Details for: ENC1

Gene ID: 8507

Symbol: ENC1

Ensembl ID: ENSG00000171617

Description: ectodermal-neural cortex 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 201.9027
    Cell Significance Index: -31.4100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 125.9643
    Cell Significance Index: -31.9500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 69.9846
    Cell Significance Index: -28.8300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 65.1526
    Cell Significance Index: -30.7600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 60.4051
    Cell Significance Index: -24.5400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 58.7789
    Cell Significance Index: -30.2400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 25.7452
    Cell Significance Index: -24.5800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 25.5565
    Cell Significance Index: -31.5100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.0536
    Cell Significance Index: -31.7800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 4.2927
    Cell Significance Index: 122.5000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 3.2641
    Cell Significance Index: 219.4800
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 2.3179
    Cell Significance Index: 30.9200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.8709
    Cell Significance Index: 23.9600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.8235
    Cell Significance Index: 52.5400
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.6868
    Cell Significance Index: 9.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.6748
    Cell Significance Index: 87.0000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.5597
    Cell Significance Index: 21.2800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.4791
    Cell Significance Index: 90.9100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.4122
    Cell Significance Index: 64.0100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3061
    Cell Significance Index: 78.4100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2494
    Cell Significance Index: 247.9400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2317
    Cell Significance Index: 133.9800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.1243
    Cell Significance Index: 39.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.1238
    Cell Significance Index: 49.7100
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 1.0820
    Cell Significance Index: 6.1500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.0247
    Cell Significance Index: 22.2000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0222
    Cell Significance Index: 166.2600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.9525
    Cell Significance Index: 36.0700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.9410
    Cell Significance Index: 24.7400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.7468
    Cell Significance Index: 17.9100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5685
    Cell Significance Index: 310.4700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.5318
    Cell Significance Index: 7.5700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.4908
    Cell Significance Index: 4.5200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4755
    Cell Significance Index: 429.3000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3932
    Cell Significance Index: 78.8700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.3625
    Cell Significance Index: 7.5200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3224
    Cell Significance Index: 7.0600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2740
    Cell Significance Index: 6.8500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2586
    Cell Significance Index: 46.6100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2487
    Cell Significance Index: 47.3300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2386
    Cell Significance Index: 105.4800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2172
    Cell Significance Index: 26.7100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1792
    Cell Significance Index: 17.7300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1772
    Cell Significance Index: 63.5600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1505
    Cell Significance Index: 20.6700
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.0925
    Cell Significance Index: 0.8800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0561
    Cell Significance Index: 8.1600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0470
    Cell Significance Index: 1.6500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0032
    Cell Significance Index: -2.2200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0072
    Cell Significance Index: -1.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0101
    Cell Significance Index: -18.9700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0166
    Cell Significance Index: -30.6400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0171
    Cell Significance Index: -12.6600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0218
    Cell Significance Index: -33.5100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0221
    Cell Significance Index: -13.7800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0227
    Cell Significance Index: -14.4000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0250
    Cell Significance Index: -18.9000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0290
    Cell Significance Index: -0.6200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0303
    Cell Significance Index: -41.1400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0364
    Cell Significance Index: -26.7100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0426
    Cell Significance Index: -24.0200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0648
    Cell Significance Index: -7.4200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0678
    Cell Significance Index: -30.7700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0783
    Cell Significance Index: -1.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0853
    Cell Significance Index: -9.9400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0908
    Cell Significance Index: -26.1300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0947
    Cell Significance Index: -19.9400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1250
    Cell Significance Index: -6.5100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1270
    Cell Significance Index: -5.9200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1319
    Cell Significance Index: -13.4700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1755
    Cell Significance Index: -22.5000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1771
    Cell Significance Index: -1.9300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1925
    Cell Significance Index: -4.1000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1944
    Cell Significance Index: -25.1100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2152
    Cell Significance Index: -15.2200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2338
    Cell Significance Index: -2.4200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2368
    Cell Significance Index: -27.9300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2404
    Cell Significance Index: -6.4200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2524
    Cell Significance Index: -7.0600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2630
    Cell Significance Index: -30.0200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2831
    Cell Significance Index: -7.7100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2892
    Cell Significance Index: -18.6600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3108
    Cell Significance Index: -32.3600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3496
    Cell Significance Index: -27.6900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3539
    Cell Significance Index: -19.8600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3814
    Cell Significance Index: -17.9300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3920
    Cell Significance Index: -29.2200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4079
    Cell Significance Index: -31.3100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4108
    Cell Significance Index: -13.4500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4193
    Cell Significance Index: -13.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4236
    Cell Significance Index: -25.9700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4327
    Cell Significance Index: -13.8600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4366
    Cell Significance Index: -6.5800
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.4411
    Cell Significance Index: -2.8700
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.4602
    Cell Significance Index: -2.4100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4972
    Cell Significance Index: -7.4500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.5177
    Cell Significance Index: -8.0100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5185
    Cell Significance Index: -10.4100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5347
    Cell Significance Index: -33.7000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5502
    Cell Significance Index: -28.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell-type specific expression:** ENC1 is expressed in a range of cell types, including neural progenitor cells, GABAergic neurons, and pyramidal neurons, highlighting its importance in neuronal development and function. 2. **Protein binding and ubiquitination:** ENC1 interacts with various proteins, including Cul3-ring ubiquitin ligase complex, and is involved in protein ubiquitination, which plays a critical role in regulating protein degradation and cellular processes. 3. **Actin-binding and cytoskeletal regulation:** ENC1 interacts with actin-binding proteins, which suggests its involvement in regulating actin dynamics and cytoskeletal organization, essential for neuronal morphology and function. 4. **Regulation of translation:** ENC1 negatively regulates translation, which is critical for controlling protein synthesis and cellular processes. **Pathways and Functions:** 1. **Nervous system development:** ENC1 plays a crucial role in regulating neuronal cell body morphology, neuronal projection development, and negative regulation of translation, which are essential for proper nervous system development. 2. **Neuronal cell body regulation:** ENC1 regulates actin dynamics and cytoskeletal organization, which is critical for maintaining neuronal cell body morphology and function. 3. **Negative regulation of translation:** ENC1 negatively regulates translation, which is essential for controlling protein synthesis and cellular processes. 4. **Protein ubiquitination:** ENC1 is involved in protein ubiquitination, which plays a critical role in regulating protein degradation and cellular processes. **Clinical Significance:** 1. **Neurodevelopmental disorders:** Alterations in ENC1 expression have been linked to neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia, highlighting its importance in regulating neuronal development and function. 2. **Neurodegenerative diseases:** ENC1 may play a role in regulating protein degradation and cellular processes in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer:** ENC1 has been implicated in cancer development and progression, particularly in pancreatic cancer, where it regulates cell proliferation and survival. 4. **Neuromodulation:** ENC1 may play a role in regulating neuronal activity and synaptic plasticity, which is essential for learning and memory. In conclusion, ENC1 is a critical regulator of neuronal development and function, and its dysregulation has been implicated in various neurological and psychiatric disorders. Further research is necessary to fully understand the mechanisms by which ENC1 regulates neuronal processes and to explore its potential as a therapeutic target for neurodevelopmental and neurodegenerative disorders.

Genular Protein ID: 2223547996

Symbol: ENC1_HUMAN

Name: Ectoderm-neural cortex protein 1

UniProtKB Accession Codes:

O14682 B4DHJ1 E9PFU0 O75464 Q9UPG9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 4 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 6 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9305847

Title: A model for p53-induced apoptosis.

PubMed ID: 9305847

DOI: 10.1038/38525

PubMed ID: 9683534

Title: Cloning of human ENC-1 and evaluation of its expression and regulation in nervous system tumors.

PubMed ID: 9683534

DOI: 10.1006/excr.1998.4109

PubMed ID: 9566959

Title: NRP/B, a novel nuclear matrix protein, associates with p110(RB) and is involved in neuronal differentiation.

PubMed ID: 9566959

DOI: 10.1083/jcb.141.3.553

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15983046

Title: Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway.

PubMed ID: 15983046

DOI: 10.1074/jbc.m501279200

PubMed ID: 19424503

Title: Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level.

PubMed ID: 19424503

DOI: 10.1371/journal.pone.0005492

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

Sequence Information:

  • Length: 589
  • Mass: 66130
  • Checksum: DB003A1DFA65BAA0
  • Sequence:
    • MSVSVHENRK SRASSGSINI YLFHKSSYAD SVLTHLNLLR QQRLFTDVLL HAGNRTFPCH 
RAVLAACSRY FEAMFSGGLK ESQDSEVNFD NSIHPEVLEL LLDYAYSSRV IINEENAESL 
LEAGDMLEFQ DIRDACAEFL EKNLHPTNCL GMLLLSDAHQ CTKLYELSWR MCLSNFQTIR 
KNEDFLQLPQ DMVVQLLSSE ELETEDERLV YESAINWISY DLKKRYCYLP ELLQTVRLAL 
LPAIYLMENV AMEELITKQR KSKEIVEEAI RCKLKILQND GVVTSLCARP RKTGHALFLL 
GGQTFMCDKL YLVDQKAKEI IPKADIPSPR KEFSACAIGC KVYITGGRGS ENGVSKDVWV 
YDTLHEEWSK AAPMLVARFG HGSAELKHCL YVVGGHTAAT GCLPASPSVS LKQVEHYDPT 
INKWTMVAPL REGVSNAAVV SAKLKLFAFG GTSVSHDKLP KVQCYDQCEN RWTVPATCPQ 
PWRYTAAAVL GNQIFIMGGD TEFSACSAYK FNSETYQWTK VGDVTAKRMS CHAVASGNKL 
YVVGGYFGIQ RCKTLDCYDP TLDVWNSITT VPYSLIPTAF VSTWKHLPS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.