Gene H4C5 - ENSG00000276966 | NCBI Gene ID: 8367

Details for: H4C5

Gene ID: 8367

Symbol: H4C5

Ensembl ID: ENSG00000276966

Description: H4 clustered histone 5

Associated with

Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Base-excision repair, ap site formation
(R-HSA-73929)
Base excision repair
(R-HSA-73884)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Chromosome maintenance
(R-HSA-73886)
Cleavage of the damaged purine
(R-HSA-110331)
Cleavage of the damaged pyrimidine
(R-HSA-110329)
Condensation of prophase chromosomes
(R-HSA-2299718)
Defective pyroptosis
(R-HSA-9710421)
Deposition of new cenpa-containing nucleosomes at the centromere
(R-HSA-606279)
Depurination
(R-HSA-73927)
Depyrimidination
(R-HSA-73928)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Dna double-strand break repair
(R-HSA-5693532)
Dna double strand break response
(R-HSA-5693606)
Dna methylation
(R-HSA-5334118)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Epigenetic regulation of gene expression
(R-HSA-212165)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
G2/m checkpoints
(R-HSA-69481)
G2/m dna damage checkpoint
(R-HSA-69473)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hats acetylate histones
(R-HSA-3214847)
Hcmv infection
(R-HSA-9609646)
Hdacs deacetylate histones
(R-HSA-3214815)
Hdms demethylate histones
(R-HSA-3214842)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-HSA-5693567)
Homology directed repair
(R-HSA-5693538)
Infectious disease
(R-HSA-5663205)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Meiotic synapsis
(R-HSA-1221632)
Metabolism of proteins
(R-HSA-392499)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Nonhomologous end-joining (nhej)
(R-HSA-5693571)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleosome assembly
(R-HSA-774815)
Oxidative stress induced senescence
(R-HSA-2559580)
Packaging of telomere ends
(R-HSA-171306)
Pkmts methylate histone lysines
(R-HSA-3214841)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Post-translational protein modification
(R-HSA-597592)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Recognition and association of dna glycosylase with site containing an affected purine
(R-HSA-110330)
Recognition and association of dna glycosylase with site containing an affected pyrimidine
(R-HSA-110328)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-HSA-5693565)
Replacement of protamines by nucleosomes in the male pronucleus
(R-HSA-9821993)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rmts methylate histone arginines
(R-HSA-3214858)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Telomere maintenance
(R-HSA-157579)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: primitive red blood cell (CL0002355)
Fold Change: 1.15
Marker Score: 863.5
Cell Name: goblet cell (CL0000160)
Fold Change: 1.09
Marker Score: 7274.5
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.96
Marker Score: 494
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.95
Marker Score: 449
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2410
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2732
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.91
Marker Score: 5168
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.87
Marker Score: 314
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5278
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.86
Marker Score: 8747
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.81
Marker Score: 407
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.81
Marker Score: 1314
Cell Name: brush cell (CL0002204)
Fold Change: 0.76
Marker Score: 695
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.74
Marker Score: 1536
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.67
Marker Score: 171
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 0.66
Marker Score: 487
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.66
Marker Score: 507
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.65
Marker Score: 2652
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 0.64
Marker Score: 197
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.62
Marker Score: 249
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.62
Marker Score: 2602
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: 0.6
Marker Score: 233
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 0.58
Marker Score: 252
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.56
Marker Score: 544
Cell Name: follicular B cell (CL0000843)
Fold Change: 0.55
Marker Score: 601
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.54
Marker Score: 431
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.53
Marker Score: 532
Cell Name: proerythroblast (CL0000547)
Fold Change: 0.5
Marker Score: 338
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.49
Marker Score: 471
Cell Name: gut endothelial cell (CL0000131)
Fold Change: 0.49
Marker Score: 174
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.48
Marker Score: 153
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.43
Marker Score: 302.5
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.43
Marker Score: 123
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.42
Marker Score: 110
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.41
Marker Score: 265
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.41
Marker Score: 233
Cell Name: type I NK T cell (CL0000921)
Fold Change: 0.38
Marker Score: 299
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.38
Marker Score: 119
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.36
Marker Score: 367
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 0.35
Marker Score: 241
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: 0.34
Marker Score: 90
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 0.34
Marker Score: 923.5
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.33
Marker Score: 677
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.32
Marker Score: 193.5
Cell Name: rod bipolar cell (CL0000751)
Fold Change: 0.32
Marker Score: 166
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.32
Marker Score: 84
Cell Name: plasmablast (CL0000980)
Fold Change: 0.31
Marker Score: 416
Cell Name: microglial cell (CL0000129)
Fold Change: 0.31
Marker Score: 564.5
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 0.31
Marker Score: 372
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.29
Marker Score: 690
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 0.29
Marker Score: 101
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.29
Marker Score: 71
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.29
Marker Score: 189
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.28
Marker Score: 190
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.28
Marker Score: 135
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.27
Marker Score: 86
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.27
Marker Score: 268
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.27
Marker Score: 276
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.26
Marker Score: 136
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.25
Marker Score: 105
Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
Fold Change: 0.25
Marker Score: 83
Cell Name: late pro-B cell (CL0002048)
Fold Change: 0.25
Marker Score: 290
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.24
Marker Score: 2730
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.24
Marker Score: 126
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.24
Marker Score: 151
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.23
Marker Score: 570
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 0.23
Marker Score: 92
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.23
Marker Score: 82
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.23
Marker Score: 153
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 0.22
Marker Score: 230
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 62
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 0.22
Marker Score: 75
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.21
Marker Score: 313
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 0.21
Marker Score: 667
Cell Name: promyelocyte (CL0000836)
Fold Change: 0.21
Marker Score: 105
Cell Name: granulocyte (CL0000094)
Fold Change: 0.21
Marker Score: 95
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.21
Marker Score: 98
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.21
Marker Score: 98
Cell Name: germ cell (CL0000586)
Fold Change: 0.21
Marker Score: 366
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 0.2
Marker Score: 193
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.2
Marker Score: 142.5
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 0.2
Marker Score: 97
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 0.2
Marker Score: 215
Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 0.2
Marker Score: 44
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 0.2
Marker Score: 136
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 0.2
Marker Score: 47
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 0.19
Marker Score: 330
Cell Name: mast cell (CL0000097)
Fold Change: 0.19
Marker Score: 111
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.19
Marker Score: 56.5
Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 0.19
Marker Score: 40
Cell Name: B-1b B cell (CL0000821)
Fold Change: 0.19
Marker Score: 43
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 0.19
Marker Score: 59
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.19
Marker Score: 63
Cell Name: malignant cell (CL0001064)
Fold Change: 0.19
Marker Score: 2495
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.18
Marker Score: 84
Cell Name: B-1a B cell (CL0000820)
Fold Change: 0.18
Marker Score: 44
Cell Name: leukocyte (CL0000738)
Fold Change: 0.18
Marker Score: 105
Cell Name: Unknown (CL0002371)
Fold Change: 0.18
Marker Score: 194
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.18
Marker Score: 107

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Other Information

Description

**Key Characteristics:** 1. **Histone 5 variant:** H4C5 is a variant of histone 5, which is a histone protein that plays a central role in chromatin structure and function. 2. **Chromatin organization:** H4C5 is involved in the assembly of chromatin, particularly at the origin of replication and the centromere. 3. **Gene expression regulation:** H4C5 regulates gene expression through its interaction with various transcription factors and chromatin-modifying enzymes. 4. **Cell cycle regulation:** H4C5 is involved in the regulation of the cell cycle, particularly during mitosis and the G2/M checkpoint. **Pathways and Functions:** 1. **Activation of anterior hox genes:** H4C5 plays a crucial role in the activation of anterior hox genes during hindbrain development during early embryogenesis. 2. **Amyloid fiber formation:** H4C5 is involved in the formation of amyloid fibers, which are associated with neurodegenerative diseases such as Alzheimer's and Parkinson's. 3. **Assembly of the orc complex:** H4C5 is required for the assembly of the orc complex at the origin of replication. 4. **Base-excision repair:** H4C5 is involved in the recognition and association of DNA glycosylase with sites containing affected purines or pyrimidines. 5. **Cell cycle checkpoints:** H4C5 regulates the G2/M checkpoint, ensuring proper cell cycle progression. **Clinical Significance:** 1. **Neurodegenerative diseases:** Abnormalities in H4C5 have been linked to neurodegenerative diseases such as Alzheimer's and Parkinson's. 2. **Cancer:** H4C5 is often deregulated in cancer cells, contributing to tumorigenesis and cancer progression. 3. **DNA damage response:** H4C5 plays a critical role in the recognition and response to DNA double-strand breaks. 4. **Epigenetic regulation:** H4C5 is involved in the regulation of gene expression through its interaction with epigenetic enzymes and transcription factors. 5. **Developmental biology:** H4C5 is essential for proper embryogenesis and development, particularly during hindbrain development. In conclusion, the H4C5 gene is a critical component of chromatin structure and function, playing a central role in regulating gene expression, cell cycle progression, and DNA damage response. Its dysregulation has been implicated in various diseases, including neurodegenerative disorders, cancer, and developmental abnormalities. Further research is necessary to fully elucidate the complex functions of H4C5 and its role in maintaining cellular homeostasis.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.