Details for: PIP5K1A

Gene ID: 8394

Symbol: PIP5K1A

Ensembl ID: ENSG00000143398

Description: phosphatidylinositol-4-phosphate 5-kinase type 1 alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 279.6614
    Cell Significance Index: -43.5000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 168.6029
    Cell Significance Index: -42.7700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 97.1483
    Cell Significance Index: -40.0200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 90.1646
    Cell Significance Index: -36.6300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 38.3664
    Cell Significance Index: -36.6300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 35.5649
    Cell Significance Index: -43.8500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.8202
    Cell Significance Index: -42.3800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.1579
    Cell Significance Index: -24.4200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.1479
    Cell Significance Index: -43.9900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.8493
    Cell Significance Index: 76.0800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.7740
    Cell Significance Index: 550.5100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.4568
    Cell Significance Index: 467.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.1789
    Cell Significance Index: 437.0900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.9619
    Cell Significance Index: 50.4300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.9576
    Cell Significance Index: 150.2200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.4883
    Cell Significance Index: 42.8800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.3127
    Cell Significance Index: 470.8500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.9146
    Cell Significance Index: 17.8500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.8929
    Cell Significance Index: 50.1100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7672
    Cell Significance Index: 21.4400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7557
    Cell Significance Index: 20.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7455
    Cell Significance Index: 33.7900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7381
    Cell Significance Index: 38.3400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5817
    Cell Significance Index: 39.1200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5640
    Cell Significance Index: 12.2200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4924
    Cell Significance Index: 340.5600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4920
    Cell Significance Index: 18.6300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4901
    Cell Significance Index: 21.6800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.4475
    Cell Significance Index: 6.3700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4258
    Cell Significance Index: 46.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.3871
    Cell Significance Index: 713.9000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3600
    Cell Significance Index: 22.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3546
    Cell Significance Index: 667.5800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3510
    Cell Significance Index: 57.0800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3499
    Cell Significance Index: 22.0500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3230
    Cell Significance Index: 176.4200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.3160
    Cell Significance Index: 486.4500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.3054
    Cell Significance Index: 3.6400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2814
    Cell Significance Index: 34.6000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2545
    Cell Significance Index: 15.2800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2372
    Cell Significance Index: 107.6700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2237
    Cell Significance Index: 40.3200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1996
    Cell Significance Index: 126.7500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1826
    Cell Significance Index: 25.0800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1587
    Cell Significance Index: 15.7000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1511
    Cell Significance Index: 205.5100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1503
    Cell Significance Index: 66.4300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1476
    Cell Significance Index: 133.2400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1416
    Cell Significance Index: 4.9800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0898
    Cell Significance Index: 4.2200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0549
    Cell Significance Index: 6.4700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0519
    Cell Significance Index: 0.8900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0051
    Cell Significance Index: -0.6700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0117
    Cell Significance Index: -0.1400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0189
    Cell Significance Index: -0.4600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0221
    Cell Significance Index: -1.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0226
    Cell Significance Index: -3.2900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0326
    Cell Significance Index: -23.9000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0334
    Cell Significance Index: -0.9100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0423
    Cell Significance Index: -31.3300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0459
    Cell Significance Index: -34.7600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0464
    Cell Significance Index: -3.4600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0469
    Cell Significance Index: -1.1300
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.0640
    Cell Significance Index: -0.6800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0714
    Cell Significance Index: -40.2600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0783
    Cell Significance Index: -48.9000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0815
    Cell Significance Index: -5.2600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0940
    Cell Significance Index: -1.3500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0986
    Cell Significance Index: -1.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1167
    Cell Significance Index: -5.4400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1177
    Cell Significance Index: -3.3600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1220
    Cell Significance Index: -12.7000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1299
    Cell Significance Index: -37.3800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1305
    Cell Significance Index: -1.7800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1388
    Cell Significance Index: -3.9800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1393
    Cell Significance Index: -14.2300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1456
    Cell Significance Index: -5.0600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1476
    Cell Significance Index: -25.2100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1630
    Cell Significance Index: -20.9000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1726
    Cell Significance Index: -11.9400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1850
    Cell Significance Index: -4.0500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2137
    Cell Significance Index: -24.9000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2221
    Cell Significance Index: -46.7700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2841
    Cell Significance Index: -20.0900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2867
    Cell Significance Index: -7.5400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2981
    Cell Significance Index: -34.1500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3074
    Cell Significance Index: -6.5700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3951
    Cell Significance Index: -6.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3967
    Cell Significance Index: -20.8300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3976
    Cell Significance Index: -9.9400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4263
    Cell Significance Index: -9.0800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4658
    Cell Significance Index: -6.7000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4780
    Cell Significance Index: -37.8600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4893
    Cell Significance Index: -15.6700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5272
    Cell Significance Index: -3.1900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.5562
    Cell Significance Index: -8.2100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5617
    Cell Significance Index: -9.4000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5711
    Cell Significance Index: -12.1200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6017
    Cell Significance Index: -36.8900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6552
    Cell Significance Index: -21.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Phosphatidylinositol biosynthesis:** PIP5K1A is essential for the biosynthesis of PI and its derivatives, which are involved in various cellular processes. 2. **PI3K/Akt signaling pathway:** PIP5K1A phosphorylates PI4P to produce PI5P, which activates the PI3K/Akt signaling pathway. 3. **Cell migration and chemotaxis:** PIP5K1A is involved in regulating cell migration and chemotaxis through the PI3K/Akt signaling pathway. 4. **Actin cytoskeleton organization:** PIP5K1A regulates actin cytoskeleton organization through the PI3K/Akt signaling pathway. 5. **Lipid metabolism:** PIP5K1A is involved in regulating lipid metabolism, including the synthesis and degradation of PI. **Pathways and Functions:** 1. **1-phosphatidylinositol-3-phosphate 5-kinase activity:** PIP5K1A phosphorylates PI4P to produce PI5P. 2. **1-phosphatidylinositol-4-phosphate 5-kinase activity:** PIP5K1A phosphorylates PI4P to produce PI5P. 3. **1-phosphatidylinositol-5-kinase activity:** PIP5K1A phosphorylates PI4P to produce PI5P. 4. **Actin cytoskeleton organization:** PIP5K1A regulates actin cytoskeleton organization through the PI3K/Akt signaling pathway. 5. **Activation of gtpase activity:** PIP5K1A regulates gtpase activity through the PI3K/Akt signaling pathway. 6. **Atp binding:** PIP5K1A binds to ATP, which is required for its enzymatic activity. 7. **Cell chemotaxis:** PIP5K1A regulates cell chemotaxis through the PI3K/Akt signaling pathway. 8. **Cell migration:** PIP5K1A regulates cell migration through the PI3K/Akt signaling pathway. 9. **Focal adhesion:** PIP5K1A regulates focal adhesion through the PI3K/Akt signaling pathway. 10. **Nuclear speck:** PIP5K1A regulates nuclear speck through the PI3K/Akt signaling pathway. **Clinical Significance:** 1. **Cancer:** Abnormal expression of PIP5K1A has been implicated in various types of cancer, including breast, lung, and colon cancer. 2. **Cardiovascular disease:** PIP5K1A is involved in regulating lipid metabolism, which is a key factor in the development of cardiovascular disease. 3. **Neurodegenerative disorders:** PIP5K1A has been implicated in the regulation of neuronal function and survival, which is relevant to the development of neurodegenerative disorders such as Alzheimer's and Parkinson's disease. 4. **Inflammatory disorders:** PIP5K1A is involved in regulating inflammation, which is a key factor in the development of inflammatory disorders such as arthritis and asthma. 5. **Regenerative medicine:** PIP5K1A has been identified as a potential biomarker for tissue regeneration and repair. In conclusion, PIP5K1A is a critical gene involved in the biosynthesis of phosphatidylinositol and its derivatives, which play a key role in various cellular processes, including cell signaling, actin cytoskeleton organization, and lipid metabolism. Abnormal expression of PIP5K1A has been implicated in various diseases, including cancer, cardiovascular disease, and neurodegenerative disorders. Further research is needed to fully understand the molecular mechanisms underlying PIP5K1A and its clinical significance.

Genular Protein ID: 2906213780

Symbol: PI51A_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q99755 A8K4Q0 B4DIN0 Q99754 Q99756

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CPTAC 1 CTD 1 ChEBI 40 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 1 EMBL 8 Ensembl 4 ExpressionAtlas 1 GO 30 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 2 RefSeq 5 Rhea 16 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 2 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8955136

Title: Type I phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid kinase family.

PubMed ID: 8955136

DOI: 10.1074/jbc.271.51.32937

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15157668

Title: Diacylglycerol kinase zeta regulates phosphatidylinositol 4-phosphate 5-kinase Ialpha by a novel mechanism.

PubMed ID: 15157668

DOI: 10.1016/j.cellsig.2004.01.010

PubMed ID: 18288197

Title: A PtdIns4,5P2-regulated nuclear poly(A) polymerase controls expression of select mRNAs.

PubMed ID: 18288197

DOI: 10.1038/nature06666

PubMed ID: 19158393

Title: Phosphatidylinositol-4-phosphate 5-kinase 1alpha mediates extracellular calcium-induced keratinocyte differentiation.

PubMed ID: 19158393

DOI: 10.1091/mbc.e08-07-0756

PubMed ID: 20660631

Title: Type I PIPK-alpha regulates directed cell migration by modulating Rac1 plasma membrane targeting and activation.

PubMed ID: 20660631

DOI: 10.1083/jcb.200911110

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21477596

Title: Study of arachidonoyl specificity in two enzymes of the PI cycle.

PubMed ID: 21477596

DOI: 10.1016/j.jmb.2011.03.071

PubMed ID: 22942276

Title: Phosphatidylinositol-4-phosphate 5-kinase isoforms exhibit acyl chain selectivity for both substrate and lipid activator.

PubMed ID: 22942276

DOI: 10.1074/jbc.m112.370155

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 31091439

Title: PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism.

PubMed ID: 31091439

DOI: 10.1016/j.celrep.2019.04.070

Sequence Information:

  • Length: 562
  • Mass: 62633
  • Checksum: A8F7988EB73506A0
  • Sequence:
    • MASASSGPSS SVGFSSFDPA VPSCTLSSAA SGIKRPMASE VLEARQDSYI SLVPYASGMP 
IKKIGHRSVD SSGETTYKKT TSSALKGAIQ LGITHTVGSL STKPERDVLM QDFYVVESIF 
FPSEGSNLTP AHHYNDFRFK TYAPVAFRYF RELFGIRPDD YLYSLCSEPL IELCSSGASG 
SLFYVSSDDE FIIKTVQHKE AEFLQKLLPG YYMNLNQNPR TLLPKFYGLY CVQAGGKNIR 
IVVMNNLLPR SVKMHIKYDL KGSTYKRRAS QKEREKPLPT FKDLDFLQDI PDGLFLDADM 
YNALCKTLQR DCLVLQSFKI MDYSLLMSIH NIDHAQREPL SSETQYSVDT RRPAPQKALY 
STAMESIQGE ARRGGTMETD DHMGGIPARN SKGERLLLYI GIIDILQSYR FVKKLEHSWK 
ALVHDGDTVS VHRPGFYAER FQRFMCNTVF KKIPLKPSPS KKFRSGSSFS RRAGSSGNSC 
ITYQPSVSGE HKAQVTTKAE VEPGVHLGRP DVLPQTPPLE EISEGSPIPD PSFSPLVGET 
LQMLTTSTTL EKLEVAESEF TH

Genular Protein ID: 325110100

Symbol: A6PW57_HUMAN

Name: N/A

UniProtKB Accession Codes:

A6PW57

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 2 GeneTree 1 HGNC 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 550
  • Mass: 61258
  • Checksum: 169439AD1F8AE6D5
  • Sequence:
    • MASASSGPSS SVGFSSFDPA VPSCTLSSAA SGIKRPMASE VPYASGMPIK KIGHRSVDSS 
GETTYKKTTS SALKGAIQLG ITHTVGSLST KPERDVLMQD FYVVESIFFP SEGSNLTPAH 
HYNDFRFKTY APVAFRYFRE LFGIRPDDYL YSLCSEPLIE LCSSGASGSL FYVSSDDEFI 
IKTVQHKEAE FLQKLLPGYY MNLNQNPRTL LPKFYGLYCV QAGGKNIRIV VMNNLLPRSV 
KMHIKYDLKG STYKRRASQK EREKPLPTFK DLDFLQDIPD GLFLDADMYN ALCKTLQRDC 
LVLQSFKIMD YSLLMSIHNI DHAQREPLSS ETQYSVDTRR PAPQKALYST AMESIQGEAR 
RGGTMETDDH MGGIPARNSK GERLLLYIGI IDILQSYRFV KKLEHSWKAL VHDGDTVSVH 
RPGFYAERFQ RFMCNTVFKK IPLKPSPSKK FRSGSSFSRR AGSSGNSCIT YQPSVSGEHK 
AQVTTKAEVE PGVHLGRPDV LPQTPPLEEI SEGSPIPDPS FSPLVGETLQ MLTTSTTLEK 
LEVAESEFTH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.