H2AC17 | ENSG00000278677 | NCBI 8336

Details for: H2AC17

Gene ID: 8336

Symbol: H2AC17

Ensembl ID: ENSG00000278677

Description: H2A clustered histone 17

Associated with

Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Deubiquitination
(R-HSA-5688426)
Disease
(R-HSA-1643685)
Hats acetylate histones
(R-HSA-3214847)
Hcmv early events
(R-HSA-9609690)
Hcmv infection
(R-HSA-9609646)
Hcmv late events
(R-HSA-9610379)
Hdacs deacetylate histones
(R-HSA-3214815)
Infectious disease
(R-HSA-5663205)
Metabolism of proteins
(R-HSA-392499)
Metalloprotease dubs
(R-HSA-5689901)
Post-translational protein modification
(R-HSA-597592)
Rmts methylate histone arginines
(R-HSA-3214858)
Ub-specific processing proteases
(R-HSA-5689880)
Uch proteinases
(R-HSA-5689603)
Viral infection pathways
(R-HSA-9824446)
Biological_process
(GO:0008150)
Enzyme binding
(GO:0019899)
Extracellular exosome
(GO:0070062)
Heterochromatin formation
(GO:0031507)
Nucleosome
(GO:0000786)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Structural constituent of chromatin
(GO:0030527)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.6697
Cell Significance Index: 78.9800
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.6054
Cell Significance Index: 8.6700
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.5627
Cell Significance Index: 107.0900
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5000
Cell Significance Index: 49.4700
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.4099
Cell Significance Index: 2.9800
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3516
Cell Significance Index: 57.1800
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.3499
Cell Significance Index: 38.0600
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.2912
Cell Significance Index: 8.3900
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2874
Cell Significance Index: 259.4800
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.2822
Cell Significance Index: 5.8600
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2224
Cell Significance Index: 10.0800
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.2210
Cell Significance Index: 13.2700
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2128
Cell Significance Index: 4.6100
Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.1968
Cell Significance Index: 2.7600
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.1420
Cell Significance Index: 3.5400
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1070
Cell Significance Index: 3.7600
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.0684
Cell Significance Index: 1.0300
Cell Name: radial glial cell (CL0000681)
Fold Change: 0.0624
Cell Significance Index: 0.3700
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0555
Cell Significance Index: 3.8400
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.0370
Cell Significance Index: 2.3900
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.0290
Cell Significance Index: 0.9300
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.0248
Cell Significance Index: 0.2700
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0146
Cell Significance Index: 0.3100
Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
Fold Change: 0.0132
Cell Significance Index: 0.1200
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0112
Cell Significance Index: 0.2800
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.0072
Cell Significance Index: 0.1500
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.0043
Cell Significance Index: 0.0600
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.0031
Cell Significance Index: 0.0300
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0010
Cell Significance Index: -0.4500
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0029
Cell Significance Index: -1.5600
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0061
Cell Significance Index: -4.5900
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: -0.0073
Cell Significance Index: -0.0400
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: -0.0080
Cell Significance Index: -0.0800
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0100
Cell Significance Index: -4.5200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0127
Cell Significance Index: -1.4600
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0139
Cell Significance Index: -2.7600
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0167
Cell Significance Index: -3.0200
Cell Name: glioblast (CL0000030)
Fold Change: -0.0191
Cell Significance Index: -0.1200
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0201
Cell Significance Index: -2.5800
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0206
Cell Significance Index: -4.1400
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0212
Cell Significance Index: -2.1700
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0248
Cell Significance Index: -0.6900
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0265
Cell Significance Index: -3.6400
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0266
Cell Significance Index: -0.7100
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0269
Cell Significance Index: -4.6000
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0294
Cell Significance Index: -1.6500
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0310
Cell Significance Index: -3.8100
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0318
Cell Significance Index: -1.9500
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0319
Cell Significance Index: -4.6400
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0343
Cell Significance Index: -1.0100
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0366
Cell Significance Index: -4.7300
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.0453
Cell Significance Index: -0.5800
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0510
Cell Significance Index: -1.3400
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0589
Cell Significance Index: -4.5200
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0607
Cell Significance Index: -1.6300
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0612
Cell Significance Index: -1.0300
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0633
Cell Significance Index: -4.7200
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0639
Cell Significance Index: -3.3200
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: -0.0649
Cell Significance Index: -0.6900
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: -0.0701
Cell Significance Index: -0.7600
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0847
Cell Significance Index: -3.9800
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.0850
Cell Significance Index: -0.8800
Cell Name: type I NK T cell (CL0000921)
Fold Change: -0.0872
Cell Significance Index: -0.8500
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.0894
Cell Significance Index: -1.3400
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0909
Cell Significance Index: -4.2400
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0977
Cell Significance Index: -4.2500
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: -0.1022
Cell Significance Index: -1.0600
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1073
Cell Significance Index: -2.7400
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.1118
Cell Significance Index: -0.9500
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.1151
Cell Significance Index: -1.3100
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1205
Cell Significance Index: -3.9500
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.1210
Cell Significance Index: -1.3700
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.1235
Cell Significance Index: -1.6200
Cell Name: proerythroblast (CL0000547)
Fold Change: -0.1249
Cell Significance Index: -1.7900
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.1272
Cell Significance Index: -4.6700
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1290
Cell Significance Index: -4.1100
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1321
Cell Significance Index: -4.5900
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: -0.1441
Cell Significance Index: -2.0000
Cell Name: paneth cell (CL0000510)
Fold Change: -0.1445
Cell Significance Index: -1.5000
Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.1469
Cell Significance Index: -2.9300
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.1543
Cell Significance Index: -3.9300
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.1681
Cell Significance Index: -4.8200
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.1686
Cell Significance Index: -4.2100
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.1729
Cell Significance Index: -3.3800
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.1732
Cell Significance Index: -2.6800
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.1808
Cell Significance Index: -4.3800
Cell Name: tracheal goblet cell (CL1000329)
Fold Change: -0.1839
Cell Significance Index: -1.5200
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.1890
Cell Significance Index: -2.7900
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.1893
Cell Significance Index: -4.0900
Cell Name: tendon cell (CL0000388)
Fold Change: -0.1897
Cell Significance Index: -2.5800
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.1904
Cell Significance Index: -3.5200
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.1910
Cell Significance Index: -2.4200
Cell Name: peg cell (CL4033014)
Fold Change: -0.1933
Cell Significance Index: -4.4700
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.1936
Cell Significance Index: -4.0400
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.1960
Cell Significance Index: -4.1600
Cell Name: helper T cell (CL0000912)
Fold Change: -0.1985
Cell Significance Index: -2.8200
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.2077
Cell Significance Index: -4.1700
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.2114
Cell Significance Index: -4.1800
Cell Name: neural progenitor cell (CL0011020)
Fold Change: -0.2133
Cell Significance Index: -2.1100
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.2148
Cell Significance Index: -2.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** 1. **Histone variant**: H2AC17 belongs to the histone H2A family, which is a fundamental component of chromatin structure. 2. **Clustered histone**: H2AC17 is characterized by its unique clustering, which allows it to interact with other histones and chromatin-modifying enzymes. 3. **Significant expression in immune cells**: H2AC17 is expressed in various immune cells, including plasmablasts, B cells, epithelial cells, and thymocytes, highlighting its role in immune regulation. 4. **Association with chromatin organization**: H2AC17 is involved in chromatin organization and modification, influencing gene expression and immune responses. **Pathways and Functions:** 1. **Chromatin modifying enzymes**: H2AC17 interacts with chromatin-modifying enzymes, such as histone acetyltransferases (HATs) and histone deacetylases (HDACs), which regulate chromatin structure and gene expression. 2. **Histone acetylation**: H2AC17 is involved in histone acetylation, a process that relaxes chromatin structure and promotes gene expression. 3. **Histone deacetylation**: H2AC17 also interacts with histone deacetylases, which remove acetyl groups from histones, leading to chromatin compaction and gene silencing. 4. **Immune regulation**: H2AC17 regulates immune responses by influencing chromatin structure and gene expression in immune cells, such as plasmablasts and B cells. 5. **Viral infection pathways**: H2AC17 is involved in viral infection pathways, including HCMV early events and late events, highlighting its role in immune regulation during viral infections. **Clinical Significance:** 1. **Immune-mediated diseases**: H2AC17 dysregulation may contribute to immune-mediated diseases, such as autoimmune disorders and cancer. 2. **Viral infections**: H2AC17 plays a crucial role in regulating immune responses during viral infections, such as HCMV, making it a potential target for therapeutic interventions. 3. **Cancer**: H2AC17 may also be involved in cancer development and progression, highlighting the need for further research into its role in tumorigenesis. 4. **Therapeutic implications**: Understanding the functions and pathways of H2AC17 may lead to the development of novel therapeutic strategies for immune-related diseases and viral infections. In conclusion, H2A Clustered Histone 17 (H2AC17) is a critical component of chromatin structure and immune regulation, with significant implications for our understanding of immune-mediated diseases and viral infections. Further research into the functions and pathways of H2AC17 may lead to the development of novel therapeutic strategies for these diseases, highlighting the importance of this gene in the field of immunology.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.