Details for: RANBP3

Gene ID: 8498

Symbol: RANBP3

Ensembl ID: ENSG00000031823

Description: RAN binding protein 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 151.8529
    Cell Significance Index: -23.6200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 95.4095
    Cell Significance Index: -24.2000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 58.1205
    Cell Significance Index: -27.4400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 55.2852
    Cell Significance Index: -22.4600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 50.3222
    Cell Significance Index: -25.8900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 40.9375
    Cell Significance Index: -27.4700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 23.6503
    Cell Significance Index: -22.5800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.1038
    Cell Significance Index: -26.0200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.4924
    Cell Significance Index: -22.7500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.8339
    Cell Significance Index: -20.9900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.7029
    Cell Significance Index: -26.4500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.6514
    Cell Significance Index: -10.1800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2025
    Cell Significance Index: 1085.7900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9704
    Cell Significance Index: 13.2400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.9451
    Cell Significance Index: 25.3300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8662
    Cell Significance Index: 94.2200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7705
    Cell Significance Index: 152.9000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7639
    Cell Significance Index: 153.2500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7402
    Cell Significance Index: 44.4400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4529
    Cell Significance Index: 162.4500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4146
    Cell Significance Index: 11.9500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4059
    Cell Significance Index: 40.1500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3942
    Cell Significance Index: 13.7000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3819
    Cell Significance Index: 19.8400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3358
    Cell Significance Index: 63.9000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3020
    Cell Significance Index: 54.4500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2932
    Cell Significance Index: 15.4000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2668
    Cell Significance Index: 31.4600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2601
    Cell Significance Index: 179.9000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2578
    Cell Significance Index: 13.4300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2480
    Cell Significance Index: 30.4900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2480
    Cell Significance Index: 11.2400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2458
    Cell Significance Index: 6.6900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2252
    Cell Significance Index: 10.5000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2185
    Cell Significance Index: 30.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2177
    Cell Significance Index: 118.8900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1980
    Cell Significance Index: 13.7000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1830
    Cell Significance Index: 11.5400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1618
    Cell Significance Index: 12.4200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1588
    Cell Significance Index: 3.9700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1440
    Cell Significance Index: 3.1200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1398
    Cell Significance Index: 61.8300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1111
    Cell Significance Index: 14.2400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1013
    Cell Significance Index: 3.5600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0955
    Cell Significance Index: 2.6700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0831
    Cell Significance Index: 14.1900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0814
    Cell Significance Index: 4.5700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0425
    Cell Significance Index: 3.1700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0397
    Cell Significance Index: 5.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0322
    Cell Significance Index: 60.5800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0251
    Cell Significance Index: 1.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0221
    Cell Significance Index: 1.0400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0167
    Cell Significance Index: 0.3500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0099
    Cell Significance Index: 18.2700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0094
    Cell Significance Index: 14.4400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0056
    Cell Significance Index: 0.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0019
    Cell Significance Index: 0.8400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0017
    Cell Significance Index: 0.1100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0008
    Cell Significance Index: 0.5100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0001
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0069
    Cell Significance Index: -5.1200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0072
    Cell Significance Index: -4.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0162
    Cell Significance Index: -12.2400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0177
    Cell Significance Index: -13.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0354
    Cell Significance Index: -19.9600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0406
    Cell Significance Index: -4.1500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0412
    Cell Significance Index: -0.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0463
    Cell Significance Index: -0.9900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0472
    Cell Significance Index: -1.2400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0625
    Cell Significance Index: -4.2000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0684
    Cell Significance Index: -14.4000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0684
    Cell Significance Index: -0.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0748
    Cell Significance Index: -21.5100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0856
    Cell Significance Index: -9.9800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0922
    Cell Significance Index: -6.5200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0961
    Cell Significance Index: -2.4700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0972
    Cell Significance Index: -4.3000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0983
    Cell Significance Index: -11.2600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1039
    Cell Significance Index: -15.1000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1149
    Cell Significance Index: -3.6800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1412
    Cell Significance Index: -5.3500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1624
    Cell Significance Index: -4.7700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1811
    Cell Significance Index: -20.6700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2219
    Cell Significance Index: -23.1000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2524
    Cell Significance Index: -4.3300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2775
    Cell Significance Index: -21.9800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2791
    Cell Significance Index: -7.1300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3133
    Cell Significance Index: -4.7000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3399
    Cell Significance Index: -7.2700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3789
    Cell Significance Index: -10.8600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4308
    Cell Significance Index: -26.4100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4416
    Cell Significance Index: -10.5900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.4535
    Cell Significance Index: -4.9300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4541
    Cell Significance Index: -12.9600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4672
    Cell Significance Index: -3.8100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4752
    Cell Significance Index: -6.8100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4994
    Cell Significance Index: -25.2400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4996
    Cell Significance Index: -13.3700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5298
    Cell Significance Index: -11.6000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5441
    Cell Significance Index: -17.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Ran-binding protein 3 (RANBP3)**: RANBP3 is a protein that interacts with the small GTPase Ran, influencing its activity and function. 2. **Nuclear pore complex (NPC) regulation**: RANBP3 is involved in regulating the NPC, a structure responsible for nuclear transport and export. 3. **Protein binding**: RANBP3 exhibits high affinity for various proteins, including Ran, nuclear pore proteins, and transcription factors. 4. **Cell-type specificity**: RANBP3 expression is highly specific, with notable presence in pulmonary interstitial fibroblasts, cardiac muscle myoblasts, and neurons. **Pathways and Functions:** 1. **GTPase activator activity**: RANBP3 acts as a GTPase activator for Ran, modulating its GTPase activity and influencing NPC function. 2. **Nuclear export**: RANBP3 is involved in regulating nuclear export, a process crucial for cellular homeostasis and gene regulation. 3. **Protein export from nucleus**: RANBP3 facilitates the export of proteins from the nucleus, influencing cellular signaling and gene expression. 4. **R-smad binding**: RANBP3 interacts with R-Smads, a family of transcription factors involved in TGF-β signaling. **Clinical Significance:** 1. **Pulmonary fibrosis**: RANBP3 expression has been linked to pulmonary fibrosis, a condition characterized by excessive scarring in the lungs. 2. **Cardiac disease**: Abnormalities in RANBP3 expression have been observed in cardiac muscle myoblasts, potentially contributing to cardiac disease. 3. **Neurological disorders**: RANBP3's role in neuronal function and development suggests its involvement in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Cancer**: RANBP3's interaction with transcription factors and its role in regulating gene expression may contribute to its potential as a cancer biomarker. In conclusion, RANBP3 is a multifaceted gene with far-reaching implications in various cellular processes. Further research is necessary to elucidate the precise mechanisms and clinical significance of this enigmatic gene.

Genular Protein ID: 335906806

Symbol: RANB3_HUMAN

Name: Ran-binding protein 3

UniProtKB Accession Codes:

Q9H6Z4 B2RAT8 O60405 O75759 O75760 Q9BT47 Q9UG74

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 10 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9637251

Title: Human RanBP3, a group of nuclear RanGTP binding proteins.

PubMed ID: 9637251

DOI: 10.1016/s0014-5793(98)00459-1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10567565

Title: RanBP3 contains an unusual nuclear localization signal that is imported preferentially by importin-alpha3.

PubMed ID: 10567565

DOI: 10.1128/mcb.19.12.8400

PubMed ID: 11571268

Title: RanBP3 influences interactions between CRM1 and its nuclear protein export substrates.

PubMed ID: 11571268

DOI: 10.1093/embo-reports/kve200

PubMed ID: 11425870

Title: Ran-binding protein 3 is a cofactor for Crm1-mediated nuclear protein export.

PubMed ID: 11425870

DOI: 10.1083/jcb.153.7.1391

PubMed ID: 11932251

Title: Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor.

PubMed ID: 11932251

DOI: 10.1074/jbc.c100620200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18280241

Title: Ran-binding protein 3 phosphorylation links the Ras and PI3-kinase pathways to nucleocytoplasmic transport.

PubMed ID: 18280241

DOI: 10.1016/j.molcel.2007.12.024

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19289081

Title: Nuclear export of Smad2 and Smad3 by RanBP3 facilitates termination of TGF-beta signaling.

PubMed ID: 19289081

DOI: 10.1016/j.devcel.2009.01.022

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28760339

Title: Crystal structure of importin-alpha3 bound to the nuclear localization signal of Ran-binding protein 3.

PubMed ID: 28760339

DOI: 10.1016/j.bbrc.2017.07.155

Sequence Information:

  • Length: 567
  • Mass: 60210
  • Checksum: 203B5A900512743C
  • Sequence:
    • MADLANEEKP AIAPPVFVFQ KDKGQKSPAE QKNLSDSGEE PRGEAEAPHH GTGHPESAGE 
HALEPPAPAG ASASTPPPPA PEAQLPPFPR ELAGRSAGGS SPEGGEDSDR EDGNYCPPVK 
RERTSSLTQF PPSQSEERSS GFRLKPPTLI HGQAPSAGLP SQKPKEQQRS VLRPAVLQAP 
QPKALSQTVP SSGTNGVSLP ADCTGAVPAA SPDTAAWRSP SEAADEVCAL EEKEPQKNES 
SNASEEEACE KKDPATQQAF VFGQNLRDRV KLINESVDEA DMENAGHPSA DTPTATNYFL 
QYISSSLENS TNSADASSNK FVFGQNMSER VLSPPKLNEV SSDANRENAA AESGSESSSQ 
EATPEKESLA ESAAAYTKAT ARKCLLEKVE VITGEEAESN VLQMQCKLFV FDKTSQSWVE 
RGRGLLRLND MASTDDGTLQ SRLVMRTQGS LRLILNTKLW AQMQIDKASE KSIRITAMDT 
EDQGVKVFLI SASSKDTGQL YAALHHRILA LRSRVEQEQE AKMPAPEPGA APSNEEDDSD 
DDDVLAPSGA TAAGAGDEGD GQTTGST

Genular Protein ID: 2337632889

Symbol: Q53GE1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53GE1

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 1 Gene3D 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 8125298

Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.

PubMed ID: 8125298

DOI: 10.1016/0378-1119(94)90802-8

PubMed ID: 9373149

Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.

PubMed ID: 9373149

DOI: 10.1016/S0378-1119(97)00411-3

Sequence Information:

  • Length: 562
  • Mass: 59675
  • Checksum: AA710666D8101DEA
  • Sequence:
    • MADLANEEKP AIAPPVFVFQ KDKGQKSPAE QKNLSDSGEE PRGEAEAPHH GTGHPESAGE 
HALEPPAPAG ASASTPPPPA PEAQLPPFPR ELAGRSAGGS SPEGGEDSDR EDGNYCPPVK 
RERTSSLTQF PPSQSEERSS GFRLKPPTLI HGQAPSAGLP SQKPKEQQRS VLRPAVLQAP 
QPKALSQTVP SSGTNGVSLP ADCTGAVPAA SPDTAAWRSP SEAADEEKEP QKNESSNASE 
EEACEKKDPA TQQAFVFGQN LRDRVKLINE SVDEADMENA GHPSADTPTA TNYFLQYISS 
SLENSTNSAD ASSNKFVFGQ NMSERVLSPP KLNEVSSDAN RENAAAESGS ESSSQEATPE 
KESLAESAAA YTKATARKCL LEKVEVITGE EAESNVLQMQ CKLFVFDKTS QSWVERGRGL 
LRLNDMASTD DGTLQSRLVM RTQGSLRLIL NTKLWAQMQI DKASEKSIHI TAMDTEDQGV 
KVFLISASSK DTGQLYAALH HRILALRSRV EQEQEAKMPA PEPGAAPSNE EDDSDDDDVL 
APSGATAAGA GDEGDGQTTG ST

Genular Protein ID: 1326123331

Symbol: B7Z7F3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z7F3

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 GO 2 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.M111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 494
  • Mass: 52895
  • Checksum: E55958D341F078A6
  • Sequence:
    • MADLANEEKP AIAPPVFVFQ KDKGQKRSAG GSSPEGGEDS DREDGNYCPP VKRERTSSLT 
QFPPSQSEER SSGFRLKPPT LIHGQAPSAG LPSQKPKEQQ RSVLRPAVLQ APQPKALSQT 
VPSSGTNGVS LPADCTGAVP AASPDTAAWR SPSEAADEEK EPQKNESSNA SEEEACEKKD 
PATQQAFVFG QNLRDRVKLI NESVDEADME NAGHPSADTP TATNYFLQYI SSSLENSTNS 
ADASSNKFVF GQNMSERVLS PPKLNEVSSD ANRENAAAES GSESSSQEAT PEKESLAESA 
AAYTKATARK CLLEKVEVIT GEEAESNVLQ MQCKLFVFDK TSQSWVERGR GLLRLNDMAS 
TDDGTLQSRL VMRTQGSLRL ILNTKLWAQM QIDKASEKSI RITAMDTEDQ GVKVFLISAS 
SKDTGQLYAA LHHRILALRS RVEQEQEAKM PAPEPGAAPS NEEDDSDDDD VLAPSGATAA 
GAGDEGDGQT TGST

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.