CDC14B | ENSG00000081377 | NCBI 8555

Details for: CDC14B

Gene ID: 8555

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: CDC14B

Ensembl ID: ENSG00000081377

Description: cell division cycle 14B

Cell Significance Landscape

Display Count:

Associated with

Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Signal transduction
(R-HSA-162582)
Cilium assembly
(GO:0060271)
Cytoplasm
(GO:0005737)
Dna repair
(GO:0006281)
Microtubule cytoskeleton organization
(GO:0000226)
Mitotic g2 dna damage checkpoint signaling
(GO:0007095)
Mitotic spindle
(GO:0072686)
Myosin phosphatase activity
(GO:0017018)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of cytokinesis
(GO:0032467)
Positive regulation of ubiquitin protein ligase activity
(GO:1904668)
Protein binding
(GO:0005515)
Protein dephosphorylation
(GO:0006470)
Protein serine/threonine phosphatase activity
(GO:0004722)
Protein tyrosine phosphatase activity
(GO:0004725)
Regulation of exit from mitosis
(GO:0007096)
Spindle pole
(GO:0000922)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

lamp5 GABAergic cortical interneuron CL4023011

CSI 23.41

rCSI 39.29%

PRS 45.75
VIP GABAergic cortical interneuron CL4023016

CSI 18.01

rCSI 21.51%

PRS 45.56
ciliated epithelial cell CL0000067

CSI 17.7

rCSI 15.56%

PRS 52.25
pvalb GABAergic cortical interneuron CL4023018

CSI 16.35

rCSI 20.35%

PRS 43.94
rod bipolar cell CL0000751

CSI 16.1

rCSI 28.94%

PRS 57.59
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 14.84

rCSI 53.4%

PRS 44.06
centrilobular region hepatocyte CL0019029

CSI 14.74

rCSI 38.45%

PRS 67.36
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 14.34

rCSI 44.83%

PRS 49.89
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 13.91

rCSI 33.8%

PRS 44.25
sncg GABAergic cortical interneuron CL4023015

CSI 12.65

rCSI 20.34%

PRS 47.7
near-projecting glutamatergic cortical neuron CL4023012

CSI 12.23

rCSI 46.21%

PRS 46.45
retinal cone cell CL0000573

CSI 11.75

rCSI 18.91%

PRS 53.87
glioblast CL0000030

CSI 10.84

rCSI 17.29%

PRS 56.71
amacrine cell CL0000561

CSI 10.68

rCSI 30.95%

PRS 53.84
L6b glutamatergic cortical neuron CL4023038

CSI 10.33

rCSI 32.28%

PRS 47.43
alveolar adventitial fibroblast CL4028006

CSI 10.13

rCSI 16%

PRS 66.81
neural crest cell CL0011012

CSI 9.83

rCSI 7.77%

PRS 51.21
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 7.95

rCSI 9.18%

PRS 57.27
chondrocyte CL0000138

CSI 7.83

rCSI 12.45%

PRS 56.75
hepatocyte CL0000182

CSI 7.4

rCSI 13.25%

PRS 63.51
oligodendrocyte precursor cell CL0002453

CSI 7.17

rCSI 15.78%

PRS 46.62
lung secretory cell CL1000272

CSI 6.75

rCSI 16.7%

PRS 62.83
differentiation-committed oligodendrocyte precursor CL4023059

CSI 6.69

rCSI 12.15%

PRS 55.98
melanocyte CL0000148

CSI 6.33

rCSI 4.69%

PRS 56.83
oligodendrocyte CL0000128

CSI 6.27

rCSI 18.52%

PRS 54.04
fibroblast of cardiac tissue CL0002548

CSI 6.11

rCSI 29.29%

PRS 64.29
mesothelial cell CL0000077

CSI 6.03

rCSI 23.6%

PRS 41.27
retinal bipolar neuron CL0000748

CSI 5.82

rCSI 10.9%

PRS 52.49
ciliated cell CL0000064

CSI 5.73

rCSI 9.29%

PRS 60.8
hepatic stellate cell CL0000632

CSI 5.63

rCSI 21.1%

PRS 56.26
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 5.47

rCSI 32.2%

PRS 46.88
inhibitory interneuron CL0000498

CSI 5.46

rCSI 12.61%

PRS 53
glutamatergic neuron CL0000679

CSI 5.45

rCSI 11.19%

PRS 54.1
epithelial cell of lower respiratory tract CL0002632

CSI 5.3

rCSI 4.11%

PRS 66.75
adipocyte CL0000136

CSI 4.82

rCSI 6.19%

PRS 56.63
sst GABAergic cortical interneuron CL4023017

CSI 4.79

rCSI 6.17%

PRS 47.04
cerebellar granule cell CL0001031

CSI 4.51

rCSI 6.63%

PRS 57.56
periportal region hepatocyte CL0019026

CSI 4.49

rCSI 17.45%

PRS 68.53
Schwann cell CL0002573

CSI 4.41

rCSI 12.54%

PRS 62.26
renal principal cell CL0005009

CSI 4.1

rCSI 10.66%

PRS 67.66
neuron CL0000540

CSI 3.91

rCSI 10.4%

PRS 53.52
brush cell of tracheobronchial tree CL0002075

CSI 3.79

rCSI 11.24%

PRS 73.98
ependymal cell CL0000065

CSI 3.77

rCSI 7.65%

PRS 43.29
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 3.76

rCSI 6.65%

PRS 44.87
epithelial cell of proximal tubule CL0002306

CSI 3.56

rCSI 8.69%

PRS 57.46
BEST4+ enteroycte CL4030026

CSI 3.47

rCSI 4.32%

PRS 65.98
kidney interstitial alternatively activated macrophage CL1000695

CSI 3.43

rCSI 8.95%

PRS 63.99
secretory cell CL0000151

CSI 3.43

rCSI 3.58%

PRS 64.61
blood vessel endothelial cell CL0000071

CSI 3.42

rCSI 7.1%

PRS 61.44
retinal rod cell CL0000604

CSI 3.39

rCSI 5.98%

PRS 60.93
interneuron CL0000099

CSI 3.39

rCSI 6.81%

PRS 53.36
midzonal region hepatocyte CL0019028

CSI 3.16

rCSI 7.42%

PRS 68.45
perivascular cell CL4033054

CSI 3.16

rCSI 4.32%

PRS 70.3
cardiac muscle cell CL0000746

CSI 3.15

rCSI 4.52%

PRS 53.92
respiratory suprabasal cell CL4033048

CSI 3.14

rCSI 4.03%

PRS 69.05
respiratory basal cell CL0002633

CSI 3.13

rCSI 3.24%

PRS 70.16
fibroblast of lung CL0002553

CSI 3.12

rCSI 2.91%

PRS 65
cerebral cortex endothelial cell CL1001602

CSI 3.05

rCSI 5.28%

PRS 54.4
central nervous system neuron CL2000029

CSI 3.03

rCSI 22.27%

PRS 50.74
glial cell CL0000125

CSI 3.03

rCSI 11.54%

PRS 54.95
cardiac neuron CL0010022

CSI 2.97

rCSI 9.49%

PRS 61.41
astrocyte of the cerebral cortex CL0002605

CSI 2.93

rCSI 6.57%

PRS 46.46
vascular leptomeningeal cell CL4023051

CSI 2.93

rCSI 5.13%

PRS 56.3
retinal ganglion cell CL0000740

CSI 2.89

rCSI 6.38%

PRS 50.32
bronchus fibroblast of lung CL2000093

CSI 2.88

rCSI 2.34%

PRS 64.7
multi-ciliated epithelial cell CL0005012

CSI 2.85

rCSI 2.84%

PRS 57.72
paneth cell of epithelium of small intestine CL1000343

CSI 2.82

rCSI 7.9%

PRS 75.12
subcutaneous adipocyte CL0002521

CSI 2.77

rCSI 14.2%

PRS 69.2
platelet CL0000233

CSI 2.74

rCSI 11.35%

PRS 66.82
skin fibroblast CL0002620

CSI 2.67

rCSI 2.3%

PRS 69.35
small intestine goblet cell CL1000495

CSI 2.62

rCSI 5.75%

PRS 72.13
Kupffer cell CL0000091

CSI 2.62

rCSI 5.99%

PRS 64.34
glycinergic amacrine cell CL4030028

CSI 2.61

rCSI 6.8%

PRS 61.31
cardiac endothelial cell CL0010008

CSI 2.59

rCSI 10.44%

PRS 63.16
lung ciliated cell CL1000271

CSI 2.54

rCSI 2.94%

PRS 54.67
Mueller cell CL0000636

CSI 2.54

rCSI 5.79%

PRS 55.85
renal beta-intercalated cell CL0002201

CSI 2.5

rCSI 5.97%

PRS 64.89
alveolar type 1 fibroblast cell CL4028004

CSI 2.46

rCSI 2.69%

PRS 68.06
renal interstitial pericyte CL1001318

CSI 2.39

rCSI 6.58%

PRS 59.67
GABAergic amacrine cell CL4030027

CSI 2.34

rCSI 8.01%

PRS 52.91
cerebral cortex neuron CL0010012

CSI 2.28

rCSI 9.28%

PRS 58.08
mature astrocyte CL0002627

CSI 2.21

rCSI 9.37%

PRS 57.37
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 2.2

rCSI 3.12%

PRS 60.69
pancreatic D cell CL0000173

CSI 2.18

rCSI 2.15%

PRS 67.05
pancreatic A cell CL0000171

CSI 2.18

rCSI 2.28%

PRS 67.91
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 2.15

rCSI 5.56%

PRS 59.33
type B pancreatic cell CL0000169

CSI 2.01

rCSI 4.44%

PRS 62.47
kidney connecting tubule epithelial cell CL1000768

CSI 2.01

rCSI 5.09%

PRS 53.7
adventitial cell CL0002503

CSI 1.93

rCSI 4.61%

PRS 72.55
myoepithelial cell CL0000185

CSI 1.9

rCSI 4.8%

PRS 72.07
Bergmann glial cell CL0000644

CSI 1.88

rCSI 2.57%

PRS 57.43
blood vessel smooth muscle cell CL0019018

CSI 1.86

rCSI 15.17%

PRS 57.67
epicardial adipocyte CL1000309

CSI 1.74

rCSI 5.66%

PRS 64.45
retinal pigment epithelial cell CL0002586

CSI 1.68

rCSI 3.33%

PRS 61.63
indirect pathway medium spiny neuron CL4023029

CSI 1.67

rCSI 40.3%

PRS 45.6
airway submucosal gland duct basal cell CL4033024

CSI 1.63

rCSI 10.4%

PRS 73.3
choroid plexus epithelial cell CL0000706

CSI 1.59

rCSI 2.61%

PRS 53.4
stem cell CL0000034

CSI 1.59

rCSI 1.53%

PRS 55.22
GABAergic neuron CL0000617

CSI 1.47

rCSI 4.93%

PRS 49.18
intestinal crypt stem cell of small intestine CL0009017

CSI 1.43

rCSI 3.86%

PRS 71.28

OFF midget ganglion cell CL4033047

CSI 0.3

rCSI 6.5%

PRS 56.5%
kidney distal convoluted tubule epithelial cell CL1000849

CSI 0.4

rCSI 4.1%

PRS 62.4%
ON midget ganglion cell CL4033046

CSI 0.5

rCSI 10.4%

PRS 55.0%
regular ventricular cardiac myocyte CL0002131

CSI 0.6

rCSI 3.5%

PRS 56.1%
podocyte CL0000653

CSI 0.6

rCSI 2.9%

PRS 64.2%
pancreatic ductal cell CL0002079

CSI 0.7

rCSI 1.4%

PRS 67.4%
tracheobronchial smooth muscle cell CL0019019

CSI 0.7

rCSI 1.3%

PRS 72.5%
dopaminergic neuron CL0000700

CSI 0.7

rCSI 4.1%

PRS 49.4%
regular atrial cardiac myocyte CL0002129

CSI 0.8

rCSI 2.5%

PRS 62.3%
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 0.8

rCSI 1.8%

PRS 60.5%
starburst amacrine cell CL0004232

CSI 0.8

rCSI 6.5%

PRS 55.0%
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 0.8

rCSI 1.9%

PRS 51.4%
H2 horizontal cell CL0004218

CSI 0.8

rCSI 4.2%

PRS 61.3%
keratocyte CL0002363

CSI 0.9

rCSI 2.2%

PRS 71.5%
ON parasol ganglion cell CL4033052

CSI 1.0

rCSI 14.0%

PRS 55.3%
Hofbauer cell CL3000001

CSI 1.0

rCSI 1.9%

PRS 74.8%
parietal epithelial cell CL1000452

CSI 1.1

rCSI 3.0%

PRS 55.3%
S cone cell CL0003050

CSI 1.1

rCSI 5.0%

PRS 60.7%
enteroendocrine cell of small intestine CL0009006

CSI 1.2

rCSI 2.5%

PRS 76.3%
macroglial cell CL0000126

CSI 1.2

rCSI 3.0%

PRS 63.4%
conjunctival epithelial cell CL1000432

CSI 1.2

rCSI 1.8%

PRS 65.0%
microcirculation associated smooth muscle cell CL0008035

CSI 1.2

rCSI 3.5%

PRS 65.6%
contractile cell CL0000183

CSI 1.3

rCSI 3.7%

PRS 63.0%
neural progenitor cell CL0011020

CSI 1.4

rCSI 6.1%

PRS 54.5%
L5/6 near-projecting glutamatergic neuron CL4030067

CSI 1.4

rCSI 4.6%

PRS 51.1%
intestinal crypt stem cell of small intestine CL0009017

CSI 1.4

rCSI 3.9%

PRS 71.3%
GABAergic neuron CL0000617

CSI 1.5

rCSI 4.9%

PRS 49.2%
stem cell CL0000034

CSI 1.6

rCSI 1.5%

PRS 55.2%
choroid plexus epithelial cell CL0000706

CSI 1.6

rCSI 2.6%

PRS 53.4%
airway submucosal gland duct basal cell CL4033024

CSI 1.6

rCSI 10.4%

PRS 73.3%
indirect pathway medium spiny neuron CL4023029

CSI 1.7

rCSI 40.3%

PRS 45.6%
retinal pigment epithelial cell CL0002586

CSI 1.7

rCSI 3.3%

PRS 61.6%
epicardial adipocyte CL1000309

CSI 1.7

rCSI 5.7%

PRS 64.5%
blood vessel smooth muscle cell CL0019018

CSI 1.9

rCSI 15.2%

PRS 57.7%
Bergmann glial cell CL0000644

CSI 1.9

rCSI 2.6%

PRS 57.4%
myoepithelial cell CL0000185

CSI 1.9

rCSI 4.8%

PRS 72.1%
adventitial cell CL0002503

CSI 1.9

rCSI 4.6%

PRS 72.6%
kidney connecting tubule epithelial cell CL1000768

CSI 2.0

rCSI 5.1%

PRS 53.7%
type B pancreatic cell CL0000169

CSI 2.0

rCSI 4.4%

PRS 62.5%
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 2.2

rCSI 5.6%

PRS 59.3%
pancreatic A cell CL0000171

CSI 2.2

rCSI 2.3%

PRS 67.9%
pancreatic D cell CL0000173

CSI 2.2

rCSI 2.2%

PRS 67.1%
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 2.2

rCSI 3.1%

PRS 60.7%
mature astrocyte CL0002627

CSI 2.2

rCSI 9.4%

PRS 57.4%
cerebral cortex neuron CL0010012

CSI 2.3

rCSI 9.3%

PRS 58.1%
GABAergic amacrine cell CL4030027

CSI 2.3

rCSI 8.0%

PRS 52.9%
renal interstitial pericyte CL1001318

CSI 2.4

rCSI 6.6%

PRS 59.7%
alveolar type 1 fibroblast cell CL4028004

CSI 2.5

rCSI 2.7%

PRS 68.1%
renal beta-intercalated cell CL0002201

CSI 2.5

rCSI 6.0%

PRS 64.9%
Mueller cell CL0000636

CSI 2.5

rCSI 5.8%

PRS 55.9%
lung ciliated cell CL1000271

CSI 2.5

rCSI 2.9%

PRS 54.7%
cardiac endothelial cell CL0010008

CSI 2.6

rCSI 10.4%

PRS 63.2%
glycinergic amacrine cell CL4030028

CSI 2.6

rCSI 6.8%

PRS 61.3%
Kupffer cell CL0000091

CSI 2.6

rCSI 6.0%

PRS 64.3%
small intestine goblet cell CL1000495

CSI 2.6

rCSI 5.8%

PRS 72.1%
skin fibroblast CL0002620

CSI 2.7

rCSI 2.3%

PRS 69.4%
platelet CL0000233

CSI 2.7

rCSI 11.4%

PRS 66.8%
subcutaneous adipocyte CL0002521

CSI 2.8

rCSI 14.2%

PRS 69.2%
paneth cell of epithelium of small intestine CL1000343

CSI 2.8

rCSI 7.9%

PRS 75.1%
multi-ciliated epithelial cell CL0005012

CSI 2.9

rCSI 2.8%

PRS 57.7%
bronchus fibroblast of lung CL2000093

CSI 2.9

rCSI 2.3%

PRS 64.7%
retinal ganglion cell CL0000740

CSI 2.9

rCSI 6.4%

PRS 50.3%
vascular leptomeningeal cell CL4023051

CSI 2.9

rCSI 5.1%

PRS 56.3%
astrocyte of the cerebral cortex CL0002605

CSI 2.9

rCSI 6.6%

PRS 46.5%
cardiac neuron CL0010022

CSI 3.0

rCSI 9.5%

PRS 61.4%
glial cell CL0000125

CSI 3.0

rCSI 11.5%

PRS 55.0%
central nervous system neuron CL2000029

CSI 3.0

rCSI 22.3%

PRS 50.7%
cerebral cortex endothelial cell CL1001602

CSI 3.1

rCSI 5.3%

PRS 54.4%
fibroblast of lung CL0002553

CSI 3.1

rCSI 2.9%

PRS 65.0%
respiratory basal cell CL0002633

CSI 3.1

rCSI 3.2%

PRS 70.2%
respiratory suprabasal cell CL4033048

CSI 3.1

rCSI 4.0%

PRS 69.1%
cardiac muscle cell CL0000746

CSI 3.2

rCSI 4.5%

PRS 53.9%
perivascular cell CL4033054

CSI 3.2

rCSI 4.3%

PRS 70.3%
midzonal region hepatocyte CL0019028

CSI 3.2

rCSI 7.4%

PRS 68.5%
interneuron CL0000099

CSI 3.4

rCSI 6.8%

PRS 53.4%
retinal rod cell CL0000604

CSI 3.4

rCSI 6.0%

PRS 60.9%
blood vessel endothelial cell CL0000071

CSI 3.4

rCSI 7.1%

PRS 61.4%
secretory cell CL0000151

CSI 3.4

rCSI 3.6%

PRS 64.6%
kidney interstitial alternatively activated macrophage CL1000695

CSI 3.4

rCSI 9.0%

PRS 64.0%
BEST4+ enteroycte CL4030026

CSI 3.5

rCSI 4.3%

PRS 66.0%
epithelial cell of proximal tubule CL0002306

CSI 3.6

rCSI 8.7%

PRS 57.5%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 3.8

rCSI 6.7%

PRS 44.9%
ependymal cell CL0000065

CSI 3.8

rCSI 7.7%

PRS 43.3%
brush cell of tracheobronchial tree CL0002075

CSI 3.8

rCSI 11.2%

PRS 74.0%
neuron CL0000540

CSI 3.9

rCSI 10.4%

PRS 53.5%
renal principal cell CL0005009

CSI 4.1

rCSI 10.7%

PRS 67.7%
Schwann cell CL0002573

CSI 4.4

rCSI 12.5%

PRS 62.3%
periportal region hepatocyte CL0019026

CSI 4.5

rCSI 17.5%

PRS 68.5%
cerebellar granule cell CL0001031

CSI 4.5

rCSI 6.6%

PRS 57.6%
sst GABAergic cortical interneuron CL4023017

CSI 4.8

rCSI 6.2%

PRS 47.0%
adipocyte CL0000136

CSI 4.8

rCSI 6.2%

PRS 56.6%
epithelial cell of lower respiratory tract CL0002632

CSI 5.3

rCSI 4.1%

PRS 66.8%
glutamatergic neuron CL0000679

CSI 5.5

rCSI 11.2%

PRS 54.1%
inhibitory interneuron CL0000498

CSI 5.5

rCSI 12.6%

PRS 53.0%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 5.5

rCSI 32.2%

PRS 46.9%
hepatic stellate cell CL0000632

CSI 5.6

rCSI 21.1%

PRS 56.3%
ciliated cell CL0000064

CSI 5.7

rCSI 9.3%

PRS 60.8%
retinal bipolar neuron CL0000748

CSI 5.8

rCSI 10.9%

PRS 52.5%
mesothelial cell CL0000077

CSI 6.0

rCSI 23.6%

PRS 41.3%
fibroblast of cardiac tissue CL0002548

CSI 6.1

rCSI 29.3%

PRS 64.3%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [CDC14B](/details-gene/8555) (Cell Division Cycle 14B) is a protein-coding gene located on chromosome 9 that encodes a dual-specificity protein phosphatase. This enzyme plays a crucial role in fundamental cellular processes, including protein dephosphorylation ([GO:0006470](https://www.ebi.ac.uk/QuickGO/term/GO:0006470)), cell cycle control, particularly the regulation of exit from mitosis ([GO:0007096](https://www.ebi.ac.uk/QuickGO/term/GO:0007096)), and the G2 DNA damage checkpoint ([GO:0007095](https://www.ebi.ac.uk/QuickGO/term/GO:0007095)) [Link](https://doi.org/10.1016/j.cell.2008.05.043). Functionally, it is also implicated in cilium assembly ([GO:0060271](https://www.ebi.ac.uk/QuickGO/term/GO:0060271)) and microtubule cytoskeleton organization ([GO:0000226](https://www.ebi.ac.uk/QuickGO/term/GO:0000226)). Expression data reveals its significant presence in diverse, highly specialized cell types, including various neuronal subtypes such as [lamp5 GABAergic cortical interneurons](/details-cell/CL4023011) and [ciliated epithelial cells](/details-cell/CL0000067), suggesting a pleiotropic role in both the central nervous system and ciliated tissues. ## Cellular Roles and Expression Landscape In the **Overall** context, the expression profile of [CDC14B](/details-gene/8555) indicates a significant role in terminally differentiated and specialized cells, particularly within the nervous system. The gene exhibits its highest significance in several GABAergic cortical interneuron subtypes, including [lamp5 GABAergic cortical interneuron](/details-cell/CL4023011) (CSI: 23.41), [VIP GABAergic cortical interneuron](/details-cell/CL4023016) (CSI: 18.01), and [pvalb GABAergic cortical interneuron](/details-cell/CL4023018) (CSI: 16.35). Its importance extends to glutamatergic neurons, such as [L5 extratelencephalic projecting glutamatergic cortical neurons](/details-cell/CL4023041) (CSI: 14.84), and specialized retinal cells like the [rod bipolar cell](/details-cell/CL0000751) (CSI: 16.10) and [retinal cone cell](/details-cell/CL0000573) (CSI: 11.75). Outside the nervous system, [CDC14B](/details-gene/8555) is a highly significant marker for [ciliated epithelial cells](/details-cell/CL0000067) (CSI: 17.70), which aligns with its documented role in ciliogenesis. A notable level of significance is also observed in [glioblasts](/details-cell/CL0000030) (CSI: 10.84), suggesting potential relevance in the context of brain tumors. This pattern suggests that while [CDC14B](/details-gene/8555) is a core cell cycle regulator, its sustained high expression in these non-proliferating or specialized cells points towards additional, critical functions in cellular maintenance, cytoskeletal organization, and signaling. ## Pathways and Molecular Function [CDC14B](/details-gene/8555) functions as a dual-specificity protein phosphatase, capable of acting on both serine/threonine ([GO:0004722](https://www.ebi.ac.uk/QuickGO/term/GO:0004722)) and tyrosine ([GO:0004725](https://www.ebi.ac.uk/QuickGO/term/GO:0004725)) residues [Link](https://doi.org/10.1093/emboj/cdg348). Its cellular localization is diverse, including the [cytoplasm](/details-cell/GO:0005737), [nucleus](/details-cell/GO:0005634), [nucleolus](/details-cell/GO:0005730), and key mitotic structures like the [mitotic spindle](/details-cell/GO:0072686) and [spindle pole](/details-cell/GO:0000922). The gene's primary annotated functions relate to cell division and genome integrity. It is a critical component of the G2 DNA damage checkpoint, where it forms part of the Cdc14B-Cdh1-Plk1 axis that regulates cellular response to DNA damage [Link](https://doi.org/10.1016/j.cell.2008.05.043). This is consistent with its roles in DNA repair ([GO:0006281](https://www.ebi.ac.uk/QuickGO/term/GO:0006281)) and regulation of mitosis. Beyond the cell cycle, [CDC14B](/details-gene/8555) is involved in microtubule cytoskeleton organization ([GO:0000226](https://www.ebi.ac.uk/QuickGO/term/GO:0000226)) and cilium assembly ([GO:0060271](https://www.ebi.ac.uk/QuickGO/term/GO:0060271)), functions that are directly reflected in its high expression in various neurons and [ciliated epithelial cells](/details-cell/CL0000067). It is also annotated in broader signaling pathways such as MAPK family signaling cascades ([R-HSA-5683057](https://reactome.org/content/detail/R-HSA-5683057)), indicating it may act as a phosphatase for key components in these cascades. ## Research Directions The functional annotations and expression patterns of [CDC14B](/details-gene/8555) suggest several avenues for future investigation. Its dual role in both canonical cell cycle control and the maintenance of highly specialized, post-mitotic cells like neurons presents a particularly interesting area of study. **Proposed Hypotheses:** 1. Given its high significance in multiple neuronal subtypes and its function in microtubule cytoskeleton organization ([GO:0000226](https://www.ebi.ac.uk/QuickGO/term/GO:0000226)), [CDC14B](/details-gene/8555) may regulate the stability and dynamics of the neuronal cytoskeleton, thereby playing a critical role in maintaining dendritic arborization, axonal transport, or synaptic plasticity in the adult brain. 2. The strong association with [ciliated epithelial cells](/details-cell/CL0000067) and its role in cilium assembly ([GO:0060271](https://www.ebi.ac.uk/QuickGO/term/GO:0060271)) suggests that haploinsufficiency or pathogenic variants in [CDC14B](/details-gene/8555) could be an underlying cause of human ciliopathies, a class of genetic disorders characterized by defective ciliary structure or function. **Experimental Approach:** To test the second hypothesis regarding the role of [CDC14B](/details-gene/8555) in ciliogenesis, one could utilize an *in vitro* model of human airway epithelium. Primary human bronchial epithelial cells could be cultured at an air-liquid interface to induce differentiation into a mucociliary epithelium. Using CRISPR-Cas9 or shRNA-mediated knockdown to reduce [CDC14B](/details-gene/8555) expression, the impact on cilium formation could be quantified via immunofluorescence microscopy for ciliary markers (e.g., acetylated α-tubulin, IFT88). Functional consequences could be assessed by measuring ciliary beat frequency using high-speed video microscopy and analyzing mucociliary transport. **Therapeutic Potential:** As a key regulator of the G2 DNA damage checkpoint, [CDC14B](/details-gene/8555) represents a potential therapeutic target in oncology. Inhibition of [CDC14B](/details-gene/8555) could abrogate this checkpoint, thereby sensitizing cancer cells to DNA-damaging agents like chemotherapy and radiation. This strategy might be particularly effective in tumors that exhibit high expression of [CDC14B](/details-gene/8555), such as [glioblastoma](/details-cell/CL0000030). However, the gene's high significance in various neuronal populations raises potential concerns for neurotoxicity. A successful therapeutic approach would likely require the development of highly specific inhibitors with limited blood-brain barrier penetration or tumor-targeted delivery systems to achieve a favorable therapeutic window. Therefore, inhibition is the more plausible therapeutic strategy.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Dual specificity protein phosphatase CDC14B

Genular Protein ID: 1983368155

Symbol: CC14B_HUMAN

Name: Dual specificity protein phosphatase CDC14B

UniProtKB Accession Codes:

O60729 A6N5X8 A8MQ20 B1AL31 B1AL32 O43183 O60730 Q5JU08

Database IDs:

Citations:

PubMed ID: 9367992

Title: A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast.

PubMed ID: 9367992

DOI: 10.1074/jbc.272.47.29403

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 12134069

Title: Disruption of centrosome structure, chromosome segregation, and cytokinesis by misexpression of human Cdc14A phosphatase.

PubMed ID: 12134069

DOI: 10.1091/mbc.01-11-0535

PubMed ID: 11901424

Title: Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation.

PubMed ID: 11901424

DOI: 10.1038/ncb777

PubMed ID: 17488717

Title: Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation.

PubMed ID: 17488717

DOI: 10.1074/jbc.m702990200

PubMed ID: 18662541

Title: The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint.

PubMed ID: 18662541

DOI: 10.1016/j.cell.2008.05.043

PubMed ID: 12853468

Title: The structure of the cell cycle protein Cdc14 reveals a proline-directed protein phosphatase.

PubMed ID: 12853468

DOI: 10.1093/emboj/cdg348

Sequence Information:

Length: 498
Mass: 56802
Checksum: CEE15EC4DC3B1DC7
Sequence:

MKRKSERRSS WAAAPPCSRR CSSTSPGVKK IRSSTQQDPR RRDPQDDVYL DITDRLCFAI 
LYSRPKSASN VHYFSIDNEL EYENFYADFG PLNLAMVYRY CCKINKKLKS ITMLRKKIVH 
FTGSDQRKQA NAAFLVGCYM VIYLGRTPEE AYRILIFGET SYIPFRDAAY GSCNFYITLL 
DCFHAVKKAM QYGFLNFNSF NLDEYEHYEK AENGDLNWII PDRFIAFCGP HSRARLESGY 
HQHSPETYIQ YFKNHNVTTI IRLNKRMYDA KRFTDAGFDH HDLFFADGST PTDAIVKEFL 
DICENAEGAI AVHCKAGLGR TGTLIACYIM KHYRMTAAET IAWVRICRPG SVIGPQQQFL 
VMKQTNLWLE GDYFRQKLKG QENGQHRAAF SKLLSGVDDI SINGVENQDQ QEPEPYSDDD 
EINGVTQGDR LRALKSRRQS KTNAIPLTVI LQSSVQSCKT SEPNISGSAG ITKRTTRSAS 
RKSSVKSLSI SRTKTVLR

Details for: CDC14B

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast. PubMed ID: 9367992

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

Disruption of centrosome structure, chromosome segregation, and cytokinesis by misexpression of human Cdc14A phosphatase. PubMed ID: 12134069

Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation. PubMed ID: 11901424

Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation. PubMed ID: 17488717

The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint. PubMed ID: 18662541

The structure of the cell cycle protein Cdc14 reveals a proline-directed protein phosphatase. PubMed ID: 12853468