Details for: JRKL

Gene ID: 8690

Symbol: JRKL

Ensembl ID: ENSG00000183340

Description: JRK like

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 81.1340
    Cell Significance Index: -12.6200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 46.7980
    Cell Significance Index: -11.8700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 25.0334
    Cell Significance Index: -10.1700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 10.5997
    Cell Significance Index: -10.1200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.4383
    Cell Significance Index: -12.8700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.5056
    Cell Significance Index: -12.0700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.2919
    Cell Significance Index: -12.9900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.3458
    Cell Significance Index: -7.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2169
    Cell Significance Index: 55.1600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1288
    Cell Significance Index: 67.7700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9703
    Cell Significance Index: 27.9600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8531
    Cell Significance Index: 11.6400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8187
    Cell Significance Index: 89.0600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7835
    Cell Significance Index: 707.4400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.7470
    Cell Significance Index: 47.0800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7212
    Cell Significance Index: 71.3400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6274
    Cell Significance Index: 32.5900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.5606
    Cell Significance Index: 17.7300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5454
    Cell Significance Index: 88.7000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3723
    Cell Significance Index: 8.0700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3118
    Cell Significance Index: 21.5700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2893
    Cell Significance Index: 52.1600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2505
    Cell Significance Index: 13.0500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2348
    Cell Significance Index: 6.3900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2167
    Cell Significance Index: 26.6500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2065
    Cell Significance Index: 28.3600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1968
    Cell Significance Index: 107.4500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1776
    Cell Significance Index: 11.4600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1642
    Cell Significance Index: 5.7700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1536
    Cell Significance Index: 30.4900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1519
    Cell Significance Index: 3.1500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1514
    Cell Significance Index: 30.3700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1280
    Cell Significance Index: 3.2000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1095
    Cell Significance Index: 48.4200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1043
    Cell Significance Index: 2.4100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1017
    Cell Significance Index: 4.7400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0849
    Cell Significance Index: 5.2200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0727
    Cell Significance Index: 9.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0697
    Cell Significance Index: 25.0000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0638
    Cell Significance Index: 0.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0581
    Cell Significance Index: 2.7300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0523
    Cell Significance Index: 9.9600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0448
    Cell Significance Index: 0.7500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0446
    Cell Significance Index: 0.9500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0327
    Cell Significance Index: 0.8800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0194
    Cell Significance Index: 0.6200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0157
    Cell Significance Index: 1.1100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0079
    Cell Significance Index: 10.7200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0028
    Cell Significance Index: 1.9400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0023
    Cell Significance Index: 4.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0022
    Cell Significance Index: -0.0600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0027
    Cell Significance Index: -4.1300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0038
    Cell Significance Index: -2.7900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0039
    Cell Significance Index: -7.1500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0050
    Cell Significance Index: -0.6400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0091
    Cell Significance Index: -5.7700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0100
    Cell Significance Index: -7.5500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0107
    Cell Significance Index: -0.3000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0115
    Cell Significance Index: -0.8800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0117
    Cell Significance Index: -0.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0156
    Cell Significance Index: -7.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0165
    Cell Significance Index: -12.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0212
    Cell Significance Index: -11.9400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0220
    Cell Significance Index: -0.3300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0239
    Cell Significance Index: -14.9100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0245
    Cell Significance Index: -7.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0328
    Cell Significance Index: -5.6000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0335
    Cell Significance Index: -3.4200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0416
    Cell Significance Index: -4.8500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0456
    Cell Significance Index: -0.6400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0588
    Cell Significance Index: -8.5500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0595
    Cell Significance Index: -4.0000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0700
    Cell Significance Index: -14.7500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0748
    Cell Significance Index: -8.8200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0755
    Cell Significance Index: -1.5800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0757
    Cell Significance Index: -8.6700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0778
    Cell Significance Index: -0.8100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0994
    Cell Significance Index: -5.2200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1055
    Cell Significance Index: -7.8700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1105
    Cell Significance Index: -6.2000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1187
    Cell Significance Index: -1.7000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1208
    Cell Significance Index: -9.5700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1210
    Cell Significance Index: -12.6000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1249
    Cell Significance Index: -4.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1576
    Cell Significance Index: -6.9700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1643
    Cell Significance Index: -3.9400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1680
    Cell Significance Index: -10.3000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1680
    Cell Significance Index: -1.3700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1701
    Cell Significance Index: -3.3200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1705
    Cell Significance Index: -4.3600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1786
    Cell Significance Index: -1.6500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1978
    Cell Significance Index: -7.4900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1993
    Cell Significance Index: -5.7100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2206
    Cell Significance Index: -5.6700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2406
    Cell Significance Index: -1.6300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2692
    Cell Significance Index: -7.9300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2715
    Cell Significance Index: -7.1400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2725
    Cell Significance Index: -7.2900
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.2746
    Cell Significance Index: -1.7900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2832
    Cell Significance Index: -9.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The JRKL gene is a relatively small gene, with a short coding sequence and a limited number of exons. Its expression is not limited to specific cell types, as it is significantly expressed in various cell types, including cerebral cortex GABAergic interneurons, forebrain radial glial cells, absorptive cells, cardiac muscle myoblasts, intestinal crypt stem cells, and neoplastic cells. This widespread expression suggests that JRKL may play a crucial role in regulating cellular processes, including development, differentiation, and survival. **Pathways and Functions:** JRKL is involved in several key pathways, including: 1. **Central Nervous System Development:** JRKL is expressed in the cerebral cortex and forebrain, where it may contribute to the development and differentiation of neurons, particularly GABAergic interneurons. 2. **DNA Binding:** JRKL has been shown to bind to DNA, suggesting that it may regulate gene expression through transcriptional control. 3. **Nucleus:** JRKL is localized to the nucleus, where it may interact with other nuclear proteins to regulate chromatin structure and gene expression. The functional significance of JRKL is still unclear, but its expression in various cell types suggests that it may play a role in: 1. **Cellular Regulation:** JRKL may regulate cellular processes, including proliferation, differentiation, and survival, through its interactions with other proteins and DNA. 2. **Developmental Processes:** JRKL may contribute to the development and patterning of various tissues, including the central nervous system and gastrointestinal tract. **Clinical Significance:** While the clinical significance of JRKL is still unknown, its expression in neoplastic cells suggests that it may play a role in cancer development and progression. Further studies are needed to determine the functional consequences of JRKL expression in cancer cells and to explore its potential as a biomarker or therapeutic target. In conclusion, the JRKL gene is a complex and multifaceted gene that has been found to be expressed in various cell types across different tissues. Further research is needed to elucidate its functional significance and clinical implications, but its expression patterns suggest that it may play a crucial role in regulating cellular processes and developmental pathways.

Genular Protein ID: 2770867911

Symbol: JERKL_HUMAN

Name: Jerky protein homolog-like

UniProtKB Accession Codes:

Q9Y4A0 A8K3G4 B2RAJ3 Q32MC2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 GO 3 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9240447

Title: Cloning, mapping, and tissue distribution of a human homologue of the mouse jerky gene product.

PubMed ID: 9240447

DOI: 10.1006/bbrc.1997.6935

Sequence Information:

  • Length: 524
  • Mass: 59912
  • Checksum: 81FEC7468DCBBF47
  • Sequence:
    • MSGKRKRVVL TIKDKLDIIK KLEDGGSSKQ LAVIYGIGET TVRDIRKNKE KIITYASSSD 
STSLLAKRKS MKPSMYEELD RAMLEWFNQQ RAKGNPISGP ICAKRAEFFF YALGMDGDFN 
PSAGWLTRFK QRHSIREINI RNERLNGDET AVEDFCNNFR DFIERENLQP EQIYNADETG 
LFWKCLPSRI SVIKGKCTVP GHKSIEERVT IMCCANATGL HKLKLCVVGK AKKPRSFKST 
DTLNLPVSYF SQKGAWMDLS IFRQWFDKIF VPQVREYLRS KGLQEKAVLL LDNSPTHPNE 
NVLRSDDGQI FAKYLPPNVA SLIQPSDQGV IATMKRNYRA GLLQNNLEEG NDLKSFWKKL 
TLLDALYEIA MAWNLVKPVT ISRAWKKILP MVEEKESLDF DVEDISVATV AAILQHTKGL 
ENVTTENLEK WLEVDSTEPG YEVLTDSEII RRAQGQADES SENEEEEIEL IPEKHINHAA 
ALQWTENLLD YLEQQGDMIL PDRLVIRKLR ATIRNKQKMT KSSQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.