Details for: CDC14B

Gene ID: 8555

Symbol: CDC14B

Ensembl ID: ENSG00000081377

Description: cell division cycle 14B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 273.2967
    Cell Significance Index: -42.5100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 168.4254
    Cell Significance Index: -42.7200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 75.5679
    Cell Significance Index: -30.7000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 71.4251
    Cell Significance Index: -36.7400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 34.4862
    Cell Significance Index: -42.5200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.2635
    Cell Significance Index: -38.2100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.7956
    Cell Significance Index: -42.6000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 2.9280
    Cell Significance Index: 48.2500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.5810
    Cell Significance Index: 512.2100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.4470
    Cell Significance Index: 41.2200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.1166
    Cell Significance Index: 162.4300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.8547
    Cell Significance Index: 372.0500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.3235
    Cell Significance Index: 25.8300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.2846
    Cell Significance Index: 149.7000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1230
    Cell Significance Index: 402.8100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9343
    Cell Significance Index: 843.6100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.9341
    Cell Significance Index: 23.3500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.8725
    Cell Significance Index: 20.9300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7694
    Cell Significance Index: 46.1900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.7661
    Cell Significance Index: 47.0900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.7473
    Cell Significance Index: 9.4100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7473
    Cell Significance Index: 16.1900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7404
    Cell Significance Index: 38.4600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7143
    Cell Significance Index: 9.7500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.7021
    Cell Significance Index: 20.0400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6654
    Cell Significance Index: 72.3800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5873
    Cell Significance Index: 95.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.5842
    Cell Significance Index: 1099.8900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5765
    Cell Significance Index: 16.6100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5644
    Cell Significance Index: 101.7500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4708
    Cell Significance Index: 57.9000
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.4062
    Cell Significance Index: 5.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3537
    Cell Significance Index: 19.8500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3126
    Cell Significance Index: 21.6200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2987
    Cell Significance Index: 189.7000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2908
    Cell Significance Index: 28.7700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2799
    Cell Significance Index: 127.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2120
    Cell Significance Index: 9.6100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1735
    Cell Significance Index: 4.8500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1405
    Cell Significance Index: 191.0500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.1361
    Cell Significance Index: 1.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1280
    Cell Significance Index: 69.9200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1120
    Cell Significance Index: 206.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1058
    Cell Significance Index: 162.8800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0955
    Cell Significance Index: 16.3100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0765
    Cell Significance Index: 1.1300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0546
    Cell Significance Index: 3.6700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0538
    Cell Significance Index: 10.2400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0322
    Cell Significance Index: 4.1300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0250
    Cell Significance Index: 1.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0029
    Cell Significance Index: -0.4200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0153
    Cell Significance Index: -9.5800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0179
    Cell Significance Index: -13.2500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0289
    Cell Significance Index: -21.1700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0364
    Cell Significance Index: -0.4600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0390
    Cell Significance Index: -17.2500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0511
    Cell Significance Index: -38.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0512
    Cell Significance Index: -28.8500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0570
    Cell Significance Index: -2.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1182
    Cell Significance Index: -34.0200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1206
    Cell Significance Index: -25.4100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1409
    Cell Significance Index: -4.9500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1769
    Cell Significance Index: -24.3000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1785
    Cell Significance Index: -20.3800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1794
    Cell Significance Index: -3.8200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2019
    Cell Significance Index: -2.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2021
    Cell Significance Index: -23.1500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2237
    Cell Significance Index: -22.8600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2406
    Cell Significance Index: -31.0800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2563
    Cell Significance Index: -26.6900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2905
    Cell Significance Index: -18.3100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3159
    Cell Significance Index: -37.2500
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.3342
    Cell Significance Index: -1.4600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3515
    Cell Significance Index: -21.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3526
    Cell Significance Index: -16.5700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3864
    Cell Significance Index: -30.6100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4011
    Cell Significance Index: -10.7100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4106
    Cell Significance Index: -11.7700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4197
    Cell Significance Index: -31.2800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4281
    Cell Significance Index: -8.8800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4434
    Cell Significance Index: -14.2000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5097
    Cell Significance Index: -10.9000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5115
    Cell Significance Index: -11.2000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5293
    Cell Significance Index: -9.0700
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.5359
    Cell Significance Index: -6.9500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5743
    Cell Significance Index: -37.0500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.5755
    Cell Significance Index: -15.6700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5791
    Cell Significance Index: -12.2900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5808
    Cell Significance Index: -30.2500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.6006
    Cell Significance Index: -9.0500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.6083
    Cell Significance Index: -43.0200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6540
    Cell Significance Index: -13.1300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.6589
    Cell Significance Index: -30.7200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.6923
    Cell Significance Index: -6.3800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7510
    Cell Significance Index: -39.4300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7799
    Cell Significance Index: -27.1000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7951
    Cell Significance Index: -26.0300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.8238
    Cell Significance Index: -13.0700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8393
    Cell Significance Index: -26.7300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.8930
    Cell Significance Index: -15.4400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Dual-Specificity Phosphatase Activity:** CDC14B exhibits dual-specificity phosphatase activity, meaning it can dephosphorylate both serine/threonine and tyrosine residues on target proteins. 2. **Cell Cycle Regulation:** CDC14B is involved in regulating the cell cycle, particularly during the G2/M phase, where it dephosphorylates and activates key regulators of the cell cycle. 3. **DNA Damage Repair:** CDC14B is also involved in the repair of DNA damage, particularly during the G2/M phase, where it dephosphorylates and activates DNA repair enzymes. 4. **Cytoskeleton Organization:** CDC14B is involved in regulating the organization of the cytoskeleton, particularly during cell division and migration. 5. **Neurological Expression:** CDC14B is predominantly expressed in cells of the central nervous system, including astrocytes, oligodendrocytes, and GABAergic cortical interneurons. **Pathways and Functions:** 1. **Centrosome and Cilium Assembly:** CDC14B is involved in regulating the assembly of centrosomes and cilia, critical structures involved in cell division and motility. 2. **Mitotic Spindle:** CDC14B is involved in regulating the formation and function of the mitotic spindle, a critical structure involved in cell division. 3. **Microtubule Cytoskeleton Organization:** CDC14B is involved in regulating the organization of microtubules, critical components of the cytoskeleton. 4. **Mapk6/Mapk4 Signaling:** CDC14B is involved in regulating the MAPK6/4 signaling pathway, critical for cell proliferation and survival. 5. **Protein Phosphatase Activity:** CDC14B exhibits protein phosphatase activity, dephosphorylating and regulating the activity of various proteins involved in cellular processes. **Clinical Significance:** 1. **Neurological Disorders:** Dysregulation of CDC14B has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. 2. **Cancer:** CDC14B has been implicated in cancer development and progression, particularly in cells of the central nervous system. 3. **Neurodevelopmental Disorders:** CDC14B has been implicated in neurodevelopmental disorders, including autism spectrum disorder and intellectual disability. 4. **Neuroprotection:** CDC14B has been shown to have neuroprotective effects, particularly in models of neurodegenerative disease. In conclusion, CDC14B is a critical gene involved in various cellular processes, including cell division, cytoskeleton organization, and signal transduction. Its dysregulation has been implicated in various neurological disorders, cancer, and neurodevelopmental disorders, highlighting its importance in human health and disease. Further research is needed to fully elucidate the role of CDC14B in human disease and to develop therapeutic strategies targeting this gene.

Genular Protein ID: 1983368155

Symbol: CC14B_HUMAN

Name: Dual specificity protein phosphatase CDC14B

UniProtKB Accession Codes:

O60729 A6N5X8 A8MQ20 B1AL31 B1AL32 O43183 O60730 Q5JU08

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 2 CTD 1 ChEBI 12 ChiTaRS 1 DEPOD 1 DNASU 1 DisGeNET 1 EC 5 EMBL 10 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 Reactome 1 RefSeq 5 Rhea 9 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9367992

Title: A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast.

PubMed ID: 9367992

DOI: 10.1074/jbc.272.47.29403

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 12134069

Title: Disruption of centrosome structure, chromosome segregation, and cytokinesis by misexpression of human Cdc14A phosphatase.

PubMed ID: 12134069

DOI: 10.1091/mbc.01-11-0535

PubMed ID: 11901424

Title: Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation.

PubMed ID: 11901424

DOI: 10.1038/ncb777

PubMed ID: 17488717

Title: Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation.

PubMed ID: 17488717

DOI: 10.1074/jbc.m702990200

PubMed ID: 18662541

Title: The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint.

PubMed ID: 18662541

DOI: 10.1016/j.cell.2008.05.043

PubMed ID: 12853468

Title: The structure of the cell cycle protein Cdc14 reveals a proline-directed protein phosphatase.

PubMed ID: 12853468

DOI: 10.1093/emboj/cdg348

Sequence Information:

  • Length: 498
  • Mass: 56802
  • Checksum: CEE15EC4DC3B1DC7
  • Sequence:
    • MKRKSERRSS WAAAPPCSRR CSSTSPGVKK IRSSTQQDPR RRDPQDDVYL DITDRLCFAI 
LYSRPKSASN VHYFSIDNEL EYENFYADFG PLNLAMVYRY CCKINKKLKS ITMLRKKIVH 
FTGSDQRKQA NAAFLVGCYM VIYLGRTPEE AYRILIFGET SYIPFRDAAY GSCNFYITLL 
DCFHAVKKAM QYGFLNFNSF NLDEYEHYEK AENGDLNWII PDRFIAFCGP HSRARLESGY 
HQHSPETYIQ YFKNHNVTTI IRLNKRMYDA KRFTDAGFDH HDLFFADGST PTDAIVKEFL 
DICENAEGAI AVHCKAGLGR TGTLIACYIM KHYRMTAAET IAWVRICRPG SVIGPQQQFL 
VMKQTNLWLE GDYFRQKLKG QENGQHRAAF SKLLSGVDDI SINGVENQDQ QEPEPYSDDD 
EINGVTQGDR LRALKSRRQS KTNAIPLTVI LQSSVQSCKT SEPNISGSAG ITKRTTRSAS 
RKSSVKSLSI SRTKTVLR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.