H4C5 | ENSG00000276966 | NCBI 8367

Details for: H4C5

Gene ID: 8367

Symbol: H4C5

Ensembl ID: ENSG00000276966

Description: H4 clustered histone 5

Associated with

Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Base-excision repair, ap site formation
(R-HSA-73929)
Base excision repair
(R-HSA-73884)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Chromosome maintenance
(R-HSA-73886)
Defective pyroptosis
(R-HSA-9710421)
Deposition of new cenpa-containing nucleosomes at the centromere
(R-HSA-606279)
Depurination
(R-HSA-73927)
Depyrimidination
(R-HSA-73928)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Dna double-strand break repair
(R-HSA-5693532)
Dna double strand break response
(R-HSA-5693606)
Dna methylation
(R-HSA-5334118)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
G2/m checkpoints
(R-HSA-69481)
G2/m dna damage checkpoint
(R-HSA-69473)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hats acetylate histones
(R-HSA-3214847)
Hcmv infection
(R-HSA-9609646)
Hdacs deacetylate histones
(R-HSA-3214815)
Hdms demethylate histones
(R-HSA-3214842)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-HSA-5693567)
Homology directed repair
(R-HSA-5693538)
Infectious disease
(R-HSA-5663205)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Meiotic synapsis
(R-HSA-1221632)
Metabolism of proteins
(R-HSA-392499)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Nonhomologous end-joining (nhej)
(R-HSA-5693571)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleosome assembly
(R-HSA-774815)
Oxidative stress induced senescence
(R-HSA-2559580)
Packaging of telomere ends
(R-HSA-171306)
Pkmts methylate histone lysines
(R-HSA-3214841)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Post-translational protein modification
(R-HSA-597592)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-HSA-5693565)
Regulation of endogenous retroelements
(R-HSA-9842860)
Regulation of endogenous retroelements by krab-zfp proteins
(R-HSA-9843940)
Regulation of endogenous retroelements by the human silencing hub (hush) complex
(R-HSA-9843970)
Replacement of protamines by nucleosomes in the male pronucleus
(R-HSA-9821993)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rmts methylate histone arginines
(R-HSA-3214858)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Telomere maintenance
(R-HSA-157579)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 2.2266
Cell Significance Index: 23.0500
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 1.9500
Cell Significance Index: 15.0300
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.8905
Cell Significance Index: 54.4700
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 1.7323
Cell Significance Index: 17.3700
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.3645
Cell Significance Index: 259.6800
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.3232
Cell Significance Index: 59.9800
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 1.2513
Cell Significance Index: 18.7500
Cell Name: pro-T cell (CL0000827)
Fold Change: 1.1726
Cell Significance Index: 29.9600
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 1.0718
Cell Significance Index: 8.3300
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.9854
Cell Significance Index: 63.5800
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.8910
Cell Significance Index: 53.4900
Cell Name: sensory neuron (CL0000101)
Fold Change: 0.8066
Cell Significance Index: 4.5900
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.6434
Cell Significance Index: 69.9900
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.5636
Cell Significance Index: 508.8700
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 0.4948
Cell Significance Index: 5.1300
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.4317
Cell Significance Index: 15.1700
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.4020
Cell Significance Index: 65.3900
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.3617
Cell Significance Index: 3.9200
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.3466
Cell Significance Index: 4.8700
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 0.3374
Cell Significance Index: 3.5900
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3320
Cell Significance Index: 22.9600
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.3136
Cell Significance Index: 6.8000
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.2936
Cell Significance Index: 15.2500
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.2774
Cell Significance Index: 4.1800
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.2363
Cell Significance Index: 6.3200
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1902
Cell Significance Index: 26.1200
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.1795
Cell Significance Index: 5.7500
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1687
Cell Significance Index: 16.6900
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.1584
Cell Significance Index: 3.9600
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.1545
Cell Significance Index: 3.2900
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.1027
Cell Significance Index: 5.3900
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0994
Cell Significance Index: 12.7400
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0975
Cell Significance Index: 17.5700
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.0891
Cell Significance Index: 10.2100
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0870
Cell Significance Index: 17.2600
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.0857
Cell Significance Index: 4.8100
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.0762
Cell Significance Index: 1.9000
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0630
Cell Significance Index: 34.4000
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.0583
Cell Significance Index: 5.9600
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0571
Cell Significance Index: 25.2400
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0522
Cell Significance Index: 1.4600
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.0306
Cell Significance Index: 1.4400
Cell Name: peg cell (CL4033014)
Fold Change: 0.0281
Cell Significance Index: 0.6500
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0262
Cell Significance Index: 1.2200
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0147
Cell Significance Index: 5.2800
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0024
Cell Significance Index: 0.2900
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0034
Cell Significance Index: -6.4900
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0044
Cell Significance Index: -0.1800
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0057
Cell Significance Index: -8.7400
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0065
Cell Significance Index: -8.8100
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0068
Cell Significance Index: -5.0200
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0077
Cell Significance Index: -4.3600
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0079
Cell Significance Index: -6.0000
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0083
Cell Significance Index: -1.7500
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0090
Cell Significance Index: -6.6200
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0103
Cell Significance Index: -6.5200
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0112
Cell Significance Index: -2.2500
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0148
Cell Significance Index: -6.7000
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0160
Cell Significance Index: -1.0100
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0160
Cell Significance Index: -2.7400
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0176
Cell Significance Index: -2.0800
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0187
Cell Significance Index: -0.5100
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: -0.0194
Cell Significance Index: -0.1700
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0221
Cell Significance Index: -1.5600
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0286
Cell Significance Index: -3.7000
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0351
Cell Significance Index: -2.1600
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0406
Cell Significance Index: -0.8500
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0456
Cell Significance Index: -6.6300
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0456
Cell Significance Index: -3.5000
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0544
Cell Significance Index: -1.4300
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0673
Cell Significance Index: -7.0100
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0688
Cell Significance Index: -5.1300
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0778
Cell Significance Index: -2.0000
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0832
Cell Significance Index: -6.5900
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.0847
Cell Significance Index: -1.3100
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0886
Cell Significance Index: -3.0800
Cell Name: type I NK T cell (CL0000921)
Fold Change: -0.0893
Cell Significance Index: -0.8700
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1097
Cell Significance Index: -2.9300
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.1159
Cell Significance Index: -1.6600
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.1176
Cell Significance Index: -1.4900
Cell Name: proerythroblast (CL0000547)
Fold Change: -0.1235
Cell Significance Index: -1.7700
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.1312
Cell Significance Index: -1.7900
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1344
Cell Significance Index: -2.2500
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.1447
Cell Significance Index: -1.2300
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: -0.1478
Cell Significance Index: -2.0500
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1497
Cell Significance Index: -6.6200
Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: -0.1636
Cell Significance Index: -1.6500
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1689
Cell Significance Index: -5.5300
Cell Name: ON-bipolar cell (CL0000749)
Fold Change: -0.1691
Cell Significance Index: -1.9100
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.1773
Cell Significance Index: -6.5100
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.1785
Cell Significance Index: -6.7600
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.1796
Cell Significance Index: -2.0400
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.1867
Cell Significance Index: -5.5000
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1947
Cell Significance Index: -6.2000
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1975
Cell Significance Index: -6.9200
Cell Name: pancreatic epsilon cell (CL0005019)
Fold Change: -0.2029
Cell Significance Index: -1.8800
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.2030
Cell Significance Index: -5.8200
Cell Name: keratocyte (CL0002363)
Fold Change: -0.2036
Cell Significance Index: -3.2300
Cell Name: PP cell (CL0000696)
Fold Change: -0.2036
Cell Significance Index: -2.0700
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: -0.2165
Cell Significance Index: -2.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** 1. **Histone 5 variant:** H4C5 is a variant of histone 5, which is a histone protein that plays a central role in chromatin structure and function. 2. **Chromatin organization:** H4C5 is involved in the assembly of chromatin, particularly at the origin of replication and the centromere. 3. **Gene expression regulation:** H4C5 regulates gene expression through its interaction with various transcription factors and chromatin-modifying enzymes. 4. **Cell cycle regulation:** H4C5 is involved in the regulation of the cell cycle, particularly during mitosis and the G2/M checkpoint. **Pathways and Functions:** 1. **Activation of anterior hox genes:** H4C5 plays a crucial role in the activation of anterior hox genes during hindbrain development during early embryogenesis. 2. **Amyloid fiber formation:** H4C5 is involved in the formation of amyloid fibers, which are associated with neurodegenerative diseases such as Alzheimer's and Parkinson's. 3. **Assembly of the orc complex:** H4C5 is required for the assembly of the orc complex at the origin of replication. 4. **Base-excision repair:** H4C5 is involved in the recognition and association of DNA glycosylase with sites containing affected purines or pyrimidines. 5. **Cell cycle checkpoints:** H4C5 regulates the G2/M checkpoint, ensuring proper cell cycle progression. **Clinical Significance:** 1. **Neurodegenerative diseases:** Abnormalities in H4C5 have been linked to neurodegenerative diseases such as Alzheimer's and Parkinson's. 2. **Cancer:** H4C5 is often deregulated in cancer cells, contributing to tumorigenesis and cancer progression. 3. **DNA damage response:** H4C5 plays a critical role in the recognition and response to DNA double-strand breaks. 4. **Epigenetic regulation:** H4C5 is involved in the regulation of gene expression through its interaction with epigenetic enzymes and transcription factors. 5. **Developmental biology:** H4C5 is essential for proper embryogenesis and development, particularly during hindbrain development. In conclusion, the H4C5 gene is a critical component of chromatin structure and function, playing a central role in regulating gene expression, cell cycle progression, and DNA damage response. Its dysregulation has been implicated in various diseases, including neurodegenerative disorders, cancer, and developmental abnormalities. Further research is necessary to fully elucidate the complex functions of H4C5 and its role in maintaining cellular homeostasis.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.