No CSI details found for gene ID: 8484
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3523835664
Symbol: GALR3_HUMAN
Name: Galanin receptor type 3
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9722565
Title: Cloned human and rat galanin GALR3 receptors: pharmacology and activation of G-protein inwardly rectifying K+ channels.
PubMed ID: 9722565
PubMed ID: 9832121
Title: Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3.
PubMed ID: 9832121
PubMed ID: 9928159
Title: Structural organization and chromosomal localization of three human galanin receptor genes.
PubMed ID: 9928159
PubMed ID: 10591208
PubMed ID: 24517231
Title: Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III.
PubMed ID: 24517231
DOI: 10.1210/en.2013-2106
PubMed ID: 25691535
Title: Galanin pathogenic mutations in temporal lobe epilepsy.
PubMed ID: 25691535
DOI: 10.1093/hmg/ddv060
Sequence Information:
- Length: 368
- Mass: 39573
- Checksum: E8F46B66422C3150
- Sequence:
MADAQNISLD SPGSVGAVAV PVVFALIFLL GTVGNGLVLA VLLQPGPSAW QEPGSTTDLF ILNLAVADLC FILCCVPFQA TIYTLDAWLF GALVCKAVHL LIYLTMYASS FTLAAVSVDR YLAVRHPLRS RALRTPRNAR AAVGLVWLLA ALFSAPYLSY YGTVRYGALE LCVPAWEDAR RRALDVATFA AGYLLPVAVV SLAYGRTLRF LWAAVGPAGA AAAEARRRAT GRAGRAMLAV AALYALCWGP HHALILCFWY GRFAFSPATY ACRLASHCLA YANSCLNPLV YALASRHFRA RFRRLWPCGR RRRHRARRAL RRVRPASSGP PGCPGDARPS GRLLAGGGQG PEPREGPVHG GEAARGPE
Details Unavailable
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{
"geneID": 8484,
"tax": {
"id": 9606,
"name": [
{
"name": "Homo sapiens Linnaeus 1758"
},
{
"name": "Homo sapiens",
"type": 0
},
{
"name": "human",
"type": 4
}
]
},
"accession": {
"gene": [
"CP068256.2"
]
},
"genePos": {
"start": 37823382,
"end": 37825485
},
"orientation": true,
"symbol": "GALR3",
"created": {
"$date": {
"$numberLong": "1738333349527"
}
},
"crossReference": {
"enseGeneID": "ENSG00000128310",
"enseRnaID": [
"ENST00000249041.3"
],
"enseProtID": [
"ENSP00000249041.2"
]
},
"chrom": {
"pos": "22",
"type": 1,
"loc": "22q13.1"
},
"desc": "galanin receptor 3",
"geneType": 5,
"ontology": [
{
"id": "R-HSA-162582",
"term": "Signal Transduction",
"cat": 10
},
{
"id": "R-HSA-372790",
"term": "Signaling by GPCR",
"cat": 11
},
{
"id": "R-HSA-388396",
"term": "GPCR downstream signalling",
"cat": 12
},
{
"id": "R-HSA-500792",
"term": "GPCR ligand binding",
"cat": 12
},
{
"id": "R-HSA-373076",
"term": "Class A\/1 (Rhodopsin-like receptors)",
"cat": 13
},
{
"id": "R-HSA-418594",
"term": "G alpha (i) signalling events",
"cat": 13
},
{
"id": "R-HSA-375276",
"term": "Peptide ligand-binding receptors",
"cat": 14
},
{
"id": "GO:0004966",
"term": "galanin receptor activity",
"cat": 0
},
{
"id": "GO:0004966",
"term": "galanin receptor activity",
"pubMed": [
9832121,
24517231
],
"cat": 0
},
{
"id": "GO:0017046",
"term": "peptide hormone binding",
"pubMed": [
24517231
],
"cat": 0
},
{
"id": "GO:0017046",
"term": "peptide hormone binding",
"pubMed": [
9832121
],
"cat": 0
},
{
"id": "GO:0007187",
"term": "G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger",
"pubMed": [
9832121
],
"cat": 1
},
{
"id": "GO:0007188",
"term": "adenylate cyclase-modulating G protein-coupled receptor signaling pathway",
"cat": 1
},
{
"id": "GO:0007194",
"term": "negative regulation of adenylate cyclase activity",
"cat": 1
},
{
"id": "GO:0007218",
"term": "neuropeptide signaling pathway",
"cat": 1
},
{
"id": "GO:0007268",
"term": "chemical synaptic transmission",
"pubMed": [
9722565
],
"cat": 1
},
{
"id": "GO:0007611",
"term": "learning or memory",
"pubMed": [
9722565
],
"cat": 1
},
{
"id": "GO:0007631",
"term": "feeding behavior",
"pubMed": [
9722565
],
"cat": 1
},
{
"id": "GO:0045944",
"term": "positive regulation of transcription by RNA polymerase II",
"pubMed": [
24517231
],
"cat": 1
},
{
"id": "GO:0090663",
"term": "galanin-activated signaling pathway",
"pubMed": [
9832121
],
"cat": 1
},
{
"id": "GO:0005886",
"term": "plasma membrane",
"cat": 2
},
{
"id": "GO:0005929",
"term": "cilium",
"pubMed": [
28154160
],
"cat": 2
},
{
"id": "GO:0016020",
"term": "membrane",
"pubMed": [
9722565
],
"cat": 2
},
{
"id": "GO:0045202",
"term": "synapse",
"cat": 2
},
{
"id": "GO:0097730",
"term": "non-motile cilium",
"cat": 2
}
],
"protein": [
{
"symbol": "GALR3_HUMAN",
"name": "Galanin receptor type 3",
"accession": [
"O60755",
"Q53YJ4"
],
"databaseIDs": {
"NCBI Taxonomy": [
"9606"
],
"EMBL": [
"AF073799",
"AF067733",
"AF129514",
"AF129513",
"AY587582",
"AB065934",
"Z97630",
"CH471095"
],
"CCDS": [
"CCDS13958.1"
],
"RefSeq": [
"NP_003605.1"
],
"AlphaFoldDB": [
"O60755"
],
"SMR": [
"O60755"
],
"BioGRID": [
"114058"
],
"IntAct": [
"O60755"
],
"STRING": [
"9606.ENSP00000249041"
],
"BindingDB": [
"O60755"
],
"ChEMBL": [
"CHEMBL2731"
],
"GuidetoPHARMACOLOGY": [
"245"
],
"GlyCosmos": [
"O60755"
],
"GlyGen": [
"O60755"
],
"iPTMnet": [
"O60755"
],
"PhosphoSitePlus": [
"O60755"
],
"BioMuta": [
"GALR3"
],
"MassIVE": [
"O60755"
],
"PaxDb": [
"9606-ENSP00000249041"
],
"PeptideAtlas": [
"O60755"
],
"Antibodypedia": [
"12147"
],
"DNASU": [
"8484"
],
"Ensembl": [
"ENST00000249041.3"
],
"KEGG": [
"hsa:8484"
],
"MANE-Select": [
"ENST00000249041.3"
],
"UCSC": [
"uc003aub.1"
],
"AGR": [
"HGNC:4134"
],
"CTD": [
"8484"
],
"DisGeNET": [
"8484"
],
"GeneCards": [
"GALR3"
],
"HGNC": [
"HGNC:4134"
],
"HPA": [
"ENSG00000128310"
],
"MIM": [
"603692"
],
"neXtProt": [
"NX_O60755"
],
"OpenTargets": [
"ENSG00000128310"
],
"PharmGKB": [
"PA28547"
],
"VEuPathDB": [
"HostDB:ENSG00000128310"
],
"eggNOG": [
"KOG3656"
],
"GeneTree": [
"ENSGT01120000271840"
],
"HOGENOM": [
"CLU_009579_6_4_1"
],
"InParanoid": [
"O60755"
],
"OMA": [
"YQIVHYH"
],
"OrthoDB": [
"2915794at2759"
],
"PhylomeDB": [
"O60755"
],
"TreeFam": [
"TF315737"
],
"PathwayCommons": [
"O60755"
],
"Reactome": [
"R-HSA-375276",
"R-HSA-418594"
],
"SignaLink": [
"O60755"
],
"SIGNOR": [
"O60755"
],
"BioGRID-ORCS": [
"8484"
],
"ChiTaRS": [
"GALR3"
],
"GeneWiki": [
"Galanin_receptor_3"
],
"GenomeRNAi": [
"8484"
],
"Pharos": [
"O60755"
],
"PRO": [
"PR:O60755"
],
"Proteomes": [
"UP000005640"
],
"RNAct": [
"O60755"
],
"Bgee": [
"ENSG00000128310"
],
"GO": [
"GO:0005929",
"GO:0016020",
"GO:0097730",
"GO:0005886",
"GO:0045202",
"GO:0004966",
"GO:0017046",
"GO:0007188",
"GO:0007268",
"GO:0007631",
"GO:0007187",
"GO:0090663",
"GO:0007611",
"GO:0007218",
"GO:0045944"
],
"CDD": [
"cd15097"
],
"Gene3D": [
"1.20.1070.10"
],
"InterPro": [
"IPR000405",
"IPR003908",
"IPR000276",
"IPR017452"
],
"PANTHER": [
"PTHR24230",
"PTHR24230:SF17"
],
"Pfam": [
"PF00001"
],
"PRINTS": [
"PR01420",
"PR00663",
"PR00237"
],
"SUPFAM": [
"SSF81321"
],
"PROSITE": [
"PS00237",
"PS50262"
]
},
"citations": [
{
"title": "Cloned human and rat galanin GALR3 receptors: pharmacology and activation of G-protein inwardly rectifying K+ channels.",
"pubmedID": "9722565",
"doi": "10.1074\/jbc.273.36.23321"
},
{
"title": "Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3.",
"pubmedID": "9832121",
"doi": "10.1046\/j.1471-4159.1998.71062239.x"
},
{
"title": "Structural organization and chromosomal localization of three human galanin receptor genes.",
"pubmedID": "9928159",
"doi": "10.1111\/j.1749-6632.1998.tb10683.x"
},
{
"title": "The DNA sequence of human chromosome 22.",
"pubmedID": "10591208",
"doi": "10.1038\/990031"
},
{
"title": "Coevolution of the spexin\/galanin\/kisspeptin family: Spexin activates galanin receptor type II and III.",
"pubmedID": "24517231",
"doi": "10.1210\/en.2013-2106"
},
{
"title": "Galanin pathogenic mutations in temporal lobe epilepsy.",
"pubmedID": "25691535",
"doi": "10.1093\/hmg\/ddv060"
}
],
"sequence": {
"length": 368,
"mass": 39573,
"checksum": "E8F46B66422C3150",
"modified": {
"$date": {
"$numberLong": "901929600000"
}
},
"version": 1,
"sequence": "MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE"
},
"existence": 0,
"relevance": 1,
"proteinID": 3523835664
}
],
"singleCellExpressions": {
"cellSignificanceIndex": []
}
}