Details for: BLZF1

Gene ID: 8548

Symbol: BLZF1

Ensembl ID: ENSG00000117475

Description: basic leucine zipper nuclear factor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 171.8471
    Cell Significance Index: -26.7300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 104.2803
    Cell Significance Index: -26.4500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 63.5760
    Cell Significance Index: -26.1900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 60.0903
    Cell Significance Index: -28.3700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 58.5097
    Cell Significance Index: -23.7700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 24.8968
    Cell Significance Index: -23.7700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.7583
    Cell Significance Index: -28.0600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.3118
    Cell Significance Index: -24.9500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.2066
    Cell Significance Index: -28.4400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.8632
    Cell Significance Index: -21.0800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.0078
    Cell Significance Index: -10.9600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 2.5797
    Cell Significance Index: 42.5100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.9513
    Cell Significance Index: 31.3100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.8767
    Cell Significance Index: 25.6100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2093
    Cell Significance Index: 62.8200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1247
    Cell Significance Index: 1015.5500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0206
    Cell Significance Index: 204.7300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.9479
    Cell Significance Index: 59.7400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7923
    Cell Significance Index: 86.1800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7075
    Cell Significance Index: 115.0600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6951
    Cell Significance Index: 18.9200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6827
    Cell Significance Index: 135.4800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.6236
    Cell Significance Index: 12.1700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5645
    Cell Significance Index: 16.2700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5528
    Cell Significance Index: 198.2800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4737
    Cell Significance Index: 26.5800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4607
    Cell Significance Index: 20.8800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4165
    Cell Significance Index: 51.2200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3438
    Cell Significance Index: 26.3900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3200
    Cell Significance Index: 57.6800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3081
    Cell Significance Index: 18.9400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.2919
    Cell Significance Index: 3.4800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2678
    Cell Significance Index: 36.7700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2333
    Cell Significance Index: 103.1600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2200
    Cell Significance Index: 5.5000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2028
    Cell Significance Index: 9.5300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1996
    Cell Significance Index: 109.0100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1877
    Cell Significance Index: 4.1100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1747
    Cell Significance Index: 12.0800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1618
    Cell Significance Index: 16.0100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1409
    Cell Significance Index: 6.5700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1377
    Cell Significance Index: 4.8400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1363
    Cell Significance Index: 25.9400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1346
    Cell Significance Index: 17.2500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1207
    Cell Significance Index: 83.4700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1077
    Cell Significance Index: 7.2400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1066
    Cell Significance Index: 2.9800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0702
    Cell Significance Index: 9.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0654
    Cell Significance Index: 2.9000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0631
    Cell Significance Index: 4.4600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0505
    Cell Significance Index: 3.7600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0347
    Cell Significance Index: 0.9300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0259
    Cell Significance Index: 48.7200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0257
    Cell Significance Index: 0.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0154
    Cell Significance Index: 23.7800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0129
    Cell Significance Index: 23.8200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0050
    Cell Significance Index: 3.1600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0023
    Cell Significance Index: 0.0500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0007
    Cell Significance Index: 0.0200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0005
    Cell Significance Index: 0.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0041
    Cell Significance Index: -5.6300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0070
    Cell Significance Index: -3.1800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0140
    Cell Significance Index: -10.2300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0175
    Cell Significance Index: -0.3000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0254
    Cell Significance Index: -19.2300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0299
    Cell Significance Index: -22.1400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0422
    Cell Significance Index: -7.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0424
    Cell Significance Index: -23.9000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0436
    Cell Significance Index: -1.0500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0492
    Cell Significance Index: -5.0300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0493
    Cell Significance Index: -30.7800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0780
    Cell Significance Index: -22.4400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0844
    Cell Significance Index: -9.6700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0884
    Cell Significance Index: -10.4200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0975
    Cell Significance Index: -5.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1050
    Cell Significance Index: -15.2700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1074
    Cell Significance Index: -3.4400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1231
    Cell Significance Index: -7.9400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1359
    Cell Significance Index: -15.8400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1362
    Cell Significance Index: -2.9500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1396
    Cell Significance Index: -29.4100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1470
    Cell Significance Index: -3.0500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2281
    Cell Significance Index: -1.8600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2283
    Cell Significance Index: -3.2500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2522
    Cell Significance Index: -26.2600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2843
    Cell Significance Index: -22.5200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3124
    Cell Significance Index: -19.1500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3233
    Cell Significance Index: -8.3100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3473
    Cell Significance Index: -9.9100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3858
    Cell Significance Index: -20.1000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3869
    Cell Significance Index: -11.0900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4197
    Cell Significance Index: -3.8700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4233
    Cell Significance Index: -14.7100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4370
    Cell Significance Index: -11.4900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4415
    Cell Significance Index: -11.2800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4599
    Cell Significance Index: -9.7600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4843
    Cell Significance Index: -11.1900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5034
    Cell Significance Index: -25.4400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.5045
    Cell Significance Index: -7.2500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.5059
    Cell Significance Index: -7.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** BLZF1 is a member of the basic leucine zipper (bZIP) transcription factor family, which is characterized by its ability to bind to specific DNA sequences and regulate gene expression. The BLZF1 protein is a nuclear factor, meaning it resides in the nucleus, where it interacts with other proteins and DNA to modulate gene transcription. BLZF1 is also associated with the Golgi apparatus, a complex organelle involved in protein transport and modification. **Pathways and Functions:** BLZF1 is involved in multiple cellular pathways, including: 1. **Cell Cycle Regulation:** BLZF1 plays a role in regulating the cell cycle, particularly during the mitotic phase. It interacts with other proteins to modulate the expression of genes involved in cell division. 2. **Protein Transport:** BLZF1 is associated with the Golgi apparatus, where it regulates the transport of proteins to the plasma membrane. This process is crucial for maintaining cellular homeostasis and responding to external stimuli. 3. **Gene Expression:** BLZF1 regulates the expression of genes involved in various cellular processes, including cell growth, differentiation, and survival. **Clinical Significance:** The clinical significance of BLZF1 is still being elucidated, but its dysregulation has been implicated in several diseases. For example: 1. **Cancer:** BLZF1 has been shown to be overexpressed in certain types of cancer, including lung and bladder cancer. Its dysregulation may contribute to tumorigenesis and cancer progression. 2. **Neurological Disorders:** BLZF1 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. Its dysregulation may contribute to neurodegeneration and cognitive decline. 3. **Autoimmune Diseases:** BLZF1 has been shown to play a role in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. Its dysregulation may contribute to immune system dysfunction and disease progression. **Conclusion:** In conclusion, BLZF1 is a multifunctional gene that plays a crucial role in various cellular processes, including cell cycle regulation, protein transport, and gene expression. Its dysregulation has been implicated in several diseases, highlighting the importance of further research into the mechanisms underlying BLZF1 function. As an immunologist, understanding the complexities of BLZF1 can provide valuable insights into the regulation of the immune system and the development of novel therapeutic strategies for autoimmune and inflammatory disorders.

Genular Protein ID: 76289090

Symbol: GO45_HUMAN

Name: Golgin-45

UniProtKB Accession Codes:

Q9H2G9 O15298 Q5T531 Q5T533 Q9GZX4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 3 ExpressionAtlas 1 GO 10 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9129147

Title: JEM-1, a novel gene encoding a leucine-zipper nuclear factor upregulated during retinoid-induced maturation of NB4 promyelocytic leukaemia.

PubMed ID: 9129147

DOI: 10.1038/sj.onc.1200995

PubMed ID: 11056056

Title: Genomic organization of the JEM-1 (BLZF1) gene on human chromosome 1q24: molecular cloning and analysis of its promoter region.

PubMed ID: 11056056

DOI: 10.1006/geno.2000.6347

PubMed ID: 11739401

Title: A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic.

PubMed ID: 11739401

DOI: 10.1083/jcb.200108079

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21478859

Title: RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling.

PubMed ID: 21478859

DOI: 10.1038/ncb2222

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 400
  • Mass: 44910
  • Checksum: F3F9DA9B13DF45B5
  • Sequence:
    • MTTKNLETKV TVTSSPIRGA GDGMETEEPP KSVEVTSGVQ SRKHHSLQSP WKKAVPSESP 
GVLQLGKMLT EKAMEVKAVR ILVPKAAITH DIPNKNTKVK SLGHHKGEFL GQSEGVIEPN 
KELSEVKNVL EKLKNSERRL LQDKEGLSNQ LRVQTEVNRE LKKLLVASVG DDLQYHFERL 
AREKNQLILE NEALGRNTAQ LSEQLERMSI QCDVWRSKFL ASRVMADELT NSRAALQRQN 
RDAHGAIQDL LSEREQFRQE MIATQKLLEE LLVSLQWGRE QTYSPSVQPH STAELALTNH 
KLAKAVNSHL LGNVGINNQK KIPSTVEFCS TPAEKMAETV LRILDPVTCK ESSPDNPFFE 
SSPTTLLATK KNIGRFHPYT RYENITFNCC NHCRGELIAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.