Details for: AGPS

Gene ID: 8540

Symbol: AGPS

Ensembl ID: ENSG00000018510

Description: alkylglycerone phosphate synthase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 223.7291
    Cell Significance Index: -34.8000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 136.8063
    Cell Significance Index: -34.7000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 82.6480
    Cell Significance Index: -39.0200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 81.1555
    Cell Significance Index: -32.9700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 71.8722
    Cell Significance Index: -36.9700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 58.1799
    Cell Significance Index: -39.0400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 34.8052
    Cell Significance Index: -33.2300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 30.4147
    Cell Significance Index: -37.5000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.6887
    Cell Significance Index: -36.6700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.9101
    Cell Significance Index: -33.5100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.6045
    Cell Significance Index: -37.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.2531
    Cell Significance Index: 447.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6227
    Cell Significance Index: 325.5200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3863
    Cell Significance Index: 150.7900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3039
    Cell Significance Index: 212.0700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.1997
    Cell Significance Index: 23.4200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1906
    Cell Significance Index: 71.4800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.1742
    Cell Significance Index: 65.8900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9960
    Cell Significance Index: 357.2300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8565
    Cell Significance Index: 65.7300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.7913
    Cell Significance Index: 19.7800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6880
    Cell Significance Index: 42.2900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6736
    Cell Significance Index: 46.5900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6724
    Cell Significance Index: 465.0600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.5408
    Cell Significance Index: 20.4800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4996
    Cell Significance Index: 22.1000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4796
    Cell Significance Index: 10.3900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.4681
    Cell Significance Index: 10.2500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4253
    Cell Significance Index: 383.9800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.4212
    Cell Significance Index: 28.3300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3646
    Cell Significance Index: 199.0900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3351
    Cell Significance Index: 15.1900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.3334
    Cell Significance Index: 8.0000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2995
    Cell Significance Index: 53.9900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2763
    Cell Significance Index: 7.9600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2487
    Cell Significance Index: 30.5900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.2416
    Cell Significance Index: 5.1700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2120
    Cell Significance Index: 9.9700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1617
    Cell Significance Index: 16.0000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1449
    Cell Significance Index: 4.0500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1418
    Cell Significance Index: 9.1500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1349
    Cell Significance Index: 6.2900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1049
    Cell Significance Index: 5.4500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0920
    Cell Significance Index: 125.1100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0761
    Cell Significance Index: 10.4500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0735
    Cell Significance Index: 1.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0714
    Cell Significance Index: 109.9300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0599
    Cell Significance Index: 1.5400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0527
    Cell Significance Index: 10.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0376
    Cell Significance Index: 69.3600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0362
    Cell Significance Index: 68.2000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0249
    Cell Significance Index: 0.5300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0240
    Cell Significance Index: 10.6100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0194
    Cell Significance Index: 12.3300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0189
    Cell Significance Index: 3.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0033
    Cell Significance Index: 1.4900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0063
    Cell Significance Index: -0.2200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0118
    Cell Significance Index: -0.3200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0183
    Cell Significance Index: -0.4900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0344
    Cell Significance Index: -25.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0355
    Cell Significance Index: -26.3200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0421
    Cell Significance Index: -4.9600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0422
    Cell Significance Index: -31.9100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0493
    Cell Significance Index: -7.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0634
    Cell Significance Index: -35.7500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0683
    Cell Significance Index: -42.6600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0718
    Cell Significance Index: -0.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0910
    Cell Significance Index: -9.3000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1132
    Cell Significance Index: -32.5700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1258
    Cell Significance Index: -0.7600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1278
    Cell Significance Index: -16.3800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1400
    Cell Significance Index: -2.0100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1715
    Cell Significance Index: -22.1600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1716
    Cell Significance Index: -2.8900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1891
    Cell Significance Index: -22.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1957
    Cell Significance Index: -41.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2478
    Cell Significance Index: -28.3900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2607
    Cell Significance Index: -3.7500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2670
    Cell Significance Index: -18.8800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2901
    Cell Significance Index: -15.1100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3045
    Cell Significance Index: -19.1900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3181
    Cell Significance Index: -33.1200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3455
    Cell Significance Index: -9.8600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3903
    Cell Significance Index: -12.5000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4049
    Cell Significance Index: -32.0700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4178
    Cell Significance Index: -31.1400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4403
    Cell Significance Index: -6.5000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4497
    Cell Significance Index: -12.0300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4852
    Cell Significance Index: -8.1200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5083
    Cell Significance Index: -26.6900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5319
    Cell Significance Index: -11.2900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5334
    Cell Significance Index: -32.7000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5360
    Cell Significance Index: -17.0700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5516
    Cell Significance Index: -18.0600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5758
    Cell Significance Index: -11.5600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.5826
    Cell Significance Index: -11.5200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5845
    Cell Significance Index: -15.3700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.6239
    Cell Significance Index: -7.7800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.6663
    Cell Significance Index: -9.8400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.6842
    Cell Significance Index: -34.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Peroxisomal localization:** AGPS is primarily localized to the peroxisome, a organelle responsible for lipid metabolism and detoxification. 2. **Ether lipid biosynthesis:** AGPS is involved in the biosynthesis of ether lipids, which are distinct from traditional phospholipids and possess unique structural and functional properties. 3. **Cytosolic and mitochondrial expression:** AGPS is also expressed in the cytosol and mitochondria, suggesting its involvement in multiple cellular compartments. 4. **Conserved expression in neurons:** AGPS is highly expressed in neurons, including GABAergic cortical interneurons, dopaminergic neurons, and corticothalamic-projecting glutamatergic neurons. **Pathways and Functions:** AGPS plays a crucial role in the biosynthesis of ether lipids, which are involved in various cellular processes, including: 1. **Lipid metabolism:** AGPS contributes to the regulation of lipid metabolism, influencing the balance of phospholipids and ether lipids in the cell. 2. **Protein binding and localization:** AGPS interacts with other proteins, influencing their localization and function within the cell. 3. **Peroxisomal protein import:** AGPS is involved in the import of peroxisomal proteins, regulating the function of this organelle. 4. **Wax and plasmalogen biosynthesis:** AGPS is also involved in the biosynthesis of waxes and plasmalogens, which are essential components of cellular membranes. **Clinical Significance:** Dysregulation of AGPS has been implicated in various neurological disorders, including: 1. **Neurodegenerative diseases:** AGPS dysfunction has been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where lipid metabolism is disrupted. 2. **Neurodevelopmental disorders:** AGPS expression is altered in neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia, where lipid metabolism is impaired. 3. **Cancer:** AGPS has been implicated in cancer, where its dysregulation contributes to tumor growth and metastasis. In conclusion, AGPS is a critical enzyme involved in lipid metabolism and neurological function. Its dysregulation has been implicated in various neurological disorders, highlighting the need for further research into the role of AGPS in human health and disease.

Genular Protein ID: 3764609298

Symbol: ADAS_HUMAN

Name: Alkyldihydroxyacetonephosphate synthase, peroxisomal

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9187299

Title: Nucleotide sequence of human alkyl-dihydroxyacetonephosphate synthase cDNA reveals the presence of a peroxisomal targeting signal 2.

PubMed ID: 9187299

DOI: 10.1016/s0005-2760(97)00014-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8399344

Title: Ether lipid synthesis: purification and identification of alkyl dihydroxyacetone phosphate synthase from guinea-pig liver.

PubMed ID: 8399344

DOI: 10.1016/0005-2760(93)90070-p

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 9553082

Title: Alkyl-dihydroxyacetonephosphate synthase. Fate in peroxisome biogenesis disorders and identification of the point mutation underlying a single enzyme deficiency.

PubMed ID: 9553082

DOI: 10.1074/jbc.273.17.10296

PubMed ID: 11152660

Title: Impaired membrane traffic in defective ether lipid biosynthesis.

PubMed ID: 11152660

DOI: 10.1093/hmg/10.2.127

PubMed ID: 21990100

Title: Functional characterization of novel mutations in GNPAT and AGPS, causing rhizomelic chondrodysplasia punctata (RCDP) types 2 and 3.

PubMed ID: 21990100

DOI: 10.1002/humu.21623

Sequence Information:

  • Length: 658
  • Mass: 72912
  • Checksum: 0E97AE86B513DF32
  • Sequence:
  • MAEAAAAAGG TGLGAGASYG SAADRDRDPD PDRAGRRLRV LSGHLLGRPR EALSTNECKA 
    RRAASAATAA PTATPAAQES GTIPKKRQEV MKWNGWGYND SKFIFNKKGQ IELTGKRYPL 
    SGMGLPTFKE WIQNTLGVNV EHKTTSKASL NPSDTPPSVV NEDFLHDLKE TNISYSQEAD 
    DRVFRAHGHC LHEIFLLREG MFERIPDIVL WPTCHDDVVK IVNLACKYNL CIIPIGGGTS 
    VSYGLMCPAD ETRTIISLDT SQMNRILWVD ENNLTAHVEA GITGQELERQ LKESGYCTGH 
    EPDSLEFSTV GGWVSTRASG MKKNIYGNIE DLVVHIKMVT PRGIIEKSCQ GPRMSTGPDI 
    HHFIMGSEGT LGVITEATIK IRPVPEYQKY GSVAFPNFEQ GVACLREIAK QRCAPASIRL 
    MDNKQFQFGH ALKPQVSSIF TSFLDGLKKF YITKFKGFDP NQLSVATLLF EGDREKVLQH 
    EKQVYDIAAK FGGLAAGEDN GQRGYLLTYV IAYIRDLALE YYVLGESFET SAPWDRVVDL 
    CRNVKERITR ECKEKGVQFA PFSTCRVTQT YDAGACIYFY FAFNYRGISD PLTVFEQTEA 
    AAREEILANG GSLSHHHGVG KLRKQWLKES ISDVGFGMLK SVKEYVDPNN IFGNRNLL

Genular Protein ID: 358844736

Symbol: B7Z3Q4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 568
  • Mass: 63847
  • Checksum: F0C426A5CAF6E859
  • Sequence:
  • MKWNGWGYND SKFIFNKKGQ IELTGKRYPL SGMGLPTFKE WIQNTLGVNV EHKTTSKASL 
    NPSDTPPSVV NEDFLHDLKE TNISYSQEAD DRVFRAHGHC LHEIFLLREG MFERIPDIVL 
    WPTCHDDVVK IVNLACKYNL CIIPIGGGTS VSYGLMCPAD ETRTIISLDT SQMNRILWVD 
    ENNLTAHVEA GITGQELERQ LKESGYCTGH EPDSLEFSTV GGWVSTRASG MKKNIYGNIE 
    DLVVHIKMVT PRGIIEKSCQ GPRMSTGPDI HHFIMGSEGT LGVITEATIK IRPVPEYQKY 
    GSVAFPNFEQ GVACLREIAK QRCAPASIRL MDNKQFQFGH ALKPQVSSIF TSFLDGLKKF 
    YITKFKGFDP NQLSVATLLF EGDREKVLQH EKQVYDIAAK FGGLAAGEDN GQRGYLLTYV 
    IAYIRDLALE YYVLGESFET SAPWDRVVDL CRNVKERITR ECKEKGVQFA PFSTCRVTQT 
    YDAGACIYFY FAFNYRGISD PLTVFEQTEA AAREEILANG GSLSHHHGVG KLRKQWLKES 
    ISDVGFGMLK SVKEYVDPNN IFGNRNLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.