H3C10 | ENSG00000278828 | NCBI 8357

Details for: H3C10

Gene ID: 8357

Symbol: H3C10

Ensembl ID: ENSG00000278828

Description: H3 clustered histone 10

Associated with

Activated pkn1 stimulates transcription of ar (androgen receptor) regulated genes klk2 and klk3
(R-HSA-5625886)
Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromatin modifying enzymes
(R-HSA-3247509)
Condensation of prophase chromosomes
(R-HSA-2299718)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective pyroptosis
(R-HSA-9710421)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna methylation
(R-HSA-5334118)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of adipogenesis genes by mll3 and mll4 complexes
(R-HSA-9851695)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hats acetylate histones
(R-HSA-3214847)
Hcmv early events
(R-HSA-9609690)
Hcmv infection
(R-HSA-9609646)
Hcmv late events
(R-HSA-9610379)
Hdacs deacetylate histones
(R-HSA-3214815)
Hdms demethylate histones
(R-HSA-3214842)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Interleukin-7 signaling
(R-HSA-1266695)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Metabolism of proteins
(R-HSA-392499)
Mitotic prophase
(R-HSA-68875)
Mll4 and mll3 complexes regulate expression of pparg target genes in adipogenesis and hepatic steatosis
(R-HSA-9841922)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Norc negatively regulates rrna expression
(R-HSA-427413)
Oxidative stress induced senescence
(R-HSA-2559580)
Pkmts methylate histone lysines
(R-HSA-3214841)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Regulation of endogenous retroelements
(R-HSA-9842860)
Regulation of endogenous retroelements by krab-zfp proteins
(R-HSA-9843940)
Regulation of endogenous retroelements by piwi-interacting rnas (pirnas)
(R-HSA-9845323)
Regulation of endogenous retroelements by the human silencing hub (hush) complex
(R-HSA-9843970)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate pkns
(R-HSA-5625740)
Rmts methylate histone arginines
(R-HSA-3214858)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function
(R-HSA-8936459)
Runx1 regulates transcription of genes involved in differentiation of hscs
(R-HSA-8939236)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by interleukins
(R-HSA-449147)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Viral infection pathways
(R-HSA-9824446)
Cadherin binding
(GO:0045296)
Chromatin organization
(GO:0006325)
Dna binding
(GO:0003677)
Gene expression
(GO:0010467)
Nucleosome assembly
(GO:0006334)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Structural constituent of chromatin
(GO:0030527)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 12.6753
Cell Significance Index: -6.5200
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 2.0663
Cell Significance Index: 21.3900
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.5632
Cell Significance Index: 45.0400
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 1.1759
Cell Significance Index: 17.6200
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 1.0060
Cell Significance Index: -3.0900
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.9670
Cell Significance Index: 62.3900
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.9007
Cell Significance Index: 171.4100
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.8641
Cell Significance Index: 18.7200
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.7768
Cell Significance Index: 19.3700
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.7652
Cell Significance Index: 6.6900
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.7383
Cell Significance Index: 33.4700
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.5426
Cell Significance Index: 5.8800
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4719
Cell Significance Index: 426.1200
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.4418
Cell Significance Index: 48.0500
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.4358
Cell Significance Index: 9.0400
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.4268
Cell Significance Index: 69.4200
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.3583
Cell Significance Index: 12.5900
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.3560
Cell Significance Index: 4.9400
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.3510
Cell Significance Index: 4.5000
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.3345
Cell Significance Index: 20.0800
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.3264
Cell Significance Index: 8.7300
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.2724
Cell Significance Index: 32.1200
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2223
Cell Significance Index: 15.3700
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1799
Cell Significance Index: 17.8000
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1088
Cell Significance Index: 5.6500
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.0948
Cell Significance Index: 9.6800
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.0695
Cell Significance Index: 3.6500
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.0471
Cell Significance Index: 1.5100
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0420
Cell Significance Index: 1.0500
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.0411
Cell Significance Index: 1.0500
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0384
Cell Significance Index: 4.9200
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0361
Cell Significance Index: 19.7200
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.0330
Cell Significance Index: 0.6900
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0322
Cell Significance Index: 0.9000
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0305
Cell Significance Index: 5.4900
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0277
Cell Significance Index: 0.5900
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0185
Cell Significance Index: 8.1700
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.0175
Cell Significance Index: 0.1900
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0081
Cell Significance Index: 1.6100
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0004
Cell Significance Index: -0.2800
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0005
Cell Significance Index: -0.3000
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0018
Cell Significance Index: -0.3900
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0023
Cell Significance Index: -0.1200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0031
Cell Significance Index: -5.8500
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0039
Cell Significance Index: -0.1600
Cell Name: urothelial cell (CL0000731)
Fold Change: -0.0043
Cell Significance Index: -0.0300
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0055
Cell Significance Index: -0.7600
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0072
Cell Significance Index: -5.4400
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0082
Cell Significance Index: -6.0100
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: -0.0088
Cell Significance Index: -0.0900
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0095
Cell Significance Index: -6.0300
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0105
Cell Significance Index: -0.4600
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0137
Cell Significance Index: -1.5700
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0141
Cell Significance Index: -0.3600
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0147
Cell Significance Index: -6.6500
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0147
Cell Significance Index: -5.2800
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: -0.0199
Cell Significance Index: -0.2500
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0217
Cell Significance Index: -3.7100
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0235
Cell Significance Index: -2.9000
Cell Name: slow muscle cell (CL0000189)
Fold Change: -0.0247
Cell Significance Index: -0.3700
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0260
Cell Significance Index: -1.8400
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0266
Cell Significance Index: -5.3300
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0322
Cell Significance Index: -0.8600
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0356
Cell Significance Index: -2.1800
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: -0.0387
Cell Significance Index: -0.4000
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0400
Cell Significance Index: -2.5200
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0421
Cell Significance Index: -6.1200
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.0435
Cell Significance Index: -0.6100
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0451
Cell Significance Index: -0.5100
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0488
Cell Significance Index: -6.3000
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0527
Cell Significance Index: -1.3900
Cell Name: radial glial cell (CL0000681)
Fold Change: -0.0590
Cell Significance Index: -0.3500
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0596
Cell Significance Index: -2.8000
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.0597
Cell Significance Index: -0.9000
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0617
Cell Significance Index: -3.4600
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0689
Cell Significance Index: -0.9400
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0782
Cell Significance Index: -6.1900
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0795
Cell Significance Index: -1.3300
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.0830
Cell Significance Index: -0.9400
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0868
Cell Significance Index: -6.6600
Cell Name: helper T cell (CL0000912)
Fold Change: -0.0929
Cell Significance Index: -1.3200
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0970
Cell Significance Index: -7.2300
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.1014
Cell Significance Index: -2.7600
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: -0.1035
Cell Significance Index: -0.6800
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.1071
Cell Significance Index: -0.9100
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.1159
Cell Significance Index: -1.6600
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1190
Cell Significance Index: -5.5500
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1298
Cell Significance Index: -4.5100
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1338
Cell Significance Index: -5.9200
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.1346
Cell Significance Index: -4.9400
Cell Name: proerythroblast (CL0000547)
Fold Change: -0.1382
Cell Significance Index: -1.9800
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.1501
Cell Significance Index: -2.7800
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.1525
Cell Significance Index: -3.8100
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.1566
Cell Significance Index: -5.9300
Cell Name: thymocyte (CL0000893)
Fold Change: -0.1650
Cell Significance Index: -2.0900
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1706
Cell Significance Index: -5.4400
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1718
Cell Significance Index: -6.0200
Cell Name: neural progenitor cell (CL0011020)
Fold Change: -0.1728
Cell Significance Index: -1.7100
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1770
Cell Significance Index: -5.8000
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: -0.1774
Cell Significance Index: -1.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** 1. **Chromatin organization**: CH10 is involved in the assembly of the pre-replicative complex and the origin of replication, suggesting its role in chromatin organization and DNA replication. 2. **Transcriptional regulation**: CH10 has been shown to regulate the expression of genes involved in differentiation, development, and immune responses, highlighting its importance in transcriptional regulation. 3. **Cell cycle progression**: CH10 has been implicated in the regulation of cell cycle progression, particularly during mitosis, suggesting its role in cell cycle control. 4. **Immune system**: CH10 has been shown to be involved in immune responses, including cytokine signaling and immune system development, highlighting its potential as a therapeutic target. 5. **Disease association**: CH10 has been implicated in various disease processes, including programmed cell death, viral infections, and cancer, suggesting its potential as a diagnostic or therapeutic target. **Pathways and Functions** 1. **Activated pkn1 stimulates transcription**: CH10 is activated by Protein Kinase 1 (PK1), which stimulates the transcription of androgen-regulated genes, including KLK2 and KLK3. 2. **Anterior hox genes**: CH10 is involved in the activation of anterior Hox genes in hindbrain development during early embryogenesis. 3. **Amyloid fiber formation**: CH10 has been implicated in the formation of amyloid fibers, a hallmark of neurodegenerative diseases such as Alzheimer's disease. 4. **Chromatin modifications**: CH10 has been shown to participate in chromatin modifications, including histone acetylation and deacetylation, which regulate gene expression. 5. **Immune system signaling**: CH10 has been involved in various immune system signaling pathways, including cytokine signaling and interleukin-7 signaling. **Clinical Significance** 1. **Viral infections**: CH10 has been implicated in viral infections, including HCMV (Human Cytomegalovirus) infection, which highlights its potential as a diagnostic or therapeutic target. 2. **Cancer**: CH10 has been shown to be involved in cancer development and progression, particularly in megakaryocyte-erythroid progenitor cells. 3. **Programmed cell death**: CH10 has been implicated in programmed cell death, including senescence-associated secretory phenotype (SASP), which highlights its potential as a therapeutic target. 4. **Immune system disorders**: CH10 has been involved in immune system disorders, including autoimmune diseases and inflammatory conditions, which highlights its potential as a therapeutic target. In conclusion, H3C10 is a multifunctional gene that plays a crucial role in various cellular processes, including transcriptional regulation, chromatin organization, and cell cycle progression. Its involvement in disease processes highlights its potential as a diagnostic or therapeutic target, and further research is needed to fully understand its role in human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.