Details for: PPFIBP1

Gene ID: 8496

Symbol: PPFIBP1

Ensembl ID: ENSG00000110841

Description: PPFIA binding protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 423.4138
    Cell Significance Index: -65.8600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 248.9716
    Cell Significance Index: -63.1500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 132.1690
    Cell Significance Index: -62.4000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 125.0932
    Cell Significance Index: -50.8200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 53.5137
    Cell Significance Index: -65.9800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 53.3337
    Cell Significance Index: -50.9200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 22.8869
    Cell Significance Index: -50.0900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.6141
    Cell Significance Index: -60.5800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.7256
    Cell Significance Index: -66.0000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 7.8213
    Cell Significance Index: 112.4900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 5.2900
    Cell Significance Index: 405.9500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.9010
    Cell Significance Index: 77.4600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.8777
    Cell Significance Index: 193.5000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.7174
    Cell Significance Index: 545.1100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.5784
    Cell Significance Index: 73.5800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.5639
    Cell Significance Index: 50.0400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.4531
    Cell Significance Index: 879.8800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.3849
    Cell Significance Index: 29.5800
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 2.1901
    Cell Significance Index: 17.2900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.9379
    Cell Significance Index: 119.1100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.8054
    Cell Significance Index: 358.2800
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.6234
    Cell Significance Index: 14.4100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.3773
    Cell Significance Index: 38.4900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.3231
    Cell Significance Index: 36.0200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2052
    Cell Significance Index: 1088.2100
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.0002
    Cell Significance Index: 10.3600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9383
    Cell Significance Index: 152.6000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7476
    Cell Significance Index: 81.3200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7044
    Cell Significance Index: 384.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6907
    Cell Significance Index: 84.9300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.5996
    Cell Significance Index: 14.3800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.5898
    Cell Significance Index: 8.4700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5855
    Cell Significance Index: 30.5000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5701
    Cell Significance Index: 252.0600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5520
    Cell Significance Index: 11.9600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.5050
    Cell Significance Index: 229.2000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4067
    Cell Significance Index: 73.3200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3948
    Cell Significance Index: 10.3800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.3888
    Cell Significance Index: 5.7400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3696
    Cell Significance Index: 9.2400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3629
    Cell Significance Index: 16.4500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.3343
    Cell Significance Index: 2.0200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3009
    Cell Significance Index: 8.6700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2793
    Cell Significance Index: 193.1800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2787
    Cell Significance Index: 19.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1873
    Cell Significance Index: 288.4000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1807
    Cell Significance Index: 23.1600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1600
    Cell Significance Index: 15.8300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1185
    Cell Significance Index: 22.5600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0787
    Cell Significance Index: 145.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0685
    Cell Significance Index: 93.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0084
    Cell Significance Index: 15.7300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0028
    Cell Significance Index: 0.1000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0003
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0310
    Cell Significance Index: -5.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0310
    Cell Significance Index: -4.2600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0311
    Cell Significance Index: -19.7300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0466
    Cell Significance Index: -34.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0505
    Cell Significance Index: -37.3900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0699
    Cell Significance Index: -43.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0742
    Cell Significance Index: -56.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0878
    Cell Significance Index: -49.5100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1039
    Cell Significance Index: -2.6700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1041
    Cell Significance Index: -5.8400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1381
    Cell Significance Index: -3.9600
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.1413
    Cell Significance Index: -2.1500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1575
    Cell Significance Index: -8.1800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1797
    Cell Significance Index: -12.7100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1926
    Cell Significance Index: -55.4100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1940
    Cell Significance Index: -40.8700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2043
    Cell Significance Index: -9.6000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2364
    Cell Significance Index: -30.5400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2423
    Cell Significance Index: -35.2200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2448
    Cell Significance Index: -25.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2852
    Cell Significance Index: -32.6800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2869
    Cell Significance Index: -33.4400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3372
    Cell Significance Index: -4.6000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3486
    Cell Significance Index: -39.7900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3694
    Cell Significance Index: -23.8300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4230
    Cell Significance Index: -11.3400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.5003
    Cell Significance Index: -59.0000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5145
    Cell Significance Index: -53.5700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5338
    Cell Significance Index: -39.7800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5517
    Cell Significance Index: -11.7500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5948
    Cell Significance Index: -9.9600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6928
    Cell Significance Index: -54.8700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7051
    Cell Significance Index: -31.1900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.7340
    Cell Significance Index: -12.9700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8098
    Cell Significance Index: -49.6500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.8543
    Cell Significance Index: -14.3900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.9032
    Cell Significance Index: -34.2000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.9119
    Cell Significance Index: -13.4600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.9155
    Cell Significance Index: -11.7400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9916
    Cell Significance Index: -31.7600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -1.0397
    Cell Significance Index: -14.8000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.0816
    Cell Significance Index: -56.7900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.0865
    Cell Significance Index: -68.4800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.1618
    Cell Significance Index: -25.1000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.2273
    Cell Significance Index: -28.3600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.2875
    Cell Significance Index: -44.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular localization:** PPFIBP1 is primarily localized to the plasma membrane and cytoskeleton, where it interacts with various proteins to regulate cell adhesion and signaling. 2. **Protein-protein interactions:** Liprin-beta-1 interacts with numerous proteins, including cadherins, receptors, and signaling molecules, to modulate cell adhesion and signaling pathways. 3. **Signaling pathways:** PPFIBP1 is involved in various signaling pathways, including those related to growth factor receptors, second messengers, and receptor-type tyrosine-protein phosphatases. 4. **Expression profile:** PPFIBP1 is expressed in multiple cell types, including cardiac myocytes, endothelial cells, and neurons, highlighting its role in maintaining cellular homeostasis. **Pathways and Functions:** 1. **Cell adhesion:** PPFIBP1 regulates cell adhesion by interacting with cadherins and other proteins to modulate cell-cell interactions and maintain tissue structure. 2. **Signaling by growth factor receptors:** Liprin-beta-1 interacts with growth factor receptors to regulate signaling pathways involved in cell proliferation, differentiation, and survival. 3. **Neuromuscular junction development:** PPFIBP1 plays a crucial role in the development and maintenance of neuromuscular junctions, a critical interface between neurons and muscle fibers. 4. **Cancer signaling:** Liprin-beta-1 is involved in signaling pathways that regulate cancer cell growth, invasion, and metastasis. **Clinical Significance:** 1. **Cancer:** Alterations in PPFIBP1 expression or function have been implicated in various cancers, including breast, lung, and colon cancer. Liprin-beta-1 may serve as a potential biomarker for cancer diagnosis or as a therapeutic target for cancer treatment. 2. **Neurological disorders:** PPFIBP1 is involved in the regulation of neuronal signaling and plasticity, making it a potential target for the treatment of neurological disorders, such as Alzheimer's disease or Parkinson's disease. 3. **Cardiovascular disease:** Liprin-beta-1 plays a critical role in maintaining cardiac function and structure, making it a potential target for the treatment of cardiovascular disease. 4. **Neuromuscular disorders:** PPFIBP1 is involved in the development and maintenance of neuromuscular junctions, making it a potential target for the treatment of neuromuscular disorders, such as myasthenia gravis. In conclusion, PPFIBP1 is a gene that encodes a protein involved in various cellular processes, including cell adhesion, signaling, and protein-protein interactions. Its dysregulation has been implicated in various diseases, including cancer, neurological disorders, and cardiovascular disease. Further research is needed to fully understand the role of PPFIBP1 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 544340698

Symbol: LIPB1_HUMAN

Name: Liprin-beta-1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9624153

Title: Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins.

PubMed ID: 9624153

DOI: 10.1074/jbc.273.25.15611

PubMed ID: 10574462

Title: Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10574462

DOI: 10.1093/dnares/6.5.337

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11836260

Title: Liprin beta 1, a member of the family of LAR transmembrane tyrosine phosphatase-interacting proteins, is a new target for the metastasis-associated protein S100A4 (Mts1).

PubMed ID: 11836260

DOI: 10.1074/jbc.m110976200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 24120883

Title: CFEOM1-associated kinesin KIF21A is a cortical microtubule growth inhibitor.

PubMed ID: 24120883

DOI: 10.1016/j.devcel.2013.09.010

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27410476

Title: Talin-KANK1 interaction controls the recruitment of cortical microtubule stabilizing complexes to focal adhesions.

PubMed ID: 27410476

DOI: 10.7554/elife.18124

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 35830857

Title: Bi-allelic loss-of-function variants in PPFIBP1 cause a neurodevelopmental disorder with microcephaly, epilepsy, and periventricular calcifications.

PubMed ID: 35830857

DOI: 10.1016/j.ajhg.2022.06.008

Sequence Information:

  • Length: 1011
  • Mass: 114024
  • Checksum: 20E30DD99ACD5A92
  • Sequence:
  • MMSDASDMLA AALEQMDGII AGSKALEYSN GIFDCQSPTS PFMGSLRALH LVEDLRGLLE 
    MMETDEKEGL RCQIPDSTAE TLVEWLQSQM TNGHLPGNGD VYQERLARLE NDKESLVLQV 
    SVLTDQVEAQ GEKIRDLEFC LEEHREKVNA TEEMLQQELL SRTSLETQKL DLMAEISNLK 
    LKLTAVEKDR LDYEDKFRDT EGLIQEINDL RLKVSEMDSE RLQYEKKLKS TKSLMAKLSS 
    MKIKVGQMQY EKQRMEQKWE SLKDELASLK EQLEEKESEV KRLQEKLVCK MKGEGVEIVD 
    RDIEVQKMKK AVESLMAANE EKDRKIEDLR QCLNRYKKMQ DTVVLAQGKD GEYEELLNSS 
    SISSLLDAQG FSDLEKSPSP TPVMGSPSCD PFNTSVPEEF HTTILQVSIP SLLPATVSME 
    TSEKSKLTPK PETSFEENDG NIILGATVDT QLCDKLLTSS LQKSSSLGNL KKETSDGEKE 
    TIQKTSEDRA PAESRPFGTL PPRPPGQDTS MDDNPFGTRK VRSSFGRGFF KIKSNKRTAS 
    APNLAETEKE TAEHLDLAGA SSRPKDSQRN SPFQIPPPSP DSKKKSRGIM KLFGKLRRSQ 
    STTFNPDDMS EPEFKRGGTR ATAGPRLGWS RDLGQSNSDL DMPFAKWTKE QVCNWLMEQG 
    LGSYLNSGKH WIASGQTLLQ ASQQDLEKEL GIKHSLHRKK LQLALQALGS EEETNHGKLD 
    FNWVTRWLDD IGLPQYKTQF DEGRVDGRML HYMTVDDLLS LKVVSVLHHL SIKRAIQVLR 
    INNFEPNCLR RRPSDENTIA PSEVQKWTNH RVMEWLRSVD LAEYAPNLRG SGVHGGLMVL 
    EPRFNVETMA QLLNIPPNKT LLRRHLATHF NLLIGAEAQH QKRDAMELPD YVLLTATAKV 
    KPKKLAFSNF GNLRKKKQED GEEYVCPMEL GQASGSASKK GFKPGLDMRL YEEDDLDRLE 
    QMEDSEGTVR QIGAFSEGIN NLTHMLKEDD MFKDFAARSP SASITDEDSN V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.