Details for: PPFIBP1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 423.4138
Cell Significance Index: -65.8600 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 248.9716
Cell Significance Index: -63.1500 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 132.1690
Cell Significance Index: -62.4000 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 125.0932
Cell Significance Index: -50.8200 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 53.5137
Cell Significance Index: -65.9800 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 53.3337
Cell Significance Index: -50.9200 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 22.8869
Cell Significance Index: -50.0900 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 22.6141
Cell Significance Index: -60.5800 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 16.7256
Cell Significance Index: -66.0000 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 7.8213
Cell Significance Index: 112.4900 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 5.2900
Cell Significance Index: 405.9500 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.9010
Cell Significance Index: 77.4600 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 2.8777
Cell Significance Index: 193.5000 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.7174
Cell Significance Index: 545.1100 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 2.5784
Cell Significance Index: 73.5800 - Cell Name: preadipocyte (CL0002334)
Fold Change: 2.5639
Cell Significance Index: 50.0400 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.4531
Cell Significance Index: 879.8800 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 2.3849
Cell Significance Index: 29.5800 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 2.1901
Cell Significance Index: 17.2900 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 1.9379
Cell Significance Index: 119.1100 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.8054
Cell Significance Index: 358.2800 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 1.6234
Cell Significance Index: 14.4100 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.3773
Cell Significance Index: 38.4900 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.3231
Cell Significance Index: 36.0200 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.2052
Cell Significance Index: 1088.2100 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.0002
Cell Significance Index: 10.3600 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9383
Cell Significance Index: 152.6000 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.7476
Cell Significance Index: 81.3200 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.7044
Cell Significance Index: 384.7100 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.6907
Cell Significance Index: 84.9300 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.5996
Cell Significance Index: 14.3800 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.5898
Cell Significance Index: 8.4700 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.5855
Cell Significance Index: 30.5000 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.5701
Cell Significance Index: 252.0600 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.5520
Cell Significance Index: 11.9600 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.5050
Cell Significance Index: 229.2000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.4067
Cell Significance Index: 73.3200 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.3948
Cell Significance Index: 10.3800 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.3888
Cell Significance Index: 5.7400 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.3696
Cell Significance Index: 9.2400 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3629
Cell Significance Index: 16.4500 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.3343
Cell Significance Index: 2.0200 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3009
Cell Significance Index: 8.6700 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.2793
Cell Significance Index: 193.1800 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2787
Cell Significance Index: 19.2800 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.1873
Cell Significance Index: 288.4000 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.1807
Cell Significance Index: 23.1600 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1600
Cell Significance Index: 15.8300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1185
Cell Significance Index: 22.5600 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0787
Cell Significance Index: 145.0800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0685
Cell Significance Index: 93.1500 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0084
Cell Significance Index: 15.7300 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0028
Cell Significance Index: 0.1000 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0003
Cell Significance Index: -0.0200 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0310
Cell Significance Index: -5.2900 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0310
Cell Significance Index: -4.2600 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0311
Cell Significance Index: -19.7300 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0466
Cell Significance Index: -34.1600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0505
Cell Significance Index: -37.3900 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0699
Cell Significance Index: -43.6600 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0742
Cell Significance Index: -56.2000 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0878
Cell Significance Index: -49.5100 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1039
Cell Significance Index: -2.6700 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1041
Cell Significance Index: -5.8400 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.1381
Cell Significance Index: -3.9600 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: -0.1413
Cell Significance Index: -2.1500 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1575
Cell Significance Index: -8.1800 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1797
Cell Significance Index: -12.7100 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1926
Cell Significance Index: -55.4100 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1940
Cell Significance Index: -40.8700 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.2043
Cell Significance Index: -9.6000 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.2364
Cell Significance Index: -30.5400 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2423
Cell Significance Index: -35.2200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.2448
Cell Significance Index: -25.0100 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2852
Cell Significance Index: -32.6800 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2869
Cell Significance Index: -33.4400 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.3372
Cell Significance Index: -4.6000 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.3486
Cell Significance Index: -39.7900 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.3694
Cell Significance Index: -23.8300 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.4230
Cell Significance Index: -11.3400 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.5003
Cell Significance Index: -59.0000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.5145
Cell Significance Index: -53.5700 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.5338
Cell Significance Index: -39.7800 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.5517
Cell Significance Index: -11.7500 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.5948
Cell Significance Index: -9.9600 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.6928
Cell Significance Index: -54.8700 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.7051
Cell Significance Index: -31.1900 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.7340
Cell Significance Index: -12.9700 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.8098
Cell Significance Index: -49.6500 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.8543
Cell Significance Index: -14.3900 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.9032
Cell Significance Index: -34.2000 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.9119
Cell Significance Index: -13.4600 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.9155
Cell Significance Index: -11.7400 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.9916
Cell Significance Index: -31.7600 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -1.0397
Cell Significance Index: -14.8000 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -1.0816
Cell Significance Index: -56.7900 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -1.0865
Cell Significance Index: -68.4800 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -1.1618
Cell Significance Index: -25.1000 - Cell Name: peg cell (CL4033014)
Fold Change: -1.2273
Cell Significance Index: -28.3600 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -1.2875
Cell Significance Index: -44.7400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 544340698
Symbol: LIPB1_HUMAN
Name: Liprin-beta-1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9624153
Title: Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins.
PubMed ID: 9624153
PubMed ID: 10574462
Title: Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 10574462
PubMed ID: 12168954
Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.
PubMed ID: 12168954
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11836260
Title: Liprin beta 1, a member of the family of LAR transmembrane tyrosine phosphatase-interacting proteins, is a new target for the metastasis-associated protein S100A4 (Mts1).
PubMed ID: 11836260
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 24120883
Title: CFEOM1-associated kinesin KIF21A is a cortical microtubule growth inhibitor.
PubMed ID: 24120883
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 27410476
Title: Talin-KANK1 interaction controls the recruitment of cortical microtubule stabilizing complexes to focal adhesions.
PubMed ID: 27410476
DOI: 10.7554/elife.18124
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 35830857
Title: Bi-allelic loss-of-function variants in PPFIBP1 cause a neurodevelopmental disorder with microcephaly, epilepsy, and periventricular calcifications.
PubMed ID: 35830857
Sequence Information:
- Length: 1011
- Mass: 114024
- Checksum: 20E30DD99ACD5A92
- Sequence:
MMSDASDMLA AALEQMDGII AGSKALEYSN GIFDCQSPTS PFMGSLRALH LVEDLRGLLE MMETDEKEGL RCQIPDSTAE TLVEWLQSQM TNGHLPGNGD VYQERLARLE NDKESLVLQV SVLTDQVEAQ GEKIRDLEFC LEEHREKVNA TEEMLQQELL SRTSLETQKL DLMAEISNLK LKLTAVEKDR LDYEDKFRDT EGLIQEINDL RLKVSEMDSE RLQYEKKLKS TKSLMAKLSS MKIKVGQMQY EKQRMEQKWE SLKDELASLK EQLEEKESEV KRLQEKLVCK MKGEGVEIVD RDIEVQKMKK AVESLMAANE EKDRKIEDLR QCLNRYKKMQ DTVVLAQGKD GEYEELLNSS SISSLLDAQG FSDLEKSPSP TPVMGSPSCD PFNTSVPEEF HTTILQVSIP SLLPATVSME TSEKSKLTPK PETSFEENDG NIILGATVDT QLCDKLLTSS LQKSSSLGNL KKETSDGEKE TIQKTSEDRA PAESRPFGTL PPRPPGQDTS MDDNPFGTRK VRSSFGRGFF KIKSNKRTAS APNLAETEKE TAEHLDLAGA SSRPKDSQRN SPFQIPPPSP DSKKKSRGIM KLFGKLRRSQ STTFNPDDMS EPEFKRGGTR ATAGPRLGWS RDLGQSNSDL DMPFAKWTKE QVCNWLMEQG LGSYLNSGKH WIASGQTLLQ ASQQDLEKEL GIKHSLHRKK LQLALQALGS EEETNHGKLD FNWVTRWLDD IGLPQYKTQF DEGRVDGRML HYMTVDDLLS LKVVSVLHHL SIKRAIQVLR INNFEPNCLR RRPSDENTIA PSEVQKWTNH RVMEWLRSVD LAEYAPNLRG SGVHGGLMVL EPRFNVETMA QLLNIPPNKT LLRRHLATHF NLLIGAEAQH QKRDAMELPD YVLLTATAKV KPKKLAFSNF GNLRKKKQED GEEYVCPMEL GQASGSASKK GFKPGLDMRL YEEDDLDRLE QMEDSEGTVR QIGAFSEGIN NLTHMLKEDD MFKDFAARSP SASITDEDSN V
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.