Details for: SCARF1

Gene ID: 8578

Symbol: SCARF1

Ensembl ID: ENSG00000074660

Description: scavenger receptor class F member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 53.2321
    Cell Significance Index: -8.2800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 27.2824
    Cell Significance Index: -6.9200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.9021
    Cell Significance Index: -8.5100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.0894
    Cell Significance Index: -10.9600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.7004
    Cell Significance Index: -5.9100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.1895
    Cell Significance Index: -8.6400
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.5400
    Cell Significance Index: 11.0600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.0460
    Cell Significance Index: 18.4900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.0200
    Cell Significance Index: 14.6700
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.8740
    Cell Significance Index: 5.1600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8493
    Cell Significance Index: 161.6200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.8345
    Cell Significance Index: 9.4800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.5316
    Cell Significance Index: 14.2200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3259
    Cell Significance Index: 14.7700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3108
    Cell Significance Index: 23.8500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3048
    Cell Significance Index: 275.2300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2857
    Cell Significance Index: 28.2600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2682
    Cell Significance Index: 5.8100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2450
    Cell Significance Index: 7.0600
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.1916
    Cell Significance Index: 1.2000
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.1731
    Cell Significance Index: 0.6500
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.1695
    Cell Significance Index: 1.7300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1524
    Cell Significance Index: 24.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1416
    Cell Significance Index: 28.4000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1342
    Cell Significance Index: 19.5100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1328
    Cell Significance Index: 1.9600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1308
    Cell Significance Index: 0.7900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1243
    Cell Significance Index: 13.5200
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.1093
    Cell Significance Index: 0.9300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1049
    Cell Significance Index: 18.9100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1043
    Cell Significance Index: 72.1100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0981
    Cell Significance Index: 0.8000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0958
    Cell Significance Index: 5.7500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0902
    Cell Significance Index: 3.1700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0799
    Cell Significance Index: 5.5300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0774
    Cell Significance Index: 4.0200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0407
    Cell Significance Index: 4.7400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0341
    Cell Significance Index: 12.2200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0268
    Cell Significance Index: 50.5500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0191
    Cell Significance Index: 3.8000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0126
    Cell Significance Index: 0.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0120
    Cell Significance Index: 22.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0106
    Cell Significance Index: 6.7300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0085
    Cell Significance Index: 1.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0021
    Cell Significance Index: 0.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0004
    Cell Significance Index: 0.5400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0020
    Cell Significance Index: -0.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0033
    Cell Significance Index: -2.5300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0053
    Cell Significance Index: -2.3300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0059
    Cell Significance Index: -0.3800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0065
    Cell Significance Index: -8.8100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0102
    Cell Significance Index: -7.5000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0109
    Cell Significance Index: -5.9300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0143
    Cell Significance Index: -10.6000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0154
    Cell Significance Index: -1.9700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0181
    Cell Significance Index: -8.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0194
    Cell Significance Index: -10.9600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0224
    Cell Significance Index: -6.4500
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.0337
    Cell Significance Index: -0.3200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0339
    Cell Significance Index: -0.5000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0392
    Cell Significance Index: -4.0100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0460
    Cell Significance Index: -0.5900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0533
    Cell Significance Index: -7.3200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0542
    Cell Significance Index: -11.4200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0559
    Cell Significance Index: -9.5500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0590
    Cell Significance Index: -1.5800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0622
    Cell Significance Index: -1.5900
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0643
    Cell Significance Index: -0.8800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0676
    Cell Significance Index: -3.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0725
    Cell Significance Index: -8.3100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0785
    Cell Significance Index: -8.1800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0795
    Cell Significance Index: -10.2700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0806
    Cell Significance Index: -5.7000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0824
    Cell Significance Index: -1.1800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0862
    Cell Significance Index: -4.0200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0911
    Cell Significance Index: -3.9600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0917
    Cell Significance Index: -10.8200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1045
    Cell Significance Index: -1.7900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1108
    Cell Significance Index: -3.8800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1131
    Cell Significance Index: -2.0900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1247
    Cell Significance Index: -7.8600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1262
    Cell Significance Index: -10.0000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1372
    Cell Significance Index: -10.2300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1413
    Cell Significance Index: -6.2500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1440
    Cell Significance Index: -7.5600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1451
    Cell Significance Index: -4.6200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1523
    Cell Significance Index: -7.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1530
    Cell Significance Index: -8.5900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1568
    Cell Significance Index: -3.3400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1650
    Cell Significance Index: -6.2500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1668
    Cell Significance Index: -3.5400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1719
    Cell Significance Index: -3.6800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1720
    Cell Significance Index: -4.2900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1747
    Cell Significance Index: -5.7200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1803
    Cell Significance Index: -5.0400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1831
    Cell Significance Index: -3.0900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1844
    Cell Significance Index: -5.0200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1902
    Cell Significance Index: -3.9700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1990
    Cell Significance Index: -3.4400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2105
    Cell Significance Index: -5.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SCARF1 is a member of the scavenger receptor class F (SRF) family, characterized by its ability to bind and internalize low-density lipoproteins (LDL) and other ligands. This receptor is expressed on various cell types, including endothelial cells, neurons, and immune cells, suggesting its involvement in multiple biological processes. SCARF1 is also known for its homophilic and heterophilic interactions with other receptors, enabling its role in cell-cell adhesion and signaling. **Pathways and Functions:** SCARF1 is involved in several signaling pathways, including: 1. **Receptor-mediated endocytosis**: SCARF1 mediates the uptake of LDL and other ligands, leading to the formation of endocytic vesicles and the regulation of cellular metabolism. 2. **Cell-cell adhesion**: SCARF1 interacts with other receptors, such as integrins and cadherins, to facilitate cell-cell adhesion and the maintenance of tissue architecture. 3. **Neuroregulation**: SCARF1 is expressed in neuronal cells and plays a role in axon regeneration, neuron projection development, and dendrite development. 4. **Immune regulation**: SCARF1 is involved in the regulation of immune responses, including the binding and uptake of pathogens and the modulation of immune cell activity. **Clinical Significance:** SCARF1 has been implicated in various diseases and disorders, including: 1. **Atherosclerosis**: SCARF1 has been linked to the development of atherosclerosis, a disease characterized by the buildup of LDL in arterial walls. 2. **Neurodegenerative diseases**: SCARF1 may play a role in neurodegenerative diseases, such as Alzheimer's and Parkinson's, due to its involvement in axon regeneration and dendrite development. 3. **Inflammatory disorders**: SCARF1 may contribute to inflammatory disorders, such as rheumatoid arthritis and multiple sclerosis, by regulating immune cell activity and modulating the response to pathogens. In conclusion, SCARF1 is a multifunctional receptor that plays a critical role in immune regulation, cellular homeostasis, and development. Further research is necessary to fully elucidate the mechanisms by which SCARF1 regulates various biological processes and to explore its potential as a therapeutic target for diseases associated with its dysfunction. **Recommendations:** 1. **Investigate the role of SCARF1 in specific diseases**: Further studies are needed to determine the specific role of SCARF1 in various diseases and disorders. 2. **Develop therapeutic strategies**: Researchers should explore potential therapeutic strategies that target SCARF1, such as inhibitors of its activity or modulators of its expression. 3. **Characterize the ligands of SCARF1**: The identification of the specific ligands that bind to SCARF1 will provide valuable insights into its mechanisms of action and potential therapeutic applications. By advancing our understanding of SCARF1 and its role in biological processes, we can uncover new avenues for the treatment and prevention of diseases associated with its dysfunction.

Genular Protein ID: 3741843233

Symbol: SREC_HUMAN

Name: Scavenger receptor class F member 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9395444

Title: Expression cloning of a novel scavenger receptor from human endothelial cells.

PubMed ID: 9395444

DOI: 10.1074/jbc.272.50.31217

PubMed ID: 11978792

Title: Characterization of the human gene encoding the scavenger receptor expressed by endothelial cell and its regulation by a novel transcription factor, endothelial zinc finger protein-2.

PubMed ID: 11978792

DOI: 10.1074/jbc.m201854200

PubMed ID: 8590280

Title: Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 8590280

DOI: 10.1093/dnares/2.4.167

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 830
  • Mass: 87387
  • Checksum: 3D1CBF0D6F2BA055
  • Sequence:
  • MGLGLLLPLL LLWTRGTQGS ELDPKGQHVC VASSPSAELQ CCAGWRQKDQ ECTIPICEGP 
    DACQKDEVCV KPGLCRCKPG FFGAHCSSRC PGQYWGPDCR ESCPCHPHGQ CEPATGACQC 
    QADRWGARCE FPCACGPHGR CDPATGVCHC EPGWWSSTCR RPCQCNTAAA RCEQATGACV 
    CKPGWWGRRC SFRCNCHGSP CEQDSGRCAC RPGWWGPECQ QQCECVRGRC SAASGECTCP 
    PGFRGARCEL PCPAGSHGVQ CAHSCGRCKH NEPCSPDTGS CESCEPGWNG TQCQQPCLPG 
    TFGESCEQQC PHCRHGEACE PDTGHCQRCD PGWLGPRCED PCPTGTFGED CGSTCPTCVQ 
    GSCDTVTGDC VCSAGYWGPS CNASCPAGFH GNNCSVPCEC PEGLCHPVSG SCQPGSGSRD 
    TALIAGSLVP LLLLFLGLAC CACCCWAPRS DLKDRPARDG ATVSRMKLQV WGTLTSLGST 
    LPCRSLSSHK LPWVTVSHHD PEVPFNHSFI EPPSAGWATD DSFSSDPESG EADEVPAYCV 
    PPQEGMVPVA QAGSSEASLA AGAFPPPEDA STPFAIPRTS SLARAKRPSV SFAEGTKFAP 
    QSRRSSGELS SPLRKPKRLS RGAQSGPEGR EAEESTGPEE AEAPESFPAA ASPGDSATGH 
    RRPPLGGRTV AEHVEAIEGS VQESSGPVTT IYMLAGKPRG SEGPVRSVFR HFGSFQKGQA 
    EAKVKRAIPK PPRQALNRKK GSPGLASGSV GQSPNSAPKA GLPGATGPMA VRPEEAVRGL 
    GAGTESSRRA QEPVSGCGSP EQDPQKQAEE ERQEEPEYEN VVPISRPPEP

Genular Protein ID: 1481099945

Symbol: A8K6Z5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 830
  • Mass: 87449
  • Checksum: 676951CE5719ABA0
  • Sequence:
  • MGLGLLLPLL LLWTRGTQGS ELDPKGQHVC VASSPSAELQ CCAGWRQKDQ ECTIPICEGP 
    DACQKDEVCV KPGLCRCKPG FFGAHCSSRC PGQYWGPDCR ESCPCHPHGQ CEPATGACQC 
    QADRWGARCE FPCACGPHGR CDPATGVCHC EPGWWSSTCR RPCQCNTAAA RCEQATGACV 
    CKPGWWGRRC SFRCNCHGSP CEQDSGRCAC RPGWWGPECQ QQCECVRGRC SAASGECTCP 
    PGFRGARCEL PCPAGSHGVQ CAHSCGRCKH NEPCSPDTGS CESCEPGWNG TQCQQPCLPG 
    TFGESCEQQC PHCRHGEACE PDTGHCQRCD PGWLGPRCED PCPTGTFGED CGSTCPTCVQ 
    GSCDTVTGDC VCSAGYWGPS CNASCPAGFH GNNCSVPCEC PEGLCHPVSG SCQPGSGSRD 
    TALIAGSLVP LLLLFLGLAC CACCCWAPRS DLKDRPARDG ATVSRMKLQV WGTLTSLGST 
    LPCRSLSSHK LPWVTVSHHD PEVPFNHSFI EPPSAGWATD DSFSSDPESG EADEVPAYCV 
    PPQEGMVPVA QAGSSEASLA AGAFPPPEDA STPFAIPRTS SLARAKRLSV SFAEGTKFAP 
    QSRRSSGELS SPLRKPKRLS RGAQSSPEGR EAEESTGPDE AEAPESFPAA ASPGDSATGH 
    RRPPLGSRTV AEHVEAIEGS VQESSGPVTT IYMLAGKPRG SEGPVRSVFR HFGSFQKGQA 
    EAKVKRAIPK PPRQALNRKK GSPGLASGSV GQSPNSAPKA GLPGATGPMA VRPEEAVRGL 
    GAGTESSRRA QEPVSGCGSP EQDPQKQAEE ERQEEPEYEN VVPISRPPEP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.