H4C4 | ENSG00000277157 | NCBI 8360

Details for: H4C4

Gene ID: 8360

Symbol: H4C4

Ensembl ID: ENSG00000277157

Description: H4 clustered histone 4

Associated with

Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Base-excision repair, ap site formation
(R-HSA-73929)
Base excision repair
(R-HSA-73884)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Chromosome maintenance
(R-HSA-73886)
Defective pyroptosis
(R-HSA-9710421)
Deposition of new cenpa-containing nucleosomes at the centromere
(R-HSA-606279)
Depurination
(R-HSA-73927)
Depyrimidination
(R-HSA-73928)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Dna double-strand break repair
(R-HSA-5693532)
Dna double strand break response
(R-HSA-5693606)
Dna methylation
(R-HSA-5334118)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
G2/m checkpoints
(R-HSA-69481)
G2/m dna damage checkpoint
(R-HSA-69473)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hats acetylate histones
(R-HSA-3214847)
Hcmv infection
(R-HSA-9609646)
Hdacs deacetylate histones
(R-HSA-3214815)
Hdms demethylate histones
(R-HSA-3214842)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-HSA-5693567)
Homology directed repair
(R-HSA-5693538)
Infectious disease
(R-HSA-5663205)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Meiotic synapsis
(R-HSA-1221632)
Metabolism of proteins
(R-HSA-392499)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Nonhomologous end-joining (nhej)
(R-HSA-5693571)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleosome assembly
(R-HSA-774815)
Oxidative stress induced senescence
(R-HSA-2559580)
Packaging of telomere ends
(R-HSA-171306)
Pkmts methylate histone lysines
(R-HSA-3214841)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Post-translational protein modification
(R-HSA-597592)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-HSA-5693565)
Regulation of endogenous retroelements
(R-HSA-9842860)
Regulation of endogenous retroelements by krab-zfp proteins
(R-HSA-9843940)
Regulation of endogenous retroelements by the human silencing hub (hush) complex
(R-HSA-9843970)
Replacement of protamines by nucleosomes in the male pronucleus
(R-HSA-9821993)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rmts methylate histone arginines
(R-HSA-3214858)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Telomere maintenance
(R-HSA-157579)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.9243
Cell Significance Index: 26.6300
Cell Name: sensory neuron (CL0000101)
Fold Change: 0.8691
Cell Significance Index: 4.9400
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.7840
Cell Significance Index: 19.5500
Cell Name: thymocyte (CL0000893)
Fold Change: 0.5793
Cell Significance Index: 7.3200
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.4592
Cell Significance Index: 9.5300
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.4431
Cell Significance Index: 6.6400
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.4318
Cell Significance Index: 4.3300
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.4085
Cell Significance Index: 8.8500
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 0.3294
Cell Significance Index: 2.5600
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.2913
Cell Significance Index: 31.6800
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.2778
Cell Significance Index: 16.6800
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2633
Cell Significance Index: 26.0500
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.2613
Cell Significance Index: 9.1800
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2391
Cell Significance Index: 38.8900
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.2274
Cell Significance Index: 26.8200
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.2155
Cell Significance Index: 3.0300
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.1993
Cell Significance Index: 5.2400
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1638
Cell Significance Index: 147.9000
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.1113
Cell Significance Index: 7.1800
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.1102
Cell Significance Index: 3.5300
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1036
Cell Significance Index: 5.3800
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0984
Cell Significance Index: 6.8100
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.0904
Cell Significance Index: 1.3000
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0883
Cell Significance Index: 16.8100
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.0810
Cell Significance Index: 1.2200
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0742
Cell Significance Index: 1.5800
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.0701
Cell Significance Index: 0.7600
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.0663
Cell Significance Index: 0.5800
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0407
Cell Significance Index: 1.8500
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0170
Cell Significance Index: 7.5000
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0164
Cell Significance Index: 0.4100
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0140
Cell Significance Index: 1.8000
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.0119
Cell Significance Index: 1.3600
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0081
Cell Significance Index: 4.4300
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 0.0032
Cell Significance Index: 0.0200
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0016
Cell Significance Index: 0.2900
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0005
Cell Significance Index: 0.0800
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0002
Cell Significance Index: -0.0100
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0008
Cell Significance Index: -0.6200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0021
Cell Significance Index: -3.8800
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0024
Cell Significance Index: -0.4700
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0026
Cell Significance Index: -1.4700
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0028
Cell Significance Index: -0.5900
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0038
Cell Significance Index: -1.3800
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0039
Cell Significance Index: -0.5400
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0041
Cell Significance Index: -3.0100
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0055
Cell Significance Index: -3.4900
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0055
Cell Significance Index: -4.1300
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0087
Cell Significance Index: -3.9500
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0142
Cell Significance Index: -0.6600
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0156
Cell Significance Index: -3.1400
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: -0.0186
Cell Significance Index: -0.2400
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0187
Cell Significance Index: -1.3200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0209
Cell Significance Index: -2.5700
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0232
Cell Significance Index: -2.3700
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0245
Cell Significance Index: -3.5600
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0264
Cell Significance Index: -1.6200
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0268
Cell Significance Index: -1.6900
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0272
Cell Significance Index: -0.7400
Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.0285
Cell Significance Index: -0.4000
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0320
Cell Significance Index: -0.6700
Cell Name: helper T cell (CL0000912)
Fold Change: -0.0324
Cell Significance Index: -0.4600
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0362
Cell Significance Index: -2.8700
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0367
Cell Significance Index: -1.0300
Cell Name: germ cell (CL0000586)
Fold Change: -0.0430
Cell Significance Index: -0.3300
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: -0.0434
Cell Significance Index: -0.4500
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: -0.0453
Cell Significance Index: -0.5700
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0476
Cell Significance Index: -0.6500
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0485
Cell Significance Index: -2.7200
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0486
Cell Significance Index: -6.2800
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0623
Cell Significance Index: -4.7800
Cell Name: paneth cell (CL0000510)
Fold Change: -0.0628
Cell Significance Index: -0.6500
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0697
Cell Significance Index: -3.2800
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0743
Cell Significance Index: -3.9000
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.0765
Cell Significance Index: -0.9800
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0833
Cell Significance Index: -6.2100
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: -0.0834
Cell Significance Index: -0.8400
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.0846
Cell Significance Index: -0.9200
Cell Name: proerythroblast (CL0000547)
Fold Change: -0.0858
Cell Significance Index: -1.2300
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0920
Cell Significance Index: -1.5400
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.0928
Cell Significance Index: -1.0500
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.0964
Cell Significance Index: -1.4000
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0989
Cell Significance Index: -2.6400
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0992
Cell Significance Index: -4.3900
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1011
Cell Significance Index: -3.5400
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1045
Cell Significance Index: -3.6300
Cell Name: peg cell (CL4033014)
Fold Change: -0.1095
Cell Significance Index: -2.5300
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.1107
Cell Significance Index: -3.2600
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.1173
Cell Significance Index: -4.4400
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1191
Cell Significance Index: -3.9000
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1213
Cell Significance Index: -3.1000
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.1215
Cell Significance Index: -1.5400
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.1229
Cell Significance Index: -3.0700
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.1342
Cell Significance Index: -3.4200
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.1352
Cell Significance Index: -2.3300
Cell Name: decidual cell (CL2000002)
Fold Change: -0.1359
Cell Significance Index: -2.1800
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1375
Cell Significance Index: -4.3800
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.1425
Cell Significance Index: -5.2300
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.1459
Cell Significance Index: -1.2400
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.1462
Cell Significance Index: -2.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** The H4C4 gene is a member of the histone family, specifically the H4 variant, which is one of the five main histone proteins that make up chromatin. Histones are highly conserved proteins that play a central role in DNA packaging and regulation. The H4C4 gene is highly expressed in various cell types, including epithelial cells, stem cells, and immune cells. **Pathways and Functions** The H4C4 gene is involved in multiple cellular pathways, including: 1. **DNA Replication and Repair**: H4C4 plays a crucial role in the assembly of the pre-replicative complex and the packaging of DNA into chromatin during the S phase of the cell cycle. 2. **Transcriptional Regulation**: H4C4 interacts with transcription factors and chromatin-modifying enzymes to regulate gene expression, including the regulation of RNA polymerase II and RNA polymerase I. 3. **Cell Cycle Control**: H4C4 is involved in the regulation of the cell cycle, including the G2/M checkpoint and the DNA damage response. 4. **Epigenetic Regulation**: H4C4 is involved in the regulation of DNA methylation and histone modifications, including acetylation, methylation, and demethylation. **Clinical Significance** The H4C4 gene has been implicated in various diseases, including: 1. **Cancer**: Aberrant expression of H4C4 has been observed in several types of cancer, including colon cancer, where it is often associated with poor prognosis. 2. **Autoimmune Diseases**: H4C4 has been implicated in autoimmune diseases, such as rheumatoid arthritis, where it is thought to play a role in the regulation of immune cell function. 3. **Neurological Disorders**: H4C4 has been implicated in neurological disorders, such as Alzheimer's disease, where it is thought to play a role in the regulation of gene expression and chromatin modification. In conclusion, the H4C4 gene plays a critical role in various cellular processes, including DNA replication, transcriptional regulation, and cell cycle control. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functions and clinical significance of this gene. **Signaling Pathways** The H4C4 gene is involved in various signaling pathways, including: 1. **Notch Signaling**: H4C4 interacts with Notch receptors to regulate cell fate decisions and development. 2. **Wnt Signaling**: H4C4 is involved in the regulation of Wnt signaling, which is critical for cell proliferation and differentiation. 3. **Rho GTPase Signaling**: H4C4 is involved in the regulation of Rho GTPase signaling, which is critical for cell migration and cytoskeleton organization. 4. **Cellular Stress Response**: H4C4 is involved in the regulation of the cellular stress response, including the activation of heat shock proteins and the regulation of apoptosis. **Regulation of H4C4** The expression of H4C4 is regulated by various mechanisms, including: 1. **Transcriptional Regulation**: H4C4 expression is regulated by transcription factors, including NF-κB and AP-1. 2. **Post-translational Modification**: H4C4 is modified by various enzymes, including histone acetyltransferases and histone methyltransferases. 3. **Epigenetic Regulation**: H4C4 expression is regulated by epigenetic mechanisms, including DNA methylation and histone modifications. In conclusion, the H4C4 gene plays a critical role in various cellular processes, including DNA replication, transcriptional regulation, and cell cycle control. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functions and clinical significance of this gene.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.