H3C10 | ENSG00000278828 | NCBI 8357

Details for: H3C10

Associated with

Activated pkn1 stimulates transcription of ar (androgen receptor) regulated genes klk2 and klk3
(R-HSA-5625886)
Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromatin modifying enzymes
(R-HSA-3247509)
Condensation of prophase chromosomes
(R-HSA-2299718)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective pyroptosis
(R-HSA-9710421)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna methylation
(R-HSA-5334118)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of adipogenesis genes by mll3 and mll4 complexes
(R-HSA-9851695)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hats acetylate histones
(R-HSA-3214847)
Hcmv early events
(R-HSA-9609690)
Hcmv infection
(R-HSA-9609646)
Hcmv late events
(R-HSA-9610379)
Hdacs deacetylate histones
(R-HSA-3214815)
Hdms demethylate histones
(R-HSA-3214842)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Interleukin-7 signaling
(R-HSA-1266695)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Metabolism of proteins
(R-HSA-392499)
Mitotic prophase
(R-HSA-68875)
Mll4 and mll3 complexes regulate expression of pparg target genes in adipogenesis and hepatic steatosis
(R-HSA-9841922)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Norc negatively regulates rrna expression
(R-HSA-427413)
Oxidative stress induced senescence
(R-HSA-2559580)
Pkmts methylate histone lysines
(R-HSA-3214841)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Regulation of endogenous retroelements
(R-HSA-9842860)
Regulation of endogenous retroelements by krab-zfp proteins
(R-HSA-9843940)
Regulation of endogenous retroelements by piwi-interacting rnas (pirnas)
(R-HSA-9845323)
Regulation of endogenous retroelements by the human silencing hub (hush) complex
(R-HSA-9843970)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate pkns
(R-HSA-5625740)
Rmts methylate histone arginines
(R-HSA-3214858)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function
(R-HSA-8936459)
Runx1 regulates transcription of genes involved in differentiation of hscs
(R-HSA-8939236)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by interleukins
(R-HSA-449147)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Viral infection pathways
(R-HSA-9824446)
Cadherin binding
(GO:0045296)
Chromatin organization
(GO:0006325)
Dna binding
(GO:0003677)
Epigenetic regulation of gene expression
(GO:0040029)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Gene expression
(GO:0010467)
Membrane
(GO:0016020)
Nucleoplasm
(GO:0005654)
Nucleosome
(GO:0000786)
Nucleosome assembly
(GO:0006334)
Nucleus
(GO:0005634)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Structural constituent of chromatin
(GO:0030527)
Telomere organization
(GO:0032200)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

early lymphoid progenitor CL0000936

CSI 9.57

rCSI 8.4%

PRS 93.42
IgA plasma cell CL0000987

CSI 7.41

rCSI 7.59%

PRS 92.38
megakaryocyte CL0000556

CSI 5.05

rCSI 21.92%

PRS 91.85
pro-B cell CL0000826

CSI 3.79

rCSI 3.14%

PRS 91.82
intestine goblet cell CL0019031

CSI 3.61

rCSI 3.21%

PRS 88.33
intestinal tuft cell CL0019032

CSI 3.2

rCSI 4.89%

PRS 92.37
double-positive, alpha-beta thymocyte CL0000809

CSI 2.84

rCSI 2.89%

PRS 95.26
fraction A pre-pro B cell CL0002045

CSI 2.69

rCSI 3.08%

PRS 94.34
erythrocyte CL0000232

CSI 2.68

rCSI 6.08%

PRS 89
platelet CL0000233

CSI 2.6

rCSI 10.8%

PRS 87.3
colon epithelial cell CL0011108

CSI 2.18

rCSI 2.29%

PRS 88.54
megakaryocyte-erythroid progenitor cell CL0000050

CSI 1.68

rCSI 1.51%

PRS 89.32
promonocyte CL0000559

CSI 1.62

rCSI 2.78%

PRS 92.57
basal cell of epidermis CL0002187

CSI 1.53

rCSI 2.72%

PRS 62.39
melanocyte of skin CL1000458

CSI 1.42

rCSI 1.94%

PRS 62.08
large pre-B-II cell CL0000957

CSI 1.27

rCSI 3.61%

PRS 90.83
primitive red blood cell CL0002355

CSI 1.18

rCSI 6.38%

PRS 92.37
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 0.93

rCSI 1.12%

PRS 72
group 2 innate lymphoid cell CL0001069

CSI 0.47

rCSI 2.53%

PRS 97.77

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description

## Summary [H3C10](/details-gene/8357) is a protein-coding gene that encodes a replication-dependent core histone H3. As a fundamental component of the nucleosome, [H3C10](/details-gene/8357) plays a central role in DNA packaging, chromatin structure, and the epigenetic regulation of gene expression. Its primary function is to serve as a structural scaffold for DNA, and modifications to its N-terminal tail are critical for modulating transcriptional activity. **Overall**, expression data indicates that [H3C10](/details-gene/8357) is a gene of high significance in rapidly proliferating and differentiating cell populations. It is particularly prominent in hematopoietic progenitors, such as the [early lymphoid progenitor](/details-cell/CL0000936), and in terminally differentiated cells with high secretory activity, including the [IgA plasma cell](/details-cell/CL0000987) and [intestine goblet cell](/details-cell/CL0019031), suggesting a critical role in establishing and maintaining specialized cellular states. ## Cellular Roles and Expression Landscape The expression profile of [H3C10](/details-gene/8357) underscores its essential function in cell division, differentiation, and specialized transcriptional programs. A detailed analysis reveals two major functional clusters where the gene holds high significance. First, [H3C10](/details-gene/8357) is a key marker across multiple stages of hematopoiesis. Its highest significance is observed in the [early lymphoid progenitor](/details-cell/CL0000936) (CSI: 9.57), indicating a foundational role in the development of the lymphoid lineage. High significance is also noted in various committed progenitors and their differentiated progeny, including [IgA plasma cell](/details-cell/CL0000987), [megakaryocyte](/details-cell/CL0000556), [pro-B cell](/details-cell/CL0000826), [double-positive, alpha-beta thymocyte](/details-cell/CL0000809), [megakaryocyte-erythroid progenitor cell](/details-cell/CL0000050), and [platelet](/details-cell/CL0000233). This widespread importance across hematopoietic lineages suggests that [H3C10](/details-gene/8357) is indispensable for the extensive cell division and chromatin remodeling required to generate the diverse cell types of the immune system and blood. Second, [H3C10](/details-gene/8357) shows significant expression in specialized epithelial and secretory cells that undergo constant renewal or have high metabolic activity. This includes high significance in [intestine goblet cell](/details-cell/CL0019031), [intestinal tuft cell](/details-cell/CL0019032), and [colon epithelial cell](/details-cell/CL0011108). Its role in the [basal cell of epidermis](/details-cell/CL0002187) is consistent with its function in maintaining the proliferative capacity of skin tissue. This pattern suggests that beyond general cell division, [H3C10](/details-gene/8357) is involved in organizing the chromatin architecture necessary for the high-level transcription of lineage-specific genes, such as mucins in goblet cells or immunoglobulins in plasma cells. The absence of neuronal, muscle, or mature stromal cells from the top expression list further refines its role to highly dynamic and proliferative cell populations. ## Pathways and Molecular Function The functional annotations for [H3C10](/details-gene/8357) confirm its identity as a cornerstone of nuclear biology. Gene Ontology terms place it centrally within [Chromatin organization](/details-go/GO:0006325), [Nucleosome assembly](/details-go/GO:0006334), and [Epigenetic regulation of gene expression](/details-go/GO:0040029). As a [Structural constituent of chromatin](/details-go/GO:0030527), it directly participates in the physical compaction of the genome. Its molecular functions include [Dna binding](/details-go/GO:0003677) and [Protein binding](/details-go/GO:0005515), reflecting its role within the octameric histone core and its interaction with chromatin-modifying enzymes. Reactome pathway analysis provides a granular view of its involvement in cellular processes. The gene is integral to fundamental mechanisms such as [Cell cycle](/details-reactome/R-HSA-1640170), [Dna replication](/details-reactome/R-HSA-69306), and [Gene expression (transcription)](/details-reactome/R-HSA-74160). Its association with pathways like [Chromatin modifying enzymes](/details-reactome/R-HSA-3247509) and [Epigenetic regulation of gene expression](/details-reactome/R-HSA-212165) highlights that it is not merely a static structural component but a dynamic substrate for signals that control gene accessibility. This is highly consistent with its significant expression in differentiating hematopoietic cells, which rely on pathways such as [Transcriptional regulation by runx1](/details-reactome/R-HSA-8878171) and [Signaling by interleukins](/details-reactome/R-HSA-449147). Furthermore, its role in broad developmental programs like [Developmental biology](/details-reactome/R-HSA-1266738) aligns with its importance in progenitor cell populations. ## Research Directions Based on its expression profile and functional annotations, [H3C10](/details-gene/8357) presents several avenues for future investigation, particularly concerning its role in cell-type-specific gene regulation and disease. ### Proposed Hypotheses: 1. **Hypothesis 1:** The high significance of [H3C10](/details-gene/8357) in terminally differentiated, high-output secretory cells like [IgA plasma cell](/details-cell/CL0000987) and [intestine goblet cell](/details-cell/CL0019031) suggests that its incorporation or specific post-translational modification patterns are critical for establishing and maintaining the open chromatin domains required for massive transcription of secretory products (e.g., immunoglobulins, mucins). 2. **Hypothesis 2:** Given its top-ranking significance in [early lymphoid progenitor](/details-cell/CL0000936), dysregulation of [H3C10](/details-gene/8357) expression or deposition may be an early event in lymphoid malignancies. Altered levels of [H3C10](/details-gene/8357) could disrupt the epigenetic landscape, leading to a block in differentiation and promoting uncontrolled proliferation. ### Key Experiment: To test the first hypothesis, a targeted experiment could be designed to investigate the role of [H3C10](/details-gene/8357) in plasma cell function. * **Approach:** Utilize an *in vitro* B-cell to plasma cell differentiation model. Introduce a doxycycline-inducible shRNA or CRISPR interference (CRISPRi) system targeting [H3C10](/details-gene/8357] into primary human B cells before initiating differentiation. Upon differentiation, induce knockdown of [H3C10](/details-gene/8357). The functional consequences would be assessed by measuring immunoglobulin secretion via ELISA. Mechanistically, changes in chromatin accessibility at the immunoglobulin heavy and light chain loci could be profiled using ATAC-seq, and key histone modifications could be mapped with ChIP-seq to determine if loss of [H3C10](/details-gene/8357) disrupts the active chromatin state. ### Therapeutic Potential: As a core histone, [H3C10](/details-gene/8357) itself is a poor therapeutic target for direct inhibition due to its ubiquitous and essential role in all dividing cells, which would likely lead to severe, non-specific toxicity. However, the processes that regulate its function, particularly the "writer" and "eraser" enzymes that add or remove post-translational modifications, are highly attractive drug targets. Given its link to proliferation and differentiation, therapies targeting the specific histone acetyltransferases (HATs) or methyltransferases that act on [H3C10](/details-gene/8357) in malignant cells could offer a more precise strategy. Therefore, while direct targeting is unadvisable, understanding the specific regulatory network around [H3C10](/details-gene/8357) in cancers with high hematopoietic involvement could reveal novel avenues for epigenetic-based therapies.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.