Gene NCOA1 - ENSG00000084676 | NCBI Gene ID: 8648

Details for: NCOA1

Gene ID: 8648

Symbol: NCOA1

Ensembl ID: ENSG00000084676

Description: nuclear receptor coactivator 1

Associated with

Activation of gene expression by srebf (srebp)
(R-HSA-2426168)
Bile acid and bile salt metabolism
(R-HSA-194068)
Biological oxidations
(R-HSA-211859)
Bmal1:clock,npas2 activates circadian gene expression
(R-HSA-1368108)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Circadian clock
(R-HSA-400253)
Cytochrome p450 - arranged by substrate type
(R-HSA-211897)
Cytoprotection by hmox1
(R-HSA-9707564)
Developmental biology
(R-HSA-1266738)
Endogenous sterols
(R-HSA-211976)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Hats acetylate histones
(R-HSA-3214847)
Heme signaling
(R-HSA-9707616)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Metabolism of proteins
(R-HSA-392499)
Metabolism of steroids
(R-HSA-8957322)
Mitochondrial biogenesis
(R-HSA-1592230)
Nr1h2 & nr1h3 regulate gene expression to control bile acid homeostasis
(R-HSA-9623433)
Nr1h2 and nr1h3-mediated signaling
(R-HSA-9024446)
Nr1h3 & nr1h2 regulate gene expression linked to cholesterol transport and efflux
(R-HSA-9029569)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Phase i - functionalization of compounds
(R-HSA-211945)
Post-translational protein modification
(R-HSA-597592)
Ppara activates gene expression
(R-HSA-1989781)
Recycling of bile acids and salts
(R-HSA-159418)
Regulation of cholesterol biosynthesis by srebp (srebf)
(R-HSA-1655829)
Regulation of lipid metabolism by pparalpha
(R-HSA-400206)
Rora activates gene expression
(R-HSA-1368082)
Signaling by nuclear receptors
(R-HSA-9006931)
Signal transduction
(R-HSA-162582)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Sumoylation of transcription cofactors
(R-HSA-3899300)
Synthesis of bile acids and bile salts
(R-HSA-192105)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
(R-HSA-193368)
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
(R-HSA-193807)
Transcriptional activation of mitochondrial biogenesis
(R-HSA-2151201)
Transcriptional regulation of white adipocyte differentiation
(R-HSA-381340)
Cellular response to hormone stimulus
(GO:0032870)
Cellular response to thyroglobulin triiodothyronine
(GO:1904017)
Cerebellum development
(GO:0021549)
Cerebral cortex development
(GO:0021987)
Chromatin
(GO:0000785)
Chromatin binding
(GO:0003682)
Chromatin remodeling
(GO:0006338)
Cytosol
(GO:0005829)
Estrous cycle
(GO:0044849)
Hippocampus development
(GO:0021766)
Histone acetyltransferase activity
(GO:0004402)
Hypothalamus development
(GO:0021854)
Labyrinthine layer morphogenesis
(GO:0060713)
Lactation
(GO:0007595)
Male gonad development
(GO:0008584)
Male mating behavior
(GO:0060179)
Mrna transcription by rna polymerase ii
(GO:0042789)
Nuclear estrogen receptor binding
(GO:0030331)
Nuclear receptor binding
(GO:0016922)
Nuclear receptor coactivator activity
(GO:0030374)
Nuclear retinoid x receptor binding
(GO:0046965)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Peroxisome proliferator activated receptor signaling pathway
(GO:0035357)
Plasma membrane
(GO:0005886)
Positive regulation of adipose tissue development
(GO:1904179)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of female receptivity
(GO:0045925)
Positive regulation of neuron differentiation
(GO:0045666)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of transcription from rna polymerase ii promoter by galactose
(GO:0000435)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Regulation of cellular response to insulin stimulus
(GO:1900076)
Regulation of thyroid hormone mediated signaling pathway
(GO:0002155)
Response to estradiol
(GO:0032355)
Response to progesterone
(GO:0032570)
Response to retinoic acid
(GO:0032526)
Rna polymerase ii transcription regulator complex
(GO:0090575)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Transcription coactivator activity
(GO:0003713)
Transcription regulator complex
(GO:0005667)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 5.4
Marker Score: 13524
Cell Name: Purkinje cell (CL0000121)
Fold Change: 4.48
Marker Score: 151159
Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: 4.27
Marker Score: 3252
Cell Name: mature astrocyte (CL0002627)
Fold Change: 4.09
Marker Score: 2691
Cell Name: photoreceptor cell (CL0000210)
Fold Change: 4.05
Marker Score: 3051
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 3.98
Marker Score: 2621
Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 3.77
Marker Score: 19773
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 3.69
Marker Score: 17092
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 3.65
Marker Score: 64736
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 3.37
Marker Score: 7406.5
Cell Name: anterior lens cell (CL0002223)
Fold Change: 3.34
Marker Score: 4491
Cell Name: cardiac neuron (CL0010022)
Fold Change: 3.33
Marker Score: 4152
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 3.26
Marker Score: 6263
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 3.22
Marker Score: 7718
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 3.21
Marker Score: 3692
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 3.18
Marker Score: 67787
Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 3.14
Marker Score: 1748
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 3.13
Marker Score: 3786
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 3.12
Marker Score: 69755
Cell Name: stellate neuron (CL0000122)
Fold Change: 3.07
Marker Score: 16469
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 2.97
Marker Score: 12444
Cell Name: granule cell (CL0000120)
Fold Change: 2.96
Marker Score: 22283
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 2.91
Marker Score: 2020
Cell Name: contractile cell (CL0000183)
Fold Change: 2.89
Marker Score: 1568
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 2.86
Marker Score: 837
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 2.86
Marker Score: 1915
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 2.86
Marker Score: 8149
Cell Name: renal principal cell (CL0005009)
Fold Change: 2.85
Marker Score: 2197
Cell Name: neuronal brush cell (CL0000555)
Fold Change: 2.8
Marker Score: 9403
Cell Name: macroglial cell (CL0000126)
Fold Change: 2.8
Marker Score: 6434
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 2.79
Marker Score: 55579
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 2.78
Marker Score: 11595
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 2.77
Marker Score: 1652
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 2.76
Marker Score: 1609
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 2.71
Marker Score: 20746
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 2.68
Marker Score: 40124
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 2.67
Marker Score: 101528
Cell Name: skin fibroblast (CL0002620)
Fold Change: 2.65
Marker Score: 687
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 2.63
Marker Score: 1388
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 2.58
Marker Score: 4326
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 2.57
Marker Score: 2276
Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 2.54
Marker Score: 807
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 2.53
Marker Score: 10507
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 2.46
Marker Score: 2345
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 2.43
Marker Score: 769
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 2.42
Marker Score: 1201
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 2.39
Marker Score: 88124
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 2.39
Marker Score: 1395
Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 2.37
Marker Score: 1377
Cell Name: astrocyte (CL0000127)
Fold Change: 2.37
Marker Score: 2050
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 2.34
Marker Score: 1310
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 2.32
Marker Score: 591
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 2.32
Marker Score: 2630
Cell Name: fat cell (CL0000136)
Fold Change: 2.3
Marker Score: 1288
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 2.3
Marker Score: 962
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.28
Marker Score: 8834
Cell Name: mature microglial cell (CL0002629)
Fold Change: 2.28
Marker Score: 822.5
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 2.21
Marker Score: 2730
Cell Name: hepatoblast (CL0005026)
Fold Change: 2.2
Marker Score: 7195
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 2.18
Marker Score: 7760.5
Cell Name: rod bipolar cell (CL0000751)
Fold Change: 2.17
Marker Score: 1134
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 2.12
Marker Score: 2283
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 2.12
Marker Score: 19911
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.05
Marker Score: 126120
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 2.04
Marker Score: 2183
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 2.03
Marker Score: 1005
Cell Name: podocyte (CL0000653)
Fold Change: 2.03
Marker Score: 750
Cell Name: neuron (CL0000540)
Fold Change: 2.01
Marker Score: 8190
Cell Name: lactocyte (CL0002325)
Fold Change: 2
Marker Score: 32134
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 2
Marker Score: 2204
Cell Name: mesangial cell (CL0000650)
Fold Change: 1.99
Marker Score: 2406
Cell Name: chromaffin cell (CL0000166)
Fold Change: 1.98
Marker Score: 2782.5
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.97
Marker Score: 20364
Cell Name: germ cell (CL0000586)
Fold Change: 1.97
Marker Score: 3434
Cell Name: taste receptor cell (CL0000209)
Fold Change: 1.95
Marker Score: 1685
Cell Name: CNS interneuron (CL0000402)
Fold Change: 1.94
Marker Score: 932
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.94
Marker Score: 745.5
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.9
Marker Score: 18019
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 1.88
Marker Score: 2727
Cell Name: endocrine cell (CL0000163)
Fold Change: 1.87
Marker Score: 970
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.85
Marker Score: 1982.5
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.85
Marker Score: 15880
Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 1.83
Marker Score: 668
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 1.82
Marker Score: 1498
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 1.8
Marker Score: 654
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 1.79
Marker Score: 6367.5
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 1.78
Marker Score: 487
Cell Name: lung goblet cell (CL1000143)
Fold Change: 1.77
Marker Score: 509
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 1.7
Marker Score: 577
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.64
Marker Score: 2322
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.63
Marker Score: 613
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 1.59
Marker Score: 505
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.58
Marker Score: 2441
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.56
Marker Score: 757
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 1.49
Marker Score: 1864
Cell Name: cholangiocyte (CL1000488)
Fold Change: 1.48
Marker Score: 553
Cell Name: fast muscle cell (CL0000190)
Fold Change: 1.45
Marker Score: 437.5
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 1.4
Marker Score: 1488
Cell Name: sympathetic neuron (CL0011103)
Fold Change: 1.37
Marker Score: 453
Cell Name: acinar cell (CL0000622)
Fold Change: 1.37
Marker Score: 965

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**Key Characteristics:** 1. **Coactivator of nuclear receptors:** NCOA1 interacts with nuclear receptors to enhance gene expression, particularly in the context of bile acid and lipid metabolism. 2. **Broad expression pattern:** NCOA1 is expressed in various cell types, including skeletal muscle, neurons, and adrenal gland cells, indicating its role in diverse biological processes. 3. **Circadian regulation:** NCOA1 is involved in the regulation of circadian gene expression, highlighting its connection to the body's internal clock. 4. **Metabolic regulation:** NCOA1 plays a crucial role in regulating lipid metabolism, cholesterol transport, and bile acid homeostasis. **Pathways and Functions:** NCOA1 is implicated in various signaling pathways, including: 1. **Bile acid and bile salt metabolism:** NCOA1 facilitates the expression of genes involved in bile acid synthesis and recycling. 2. **Cholesterol transport and efflux:** NCOA1 regulates the expression of genes involved in cholesterol transport and efflux. 3. **Circadian clock:** NCOA1 interacts with the circadian clock machinery to regulate gene expression. 4. **Gene expression regulation:** NCOA1 acts as a coactivator of nuclear receptors to enhance gene expression. 5. **Histone modification:** NCOA1 interacts with histone acetyltransferases to regulate chromatin structure and gene expression. **Clinical Significance:** Dysregulation of NCOA1 has been implicated in various diseases, including: 1. **Metabolic disorders:** Altered expression of NCOA1 has been linked to metabolic disorders, such as obesity and lipid metabolism disorders. 2. **Cancer:** NCOA1 is overexpressed in various types of cancer, including breast, prostate, and colon cancer. 3. **Neurological disorders:** NCOA1 is implicated in neurological disorders, such as Parkinson's disease and Alzheimer's disease. 4. **Circadian rhythm disorders:** Disruptions in NCOA1 expression have been linked to circadian rhythm disorders, such as delayed sleep phase syndrome. In conclusion, NCOA1 is a complex gene that plays a pivotal role in regulating gene expression, metabolism, and circadian rhythms. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms underlying NCOA1 function and its clinical significance.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Nuclear receptor coactivator 1

Genular Protein ID: 2008524260

Symbol: NCOA1_HUMAN

Name: Nuclear receptor coactivator 1

UniProtKB Accession Codes:

Q15788 O00150 O43792 O43793 Q13071 Q13420 Q2T9G5 Q53SX3 Q6GVI5 Q7KYV3

Database IDs:

Citations:

PubMed ID: 8754792

Title: Molecular cloning and properties of a full-length putative thyroid hormone receptor coactivator.

PubMed ID: 8754792

DOI: 10.1210/endo.137.8.8754792

PubMed ID: 9427757

Title: Isoforms of steroid receptor coactivator 1 differ in their ability to potentiate transcription by the oestrogen receptor.

PubMed ID: 9427757

DOI: 10.1093/emboj/17.1.232

PubMed ID: 9575154

Title: The steroid receptor coactivator-1 contains multiple receptor interacting and activation domains that cooperatively enhance the activation function 1 (AF1) and AF2 domains of steroid receptors.

PubMed ID: 9575154

DOI: 10.1074/jbc.273.20.12101

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7481822

Title: Sequence and characterization of a coactivator for the steroid hormone receptor superfamily.

PubMed ID: 7481822

DOI: 10.1126/science.270.5240.1354

PubMed ID: 11831720

Title: Analysis of human immunodeficiency virus type 1 promoter insertion in vivo.

PubMed ID: 11831720

DOI: 10.1006/viro.1995.1161

PubMed ID: 15313887

Title: Gene expression signatures identify rhabdomyosarcoma subtypes and detect a novel t(2;2)(q35;p23) translocation fusing PAX3 to NCOA1.

PubMed ID: 15313887

DOI: 10.1158/0008-5472.can-04-0844

PubMed ID: 9223431

Title: A splicing variant of steroid receptor coactivator-1 (SRC-1E): the major isoform of SRC-1 to mediate thyroid hormone action.

PubMed ID: 9223431

DOI: 10.1006/bbrc.1997.6911

PubMed ID: 9296499

Title: Steroid receptor coactivator-1 is a histone acetyltransferase.

PubMed ID: 9296499

DOI: 10.1038/38304

PubMed ID: 9223281

Title: Steroid receptor induction of gene transcription: a two-step model.

PubMed ID: 9223281

DOI: 10.1073/pnas.94.15.7879

PubMed ID: 10508479

Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.

PubMed ID: 10508479

DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5

PubMed ID: 10567404

Title: A nuclear factor ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo.

PubMed ID: 10567404

DOI: 10.1074/jbc.274.48.34283

PubMed ID: 10449719

Title: Steroid receptor coactivator-1 (SRC-1) enhances ligand-dependent and receptor-dependent cell-free transcription of chromatin.

PubMed ID: 10449719

DOI: 10.1073/pnas.96.17.9485

PubMed ID: 10660621

Title: Phosphorylation of steroid receptor coactivator-1. Identification of the phosphorylation sites and phosphorylation through the mitogen-activated protein kinase pathway.

PubMed ID: 10660621

DOI: 10.1074/jbc.275.6.4475

PubMed ID: 10722692

Title: JAB1 interacts with both the progesterone receptor and SRC-1.

PubMed ID: 10722692

DOI: 10.1074/jbc.275.12.8540

PubMed ID: 10594042

Title: Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha.

PubMed ID: 10594042

DOI: 10.1128/mcb.20.1.402-415.2000

PubMed ID: 11250900

Title: A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA.

PubMed ID: 11250900

DOI: 10.1093/emboj/20.6.1341

PubMed ID: 11773079

Title: Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a.

PubMed ID: 11773079

DOI: 10.1074/jbc.m111486200

PubMed ID: 12039952

Title: Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha.

PubMed ID: 12039952

DOI: 10.1074/jbc.m201053200

PubMed ID: 12138096

Title: An LXXLL motif in the transactivation domain of STAT6 mediates recruitment of NCoA-1/SRC-1.

PubMed ID: 12138096

DOI: 10.1074/jbc.m203556200

PubMed ID: 12529333

Title: Sumoylation of the progesterone receptor and of the steroid receptor coactivator SRC-1.

PubMed ID: 12529333

DOI: 10.1074/jbc.m207148200

PubMed ID: 12954634

Title: NCoA-1/SRC-1 is an essential coactivator of STAT5 that binds to the FDL motif in the alpha-helical region of the STAT5 transactivation domain.

PubMed ID: 12954634

DOI: 10.1074/jbc.m303644200

PubMed ID: 12917342

Title: BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation.

PubMed ID: 12917342

DOI: 10.1128/mcb.23.17.6210-6220.2003

PubMed ID: 15367689

Title: The ubiquitin-conjugating enzyme UBCH7 acts as a coactivator for steroid hormone receptors.

PubMed ID: 15367689

DOI: 10.1128/mcb.24.19.8716-8726.2004

PubMed ID: 16957778

Title: The catalytic subunit of the proteasome is engaged in the entire process of estrogen receptor-regulated transcription.

PubMed ID: 16957778

DOI: 10.1038/sj.emboj.7601306

PubMed ID: 16606617

Title: Additional sex comb-like 1 (ASXL1), in cooperation with SRC-1, acts as a ligand-dependent coactivator for retinoic acid receptor.

PubMed ID: 16606617

DOI: 10.1074/jbc.m512616200

PubMed ID: 17116691

Title: STAMP, a novel predicted factor assisting TIF2 actions in glucocorticoid receptor-mediated induction and repression.

PubMed ID: 17116691

DOI: 10.1128/mcb.01360-06

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18690216

Title: Cytosporone B is an agonist for nuclear orphan receptor Nur77.

PubMed ID: 18690216

DOI: 10.1038/nchembio.106

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19786558

Title: The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors.

PubMed ID: 19786558

DOI: 10.1124/mol.109.057000

PubMed ID: 20047962

Title: Protein arginine methyltransferase 6 regulates multiple aspects of gene expression.

PubMed ID: 20047962

DOI: 10.1093/nar/gkp1203

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25219498

Title: Modification of ASC1 by UFM1 is crucial for ERalpha transactivation and breast cancer development.

PubMed ID: 25219498

DOI: 10.1016/j.molcel.2014.08.007

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 28698609

Title: Functional analyses of a novel missense and other mutations of the vitamin D receptor in association with alopecia.

PubMed ID: 28698609

DOI: 10.1038/s41598-017-05081-x

PubMed ID: 9744270

Title: Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma.

PubMed ID: 9744270

DOI: 10.1038/25931

PubMed ID: 11698662

Title: Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors.

PubMed ID: 11698662

DOI: 10.1073/pnas.241410198

PubMed ID: 11864604

Title: Structural and functional evidence for ligand-independent transcriptional activation by the estrogen-related receptor 3.

PubMed ID: 11864604

DOI: 10.1016/s1097-2765(02)00444-6

Sequence Information:

Length: 1441
Mass: 156757
Checksum: 25EF6F389489121E
Sequence:

MSGLGDSSSD PANPDSHKRK GSPCDTLASS TEKRRREQEN KYLEELAELL SANISDIDSL 
SVKPDKCKIL KKTVDQIQLM KRMEQEKSTT DDDVQKSDIS SSSQGVIEKE SLGPLLLEAL 
DGFFFVVNCE GRIVFVSENV TSYLGYNQEE LMNTSVYSIL HVGDHAEFVK NLLPKSLVNG 
VPWPQEATRR NSHTFNCRML IHPPDEPGTE NQEACQRYEV MQCFTVSQPK SIQEDGEDFQ 
SCLICIARRL PRPPAITGVE SFMTKQDTTG KIISIDTSSL RAAGRTGWED LVRKCIYAFF 
QPQGREPSYA RQLFQEVMTR GTASSPSYRF ILNDGTMLSA HTKCKLCYPQ SPDMQPFIMG 
IHIIDREHSG LSPQDDTNSG MSIPRVNPSV NPSISPAHGV ARSSTLPPSN SNMVSTRINR 
QQSSDLHSSS HSNSSNSQGS FGCSPGSQIV ANVALNQGQA SSQSSNPSLN LNNSPMEGTG 
ISLAQFMSPR RQVTSGLATR PRMPNNSFPP NISTLSSPVG MTSSACNNNN RSYSNIPVTS 
LQGMNEGPNN SVGFSASSPV LRQMSSQNSP SRLNIQPAKA ESKDNKEIAS ILNEMIQSDN 
SSSDGKPLDS GLLHNNDRLS DGDSKYSQTS HKLVQLLTTT AEQQLRHADI DTSCKDVLSC 
TGTSNSASAN SSGGSCPSSH SSLTERHKIL HRLLQEGSPS DITTLSVEPD KKDSASTSVS 
VTGQVQGNSS IKLELDASKK KESKDHQLLR YLLDKDEKDL RSTPNLSLDD VKVKVEKKEQ 
MDPCNTNPTP MTKPTPEEIK LEAQSQFTAD LDQFDQLLPT LEKAAQLPGL CETDRMDGAV 
TSVTIKSEIL PASLQSATAR PTSRLNRLPE LELEAIDNQF GQPGTGDQIP WTNNTVTAIN 
QSKSEDQCIS SQLDELLCPP TTVEGRNDEK ALLEQLVSFL SGKDETELAE LDRALGIDKL 
VQGGGLDVLS ERFPPQQATP PLIMEERPNL YSQPYSSPSP TANLPSPFQG MVRQKPSLGT 
MPVQVTPPRG AFSPGMGMQP RQTLNRPPAA PNQLRLQLQQ RLQGQQQLIH QNRQAILNQF 
AATAPVGINM RSGMQQQITP QPPLNAQMLA QRQRELYSQQ HRQRQLIQQQ RAMLMRQQSF 
GNNLPPSSGL PVQMGNPRLP QGAPQQFPYP PNYGTNPGTP PASTSPFSQL AANPEASLAN 
RNSMVSRGMT GNIGGQFGTG INPQMQQNVF QYPGAGMVPQ GEANFAPSLS PGSSMVPMPI 
PPPQSSLLQQ TPPASGYQSP DMKAWQQGAI GNNNVFSQAV QNQPTPAQPG VYNNMSITVS 
MAGGNTNVQN MNPMMAQMQM SSLQMPGMNT VCPEQINDPA LRHTGLYCNQ LSSTDLLKTE 
ADGTQQVQQV QVFADVQCTV NLVGGDPYLN QPGPLGTQKP TSGPQTPQAQ QKSLLQQLLT 
E

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: NCOA1

Associated with

Cells (max top 100)

Other Information

Molecular cloning and properties of a full-length putative thyroid hormone receptor coactivator. PubMed ID: 8754792

Isoforms of steroid receptor coactivator 1 differ in their ability to potentiate transcription by the oestrogen receptor. PubMed ID: 9427757

The steroid receptor coactivator-1 contains multiple receptor interacting and activation domains that cooperatively enhance the activation function 1 (AF1) and AF2 domains of steroid receptors. PubMed ID: 9575154

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. PubMed ID: 7481822

Analysis of human immunodeficiency virus type 1 promoter insertion in vivo. PubMed ID: 11831720

Gene expression signatures identify rhabdomyosarcoma subtypes and detect a novel t(2;2)(q35;p23) translocation fusing PAX3 to NCOA1. PubMed ID: 15313887

A splicing variant of steroid receptor coactivator-1 (SRC-1E): the major isoform of SRC-1 to mediate thyroid hormone action. PubMed ID: 9223431

Steroid receptor coactivator-1 is a histone acetyltransferase. PubMed ID: 9296499

Steroid receptor induction of gene transcription: a two-step model. PubMed ID: 9223281

Antigens recognized by autologous antibody in patients with renal-cell carcinoma. PubMed ID: 10508479

A nuclear factor ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo. PubMed ID: 10567404

Steroid receptor coactivator-1 (SRC-1) enhances ligand-dependent and receptor-dependent cell-free transcription of chromatin. PubMed ID: 10449719

Phosphorylation of steroid receptor coactivator-1. Identification of the phosphorylation sites and phosphorylation through the mitogen-activated protein kinase pathway. PubMed ID: 10660621

JAB1 interacts with both the progesterone receptor and SRC-1. PubMed ID: 10722692

Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha. PubMed ID: 10594042

A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA. PubMed ID: 11250900

Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a. PubMed ID: 11773079

Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha. PubMed ID: 12039952

An LXXLL motif in the transactivation domain of STAT6 mediates recruitment of NCoA-1/SRC-1. PubMed ID: 12138096

Sumoylation of the progesterone receptor and of the steroid receptor coactivator SRC-1. PubMed ID: 12529333

NCoA-1/SRC-1 is an essential coactivator of STAT5 that binds to the FDL motif in the alpha-helical region of the STAT5 transactivation domain. PubMed ID: 12954634

BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation. PubMed ID: 12917342

The ubiquitin-conjugating enzyme UBCH7 acts as a coactivator for steroid hormone receptors. PubMed ID: 15367689

The catalytic subunit of the proteasome is engaged in the entire process of estrogen receptor-regulated transcription. PubMed ID: 16957778

Additional sex comb-like 1 (ASXL1), in cooperation with SRC-1, acts as a ligand-dependent coactivator for retinoic acid receptor. PubMed ID: 16606617

STAMP, a novel predicted factor assisting TIF2 actions in glucocorticoid receptor-mediated induction and repression. PubMed ID: 17116691

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. PubMed ID: 17525332

Cytosporone B is an agonist for nuclear orphan receptor Nur77. PubMed ID: 18690216

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors. PubMed ID: 19786558

Protein arginine methyltransferase 6 regulates multiple aspects of gene expression. PubMed ID: 20047962

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Modification of ASC1 by UFM1 is crucial for ERalpha transactivation and breast cancer development. PubMed ID: 25219498

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Functional analyses of a novel missense and other mutations of the vitamin D receptor in association with alopecia. PubMed ID: 28698609

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma. PubMed ID: 9744270

Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors. PubMed ID: 11698662

Structural and functional evidence for ligand-independent transcriptional activation by the estrogen-related receptor 3. PubMed ID: 11864604