NCOA1 | ENSG00000084676 | NCBI 8648

Details for: NCOA1

Gene ID: 8648

Symbol: NCOA1

Ensembl ID: ENSG00000084676

Description: nuclear receptor coactivator 1

Associated with

Activation of gene expression by srebf (srebp)
(R-HSA-2426168)
Adipogenesis
(R-HSA-9843745)
Bile acid and bile salt metabolism
(R-HSA-194068)
Biological oxidations
(R-HSA-211859)
Bmal1:clock,npas2 activates circadian gene expression
(R-HSA-1368108)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Circadian clock
(R-HSA-400253)
Cytochrome p450 - arranged by substrate type
(R-HSA-211897)
Cytoprotection by hmox1
(R-HSA-9707564)
Developmental biology
(R-HSA-1266738)
Endogenous sterols
(R-HSA-211976)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of adipogenesis genes by mll3 and mll4 complexes
(R-HSA-9851695)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Gene expression (transcription)
(R-HSA-74160)
Hats acetylate histones
(R-HSA-3214847)
Heme signaling
(R-HSA-9707616)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Metabolism of proteins
(R-HSA-392499)
Metabolism of steroids
(R-HSA-8957322)
Mitochondrial biogenesis
(R-HSA-1592230)
Mll4 and mll3 complexes regulate expression of pparg target genes in adipogenesis and hepatic steatosis
(R-HSA-9841922)
Nr1h2 & nr1h3 regulate gene expression to control bile acid homeostasis
(R-HSA-9623433)
Nr1h2 and nr1h3-mediated signaling
(R-HSA-9024446)
Nr1h3 & nr1h2 regulate gene expression linked to cholesterol transport and efflux
(R-HSA-9029569)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Phase i - functionalization of compounds
(R-HSA-211945)
Post-translational protein modification
(R-HSA-597592)
Ppara activates gene expression
(R-HSA-1989781)
Recycling of bile acids and salts
(R-HSA-159418)
Regulation of cholesterol biosynthesis by srebp (srebf)
(R-HSA-1655829)
Regulation of lipid metabolism by pparalpha
(R-HSA-400206)
Rora activates gene expression
(R-HSA-1368082)
Signaling by nuclear receptors
(R-HSA-9006931)
Signal transduction
(R-HSA-162582)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Sumoylation of transcription cofactors
(R-HSA-3899300)
Synthesis of bile acids and bile salts
(R-HSA-192105)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
(R-HSA-193368)
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
(R-HSA-193807)
Transcriptional activation of mitochondrial biogenesis
(R-HSA-2151201)
Transcriptional regulation of brown and beige adipocyte differentiation
(R-HSA-9843743)
Transcriptional regulation of brown and beige adipocyte differentiation by ebf2
(R-HSA-9844594)
Transcriptional regulation of white adipocyte differentiation
(R-HSA-381340)
Cellular response to hormone stimulus
(GO:0032870)
Cellular response to thyroglobulin triiodothyronine
(GO:1904017)
Cerebellum development
(GO:0021549)
Cerebral cortex development
(GO:0021987)
Chromatin
(GO:0000785)
Chromatin binding
(GO:0003682)
Chromatin remodeling
(GO:0006338)
Estrogen receptor signaling pathway
(GO:0030520)
Estrous cycle
(GO:0044849)
Hippocampus development
(GO:0021766)
Histone acetyltransferase activity
(GO:0004402)
Hypothalamus development
(GO:0021854)
Labyrinthine layer morphogenesis
(GO:0060713)
Lactation
(GO:0007595)
Male gonad development
(GO:0008584)
Male mating behavior
(GO:0060179)
Mrna transcription by rna polymerase ii
(GO:0042789)
Nuclear estrogen receptor binding
(GO:0030331)
Nuclear receptor binding
(GO:0016922)
Nuclear receptor coactivator activity
(GO:0030374)
Nuclear retinoid x receptor binding
(GO:0046965)
Peroxisome proliferator activated receptor signaling pathway
(GO:0035357)
Positive regulation of adipose tissue development
(GO:1904179)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of female receptivity
(GO:0045925)
Positive regulation of neuron differentiation
(GO:0045666)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of transcription from rna polymerase ii promoter by galactose
(GO:0000435)
Progesterone receptor signaling pathway
(GO:0050847)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Regulation of cellular response to insulin stimulus
(GO:1900076)
Regulation of thyroid hormone receptor signaling pathway
(GO:0002155)
Response to estradiol
(GO:0032355)
Response to progesterone
(GO:0032570)
Response to retinoic acid
(GO:0032526)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Transcription coactivator activity
(GO:0003713)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 690.1530
Cell Significance Index: -107.3500
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 427.3717
Cell Significance Index: -108.4000
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 226.4666
Cell Significance Index: -106.9200
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 205.5472
Cell Significance Index: -83.5100
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 188.7690
Cell Significance Index: -97.1000
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 88.0729
Cell Significance Index: -108.5900
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 87.9006
Cell Significance Index: -83.9200
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 37.0046
Cell Significance Index: -99.1300
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 32.9528
Cell Significance Index: -72.1200
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 32.1932
Cell Significance Index: -98.8800
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 27.9051
Cell Significance Index: -110.1200
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 5.9926
Cell Significance Index: 336.2800
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 4.4376
Cell Significance Index: 1591.6700
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 3.9493
Cell Significance Index: 265.5500
Cell Name: preadipocyte (CL0002334)
Fold Change: 3.8535
Cell Significance Index: 75.2100
Cell Name: cortical interneuron (CL0008031)
Fold Change: 3.7164
Cell Significance Index: 89.1300
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 3.5175
Cell Significance Index: 216.2000
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 3.2897
Cell Significance Index: 84.5600
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 3.2655
Cell Significance Index: 250.5900
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 3.0795
Cell Significance Index: 617.7400
Cell Name: type I muscle cell (CL0002211)
Fold Change: 3.0083
Cell Significance Index: 73.4000
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 2.6064
Cell Significance Index: 17.6600
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 2.5148
Cell Significance Index: 71.7700
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 2.5040
Cell Significance Index: 94.8200
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 2.4511
Cell Significance Index: 108.4200
Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.2968
Cell Significance Index: 455.8100
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 2.2609
Cell Significance Index: 1563.7100
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.4408
Cell Significance Index: 17.8700
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.2721
Cell Significance Index: 35.5500
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.0005
Cell Significance Index: 1883.8700
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.9768
Cell Significance Index: 620.3900
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.9223
Cell Significance Index: 19.7200
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.8350
Cell Significance Index: 379.0000
Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: 0.8117
Cell Significance Index: 11.3500
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.7493
Cell Significance Index: 81.5000
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.5823
Cell Significance Index: 104.9700
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.5418
Cell Significance Index: 66.6200
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.5179
Cell Significance Index: 797.2400
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.5095
Cell Significance Index: 939.5700
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.4802
Cell Significance Index: 8.2300
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.4459
Cell Significance Index: 26.7700
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3603
Cell Significance Index: 325.2800
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.2731
Cell Significance Index: 371.3200
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.1918
Cell Significance Index: 9.9900
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.1748
Cell Significance Index: 2.5100
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.1641
Cell Significance Index: 2.3600
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1322
Cell Significance Index: 5.9900
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1158
Cell Significance Index: 3.3400
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1121
Cell Significance Index: 49.5800
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1115
Cell Significance Index: 15.3100
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0341
Cell Significance Index: 18.6000
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0088
Cell Significance Index: 1.6800
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0348
Cell Significance Index: -5.0600
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0549
Cell Significance Index: -40.2900
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0751
Cell Significance Index: -55.6300
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0914
Cell Significance Index: -3.2100
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0963
Cell Significance Index: -16.4500
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1111
Cell Significance Index: -69.3900
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.1162
Cell Significance Index: -2.5500
Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.1324
Cell Significance Index: -13.1000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.1348
Cell Significance Index: -102.0600
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1530
Cell Significance Index: -86.2600
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2432
Cell Significance Index: -15.3300
Cell Name: odontoblast (CL0000060)
Fold Change: -0.2474
Cell Significance Index: -31.7200
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.3103
Cell Significance Index: -65.3600
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3195
Cell Significance Index: -33.2700
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.3306
Cell Significance Index: -95.1200
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.4471
Cell Significance Index: -5.3300
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.5299
Cell Significance Index: -62.4900
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.5412
Cell Significance Index: -25.4400
Cell Name: lactocyte (CL0002325)
Fold Change: -0.5527
Cell Significance Index: -71.4100
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.5675
Cell Significance Index: -57.9800
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.5835
Cell Significance Index: -40.3500
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.7194
Cell Significance Index: -83.8400
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.7475
Cell Significance Index: -34.8500
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.7746
Cell Significance Index: -88.7400
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.8349
Cell Significance Index: -43.3700
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.8458
Cell Significance Index: -96.5500
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.9484
Cell Significance Index: -70.6800
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.9912
Cell Significance Index: -63.9500
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -1.0419
Cell Significance Index: -15.3800
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.0802
Cell Significance Index: -85.5600
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -1.1862
Cell Significance Index: -83.8900
Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -1.1997
Cell Significance Index: -14.9600
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -1.2391
Cell Significance Index: -24.5000
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -1.2418
Cell Significance Index: -11.4400
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -1.2881
Cell Significance Index: -67.6300
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: -1.3422
Cell Significance Index: -20.4200
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.3701
Cell Significance Index: -84.0000
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -1.4411
Cell Significance Index: -38.6200
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -1.4495
Cell Significance Index: -29.1000
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -1.4673
Cell Significance Index: -20.0200
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -1.5606
Cell Significance Index: -41.6700
Cell Name: type II muscle cell (CL0002212)
Fold Change: -1.6300
Cell Significance Index: -26.3000
Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -1.6468
Cell Significance Index: -20.7900
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -1.6973
Cell Significance Index: -55.5700
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -1.7008
Cell Significance Index: -54.1700
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -1.7405
Cell Significance Index: -36.9400
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -1.7728
Cell Significance Index: -37.7600
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -1.9065
Cell Significance Index: -54.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **Coactivator of nuclear receptors:** NCOA1 interacts with nuclear receptors to enhance gene expression, particularly in the context of bile acid and lipid metabolism. 2. **Broad expression pattern:** NCOA1 is expressed in various cell types, including skeletal muscle, neurons, and adrenal gland cells, indicating its role in diverse biological processes. 3. **Circadian regulation:** NCOA1 is involved in the regulation of circadian gene expression, highlighting its connection to the body's internal clock. 4. **Metabolic regulation:** NCOA1 plays a crucial role in regulating lipid metabolism, cholesterol transport, and bile acid homeostasis. **Pathways and Functions:** NCOA1 is implicated in various signaling pathways, including: 1. **Bile acid and bile salt metabolism:** NCOA1 facilitates the expression of genes involved in bile acid synthesis and recycling. 2. **Cholesterol transport and efflux:** NCOA1 regulates the expression of genes involved in cholesterol transport and efflux. 3. **Circadian clock:** NCOA1 interacts with the circadian clock machinery to regulate gene expression. 4. **Gene expression regulation:** NCOA1 acts as a coactivator of nuclear receptors to enhance gene expression. 5. **Histone modification:** NCOA1 interacts with histone acetyltransferases to regulate chromatin structure and gene expression. **Clinical Significance:** Dysregulation of NCOA1 has been implicated in various diseases, including: 1. **Metabolic disorders:** Altered expression of NCOA1 has been linked to metabolic disorders, such as obesity and lipid metabolism disorders. 2. **Cancer:** NCOA1 is overexpressed in various types of cancer, including breast, prostate, and colon cancer. 3. **Neurological disorders:** NCOA1 is implicated in neurological disorders, such as Parkinson's disease and Alzheimer's disease. 4. **Circadian rhythm disorders:** Disruptions in NCOA1 expression have been linked to circadian rhythm disorders, such as delayed sleep phase syndrome. In conclusion, NCOA1 is a complex gene that plays a pivotal role in regulating gene expression, metabolism, and circadian rhythms. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms underlying NCOA1 function and its clinical significance.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Nuclear receptor coactivator 1

Genular Protein ID: 2008524260

Symbol: NCOA1_HUMAN

Name: Nuclear receptor coactivator 1

UniProtKB Accession Codes:

Q15788 O00150 O43792 O43793 Q13071 Q13420 Q2T9G5 Q53SX3 Q6GVI5 Q7KYV3

Database IDs:

Citations:

PubMed ID: 8754792

Title: Molecular cloning and properties of a full-length putative thyroid hormone receptor coactivator.

PubMed ID: 8754792

DOI: 10.1210/endo.137.8.8754792

PubMed ID: 9427757

Title: Isoforms of steroid receptor coactivator 1 differ in their ability to potentiate transcription by the oestrogen receptor.

PubMed ID: 9427757

DOI: 10.1093/emboj/17.1.232

PubMed ID: 9575154

Title: The steroid receptor coactivator-1 contains multiple receptor interacting and activation domains that cooperatively enhance the activation function 1 (AF1) and AF2 domains of steroid receptors.

PubMed ID: 9575154

DOI: 10.1074/jbc.273.20.12101

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7481822

Title: Sequence and characterization of a coactivator for the steroid hormone receptor superfamily.

PubMed ID: 7481822

DOI: 10.1126/science.270.5240.1354

PubMed ID: 11831720

Title: Analysis of human immunodeficiency virus type 1 promoter insertion in vivo.

PubMed ID: 11831720

DOI: 10.1006/viro.1995.1161

PubMed ID: 15313887

Title: Gene expression signatures identify rhabdomyosarcoma subtypes and detect a novel t(2;2)(q35;p23) translocation fusing PAX3 to NCOA1.

PubMed ID: 15313887

DOI: 10.1158/0008-5472.can-04-0844

PubMed ID: 9223431

Title: A splicing variant of steroid receptor coactivator-1 (SRC-1E): the major isoform of SRC-1 to mediate thyroid hormone action.

PubMed ID: 9223431

DOI: 10.1006/bbrc.1997.6911

PubMed ID: 9296499

Title: Steroid receptor coactivator-1 is a histone acetyltransferase.

PubMed ID: 9296499

DOI: 10.1038/38304

PubMed ID: 9223281

Title: Steroid receptor induction of gene transcription: a two-step model.

PubMed ID: 9223281

DOI: 10.1073/pnas.94.15.7879

PubMed ID: 10508479

Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.

PubMed ID: 10508479

DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5

PubMed ID: 10567404

Title: A nuclear factor ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo.

PubMed ID: 10567404

DOI: 10.1074/jbc.274.48.34283

PubMed ID: 10449719

Title: Steroid receptor coactivator-1 (SRC-1) enhances ligand-dependent and receptor-dependent cell-free transcription of chromatin.

PubMed ID: 10449719

DOI: 10.1073/pnas.96.17.9485

PubMed ID: 10660621

Title: Phosphorylation of steroid receptor coactivator-1. Identification of the phosphorylation sites and phosphorylation through the mitogen-activated protein kinase pathway.

PubMed ID: 10660621

DOI: 10.1074/jbc.275.6.4475

PubMed ID: 10722692

Title: JAB1 interacts with both the progesterone receptor and SRC-1.

PubMed ID: 10722692

DOI: 10.1074/jbc.275.12.8540

PubMed ID: 10594042

Title: Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha.

PubMed ID: 10594042

DOI: 10.1128/mcb.20.1.402-415.2000

PubMed ID: 11250900

Title: A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA.

PubMed ID: 11250900

DOI: 10.1093/emboj/20.6.1341

PubMed ID: 11773079

Title: Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a.

PubMed ID: 11773079

DOI: 10.1074/jbc.m111486200

PubMed ID: 12039952

Title: Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha.

PubMed ID: 12039952

DOI: 10.1074/jbc.m201053200

PubMed ID: 12138096

Title: An LXXLL motif in the transactivation domain of STAT6 mediates recruitment of NCoA-1/SRC-1.

PubMed ID: 12138096

DOI: 10.1074/jbc.m203556200

PubMed ID: 12529333

Title: Sumoylation of the progesterone receptor and of the steroid receptor coactivator SRC-1.

PubMed ID: 12529333

DOI: 10.1074/jbc.m207148200

PubMed ID: 12954634

Title: NCoA-1/SRC-1 is an essential coactivator of STAT5 that binds to the FDL motif in the alpha-helical region of the STAT5 transactivation domain.

PubMed ID: 12954634

DOI: 10.1074/jbc.m303644200

PubMed ID: 12917342

Title: BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation.

PubMed ID: 12917342

DOI: 10.1128/mcb.23.17.6210-6220.2003

PubMed ID: 15367689

Title: The ubiquitin-conjugating enzyme UBCH7 acts as a coactivator for steroid hormone receptors.

PubMed ID: 15367689

DOI: 10.1128/mcb.24.19.8716-8726.2004

PubMed ID: 16957778

Title: The catalytic subunit of the proteasome is engaged in the entire process of estrogen receptor-regulated transcription.

PubMed ID: 16957778

DOI: 10.1038/sj.emboj.7601306

PubMed ID: 16606617

Title: Additional sex comb-like 1 (ASXL1), in cooperation with SRC-1, acts as a ligand-dependent coactivator for retinoic acid receptor.

PubMed ID: 16606617

DOI: 10.1074/jbc.m512616200

PubMed ID: 17116691

Title: STAMP, a novel predicted factor assisting TIF2 actions in glucocorticoid receptor-mediated induction and repression.

PubMed ID: 17116691

DOI: 10.1128/mcb.01360-06

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18690216

Title: Cytosporone B is an agonist for nuclear orphan receptor Nur77.

PubMed ID: 18690216

DOI: 10.1038/nchembio.106

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19786558

Title: The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors.

PubMed ID: 19786558

DOI: 10.1124/mol.109.057000

PubMed ID: 20047962

Title: Protein arginine methyltransferase 6 regulates multiple aspects of gene expression.

PubMed ID: 20047962

DOI: 10.1093/nar/gkp1203

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25219498

Title: Modification of ASC1 by UFM1 is crucial for ERalpha transactivation and breast cancer development.

PubMed ID: 25219498

DOI: 10.1016/j.molcel.2014.08.007

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 28698609

Title: Functional analyses of a novel missense and other mutations of the vitamin D receptor in association with alopecia.

PubMed ID: 28698609

DOI: 10.1038/s41598-017-05081-x

PubMed ID: 9744270

Title: Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma.

PubMed ID: 9744270

DOI: 10.1038/25931

PubMed ID: 11698662

Title: Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors.

PubMed ID: 11698662

DOI: 10.1073/pnas.241410198

PubMed ID: 11864604

Title: Structural and functional evidence for ligand-independent transcriptional activation by the estrogen-related receptor 3.

PubMed ID: 11864604

DOI: 10.1016/s1097-2765(02)00444-6

Sequence Information:

Length: 1441
Mass: 156757
Checksum: 25EF6F389489121E
Sequence:

MSGLGDSSSD PANPDSHKRK GSPCDTLASS TEKRRREQEN KYLEELAELL SANISDIDSL 
SVKPDKCKIL KKTVDQIQLM KRMEQEKSTT DDDVQKSDIS SSSQGVIEKE SLGPLLLEAL 
DGFFFVVNCE GRIVFVSENV TSYLGYNQEE LMNTSVYSIL HVGDHAEFVK NLLPKSLVNG 
VPWPQEATRR NSHTFNCRML IHPPDEPGTE NQEACQRYEV MQCFTVSQPK SIQEDGEDFQ 
SCLICIARRL PRPPAITGVE SFMTKQDTTG KIISIDTSSL RAAGRTGWED LVRKCIYAFF 
QPQGREPSYA RQLFQEVMTR GTASSPSYRF ILNDGTMLSA HTKCKLCYPQ SPDMQPFIMG 
IHIIDREHSG LSPQDDTNSG MSIPRVNPSV NPSISPAHGV ARSSTLPPSN SNMVSTRINR 
QQSSDLHSSS HSNSSNSQGS FGCSPGSQIV ANVALNQGQA SSQSSNPSLN LNNSPMEGTG 
ISLAQFMSPR RQVTSGLATR PRMPNNSFPP NISTLSSPVG MTSSACNNNN RSYSNIPVTS 
LQGMNEGPNN SVGFSASSPV LRQMSSQNSP SRLNIQPAKA ESKDNKEIAS ILNEMIQSDN 
SSSDGKPLDS GLLHNNDRLS DGDSKYSQTS HKLVQLLTTT AEQQLRHADI DTSCKDVLSC 
TGTSNSASAN SSGGSCPSSH SSLTERHKIL HRLLQEGSPS DITTLSVEPD KKDSASTSVS 
VTGQVQGNSS IKLELDASKK KESKDHQLLR YLLDKDEKDL RSTPNLSLDD VKVKVEKKEQ 
MDPCNTNPTP MTKPTPEEIK LEAQSQFTAD LDQFDQLLPT LEKAAQLPGL CETDRMDGAV 
TSVTIKSEIL PASLQSATAR PTSRLNRLPE LELEAIDNQF GQPGTGDQIP WTNNTVTAIN 
QSKSEDQCIS SQLDELLCPP TTVEGRNDEK ALLEQLVSFL SGKDETELAE LDRALGIDKL 
VQGGGLDVLS ERFPPQQATP PLIMEERPNL YSQPYSSPSP TANLPSPFQG MVRQKPSLGT 
MPVQVTPPRG AFSPGMGMQP RQTLNRPPAA PNQLRLQLQQ RLQGQQQLIH QNRQAILNQF 
AATAPVGINM RSGMQQQITP QPPLNAQMLA QRQRELYSQQ HRQRQLIQQQ RAMLMRQQSF 
GNNLPPSSGL PVQMGNPRLP QGAPQQFPYP PNYGTNPGTP PASTSPFSQL AANPEASLAN 
RNSMVSRGMT GNIGGQFGTG INPQMQQNVF QYPGAGMVPQ GEANFAPSLS PGSSMVPMPI 
PPPQSSLLQQ TPPASGYQSP DMKAWQQGAI GNNNVFSQAV QNQPTPAQPG VYNNMSITVS 
MAGGNTNVQN MNPMMAQMQM SSLQMPGMNT VCPEQINDPA LRHTGLYCNQ LSSTDLLKTE 
ADGTQQVQQV QVFADVQCTV NLVGGDPYLN QPGPLGTQKP TSGPQTPQAQ QKSLLQQLLT 
E

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: NCOA1

Associated with

Cells (max top 100)

Other Information

Molecular cloning and properties of a full-length putative thyroid hormone receptor coactivator. PubMed ID: 8754792

Isoforms of steroid receptor coactivator 1 differ in their ability to potentiate transcription by the oestrogen receptor. PubMed ID: 9427757

The steroid receptor coactivator-1 contains multiple receptor interacting and activation domains that cooperatively enhance the activation function 1 (AF1) and AF2 domains of steroid receptors. PubMed ID: 9575154

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. PubMed ID: 7481822

Analysis of human immunodeficiency virus type 1 promoter insertion in vivo. PubMed ID: 11831720

Gene expression signatures identify rhabdomyosarcoma subtypes and detect a novel t(2;2)(q35;p23) translocation fusing PAX3 to NCOA1. PubMed ID: 15313887

A splicing variant of steroid receptor coactivator-1 (SRC-1E): the major isoform of SRC-1 to mediate thyroid hormone action. PubMed ID: 9223431

Steroid receptor coactivator-1 is a histone acetyltransferase. PubMed ID: 9296499

Steroid receptor induction of gene transcription: a two-step model. PubMed ID: 9223281

Antigens recognized by autologous antibody in patients with renal-cell carcinoma. PubMed ID: 10508479

A nuclear factor ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo. PubMed ID: 10567404

Steroid receptor coactivator-1 (SRC-1) enhances ligand-dependent and receptor-dependent cell-free transcription of chromatin. PubMed ID: 10449719

Phosphorylation of steroid receptor coactivator-1. Identification of the phosphorylation sites and phosphorylation through the mitogen-activated protein kinase pathway. PubMed ID: 10660621

JAB1 interacts with both the progesterone receptor and SRC-1. PubMed ID: 10722692

Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha. PubMed ID: 10594042

A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA. PubMed ID: 11250900

Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a. PubMed ID: 11773079

Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha. PubMed ID: 12039952

An LXXLL motif in the transactivation domain of STAT6 mediates recruitment of NCoA-1/SRC-1. PubMed ID: 12138096

Sumoylation of the progesterone receptor and of the steroid receptor coactivator SRC-1. PubMed ID: 12529333

NCoA-1/SRC-1 is an essential coactivator of STAT5 that binds to the FDL motif in the alpha-helical region of the STAT5 transactivation domain. PubMed ID: 12954634

BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation. PubMed ID: 12917342

The ubiquitin-conjugating enzyme UBCH7 acts as a coactivator for steroid hormone receptors. PubMed ID: 15367689

The catalytic subunit of the proteasome is engaged in the entire process of estrogen receptor-regulated transcription. PubMed ID: 16957778

Additional sex comb-like 1 (ASXL1), in cooperation with SRC-1, acts as a ligand-dependent coactivator for retinoic acid receptor. PubMed ID: 16606617

STAMP, a novel predicted factor assisting TIF2 actions in glucocorticoid receptor-mediated induction and repression. PubMed ID: 17116691

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. PubMed ID: 17525332

Cytosporone B is an agonist for nuclear orphan receptor Nur77. PubMed ID: 18690216

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors. PubMed ID: 19786558

Protein arginine methyltransferase 6 regulates multiple aspects of gene expression. PubMed ID: 20047962

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Modification of ASC1 by UFM1 is crucial for ERalpha transactivation and breast cancer development. PubMed ID: 25219498

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Functional analyses of a novel missense and other mutations of the vitamin D receptor in association with alopecia. PubMed ID: 28698609

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma. PubMed ID: 9744270

Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors. PubMed ID: 11698662

Structural and functional evidence for ligand-independent transcriptional activation by the estrogen-related receptor 3. PubMed ID: 11864604