Details for: GALR3

Gene ID: 8484

Symbol: GALR3

Ensembl ID: ENSG00000128310

Description: galanin receptor 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 8.6149
    Cell Significance Index: -1.3400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 5.1647
    Cell Significance Index: -1.3100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.7607
    Cell Significance Index: 79.8100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.5621
    Cell Significance Index: 8.0600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4320
    Cell Significance Index: 9.2000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3053
    Cell Significance Index: 18.3300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.2419
    Cell Significance Index: 3.4000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1739
    Cell Significance Index: 4.6600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1401
    Cell Significance Index: 15.2400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1173
    Cell Significance Index: 1.6800
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.1059
    Cell Significance Index: 1.3100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1054
    Cell Significance Index: 20.0500
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.0901
    Cell Significance Index: 0.5400
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.0844
    Cell Significance Index: 0.5600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0747
    Cell Significance Index: 7.3900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.0663
    Cell Significance Index: 0.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0610
    Cell Significance Index: 3.1700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0471
    Cell Significance Index: 1.5100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0446
    Cell Significance Index: 7.2600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0444
    Cell Significance Index: 0.9200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0326
    Cell Significance Index: 2.2600
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0326
    Cell Significance Index: 0.4100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0321
    Cell Significance Index: 0.4200
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.0290
    Cell Significance Index: 0.3500
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.0274
    Cell Significance Index: 0.3100
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0274
    Cell Significance Index: 0.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0180
    Cell Significance Index: 0.3900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0176
    Cell Significance Index: 3.4900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0150
    Cell Significance Index: 10.3500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0108
    Cell Significance Index: 0.3100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0094
    Cell Significance Index: 1.8900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0093
    Cell Significance Index: 0.2500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0072
    Cell Significance Index: 0.5100
  • Cell Name: eosinophil (CL0000771)
    Fold Change: 0.0034
    Cell Significance Index: 0.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0026
    Cell Significance Index: 0.9300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0026
    Cell Significance Index: 0.1200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0020
    Cell Significance Index: 0.0900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0016
    Cell Significance Index: 0.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0013
    Cell Significance Index: 0.7300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0012
    Cell Significance Index: 0.0300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0008
    Cell Significance Index: 0.3500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0007
    Cell Significance Index: 0.6000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0006
    Cell Significance Index: 0.0200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0003
    Cell Significance Index: 0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0005
    Cell Significance Index: -0.9000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0005
    Cell Significance Index: -0.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0007
    Cell Significance Index: -1.3000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0014
    Cell Significance Index: -0.1700
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0017
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0020
    Cell Significance Index: -1.5100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0022
    Cell Significance Index: -1.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0025
    Cell Significance Index: -0.4300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0027
    Cell Significance Index: -1.7500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0030
    Cell Significance Index: -0.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0030
    Cell Significance Index: -1.7000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0032
    Cell Significance Index: -0.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0037
    Cell Significance Index: -1.6900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0058
    Cell Significance Index: -1.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0066
    Cell Significance Index: -0.9100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0085
    Cell Significance Index: -1.7800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0096
    Cell Significance Index: -0.2400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0104
    Cell Significance Index: -0.8000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0112
    Cell Significance Index: -1.6300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0130
    Cell Significance Index: -0.2900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0146
    Cell Significance Index: -0.7700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0165
    Cell Significance Index: -1.2300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0174
    Cell Significance Index: -0.4900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0187
    Cell Significance Index: -1.2600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0193
    Cell Significance Index: -1.9700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0199
    Cell Significance Index: -0.6400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0199
    Cell Significance Index: -0.3000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0235
    Cell Significance Index: -0.6400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0243
    Cell Significance Index: -0.8000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0251
    Cell Significance Index: -0.9200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0253
    Cell Significance Index: -1.1200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0265
    Cell Significance Index: -0.9300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0266
    Cell Significance Index: -0.7000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0267
    Cell Significance Index: -1.5000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0273
    Cell Significance Index: -1.6800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0276
    Cell Significance Index: -1.3000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0279
    Cell Significance Index: -0.3800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0304
    Cell Significance Index: -1.1500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0311
    Cell Significance Index: -0.8000
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0319
    Cell Significance Index: -0.3800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0327
    Cell Significance Index: -2.1100
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0340
    Cell Significance Index: -0.4100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0341
    Cell Significance Index: -0.8500
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.0352
    Cell Significance Index: -0.2800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0386
    Cell Significance Index: -0.6200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0387
    Cell Significance Index: -0.8100
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0391
    Cell Significance Index: -0.5400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0396
    Cell Significance Index: -0.5100
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0400
    Cell Significance Index: -0.5400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0400
    Cell Significance Index: -0.6900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0407
    Cell Significance Index: -0.6700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0430
    Cell Significance Index: -0.9300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0433
    Cell Significance Index: -0.9200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0439
    Cell Significance Index: -1.0700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0450
    Cell Significance Index: -0.8900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0454
    Cell Significance Index: -1.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GALR3 is a GPCR that belongs to the Class A/1 (rhodopsin-like receptors) subfamily. It is characterized by its high expression in various cell types, including endothelial cells, plasma cells, and immune cells such as granulocytes and early T lineage precursors. GALR3 has been shown to be involved in several signaling pathways, including adenylate cyclase-modulating GPCR signaling, chemical synaptic transmission, and galanin-activated signaling pathway. **Pathways and Functions:** GALR3 is implicated in various physiological processes, including feeding behavior, learning and memory, and synaptic transmission. Its signaling pathways are complex and involve multiple downstream effectors, including Gαi signaling events, GPCR downstream signaling, and cyclic nucleotide second messenger systems. GALR3 has been shown to regulate transcription by positive regulation of RNA polymerase II, indicating its potential role in gene expression and cellular differentiation. **Clinical Significance:** GALR3 has been implicated in several disease states, including autoimmune disorders and inflammatory conditions. Its expression in immune cells suggests that it may play a role in immune system regulation and modulation. For instance, GALR3 has been shown to modulate the activity of immune cells, including T cells and B cells, and may influence the development of autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. Additionally, GALR3 has been implicated in the regulation of feeding behavior and learning and memory, suggesting its potential role in neurological disorders such as Alzheimer's disease and Parkinson's disease. **Implications for Immunology:** The study of GALR3 has significant implications for our understanding of immune system regulation and modulation. Its expression in immune cells and its involvement in various signaling pathways suggest that it may play a role in the development and progression of autoimmune diseases. Further research is needed to elucidate the mechanisms by which GALR3 regulates immune responses and to explore its potential as a therapeutic target for the treatment of immune-related disorders. In conclusion, GALR3 is a complex GPCR that plays a multifaceted role in various physiological and pathological processes. Its expression in immune cells and involvement in signaling pathways suggest that it may have significant implications for our understanding of immune system regulation and modulation. Further research is needed to fully elucidate the mechanisms by which GALR3 regulates immune responses and to explore its potential as a therapeutic target for the treatment of immune-related disorders.

Genular Protein ID: 3523835664

Symbol: GALR3_HUMAN

Name: Galanin receptor type 3

UniProtKB Accession Codes:

O60755 Q53YJ4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9722565

Title: Cloned human and rat galanin GALR3 receptors: pharmacology and activation of G-protein inwardly rectifying K+ channels.

PubMed ID: 9722565

DOI: 10.1074/jbc.273.36.23321

PubMed ID: 9832121

Title: Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3.

PubMed ID: 9832121

DOI: 10.1046/j.1471-4159.1998.71062239.x

PubMed ID: 9928159

Title: Structural organization and chromosomal localization of three human galanin receptor genes.

PubMed ID: 9928159

DOI: 10.1111/j.1749-6632.1998.tb10683.x

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 24517231

Title: Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III.

PubMed ID: 24517231

DOI: 10.1210/en.2013-2106

PubMed ID: 25691535

Title: Galanin pathogenic mutations in temporal lobe epilepsy.

PubMed ID: 25691535

DOI: 10.1093/hmg/ddv060

Sequence Information:

  • Length: 368
  • Mass: 39573
  • Checksum: E8F46B66422C3150
  • Sequence:
    • MADAQNISLD SPGSVGAVAV PVVFALIFLL GTVGNGLVLA VLLQPGPSAW QEPGSTTDLF 
ILNLAVADLC FILCCVPFQA TIYTLDAWLF GALVCKAVHL LIYLTMYASS FTLAAVSVDR 
YLAVRHPLRS RALRTPRNAR AAVGLVWLLA ALFSAPYLSY YGTVRYGALE LCVPAWEDAR 
RRALDVATFA AGYLLPVAVV SLAYGRTLRF LWAAVGPAGA AAAEARRRAT GRAGRAMLAV 
AALYALCWGP HHALILCFWY GRFAFSPATY ACRLASHCLA YANSCLNPLV YALASRHFRA 
RFRRLWPCGR RRRHRARRAL RRVRPASSGP PGCPGDARPS GRLLAGGGQG PEPREGPVHG 
GEAARGPE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.