Details for: DDX3Y

Gene ID: 8653

Symbol: DDX3Y

Ensembl ID: ENSG00000067048

Description: DEAD-box helicase 3 Y-linked

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 188.5625
    Cell Significance Index: -29.3300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 108.8142
    Cell Significance Index: -27.6000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 69.6357
    Cell Significance Index: -28.2900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 64.4750
    Cell Significance Index: -33.1700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 29.9767
    Cell Significance Index: -28.6200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 25.2077
    Cell Significance Index: -31.0800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.9790
    Cell Significance Index: -32.0900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.0638
    Cell Significance Index: -31.8200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 4.7850
    Cell Significance Index: 557.6400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.1770
    Cell Significance Index: 86.4800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.9328
    Cell Significance Index: 26.3700
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.8519
    Cell Significance Index: 13.3000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.7554
    Cell Significance Index: 285.5100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.2958
    Cell Significance Index: 81.6700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1016
    Cell Significance Index: 49.9300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0910
    Cell Significance Index: 118.6700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0397
    Cell Significance Index: 62.4200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.0256
    Cell Significance Index: 131.4700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9981
    Cell Significance Index: 179.9400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9898
    Cell Significance Index: 121.7000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.9748
    Cell Significance Index: 14.6900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7580
    Cell Significance Index: 74.9800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5525
    Cell Significance Index: 14.8100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5452
    Cell Significance Index: 37.7100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5322
    Cell Significance Index: 27.7200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5135
    Cell Significance Index: 103.0100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4451
    Cell Significance Index: 11.9100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3868
    Cell Significance Index: 24.9600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3770
    Cell Significance Index: 9.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3635
    Cell Significance Index: 18.8900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3618
    Cell Significance Index: 71.8100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.3276
    Cell Significance Index: 204.5700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2931
    Cell Significance Index: 6.3500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.2559
    Cell Significance Index: 3.5900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.2290
    Cell Significance Index: 26.1400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2209
    Cell Significance Index: 79.2200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1904
    Cell Significance Index: 6.6900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1727
    Cell Significance Index: 9.0700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1692
    Cell Significance Index: 3.1300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1600
    Cell Significance Index: 30.4400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1455
    Cell Significance Index: 11.1700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1359
    Cell Significance Index: 16.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0903
    Cell Significance Index: 57.3600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0837
    Cell Significance Index: 128.8100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0774
    Cell Significance Index: 145.6500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0772
    Cell Significance Index: 13.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0526
    Cell Significance Index: 96.9300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0522
    Cell Significance Index: 2.4400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0435
    Cell Significance Index: 39.2700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0367
    Cell Significance Index: 2.4700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0310
    Cell Significance Index: 14.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0219
    Cell Significance Index: 29.8000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0067
    Cell Significance Index: 4.9300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0065
    Cell Significance Index: -0.9400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0253
    Cell Significance Index: -1.4200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0286
    Cell Significance Index: -20.9500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0351
    Cell Significance Index: -19.8000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0380
    Cell Significance Index: -28.7700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0483
    Cell Significance Index: -1.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0533
    Cell Significance Index: -11.2200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0545
    Cell Significance Index: -29.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0624
    Cell Significance Index: -17.9500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0902
    Cell Significance Index: -9.2200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1145
    Cell Significance Index: -3.9800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1505
    Cell Significance Index: -1.7100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1613
    Cell Significance Index: -18.4800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1835
    Cell Significance Index: -1.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1944
    Cell Significance Index: -4.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2169
    Cell Significance Index: -29.7900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2548
    Cell Significance Index: -26.5300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2587
    Cell Significance Index: -5.4200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2659
    Cell Significance Index: -7.4300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2728
    Cell Significance Index: -16.7700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2865
    Cell Significance Index: -4.1200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3353
    Cell Significance Index: -5.3200
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.3487
    Cell Significance Index: -1.6100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3618
    Cell Significance Index: -2.9500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3675
    Cell Significance Index: -2.4900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3817
    Cell Significance Index: -5.7200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3846
    Cell Significance Index: -17.0100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3854
    Cell Significance Index: -30.5300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3855
    Cell Significance Index: -23.6400
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.4036
    Cell Significance Index: -0.9100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4076
    Cell Significance Index: -11.7500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4123
    Cell Significance Index: -12.1100
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.4372
    Cell Significance Index: -6.5400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4649
    Cell Significance Index: -17.6100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5060
    Cell Significance Index: -14.9100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5268
    Cell Significance Index: -13.5400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5372
    Cell Significance Index: -8.9900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5404
    Cell Significance Index: -15.4200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5997
    Cell Significance Index: -30.3100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.6314
    Cell Significance Index: -15.7700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6389
    Cell Significance Index: -23.4600
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.6438
    Cell Significance Index: -4.1100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6451
    Cell Significance Index: -16.4800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6569
    Cell Significance Index: -20.9200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6750
    Cell Significance Index: -22.1000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.6772
    Cell Significance Index: -16.2400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7115
    Cell Significance Index: -24.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **RNA Helicase Activity:** DDX3Y possesses ATP-dependent RNA helicase activity, which allows it to unwind double-stranded RNA (dsRNA) and single-stranded RNA (ssRNA) into single-stranded RNA (ssRNA). 2. **Cell Differentiation:** DDX3Y is involved in the regulation of cell differentiation, particularly in the development of thymocytes and prostate cells. 3. **Immune Regulation:** DDX3Y has been shown to play a role in the regulation of immune responses, including the activation and differentiation of T cells. 4. **Protein Interaction:** DDX3Y interacts with various proteins, including RNA-binding proteins, transcription factors, and signaling molecules, to regulate gene expression and RNA metabolism. **Pathways and Functions:** 1. **RNA Metabolism:** DDX3Y is involved in the regulation of RNA metabolism, including transcriptional regulation, RNA splicing, and RNA degradation. 2. **Cell Differentiation:** DDX3Y regulates cell differentiation by interacting with transcription factors and signaling molecules to control the expression of specific genes. 3. **Immune Regulation:** DDX3Y plays a role in the regulation of immune responses by interacting with immune-related proteins, including T-cell receptors and cytokines. 4. **Nucleus and Cytoplasm:** DDX3Y localizes to both the nucleus and cytoplasm, allowing it to regulate RNA metabolism and gene expression in different cellular compartments. **Clinical Significance:** 1. **Prostate Cancer:** DDX3Y has been identified as a potential biomarker for prostate cancer, as its expression is altered in prostate cancer cells compared to normal prostate cells. 2. **Immune-Related Diseases:** DDX3Y may play a role in the pathogenesis of immune-related diseases, such as autoimmune diseases and immunodeficiency disorders. 3. **Thymic Dysfunctions:** DDX3Y is involved in the regulation of thymocyte development and differentiation, suggesting its potential role in thymic dysfunctions, such as thymic aplasia and immunodeficiency. 4. **RNA-Associated Diseases:** DDX3Y may contribute to the pathogenesis of RNA-associated diseases, such as RNA-binding proteinopathies and neurodegenerative disorders. In conclusion, DDX3Y is a DEAD-box helicase involved in RNA helicase activity, cell differentiation, and immune regulation. Its clinical significance extends to the diagnosis and treatment of prostate cancer, immune-related diseases, and RNA-associated diseases. Further research is needed to fully elucidate the functions and clinical significance of DDX3Y.

Genular Protein ID: 609521929

Symbol: DDX3Y_HUMAN

Name: ATP-dependent RNA helicase DDX3Y

UniProtKB Accession Codes:

O15523 B4DK29 B4DXX7 Q8IYV7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 7 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 2 ELM 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRIDE 1 PRO 1 PROSITE 4 PathwayCommons 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 3 Rhea 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9381176

Title: Functional coherence of the human Y chromosome.

PubMed ID: 9381176

DOI: 10.1126/science.278.5338.675

PubMed ID: 12815422

Title: The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes.

PubMed ID: 12815422

DOI: 10.1038/nature01722

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15383328

Title: Human DDX3Y, the Y-encoded isoform of RNA helicase DDX3, rescues a hamster temperature-sensitive ET24 mutant cell line with a DDX3X mutation.

PubMed ID: 15383328

DOI: 10.1016/j.yexcr.2004.07.005

PubMed ID: 15294876

Title: The AZFa gene DBY (DDX3Y) is widely transcribed but the protein is limited to the male germ cells by translation control.

PubMed ID: 15294876

DOI: 10.1093/hmg/ddh240

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 660
  • Mass: 73154
  • Checksum: 0C370E9367952AB6
  • Sequence:
    • MSHVVVKNDP ELDQQLANLD LNSEKQSGGA STASKGRYIP PHLRNREASK GFHDKDSSGW 
SCSKDKDAYS SFGSRDSRGK PGYFSERGSG SRGRFDDRGR SDYDGIGNRE RPGFGRFERS 
GHSRWCDKSV EDDWSKPLPP SERLEQELFS GGNTGINFEK YDDIPVEATG SNCPPHIENF 
SDIDMGEIIM GNIELTRYTR PTPVQKHAIP IIKGKRDLMA CAQTGSGKTA AFLLPILSQI 
YTDGPGEALK AVKENGRYGR RKQYPISLVL APTRELAVQI YEEARKFSYR SRVRPCVVYG 
GADIGQQIRD LERGCHLLVA TPGRLVDMME RGKIGLDFCK YLVLDEADRM LDMGFEPQIR 
RIVEQDTMPP KGVRHTMMFS ATFPKEIQML ARDFLDEYIF LAVGRVGSTS ENITQKVVWV 
EDLDKRSFLL DILGATGSDS LTLVFVETKK GADSLEDFLY HEGYACTSIH GDRSQRDREE 
ALHQFRSGKS PILVATAVAA RGLDISNVRH VINFDLPSDI EEYVHRIGRT GRVGNLGLAT 
SFFNEKNMNI TKDLLDLLVE AKQEVPSWLE NMAYEHHYKG GSRGRSKSNR FSGGFGARDY 
RQSSGSSSSG FGASRGSSSR SGGGGYGNSR GFGGGGYGGF YNSDGYGGNY NSQGVDWWGN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.