Details for: PPFIBP1
Gene ID: 8496
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: PPFIBP1
Ensembl ID: ENSG00000110841
Description: PPFIA binding protein 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 41.94rCSI 59.46%PRS 72.42
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CSI 41.28rCSI 59.24%PRS 65.41
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CSI 37.1rCSI 64.17%PRS 66.82
-
CSI 33.23rCSI 55.77%PRS 57.34
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CSI 26.65rCSI 47.07%PRS 56.55
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CSI 25.03rCSI 49.61%PRS 82.42
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CSI 24.67rCSI 59.95%PRS 55.39
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CSI 22rCSI 35.13%PRS 79.72
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CSI 19.72rCSI 60.75%PRS 81.04
-
CSI 16.25rCSI 55.65%PRS 62.72
-
CSI 15.32rCSI 13.48%PRS 64.58
-
CSI 14.89rCSI 40.91%PRS 83.91
-
CSI 14.25rCSI 36.15%PRS 65.91
-
CSI 14.24rCSI 24.97%PRS 68.97
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CSI 13.1rCSI 18.15%PRS 73.97
-
CSI 13.08rCSI 10.34%PRS 63.88
-
CSI 12.95rCSI 52.25%PRS 75.32
-
CSI 12.42rCSI 30.34%PRS 68.59
-
CSI 12.33rCSI 28.13%PRS 67.09
-
CSI 12.12rCSI 32%PRS 83.42
-
CSI 12.05rCSI 19.22%PRS 67.57
-
CSI 11.78rCSI 11.34%PRS 75.32
-
CSI 11.5rCSI 30.73%PRS 67.03
-
CSI 10.98rCSI 26.27%PRS 62.56
-
CSI 10.84rCSI 15.06%PRS 74.59
-
CSI 10.83rCSI 15.45%PRS 77.27
-
CSI 10.36rCSI 20.81%PRS 65.56
-
CSI 10.34rCSI 16.62%PRS 59.06
-
CSI 10.3rCSI 8.53%PRS 78.41
-
CSI 9.99rCSI 37.75%PRS 57.74
-
CSI 9.93rCSI 7.46%PRS 81.88
-
CSI 9.79rCSI 48.26%PRS 84.57
-
CSI 9.71rCSI 30.36%PRS 59.09
-
CSI 9.25rCSI 18.76%PRS 54
-
CSI 9.17rCSI 11.78%PRS 66.39
-
CSI 8.75rCSI 9.13%PRS 75.53
-
CSI 8.52rCSI 32.14%PRS 58.83
-
CSI 8.46rCSI 21.5%PRS 69.49
-
CSI 8.28rCSI 10.63%PRS 72.23
-
CSI 7.99rCSI 5.92%PRS 68.88
-
CSI 7.88rCSI 26.69%PRS 71.88
-
CSI 7.65rCSI 6.79%PRS 73.89
-
CSI 7.55rCSI 12.15%PRS 65.7
-
CSI 7.51rCSI 8.67%PRS 67.99
-
CSI 7.37rCSI 9.51%PRS 58.6
-
CSI 7.34rCSI 10.04%PRS 80.67
-
CSI 7.33rCSI 40.09%PRS 72.99
-
CSI 7.31rCSI 18.98%PRS 77.5
-
CSI 7.18rCSI 18.57%PRS 70.99
-
CSI 7.08rCSI 12.97%PRS 82.11
-
CSI 7.02rCSI 59.12%PRS 64.95
-
CSI 6.94rCSI 6.69%PRS 68.55
-
CSI 6.48rCSI 5.26%PRS 75.71
-
CSI 6.47rCSI 17.24%PRS 63.72
-
CSI 6.2rCSI 5.77%PRS 76.66
-
CSI 6.17rCSI 11.77%PRS 86.51
-
CSI 6.15rCSI 9.39%PRS 76.29
-
CSI 5.97rCSI 7.6%PRS 81.22
-
CSI 5.85rCSI 7.27%PRS 55.29
-
CSI 5.6rCSI 34.97%PRS 67.34
-
CSI 5.4rCSI 17.28%PRS 72.99
-
CSI 5.35rCSI 20.03%PRS 67.98
-
CSI 5.29rCSI 6.32%PRS 57.29
-
CSI 5.26rCSI 17.28%PRS 62.08
-
CSI 5.16rCSI 24.74%PRS 75.81
-
CSI 5.14rCSI 4.43%PRS 77.83
-
CSI 5.12rCSI 28.42%PRS 86.45
-
CSI 5.04rCSI 5.52%PRS 78.35
-
CSI 5.02rCSI 6.21%PRS 73.65
-
CSI 5.02rCSI 13.07%PRS 76.59
-
CSI 4.92rCSI 27.82%PRS 61.5
-
CSI 4.87rCSI 4.6%PRS 75.04
-
CSI 4.85rCSI 13.96%PRS 83.68
-
CSI 4.74rCSI 8.46%PRS 85.44
-
CSI 4.7rCSI 10.85%PRS 63.87
-
CSI 4.68rCSI 11.59%PRS 75.28
-
CSI 4.64rCSI 18.9%PRS 68.17
-
CSI 4.63rCSI 6.19%PRS 74.89
-
CSI 4.54rCSI 12.92%PRS 72.15
-
CSI 4.46rCSI 19.94%PRS 59.9
-
CSI 4.44rCSI 13.19%PRS 84.9
-
CSI 4.37rCSI 7.7%PRS 82.15
-
CSI 4.35rCSI 5.92%PRS 85.28
-
CSI 4.28rCSI 24.58%PRS 82.95
-
CSI 4.26rCSI 9.99%PRS 76.97
-
CSI 4.24rCSI 29.96%PRS 69.17
-
CSI 4.2rCSI 8.71%PRS 72.82
-
CSI 4.17rCSI 7.47%PRS 75.19
-
CSI 4.16rCSI 10.51%PRS 81.62
-
CSI 4.13rCSI 11.98%PRS 64.99
-
CSI 4.09rCSI 13.27%PRS 74.27
-
CSI 4.07rCSI 7.69%PRS 88
-
CSI 4.03rCSI 3.38%PRS 79.2
-
CSI 4.03rCSI 8.28%PRS 63.62
-
CSI 3.91rCSI 14.89%PRS 66.42
-
CSI 3.73rCSI 8.89%PRS 73.95
-
CSI 3.64rCSI 9.93%PRS 85.49
-
CSI 3.49rCSI 10.29%PRS 75.33
-
CSI 3.38rCSI 4.52%PRS 82.77
-
CSI 3.28rCSI 5.37%PRS 65.16
-
CSI 0.2rCSI 4.6%PRS 86.6%
-
CSI 0.2rCSI 2.3%PRS 82.8%
-
CSI 0.2rCSI 6.0%PRS 85.0%
-
CSI 0.3rCSI 7.3%PRS 89.3%
-
CSI 0.4rCSI 10.4%PRS 56.5%
-
CSI 0.6rCSI 2.0%PRS 55.4%
-
CSI 0.6rCSI 13.5%PRS 55.9%
-
CSI 0.7rCSI 16.5%PRS 86.2%
-
CSI 0.8rCSI 3.2%PRS 91.7%
-
CSI 0.9rCSI 7.7%PRS 85.7%
-
CSI 0.9rCSI 6.8%PRS 85.6%
-
CSI 1.0rCSI 2.7%PRS 84.0%
-
CSI 1.0rCSI 6.7%PRS 84.0%
-
CSI 1.0rCSI 2.6%PRS 91.0%
-
CSI 1.0rCSI 7.5%PRS 62.8%
-
CSI 1.1rCSI 4.1%PRS 86.1%
-
CSI 1.1rCSI 2.7%PRS 77.1%
-
CSI 1.2rCSI 12.3%PRS 72.6%
-
CSI 1.2rCSI 4.2%PRS 81.2%
-
CSI 1.2rCSI 4.7%PRS 72.5%
-
CSI 1.2rCSI 23.6%PRS 85.5%
-
CSI 1.3rCSI 3.6%PRS 76.0%
-
CSI 1.3rCSI 4.4%PRS 85.1%
-
CSI 1.3rCSI 4.2%PRS 74.2%
-
CSI 1.3rCSI 1.7%PRS 81.9%
-
CSI 1.3rCSI 5.4%PRS 86.1%
-
CSI 1.4rCSI 3.8%PRS 71.1%
-
CSI 1.4rCSI 2.1%PRS 80.9%
-
CSI 1.4rCSI 3.2%PRS 61.4%
-
CSI 1.5rCSI 3.6%PRS 80.1%
-
CSI 1.5rCSI 2.4%PRS 77.7%
-
CSI 1.6rCSI 3.1%PRS 79.2%
-
CSI 1.6rCSI 3.4%PRS 83.4%
-
CSI 1.6rCSI 7.1%PRS 76.3%
-
CSI 1.7rCSI 7.5%PRS 85.0%
-
CSI 1.7rCSI 14.2%PRS 71.1%
-
CSI 1.7rCSI 3.7%PRS 75.0%
-
CSI 1.7rCSI 5.6%PRS 60.0%
-
CSI 1.7rCSI 2.5%PRS 87.4%
-
CSI 1.7rCSI 2.6%PRS 80.1%
-
CSI 1.7rCSI 8.5%PRS 71.2%
-
CSI 1.8rCSI 6.9%PRS 53.4%
-
CSI 1.8rCSI 10.6%PRS 58.2%
-
CSI 1.8rCSI 8.3%PRS 81.4%
-
CSI 1.9rCSI 1.7%PRS 73.7%
-
CSI 1.9rCSI 4.9%PRS 75.6%
-
CSI 1.9rCSI 3.7%PRS 90.5%
-
CSI 2.0rCSI 20.3%PRS 70.3%
-
CSI 2.0rCSI 1.4%PRS 78.7%
-
CSI 2.1rCSI 2.5%PRS 73.9%
-
CSI 2.1rCSI 3.2%PRS 72.6%
-
CSI 2.1rCSI 5.7%PRS 81.5%
-
CSI 2.1rCSI 2.7%PRS 79.6%
-
CSI 2.2rCSI 4.8%PRS 85.0%
-
CSI 2.2rCSI 6.4%PRS 90.0%
-
CSI 2.2rCSI 6.9%PRS 61.6%
-
CSI 2.2rCSI 3.5%PRS 85.2%
-
CSI 2.3rCSI 6.5%PRS 83.4%
-
CSI 2.3rCSI 13.3%PRS 72.9%
-
CSI 2.3rCSI 3.1%PRS 91.3%
-
CSI 2.3rCSI 12.6%PRS 84.3%
-
CSI 2.4rCSI 6.9%PRS 83.9%
-
CSI 2.4rCSI 10.3%PRS 82.5%
-
CSI 2.5rCSI 3.7%PRS 86.0%
-
CSI 2.5rCSI 6.0%PRS 76.2%
-
CSI 2.6rCSI 4.0%PRS 75.1%
-
CSI 2.6rCSI 11.5%PRS 64.5%
-
CSI 2.6rCSI 2.7%PRS 86.3%
-
CSI 2.6rCSI 2.7%PRS 80.7%
-
CSI 2.7rCSI 6.4%PRS 89.6%
-
CSI 2.7rCSI 7.4%PRS 70.9%
-
CSI 2.8rCSI 6.0%PRS 82.0%
-
CSI 2.8rCSI 6.6%PRS 80.9%
-
CSI 2.8rCSI 10.8%PRS 76.7%
-
CSI 2.8rCSI 6.2%PRS 80.0%
-
CSI 2.8rCSI 16.5%PRS 81.2%
-
CSI 2.9rCSI 3.6%PRS 77.2%
-
CSI 2.9rCSI 4.6%PRS 68.6%
-
CSI 3.0rCSI 5.5%PRS 66.9%
-
CSI 3.0rCSI 2.7%PRS 83.7%
-
CSI 3.1rCSI 9.9%PRS 72.9%
-
CSI 3.1rCSI 3.3%PRS 76.9%
-
CSI 3.1rCSI 25.5%PRS 69.4%
-
CSI 3.3rCSI 2.5%PRS 79.5%
-
CSI 3.3rCSI 5.4%PRS 65.2%
-
CSI 3.4rCSI 4.5%PRS 82.8%
-
CSI 3.5rCSI 10.3%PRS 75.3%
-
CSI 3.6rCSI 9.9%PRS 85.5%
-
CSI 3.7rCSI 8.9%PRS 74.0%
-
CSI 3.9rCSI 14.9%PRS 66.4%
-
CSI 4.0rCSI 8.3%PRS 63.6%
-
CSI 4.0rCSI 3.4%PRS 79.2%
-
CSI 4.1rCSI 7.7%PRS 88.0%
-
CSI 4.1rCSI 13.3%PRS 74.3%
-
CSI 4.1rCSI 12.0%PRS 65.0%
-
CSI 4.2rCSI 10.5%PRS 81.6%
-
CSI 4.2rCSI 7.5%PRS 75.2%
-
CSI 4.2rCSI 8.7%PRS 72.8%
-
CSI 4.2rCSI 30.0%PRS 69.2%
-
CSI 4.3rCSI 10.0%PRS 77.0%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 544340698
Symbol: LIPB1_HUMAN
Name: Liprin-beta-1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9624153
Title: Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins.
PubMed ID: 9624153
PubMed ID: 10574462
Title: Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 10574462
PubMed ID: 12168954
Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.
PubMed ID: 12168954
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11836260
Title: Liprin beta 1, a member of the family of LAR transmembrane tyrosine phosphatase-interacting proteins, is a new target for the metastasis-associated protein S100A4 (Mts1).
PubMed ID: 11836260
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 24120883
Title: CFEOM1-associated kinesin KIF21A is a cortical microtubule growth inhibitor.
PubMed ID: 24120883
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 27410476
Title: Talin-KANK1 interaction controls the recruitment of cortical microtubule stabilizing complexes to focal adhesions.
PubMed ID: 27410476
DOI: 10.7554/elife.18124
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 35830857
Title: Bi-allelic loss-of-function variants in PPFIBP1 cause a neurodevelopmental disorder with microcephaly, epilepsy, and periventricular calcifications.
PubMed ID: 35830857
Sequence Information:
- Length: 1011
- Mass: 114024
- Checksum: 20E30DD99ACD5A92
- Sequence:
MMSDASDMLA AALEQMDGII AGSKALEYSN GIFDCQSPTS PFMGSLRALH LVEDLRGLLE MMETDEKEGL RCQIPDSTAE TLVEWLQSQM TNGHLPGNGD VYQERLARLE NDKESLVLQV SVLTDQVEAQ GEKIRDLEFC LEEHREKVNA TEEMLQQELL SRTSLETQKL DLMAEISNLK LKLTAVEKDR LDYEDKFRDT EGLIQEINDL RLKVSEMDSE RLQYEKKLKS TKSLMAKLSS MKIKVGQMQY EKQRMEQKWE SLKDELASLK EQLEEKESEV KRLQEKLVCK MKGEGVEIVD RDIEVQKMKK AVESLMAANE EKDRKIEDLR QCLNRYKKMQ DTVVLAQGKD GEYEELLNSS SISSLLDAQG FSDLEKSPSP TPVMGSPSCD PFNTSVPEEF HTTILQVSIP SLLPATVSME TSEKSKLTPK PETSFEENDG NIILGATVDT QLCDKLLTSS LQKSSSLGNL KKETSDGEKE TIQKTSEDRA PAESRPFGTL PPRPPGQDTS MDDNPFGTRK VRSSFGRGFF KIKSNKRTAS APNLAETEKE TAEHLDLAGA SSRPKDSQRN SPFQIPPPSP DSKKKSRGIM KLFGKLRRSQ STTFNPDDMS EPEFKRGGTR ATAGPRLGWS RDLGQSNSDL DMPFAKWTKE QVCNWLMEQG LGSYLNSGKH WIASGQTLLQ ASQQDLEKEL GIKHSLHRKK LQLALQALGS EEETNHGKLD FNWVTRWLDD IGLPQYKTQF DEGRVDGRML HYMTVDDLLS LKVVSVLHHL SIKRAIQVLR INNFEPNCLR RRPSDENTIA PSEVQKWTNH RVMEWLRSVD LAEYAPNLRG SGVHGGLMVL EPRFNVETMA QLLNIPPNKT LLRRHLATHF NLLIGAEAQH QKRDAMELPD YVLLTATAKV KPKKLAFSNF GNLRKKKQED GEEYVCPMEL GQASGSASKK GFKPGLDMRL YEEDDLDRLE QMEDSEGTVR QIGAFSEGIN NLTHMLKEDD MFKDFAARSP SASITDEDSN V