Details for: KCNAB2

Gene ID: 8514

Symbol: KCNAB2

Ensembl ID: ENSG00000069424

Description: potassium voltage-gated channel subfamily A regulatory beta subunit 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 115.1434
    Cell Significance Index: -17.9100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 48.8853
    Cell Significance Index: -19.8600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 42.5751
    Cell Significance Index: -21.9000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 40.8447
    Cell Significance Index: -10.3600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 21.0894
    Cell Significance Index: -20.1400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.6721
    Cell Significance Index: -18.0900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.5990
    Cell Significance Index: -23.3400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.2415
    Cell Significance Index: -16.7200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.7262
    Cell Significance Index: -18.6500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.1259
    Cell Significance Index: -9.0300
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 3.3601
    Cell Significance Index: 21.4500
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 2.8474
    Cell Significance Index: 18.8900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.1278
    Cell Significance Index: 62.4900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 2.0864
    Cell Significance Index: 55.8100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.9999
    Cell Significance Index: 401.1700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.8741
    Cell Significance Index: 23.2500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.8092
    Cell Significance Index: 51.6300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.6822
    Cell Significance Index: 113.1100
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 1.3688
    Cell Significance Index: 18.2600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.3288
    Cell Significance Index: 24.5600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.2994
    Cell Significance Index: 49.2100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.2857
    Cell Significance Index: 56.8700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0650
    Cell Significance Index: 48.2800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9199
    Cell Significance Index: 175.0600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7458
    Cell Significance Index: 267.5100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7432
    Cell Significance Index: 47.9500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5651
    Cell Significance Index: 55.9000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.5506
    Cell Significance Index: 4.4900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4797
    Cell Significance Index: 36.8100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4631
    Cell Significance Index: 418.1500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.4603
    Cell Significance Index: 10.0800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4431
    Cell Significance Index: 306.4500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4041
    Cell Significance Index: 47.6500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3505
    Cell Significance Index: 18.4000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2980
    Cell Significance Index: 48.4600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2469
    Cell Significance Index: 26.8600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1782
    Cell Significance Index: 3.8000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1438
    Cell Significance Index: 28.5400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1223
    Cell Significance Index: 7.3400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0664
    Cell Significance Index: 4.6000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0652
    Cell Significance Index: 122.6900
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 0.0625
    Cell Significance Index: 0.6900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0416
    Cell Significance Index: 2.5600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0188
    Cell Significance Index: 0.4700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0048
    Cell Significance Index: 8.7700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0021
    Cell Significance Index: 3.2100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0047
    Cell Significance Index: -0.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0064
    Cell Significance Index: -8.6600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0077
    Cell Significance Index: -0.2700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0079
    Cell Significance Index: -4.9200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0101
    Cell Significance Index: -7.5100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0108
    Cell Significance Index: -0.3100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0121
    Cell Significance Index: -1.7600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0126
    Cell Significance Index: -7.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0157
    Cell Significance Index: -8.5800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0256
    Cell Significance Index: -16.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0256
    Cell Significance Index: -19.3800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0257
    Cell Significance Index: -11.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0265
    Cell Significance Index: -12.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0287
    Cell Significance Index: -21.0100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0382
    Cell Significance Index: -8.0500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0406
    Cell Significance Index: -0.8800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0440
    Cell Significance Index: -0.6300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0549
    Cell Significance Index: -15.8100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0550
    Cell Significance Index: -9.4000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0580
    Cell Significance Index: -10.4600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0580
    Cell Significance Index: -7.9700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0632
    Cell Significance Index: -1.3100
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0673
    Cell Significance Index: -0.6400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0782
    Cell Significance Index: -1.6600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0827
    Cell Significance Index: -4.6400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0846
    Cell Significance Index: -2.0300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0871
    Cell Significance Index: -8.9000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0918
    Cell Significance Index: -5.6300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1182
    Cell Significance Index: -13.7700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1195
    Cell Significance Index: -1.4900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1213
    Cell Significance Index: -14.9200
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -0.1381
    Cell Significance Index: -0.3700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1417
    Cell Significance Index: -3.6200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1446
    Cell Significance Index: -18.6800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1483
    Cell Significance Index: -4.7500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1492
    Cell Significance Index: -2.9500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1552
    Cell Significance Index: -3.1200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1553
    Cell Significance Index: -4.3400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1575
    Cell Significance Index: -20.1900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1590
    Cell Significance Index: -18.1500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1598
    Cell Significance Index: -16.6400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1623
    Cell Significance Index: -10.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1792
    Cell Significance Index: -20.5400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1831
    Cell Significance Index: -5.8300
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1890
    Cell Significance Index: -1.5600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1924
    Cell Significance Index: -6.3000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2028
    Cell Significance Index: -2.5600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2370
    Cell Significance Index: -5.1200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2519
    Cell Significance Index: -11.8400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2578
    Cell Significance Index: -11.2100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2644
    Cell Significance Index: -20.9400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2659
    Cell Significance Index: -19.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2697
    Cell Significance Index: -14.0100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2763
    Cell Significance Index: -3.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The KCNAB2 gene exhibits the following key characteristics: 1. **Voltage-gated potassium channel subunit**: KCNAB2 is a regulatory subunit of voltage-gated potassium channels, which are essential for regulating the excitability of neurons and immune cells. 2. **Regulatory function**: The gene plays a regulatory role in potassium ion transmembrane transport, influencing the excitability of neurons and immune cells. 3. **Cell-type specificity**: KCNAB2 is expressed in a wide range of cell types, including neurons, immune cells, and macrophages, indicating its importance in multiple physiological processes. 4. **Disease association**: Mutations or alterations in KCNAB2 expression have been linked to various neurological and immune disorders, highlighting the gene's potential as a therapeutic target. **Pathways and Functions** KCNAB2 is involved in various cellular pathways and functions, including: 1. **Aldo-keto reductase (NADP) activity**: KCNAB2 is involved in the regulation of NADP-dependent reductases, which play a crucial role in antioxidant defense. 2. **Cytoplasmic side of plasma membrane**: KCNAB2 regulates the activity of potassium channels on the cytoplasmic side of the plasma membrane, influencing the excitability of neurons and immune cells. 3. **Immune system**: KCNAB2 is expressed in immune cells, such as non-classical monocytes and alveolar macrophages, and plays a role in regulating immune responses. 4. **Neuronal system**: KCNAB2 is expressed in neurons, including GABAergic cortical interneurons and corticothalamic-projecting glutamatergic neurons, and regulates their excitability. 5. **Potassium channel regulation**: KCNAB2 regulates the activity of voltage-gated potassium channels, influencing the excitability of neurons and immune cells. **Clinical Significance** KCNAB2 has significant clinical implications in various neurological and immune disorders, including: 1. **Epilepsy**: Mutations in KCNAB2 have been linked to genetic epilepsy, highlighting the gene's importance in regulating neuronal excitability. 2. **Immune disorders**: KCNAB2 is expressed in immune cells, and alterations in its expression have been linked to various immune disorders, including inflammatory diseases and autoimmune disorders. 3. **Neurodegenerative diseases**: KCNAB2 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, highlighting its potential as a therapeutic target. 4. **Cancer**: KCNAB2 is expressed in cancer cells, and alterations in its expression have been linked to cancer progression and metastasis. In conclusion, KCNAB2 is a critical gene that regulates the activity of voltage-gated potassium channels, influencing the excitability of neurons and immune cells. Its clinical significance is evident in various neurological and immune disorders, highlighting its potential as a therapeutic target.

Genular Protein ID: 2655013555

Symbol: KCAB2_HUMAN

Name: Voltage-gated potassium channel subunit beta-2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7649300

Title: Alternative splicing of the human Shaker K+ channel beta 1 gene and functional expression of the beta 2 gene product.

PubMed ID: 7649300

DOI: 10.1016/0014-5793(95)00785-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11086297

Title: Subunit composition and novel localization of K+ channels in spinal cord.

PubMed ID: 11086297

DOI: 10.1002/1096-9861(20000101)429:1<166::aid-cne13>3.0.co;2-y

PubMed ID: 11825900

Title: Genetic analysis of the mammalian K+ channel beta subunit Kvbeta 2 (Kcnab2).

PubMed ID: 11825900

DOI: 10.1074/jbc.m111465200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21357749

Title: Cdk-mediated phosphorylation of the Kvbeta2 auxiliary subunit regulates Kv1 channel axonal targeting.

PubMed ID: 21357749

DOI: 10.1083/jcb.201007113

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 367
  • Mass: 41000
  • Checksum: 91A673F8992140DA
  • Sequence:
  • MYPESTTGSP ARLSLRQTGS PGMIYSTRYG SPKRQLQFYR NLGKSGLRVS CLGLGTWVTF 
    GGQITDEMAE QLMTLAYDNG INLFDTAEVY AAGKAEVVLG NIIKKKGWRR SSLVITTKIF 
    WGGKAETERG LSRKHIIEGL KASLERLQLE YVDVVFANRP DPNTPMEETV RAMTHVINQG 
    MAMYWGTSRW SSMEIMEAYS VARQFNLTPP ICEQAEYHMF QREKVEVQLP ELFHKIGVGA 
    MTWSPLACGI VSGKYDSGIP PYSRASLKGY QWLKDKILSE EGRRQQAKLK ELQAIAERLG 
    CTLPQLAIAW CLRNEGVSSV LLGASNADQL MENIGAIQVL PKLSSSIIHE IDSILGNKPY 
    SKKDYRS

Genular Protein ID: 3137677724

Symbol: B2R776_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 353
  • Mass: 39288
  • Checksum: A63FEE6258C7E867
  • Sequence:
  • MYPESTTGSP ARLSLRQTGS PGMIYRNLGK SGLRVSCLGL GTWVTFGGQI TDEMAEQLMT 
    LAYDNGIDLF DTAEVYAAGK AEVVLGNIIK KKGWRRSSLV ITTKIFWGGK AETERGLSRK 
    HIIEGLKASL ERLQLEYVDV VFANRPDPNT PMEETVRAMT HVINQGMAMY WGTSRWSSME 
    IMEAYSVARQ FNLTPPICEQ AEYHMFQREK VEVQLPELFH KIGVGAMTWS PLACGIVSGK 
    YDSGIPPYSR ASLKGYQWLK DKILSEEGRR QQAKLKELQA IAERLGCTLP QLAIAWCLRN 
    EGVSSVLLGA SNADQLMENI GAIQVLPKLS SSIIHEIDSI LGNKPYSKKD YRS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.