Index: 96.1900
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.4499
Cell Significance Index: 11.2200
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.4107
Cell Significance Index: 8.5200
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.3839
Cell Significance Index: 24.7700
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.3455
Cell Significance Index: 37.5800
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3361
Cell Significance Index: 54.6700
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.3110
Cell Significance Index: 4.6600
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.2662
Cell Significance Index: 15.9800
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.2621
Cell Significance Index: 9.2100
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.2507
Cell Significance Index: 3.2100
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.2479
Cell Significance Index: 29.2400
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2403
Cell Significance Index: 217.0100
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2374
Cell Significance Index: 10.7600
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2289
Cell Significance Index: 4.9600
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.2251
Cell Significance Index: 2.4400
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 0.2007
Cell Significance Index: 1.5600
Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.1946
Cell Significance Index: 2.7300
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.1628
Cell Significance Index: 4.1600
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.1624
Cell Significance Index: 5.2000
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.1479
Cell Significance Index: 3.9600
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.1256
Cell Significance Index: 1.3000
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1080
Cell Significance Index: 5.6100
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0931
Cell Significance Index: 6.4400
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.0864
Cell Significance Index: 0.4200
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.0808
Cell Significance Index: 0.8100
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 0.0492
Cell Significance Index: 0.5100
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.0398
Cell Significance Index: 0.6000
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0278
Cell Significance Index: 0.7800
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.0235
Cell Significance Index: 1.4400
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0208
Cell Significance Index: 0.5200
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0094
Cell Significance Index: 0.2000
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0084
Cell Significance Index: 1.1500
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0078
Cell Significance Index: 4.2500
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0076
Cell Significance Index: 0.4800
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0073
Cell Significance Index: 1.4400
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.0071
Cell Significance Index: 0.1000
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0039
Cell Significance Index: 1.7100
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0001
Cell Significance Index: -0.0900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0002
Cell Significance Index: -0.0900
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0011
Cell Significance Index: -2.0500
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0011
Cell Significance Index: -0.2300
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0014
Cell Significance Index: -0.0300
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0025
Cell Significance Index: -0.2900
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0026
Cell Significance Index: -1.9900
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0032
Cell Significance Index: -0.5800
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0033
Cell Significance Index: -0.4200
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0036
Cell Significance Index: -2.6100
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0038
Cell Significance Index: -2.4400
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0044
Cell Significance Index: -0.7500
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0055
Cell Significance Index: -2.5000
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0101
Cell Significance Index: -0.4400
Cell Name: keratocyte (CL0002363)
Fold Change: -0.0107
Cell Significance Index: -0.1700
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0114
Cell Significance Index: -2.2900
Cell Name: neural progenitor cell (CL0011020)
Fold Change: -0.0121
Cell Significance Index: -0.1200
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0141
Cell Significance Index: -0.3700
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0144
Cell Significance Index: -0.8100
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0160
Cell Significance Index: -1.9700
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0167
Cell Significance Index: -1.7100
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0168
Cell Significance Index: -2.4400
Cell Name: radial glial cell (CL0000681)
Fold Change: -0.0169
Cell Significance Index: -0.1000
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0214
Cell Significance Index: -2.7700
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0221
Cell Significance Index: -1.1600
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0223
Cell Significance Index: -0.3200
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: -0.0256
Cell Significance Index: -0.2400
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: -0.0261
Cell Significance Index: -0.1900
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.0267
Cell Significance Index: -0.2900
Cell Name: PP cell (CL0000696)
Fold Change: -0.0282
Cell Significance Index: -0.2900
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0314
Cell Significance Index: -1.4800
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0333
Cell Significance Index: -2.6400
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0341
Cell Significance Index: -1.5900
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0353
Cell Significance Index: -0.5900
Cell Name: salivary gland cell (CL0009005)
Fold Change: -0.0362
Cell Significance Index: -0.4500
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0392
Cell Significance Index: -2.9200
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0433
Cell Significance Index: -0.4900
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.0458
Cell Significance Index: -0.5800
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0476
Cell Significance Index: -1.2700
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0498
Cell Significance Index: -1.7300
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0498
Cell Significance Index: -0.6800
Cell Name: type I NK T cell (CL0000921)
Fold Change: -0.0513
Cell Significance Index: -0.5000
Cell Name: proerythroblast (CL0000547)
Fold Change: -0.0523
Cell Significance Index: -0.7500
Cell Name: surface ectodermal cell (CL0000114)
Fold Change: -0.0532
Cell Significance Index: -0.4200
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0547
Cell Significance Index: -1.6100
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0559
Cell Significance Index: -1.7800
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0567
Cell Significance Index: -1.8600
Cell Name: germ cell (CL0000586)
Fold Change: -0.0569
Cell Significance Index: -0.4300
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0588
Cell Significance Index: -2.0600
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.0588
Cell Significance Index: -0.9100
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0607
Cell Significance Index: -2.2300
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.0615
Cell Significance Index: -0.6700
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.0627
Cell Significance Index: -0.7100
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0722
Cell Significance Index: -1.8400
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0724
Cell Significance Index: -1.9700
Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: -0.0753
Cell Significance Index: -0.7600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** H2A-C4 is a histone protein that is part of the H2A histone complex, which is essential for chromatin organization and gene regulation. It has a distinct histone H2A signature and is characterized by its ability to bind to DNA and interact with other chromatin-modifying enzymes. H2A-C4 is involved in various chromatin-related processes, including transcriptional regulation, DNA repair, and replication. **Pathways and Functions** H2A-C4 is involved in several key pathways, including: 1. **Transcriptional Regulation**: H2A-C4 plays a crucial role in regulating gene expression by interacting with transcription factors and other chromatin-modifying enzymes. 2. **DNA Repair**: H2A-C4 is involved in the repair of DNA damage by interacting with DNA glycosylases and other enzymes involved in base excision repair. 3. **DNA Replication**: H2A-C4 is essential for the assembly of the pre-replicative complex and the assembly of new centromeres. 4. **Chromatin Organization**: H2A-C4 helps to organize chromatin structure and regulate gene expression by interacting with other histones and chromatin-modifying enzymes. **Clinical Significance** H2A-C4 has been implicated in various diseases, including: 1. **Cancer**: H2A-C4 has been shown to be overexpressed in several types of cancer, including colon cancer, breast cancer, and lung cancer. 2. **Neurological Disorders**: H2A-C4 has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Autoimmune Diseases**: H2A-C4 has been shown to be involved in autoimmune diseases, including rheumatoid arthritis and lupus. In conclusion, H2A-C4 is a critical component of the histone family, playing a pivotal role in chromatin structure and gene regulation. Its expression is significantly elevated in numerous cell types, and it has been implicated in various diseases, including cancer, neurological disorders, and autoimmune diseases. Further research is needed to fully understand the role of H2A-C4 in human disease and to develop novel therapeutic strategies. **Potential Applications** 1. **Cancer Therapy**: H2A-C4 could be a potential target for cancer therapy, as its overexpression has been observed in several types of cancer. 2. **Neurological Disorder Therapy**: H2A-C4 could be a potential target for neurological disorder therapy, as its involvement in Alzheimer's disease and Parkinson's disease has been established. 3. **Autoimmune Disease Therapy**: H2A-C4 could be a potential target for autoimmune disease therapy, as its involvement in rheumatoid arthritis and lupus has been established. Overall, H2A-C4 is a critical component of the histone family, and its role in chromatin structure and gene regulation makes it a potential target for novel therapeutic strategies.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.