Gene H2AC17 - ENSG00000278677 | NCBI Gene ID: 8336

Details for: H2AC17

Gene ID: 8336

Symbol: H2AC17

Ensembl ID: ENSG00000278677

Description: H2A clustered histone 17

Associated with

Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Deubiquitination
(R-HSA-5688426)
Disease
(R-HSA-1643685)
Hats acetylate histones
(R-HSA-3214847)
Hcmv early events
(R-HSA-9609690)
Hcmv infection
(R-HSA-9609646)
Hcmv late events
(R-HSA-9610379)
Hdacs deacetylate histones
(R-HSA-3214815)
Infectious disease
(R-HSA-5663205)
Metabolism of proteins
(R-HSA-392499)
Metalloprotease dubs
(R-HSA-5689901)
Post-translational protein modification
(R-HSA-597592)
Rmts methylate histone arginines
(R-HSA-3214858)
Ub-specific processing proteases
(R-HSA-5689880)
Uch proteinases
(R-HSA-5689603)
Viral infection pathways
(R-HSA-9824446)
Biological_process
(GO:0008150)
Enzyme binding
(GO:0019899)
Extracellular exosome
(GO:0070062)
Heterochromatin organization
(GO:0070828)
Nucleosomal dna binding
(GO:0031492)
Nucleosome
(GO:0000786)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Structural constituent of chromatin
(GO:0030527)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.6
Marker Score: 1163
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 0.98
Marker Score: 2662
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 501
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.96
Marker Score: 454
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.89
Marker Score: 319
Cell Name: plasmablast (CL0000980)
Fold Change: 0.84
Marker Score: 1122
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.76
Marker Score: 2262
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.7
Marker Score: 496
Cell Name: thymocyte (CL0000893)
Fold Change: 0.68
Marker Score: 707
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.67
Marker Score: 172
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.66
Marker Score: 503.5
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.66
Marker Score: 696.5
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.65
Marker Score: 2744.5
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.63
Marker Score: 253
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.62
Marker Score: 1291.5
Cell Name: germ cell (CL0000586)
Fold Change: 0.59
Marker Score: 1039
Cell Name: respiratory basal cell (CL0002633)
Fold Change: 0.57
Marker Score: 822
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.56
Marker Score: 419.5
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.49
Marker Score: 310.5
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.48
Marker Score: 467
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.46
Marker Score: 459
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.45
Marker Score: 145
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: 0.45
Marker Score: 174.5
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.44
Marker Score: 250
Cell Name: promyelocyte (CL0000836)
Fold Change: 0.44
Marker Score: 217
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.41
Marker Score: 215
Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.41
Marker Score: 509
Cell Name: osteoclast (CL0000092)
Fold Change: 0.39
Marker Score: 196
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.36
Marker Score: 95
Cell Name: pre-conventional dendritic cell (CL0002010)
Fold Change: 0.35
Marker Score: 104
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: 0.35
Marker Score: 173
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 0.34
Marker Score: 99
Cell Name: proerythroblast (CL0000547)
Fold Change: 0.32
Marker Score: 215
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 0.3
Marker Score: 313.5
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.3
Marker Score: 95
Cell Name: late pro-B cell (CL0002048)
Fold Change: 0.3
Marker Score: 350
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 0.28
Marker Score: 336
Cell Name: Unknown (CL0000548)
Fold Change: 0.27
Marker Score: 196
Cell Name: blood cell (CL0000081)
Fold Change: 0.27
Marker Score: 3096
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 0.26
Marker Score: 92
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.26
Marker Score: 82
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 0.26
Marker Score: 506
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.25
Marker Score: 159
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.25
Marker Score: 138
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.24
Marker Score: 129
Cell Name: preosteoblast (CL0007010)
Fold Change: 0.24
Marker Score: 69
Cell Name: renal principal cell (CL0005009)
Fold Change: 0.23
Marker Score: 181
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.23
Marker Score: 247
Cell Name: mesothelial cell (CL0000077)
Fold Change: 0.23
Marker Score: 93
Cell Name: myelocyte (CL0002193)
Fold Change: 0.22
Marker Score: 97
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 0.22
Marker Score: 148
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 0.22
Marker Score: 159
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.22
Marker Score: 69
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 62
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 0.21
Marker Score: 301
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.21
Marker Score: 71
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.2
Marker Score: 204
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 0.2
Marker Score: 94
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.2
Marker Score: 71
Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.2
Marker Score: 1158
Cell Name: lung neuroendocrine cell (CL1000223)
Fold Change: 0.19
Marker Score: 55
Cell Name: exhausted T cell (CL0011025)
Fold Change: 0.19
Marker Score: 111
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 0.19
Marker Score: 284
Cell Name: B-2 B cell (CL0000822)
Fold Change: 0.19
Marker Score: 235
Cell Name: tracheal goblet cell (CL1000329)
Fold Change: 0.19
Marker Score: 539
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.19
Marker Score: 1871
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.18
Marker Score: 112
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.18
Marker Score: 119
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 0.17
Marker Score: 485
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 0.17
Marker Score: 167
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.17
Marker Score: 72
Cell Name: centroblast (CL0009112)
Fold Change: 0.17
Marker Score: 83
Cell Name: germinal center B cell (CL0000844)
Fold Change: 0.17
Marker Score: 101
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 0.17
Marker Score: 81
Cell Name: oogonial cell (CL0000024)
Fold Change: 0.16
Marker Score: 237
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: 0.16
Marker Score: 43
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 0.16
Marker Score: 398
Cell Name: eosinophil (CL0000771)
Fold Change: 0.16
Marker Score: 53
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 0.16
Marker Score: 510
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 0.16
Marker Score: 508
Cell Name: male germ cell (CL0000015)
Fold Change: 0.16
Marker Score: 46
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.16
Marker Score: 259
Cell Name: granulocyte (CL0000094)
Fold Change: 0.16
Marker Score: 71
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 0.16
Marker Score: 138
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.16
Marker Score: 420
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 0.16
Marker Score: 156
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.15
Marker Score: 361
Cell Name: memory T cell (CL0000813)
Fold Change: 0.15
Marker Score: 65
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 0.15
Marker Score: 52
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.15
Marker Score: 408
Cell Name: osteoblast (CL0000062)
Fold Change: 0.15
Marker Score: 80
Cell Name: pericyte (CL0000669)
Fold Change: 0.15
Marker Score: 87
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.15
Marker Score: 308
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.15
Marker Score: 946
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.15
Marker Score: 36
Cell Name: pre-B-I cell (CL0000956)
Fold Change: 0.14
Marker Score: 37
Cell Name: basophil mast progenitor cell (CL0002028)
Fold Change: 0.14
Marker Score: 44
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.14
Marker Score: 365
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.14
Marker Score: 7505
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.14
Marker Score: 111

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Other Information

Description

**Key Characteristics:** 1. **Histone variant**: H2AC17 belongs to the histone H2A family, which is a fundamental component of chromatin structure. 2. **Clustered histone**: H2AC17 is characterized by its unique clustering, which allows it to interact with other histones and chromatin-modifying enzymes. 3. **Significant expression in immune cells**: H2AC17 is expressed in various immune cells, including plasmablasts, B cells, epithelial cells, and thymocytes, highlighting its role in immune regulation. 4. **Association with chromatin organization**: H2AC17 is involved in chromatin organization and modification, influencing gene expression and immune responses. **Pathways and Functions:** 1. **Chromatin modifying enzymes**: H2AC17 interacts with chromatin-modifying enzymes, such as histone acetyltransferases (HATs) and histone deacetylases (HDACs), which regulate chromatin structure and gene expression. 2. **Histone acetylation**: H2AC17 is involved in histone acetylation, a process that relaxes chromatin structure and promotes gene expression. 3. **Histone deacetylation**: H2AC17 also interacts with histone deacetylases, which remove acetyl groups from histones, leading to chromatin compaction and gene silencing. 4. **Immune regulation**: H2AC17 regulates immune responses by influencing chromatin structure and gene expression in immune cells, such as plasmablasts and B cells. 5. **Viral infection pathways**: H2AC17 is involved in viral infection pathways, including HCMV early events and late events, highlighting its role in immune regulation during viral infections. **Clinical Significance:** 1. **Immune-mediated diseases**: H2AC17 dysregulation may contribute to immune-mediated diseases, such as autoimmune disorders and cancer. 2. **Viral infections**: H2AC17 plays a crucial role in regulating immune responses during viral infections, such as HCMV, making it a potential target for therapeutic interventions. 3. **Cancer**: H2AC17 may also be involved in cancer development and progression, highlighting the need for further research into its role in tumorigenesis. 4. **Therapeutic implications**: Understanding the functions and pathways of H2AC17 may lead to the development of novel therapeutic strategies for immune-related diseases and viral infections. In conclusion, H2A Clustered Histone 17 (H2AC17) is a critical component of chromatin structure and immune regulation, with significant implications for our understanding of immune-mediated diseases and viral infections. Further research into the functions and pathways of H2AC17 may lead to the development of novel therapeutic strategies for these diseases, highlighting the importance of this gene in the field of immunology.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.