Details for: DDO

Gene ID: 8528

Symbol: DDO

Ensembl ID: ENSG00000203797

Description: D-aspartate oxidase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 26.2946
    Cell Significance Index: -4.0900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 13.0104
    Cell Significance Index: -3.3000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.3983
    Cell Significance Index: -4.1900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 1.4291
    Cell Significance Index: 20.8300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.0720
    Cell Significance Index: -4.2300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7331
    Cell Significance Index: 44.0100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6022
    Cell Significance Index: 543.7100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.5910
    Cell Significance Index: 26.1400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5903
    Cell Significance Index: 64.2100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5280
    Cell Significance Index: 52.2300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4288
    Cell Significance Index: 69.7400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4288
    Cell Significance Index: 11.4900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3776
    Cell Significance Index: 10.8800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3156
    Cell Significance Index: 21.8300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2835
    Cell Significance Index: 21.7600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2662
    Cell Significance Index: 5.6700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.2661
    Cell Significance Index: 4.0100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2554
    Cell Significance Index: 9.6700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2509
    Cell Significance Index: 16.8700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2474
    Cell Significance Index: 5.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2044
    Cell Significance Index: 40.5600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1628
    Cell Significance Index: 7.3800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1133
    Cell Significance Index: 21.5600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0772
    Cell Significance Index: 1.9300
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0764
    Cell Significance Index: 1.0600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0669
    Cell Significance Index: 2.3500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0307
    Cell Significance Index: 0.4600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0245
    Cell Significance Index: 0.6300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0160
    Cell Significance Index: 2.3300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0154
    Cell Significance Index: 0.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0135
    Cell Significance Index: 0.6300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0132
    Cell Significance Index: 0.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0061
    Cell Significance Index: 8.2400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0033
    Cell Significance Index: 5.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0029
    Cell Significance Index: 1.5700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0012
    Cell Significance Index: 0.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0006
    Cell Significance Index: 1.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0004
    Cell Significance Index: 0.7200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0005
    Cell Significance Index: -0.3400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0047
    Cell Significance Index: -3.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0058
    Cell Significance Index: -4.3200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0058
    Cell Significance Index: -4.3900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0065
    Cell Significance Index: -0.6600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0068
    Cell Significance Index: -4.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0080
    Cell Significance Index: -4.5300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0085
    Cell Significance Index: -3.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0087
    Cell Significance Index: -3.9300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0087
    Cell Significance Index: -1.4800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0090
    Cell Significance Index: -0.5500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0094
    Cell Significance Index: -3.3600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0125
    Cell Significance Index: -3.6100
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0137
    Cell Significance Index: -0.1800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0140
    Cell Significance Index: -2.5300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0160
    Cell Significance Index: -1.8300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0170
    Cell Significance Index: -2.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0182
    Cell Significance Index: -3.6500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0215
    Cell Significance Index: -2.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0216
    Cell Significance Index: -2.6500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0216
    Cell Significance Index: -4.5600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0219
    Cell Significance Index: -3.0100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0230
    Cell Significance Index: -0.3900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0257
    Cell Significance Index: -3.0000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0284
    Cell Significance Index: -0.4500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0307
    Cell Significance Index: -2.2900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0322
    Cell Significance Index: -1.0300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0340
    Cell Significance Index: -0.8500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0406
    Cell Significance Index: -4.2300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0408
    Cell Significance Index: -2.6300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0409
    Cell Significance Index: -3.2400
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0432
    Cell Significance Index: -0.3300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0462
    Cell Significance Index: -1.8900
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0489
    Cell Significance Index: -0.6600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0501
    Cell Significance Index: -1.4000
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0526
    Cell Significance Index: -0.6800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0556
    Cell Significance Index: -0.8200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0565
    Cell Significance Index: -2.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0573
    Cell Significance Index: -3.0100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0581
    Cell Significance Index: -3.6600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0600
    Cell Significance Index: -0.7700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0607
    Cell Significance Index: -1.2600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0624
    Cell Significance Index: -1.0500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0635
    Cell Significance Index: -3.9000
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.0700
    Cell Significance Index: -0.7500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0720
    Cell Significance Index: -1.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0772
    Cell Significance Index: -4.3300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0774
    Cell Significance Index: -4.0200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0801
    Cell Significance Index: -2.1800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0824
    Cell Significance Index: -2.0100
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0884
    Cell Significance Index: -0.6800
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.0886
    Cell Significance Index: -0.9600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0965
    Cell Significance Index: -2.2300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1033
    Cell Significance Index: -3.5900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1097
    Cell Significance Index: -2.0300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1103
    Cell Significance Index: -3.4900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1106
    Cell Significance Index: -4.0600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1168
    Cell Significance Index: -4.0900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1186
    Cell Significance Index: -2.0500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1188
    Cell Significance Index: -1.2300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1205
    Cell Significance Index: -3.5500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1212
    Cell Significance Index: -1.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DDO is a peroxisomal enzyme, meaning it resides in the peroxisomal matrix, where it facilitates the oxidation of D-aspartate into oxaloacetate. This reaction is crucial for the degradation of D-aspartate, a non-standard amino acid that can accumulate in cells and tissues. The enzyme exhibits high specificity for D-aspartate, distinguishing it from its L-aspartate counterpart. DDO has also been implicated in the regulation of cell signaling pathways, including those involved in immune responses and neuronal function. **Pathways and Functions:** DDO is integral to several metabolic pathways, including: 1. **Aspartate Catabolic Process:** DDO catalyzes the oxidation of D-aspartate into oxaloacetate, which can then be further metabolized to produce energy or used in biosynthetic reactions. 2. **Glyoxylate Metabolism and Glycine Degradation:** DDO contributes to the degradation of glyoxylate and glycine, two key intermediates in these metabolic pathways. 3. **Peroxisomal Function:** As a peroxisomal enzyme, DDO plays a critical role in the regulation of peroxisomal protein import and the maintenance of peroxisomal function. 4. **Immune Regulation:** DDO has been implicated in the regulation of immune responses, including the activation of immune cells and the modulation of inflammatory responses. **Clinical Significance:** The dysregulation of DDO has been linked to various disease states, including: 1. **Inflammatory Disorders:** Altered DDO activity has been observed in patients with inflammatory diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Metabolic Diseases:** DDO has been implicated in the regulation of metabolic pathways, including those involved in glucose and lipid metabolism. 3. **Neurological Conditions:** DDO has been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Cancer:** Altered DDO activity has been observed in certain types of cancer, including colon cancer and breast cancer. In conclusion, DDO is a multifaceted enzyme that plays a critical role in immune regulation, metabolism, and cell signaling. Further research is needed to fully elucidate the mechanisms by which DDO influences disease states, but it is clear that this enzyme is a key player in the complex interplay between cellular metabolism and immune function.

Genular Protein ID: 4139245208

Symbol: OXDD_HUMAN

Name: D-aspartate oxidase

UniProtKB Accession Codes:

Q99489 A8KAG4 Q5JXM4 Q5JXM5 Q5JXM6 Q8N552

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 33 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 3 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 2 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 2 RefSeq 2 Rhea 8 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9163533

Title: Structural and functional characterization of the human brain D-aspartate oxidase.

PubMed ID: 9163533

DOI: 10.1093/oxfordjournals.jbchem.a021655

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1991137

Title: D-aspartate oxidase, a peroxisomal enzyme in liver of rat and man.

PubMed ID: 1991137

DOI: 10.1016/0304-4165(91)90203-s

PubMed ID: 9820813

Title: C-terminal tripeptide Ser-Asn-Leu (SNL) of human D-aspartate oxidase is a functional peroxisome-targeting signal.

PubMed ID: 9820813

DOI: 10.1042/bj3360367

PubMed ID: 12209855

Title: Cellular and subcellular distribution of D-aspartate oxidase in human and rat brain.

PubMed ID: 12209855

DOI: 10.1002/cne.10320

PubMed ID: 20603179

Title: Thiolactomycin inhibits D-aspartate oxidase: a novel approach to probing the active site environment.

PubMed ID: 20603179

DOI: 10.1016/j.biochi.2010.06.021

PubMed ID: 23391306

Title: Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro.

PubMed ID: 23391306

DOI: 10.1021/jm3017865

PubMed ID: 25747990

Title: Characterization of the enzymatic and structural properties of human D-aspartate oxidase and comparison with those of the rat and mouse enzymes.

PubMed ID: 25747990

DOI: 10.1248/bpb.b14-00690

PubMed ID: 25689573

Title: A role for D-aspartate oxidase in schizophrenia and in schizophrenia-related symptoms induced by phencyclidine in mice.

PubMed ID: 25689573

DOI: 10.1038/tp.2015.2

PubMed ID: 28560262

Title: Decreased free d-aspartate levels are linked to enhanced d-aspartate oxidase activity in the dorsolateral prefrontal cortex of schizophrenia patients.

PubMed ID: 28560262

DOI: 10.1038/s41537-017-0015-7

PubMed ID: 28393897

Title: Olanzapine, but not clozapine, increases glutamate release in the prefrontal cortex of freely moving mice by inhibiting D-aspartate oxidase activity.

PubMed ID: 28393897

DOI: 10.1038/srep46288

PubMed ID: 29292239

Title: Rat d-aspartate oxidase is more similar to the human enzyme than the mouse enzyme.

PubMed ID: 29292239

DOI: 10.1016/j.bbapap.2017.12.009

PubMed ID: 30822420

Title: Free d-aspartate triggers NMDA receptor-dependent cell death in primary cortical neurons and perturbs JNK activation, Tau phosphorylation, and protein SUMOylation in the cerebral cortex of mice lacking d-aspartate oxidase activity.

PubMed ID: 30822420

DOI: 10.1016/j.expneurol.2019.02.014

PubMed ID: 32553892

Title: Biochemical characterization of mouse d-aspartate oxidase.

PubMed ID: 32553892

DOI: 10.1016/j.bbapap.2020.140472

PubMed ID: 33650155

Title: Cellular studies of the two main isoforms of human d-aspartate oxidase.

PubMed ID: 33650155

DOI: 10.1111/febs.15797

PubMed ID: 37805834

Title: On the regulation of human D-aspartate oxidase.

PubMed ID: 37805834

DOI: 10.1002/pro.4802

PubMed ID: 31914658

Title: Structure and kinetic properties of human d-aspartate oxidase, the enzyme-controlling d-aspartate levels in brain.

PubMed ID: 31914658

DOI: 10.1096/fj.201901703r

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 28629864

Title: Structure-function relationships in human d-aspartate oxidase: characterisation of variants corresponding to known single nucleotide polymorphisms.

PubMed ID: 28629864

DOI: 10.1016/j.bbapap.2017.06.010

Sequence Information:

  • Length: 341
  • Mass: 37535
  • Checksum: 8CAE7501FB7F215C
  • Sequence:
    • MDTARIAVVG AGVVGLSTAV CISKLVPRCS VTIISDKFTP DTTSDVAAGM LIPHTYPDTP 
IHTQKQWFRE TFNHLFAIAN SAEAGDAGVH LVSGWQIFQS TPTEEVPFWA DVVLGFRKMT 
EAELKKFPQY VFGQAFTTLK CECPAYLPWL EKRIKGSGGW TLTRRIEDLW ELHPSFDIVV 
NCSGLGSRQL AGDSKIFPVR GQVLQVQAPW VEHFIRDGSG LTYIYPGTSH VTLGGTRQKG 
DWNLSPDAEN SREILSRCCA LEPSLHGACN IREKVGLRPY RPGVRLQTEL LARDGQRLPV 
VHHYGHGSGG ISVHWGTALE AARLVSECVH ALRTPIPKSN L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.