Details for: FKBP6

Gene ID: 8468

Symbol: FKBP6

Ensembl ID: ENSG00000077800

Description: FKBP prolyl isomerase family member 6 (inactive)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 3.4889
    Cell Significance Index: 213.9100
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.1535
    Cell Significance Index: 8.7100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.0637
    Cell Significance Index: 23.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8820
    Cell Significance Index: 167.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7043
    Cell Significance Index: 69.6700
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.5965
    Cell Significance Index: 7.0500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5749
    Cell Significance Index: 519.1400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3564
    Cell Significance Index: 7.5900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3067
    Cell Significance Index: 33.3600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3064
    Cell Significance Index: 49.8300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2940
    Cell Significance Index: 4.2100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1729
    Cell Significance Index: 11.9600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.1688
    Cell Significance Index: 5.3400
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.0979
    Cell Significance Index: 0.8100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0946
    Cell Significance Index: 5.6800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0928
    Cell Significance Index: 1.5300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0904
    Cell Significance Index: 1.9800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0861
    Cell Significance Index: 1.4800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0423
    Cell Significance Index: 1.0900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0287
    Cell Significance Index: 1.8100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0267
    Cell Significance Index: 0.7200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0224
    Cell Significance Index: 4.4500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0132
    Cell Significance Index: 0.6000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0097
    Cell Significance Index: 1.9500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0066
    Cell Significance Index: 3.5800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0063
    Cell Significance Index: 0.0900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0045
    Cell Significance Index: 6.1100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0044
    Cell Significance Index: 0.2300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0024
    Cell Significance Index: 0.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0024
    Cell Significance Index: 0.4100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0014
    Cell Significance Index: 0.5000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0013
    Cell Significance Index: 2.3600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0009
    Cell Significance Index: 0.1400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0004
    Cell Significance Index: 0.6800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0004
    Cell Significance Index: 0.5500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0005
    Cell Significance Index: -0.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0017
    Cell Significance Index: -1.0700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0017
    Cell Significance Index: -0.0600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0025
    Cell Significance Index: -0.0800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0026
    Cell Significance Index: -1.9700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0029
    Cell Significance Index: -2.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0033
    Cell Significance Index: -1.4900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0033
    Cell Significance Index: -2.0900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0035
    Cell Significance Index: -2.0000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0039
    Cell Significance Index: -0.0800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0052
    Cell Significance Index: -0.1300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0077
    Cell Significance Index: -0.3600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0078
    Cell Significance Index: -2.2400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0089
    Cell Significance Index: -1.0200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0094
    Cell Significance Index: -1.1600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0117
    Cell Significance Index: -2.4700
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.0122
    Cell Significance Index: -0.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0129
    Cell Significance Index: -0.3500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0146
    Cell Significance Index: -2.0000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0165
    Cell Significance Index: -1.6900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0166
    Cell Significance Index: -2.1500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0189
    Cell Significance Index: -1.2700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0190
    Cell Significance Index: -0.2800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0191
    Cell Significance Index: -2.2300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0200
    Cell Significance Index: -2.0800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0212
    Cell Significance Index: -0.3200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0253
    Cell Significance Index: -2.0000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0281
    Cell Significance Index: -2.1600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0286
    Cell Significance Index: -2.1300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0288
    Cell Significance Index: -1.8600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0290
    Cell Significance Index: -3.4200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0327
    Cell Significance Index: -2.0100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0359
    Cell Significance Index: -0.4700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0369
    Cell Significance Index: -1.7400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0369
    Cell Significance Index: -0.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0371
    Cell Significance Index: -2.0800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0391
    Cell Significance Index: -1.7000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0402
    Cell Significance Index: -1.7800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0411
    Cell Significance Index: -1.3100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0428
    Cell Significance Index: -1.4000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0437
    Cell Significance Index: -1.5300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0449
    Cell Significance Index: -2.3600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0457
    Cell Significance Index: -1.7300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0473
    Cell Significance Index: -0.9900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0493
    Cell Significance Index: -1.2300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0528
    Cell Significance Index: -1.4800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0536
    Cell Significance Index: -0.8600
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0559
    Cell Significance Index: -0.6100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0563
    Cell Significance Index: -1.4800
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0577
    Cell Significance Index: -0.5300
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0588
    Cell Significance Index: -0.7100
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0599
    Cell Significance Index: -0.8400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0606
    Cell Significance Index: -0.9200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0613
    Cell Significance Index: -0.8900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0617
    Cell Significance Index: -1.5400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0624
    Cell Significance Index: -1.2700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0645
    Cell Significance Index: -1.3700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0648
    Cell Significance Index: -1.8500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0648
    Cell Significance Index: -1.0900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0655
    Cell Significance Index: -1.9300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0660
    Cell Significance Index: -0.9000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0685
    Cell Significance Index: -1.4800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0698
    Cell Significance Index: -2.0000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0738
    Cell Significance Index: -2.7100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0746
    Cell Significance Index: -2.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** FKBP6 exhibits several key characteristics that set it apart from other FKBP family members. Firstly, it is an inactive enzyme, which suggests that its primary function may not be related to protein folding or catalysis. Instead, FKBP6 may play a role in regulating gene expression and cellular differentiation. Additionally, FKBP6 is highly expressed in germ cells, suggesting a potential role in meiosis and spermatogenesis. **Pathways and Functions** FKBP6 is involved in various cellular pathways, including: 1. **Cell Cycle**: FKBP6 is expressed in cells undergoing cell cycle progression, suggesting a role in regulating cell growth and division. 2. **Cell Differentiation**: FKBP6 is involved in the differentiation of cells, particularly in the development of germ cells and intestinal cells. 3. **Hsp90 Protein Binding**: FKBP6 interacts with Hsp90, a chaperone protein that assists in the folding and stability of other proteins. 4. **Gene Expression (Transcription)**: FKBP6 may regulate gene expression by interacting with transcription factors and influencing the transcriptional landscape. 5. **Meiosis**: FKBP6 is highly expressed in germ cells, suggesting a critical role in meiosis and spermatogenesis. **Clinical Significance** The clinical significance of FKBP6 is multifaceted. For instance: 1. **Reproductive Health**: FKBP6's role in meiosis and spermatogenesis makes it a potential target for the treatment of male infertility and reproductive disorders. 2. **Cancer**: FKBP6's involvement in gene expression and cellular differentiation suggests that it may play a role in cancer development and progression. 3. **Immunology**: FKBP6's interaction with Hsp90 and its expression in immune cells may provide insights into the regulation of immune responses and the development of immunotherapies. In conclusion, FKBP6 is a multifaceted gene that plays a crucial role in various cellular processes, including cell cycle regulation, cell differentiation, and meiosis. Further research is necessary to fully elucidate the functions and clinical significance of FKBP6, but its potential implications for reproductive health, cancer, and immunology are significant and warrant further investigation.

Genular Protein ID: 2233071353

Symbol: FKBP6_HUMAN

Name: Inactive peptidyl-prolyl cis-trans isomerase FKBP6

UniProtKB Accession Codes:

O75344 B4DXT7 G3V0I2 Q7Z4T4 Q9UDS0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 2 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9782077

Title: A novel human gene FKBP6 is deleted in Williams syndrome.

PubMed ID: 9782077

DOI: 10.1006/geno.1998.5412

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15770126

Title: Autosomal dominant inheritance of Williams-Beuren syndrome in a father and son with haploinsufficiency for FKBP6.

PubMed ID: 15770126

DOI: 10.1097/00019605-200504000-00002

PubMed ID: 16227348

Title: Mutations in the chromosome pairing gene FKBP6 are not a common cause of non-obstructive azoospermia.

PubMed ID: 16227348

DOI: 10.1093/molehr/gah232

PubMed ID: 17307919

Title: Mutation screening of the FKBP6 gene and its association study with spermatogenic impairment in idiopathic infertile men.

PubMed ID: 17307919

DOI: 10.1530/rep-06-0125

PubMed ID: 18529014

Title: FKBP36 forms complexes with clathrin and Hsp72 in spermatocytes.

PubMed ID: 18529014

DOI: 10.1021/bi8001506

PubMed ID: 19001379

Title: FKBP36 is an inherent multifunctional glyceraldehyde-3-phosphate dehydrogenase inhibitor.

PubMed ID: 19001379

DOI: 10.1074/jbc.m709779200

PubMed ID: 36150389

Title: The piRNA-pathway factor FKBP6 is essential for spermatogenesis but dispensable for control of meiotic LINE-1 expression in humans.

PubMed ID: 36150389

DOI: 10.1016/j.ajhg.2022.09.002

Sequence Information:

  • Length: 327
  • Mass: 37214
  • Checksum: C137FA629B676623
  • Sequence:
    • MGGSALNQGV LEGDDAPGQS LYERLSQRML DISGDRGVLK DVIREGAGDL VAPDASVLVK 
YSGYLEHMDR PFDSNYFRKT PRLMKLGEDI TLWGMELGLL SMRRGELARF LFKPNYAYGT 
LGCPPLIPPN TTVLFEIELL DFLDCAESDK FCALSAEQQD QFPLQKVLKV AATEREFGNY 
LFRQNRFYDA KVRYKRALLL LRRRSAPPEE QHLVEAAKLP VLLNLSFTYL KLDRPTIALC 
YGEQALIIDQ KNAKALFRCG QACLLLTEYQ KARDFLVRAQ KEQPFNHDIN NELKKLASCY 
RDYVDKEKEM WHRMFAPCGD GSTAGES

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.