Details for: CDC23

Gene ID: 8697

Symbol: CDC23

Ensembl ID: ENSG00000094880

Description: cell division cycle 23

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.53
    Marker Score: 1,228
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.08
    Marker Score: 1,551
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.01
    Marker Score: 1,272
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,744
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,968
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1
    Marker Score: 8,548
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,399
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,402
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 483
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 437
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,713
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,293
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.87
    Marker Score: 8,242
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4,932
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.86
    Marker Score: 3,389
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.85
    Marker Score: 13,289
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.84
    Marker Score: 568
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.83
    Marker Score: 1,289
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.83
    Marker Score: 50,883
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.82
    Marker Score: 3,022
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.78
    Marker Score: 1,630
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,265
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.77
    Marker Score: 811
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.76
    Marker Score: 810
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.75
    Marker Score: 995
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.74
    Marker Score: 298
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 566
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.73
    Marker Score: 210
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.73
    Marker Score: 350
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.72
    Marker Score: 1,967
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 373
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.72
    Marker Score: 775
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.71
    Marker Score: 6,636
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2,929
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.7
    Marker Score: 172
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.69
    Marker Score: 379
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.68
    Marker Score: 1,159
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 609
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.66
    Marker Score: 1,102
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.65
    Marker Score: 488
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.64
    Marker Score: 319
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.63
    Marker Score: 23,312
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.63
    Marker Score: 421
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.63
    Marker Score: 6,514
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.63
    Marker Score: 630
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.63
    Marker Score: 1,702
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.62
    Marker Score: 2,381
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.61
    Marker Score: 12,123
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.6
    Marker Score: 22,825
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.59
    Marker Score: 2,293
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.59
    Marker Score: 138
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.58
    Marker Score: 5,832
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.57
    Marker Score: 3,691
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.55
    Marker Score: 593
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.55
    Marker Score: 505
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.55
    Marker Score: 1,380
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.55
    Marker Score: 8,163
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.54
    Marker Score: 511
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.54
    Marker Score: 152
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.54
    Marker Score: 142
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.53
    Marker Score: 4,088
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.53
    Marker Score: 425
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.52
    Marker Score: 214
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.52
    Marker Score: 2,124
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.52
    Marker Score: 215
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.52
    Marker Score: 549
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.51
    Marker Score: 326
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.51
    Marker Score: 339
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.51
    Marker Score: 335
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5
    Marker Score: 528
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.5
    Marker Score: 174
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.49
    Marker Score: 147
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.49
    Marker Score: 354
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.49
    Marker Score: 457
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.49
    Marker Score: 1,192
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.48
    Marker Score: 714
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.48
    Marker Score: 501
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.48
    Marker Score: 1,997
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.48
    Marker Score: 251
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.47
    Marker Score: 121
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.47
    Marker Score: 6,180
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.46
    Marker Score: 1,094
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.46
    Marker Score: 194
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.46
    Marker Score: 229
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.46
    Marker Score: 204
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.46
    Marker Score: 935
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.46
    Marker Score: 287
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.46
    Marker Score: 2,720
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.46
    Marker Score: 409
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.45
    Marker Score: 501
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.45
    Marker Score: 1,211
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.45
    Marker Score: 207
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.45
    Marker Score: 466
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.45
    Marker Score: 218
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.44
    Marker Score: 15,400
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.44
    Marker Score: 428
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.44
    Marker Score: 725
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.44
    Marker Score: 9,424

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CDC23 is a gene that encodes a protein involved in the regulation of the cell division cycle. It is part of the APC/CDK pathway, which is responsible for the degradation of mitotic proteins and the progression of cells through the cell cycle. CDC23 is also involved in the regulation of the adaptive immune system, particularly in the context of antigen processing and presentation. Its expression is widespread, with significant levels found in various cell types, including those involved in immune function. **Pathways and Functions:** CDC23 is involved in several key pathways, including: 1. **APC/CDK pathway:** CDC23 is part of the APC/CDK pathway, which regulates the degradation of mitotic proteins and the progression of cells through the cell cycle. 2. **Adaptive immune system:** CDC23 is involved in the regulation of the adaptive immune system, particularly in the context of antigen processing and presentation. 3. **Mitotic cell cycle regulation:** CDC23 regulates the progression of cells through the mitotic cell cycle, including the metaphase/anaphase transition and the regulation of mitotic metaphase/chromosome alignment. 4. **Antigen processing:** CDC23 is involved in the regulation of antigen processing, including the ubiquitination and proteasome degradation of mitotic proteins. **Functions:** 1. **Regulation of mitotic exit:** CDC23 regulates the exit from mitosis, including the regulation of the metaphase/anaphase transition and the regulation of mitotic metaphase/chromosome alignment. 2. **Degradation of mitotic proteins:** CDC23 is involved in the degradation of mitotic proteins, including the APC/CDK pathway. 3. **Regulation of adaptive immune system:** CDC23 regulates the adaptive immune system, particularly in the context of antigen processing and presentation. 4. **Regulation of cellular responses to stimuli:** CDC23 is involved in the regulation of cellular responses to stimuli, including the regulation of the cell division cycle. **Clinical Significance:** Dysregulation of CDC23 has been implicated in several diseases, including: 1. **Cancer:** CDC23 dysregulation has been implicated in several types of cancer, including breast, lung, and colon cancer. 2. **Cellular senescence:** CDC23 dysregulation has been implicated in the development of cellular senescence, a state of permanent cell cycle arrest. 3. **Immune system dysfunction:** CDC23 dysregulation has been implicated in immune system dysfunction, including the regulation of adaptive immune responses. In conclusion, CDC23 is a complex gene that plays a critical role in regulating the cell division cycle and the adaptive immune system. Its dysregulation has been implicated in several diseases, highlighting the importance of this gene in maintaining cellular homeostasis. Further research is needed to fully understand the role of CDC23 in human disease.

Genular Protein ID: 3891020282

Symbol: CDC23_HUMAN

Name: Cell division cycle protein 23 homolog

UniProtKB Accession Codes:

Q9UJX2 A8K6E5 B4E3A2 B7WP05 D3DQB7 O75433 Q53FN2 Q9BS73

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 ELM 1 EMBL 15 EMDB 17 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 22 PDBsum 18 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 18 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9790767

Title: Human CDC23: cDNA cloning, mapping to 5q31, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias.

PubMed ID: 9790767

DOI: 10.1006/geno.1998.5473

PubMed ID: 9469815

Title: Identification of a cullin homology region in a subunit of the anaphase-promoting complex.

PubMed ID: 9469815

DOI: 10.1126/science.279.5354.1219

PubMed ID: 14657031

Title: Mitotic regulation of the human anaphase-promoting complex by phosphorylation.

PubMed ID: 14657031

DOI: 10.1093/emboj/cdg627

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18485873

Title: Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex.

PubMed ID: 18485873

DOI: 10.1016/j.cell.2008.04.012

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21307936

Title: Structural basis for the subunit assembly of the anaphase-promoting complex.

PubMed ID: 21307936

DOI: 10.1038/nature09756

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 16364912

Title: Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C.

PubMed ID: 16364912

DOI: 10.1016/j.molcel.2005.11.008

PubMed ID: 25043029

Title: Molecular architecture and mechanism of the anaphase-promoting complex.

PubMed ID: 25043029

DOI: 10.1038/nature13543

PubMed ID: 26083744

Title: Atomic structure of the APC/C and its mechanism of protein ubiquitination.

PubMed ID: 26083744

DOI: 10.1038/nature14471

PubMed ID: 34595750

Title: A homozygous loss-of-function mutation in FBXO43 causes human non-obstructive azoospermia.

PubMed ID: 34595750

DOI: 10.1111/cge.14069

Sequence Information:

  • Length: 597
  • Mass: 68834
  • Checksum: 358F2B8745DB9D32
  • Sequence:
    • MAASTSMVPV AVTAAVAPVL SINSDFSDLR EIKKQLLLIA GLTRERGLLH SSKWSAELAF 
SLPALPLAEL QPPPPITEED AQDMDAYTLA KAYFDVKEYD RAAHFLHGCN SKKAYFLYMY 
SRYLSGEKKK DDETVDSLGP LEKGQVKNEA LRELRVELSK KHQARELDGF GLYLYGVVLR 
KLDLVKEAID VFVEATHVLP LHWGAWLELC NLITDKEMLK FLSLPDTWMK EFFLAHIYTE 
LQLIEEALQK YQNLIDVGFS KSSYIVSQIA VAYHNIRDID KALSIFNELR KQDPYRIENM 
DTFSNLLYVR SMKSELSYLA HNLCEIDKYR VETCCVIGNY YSLRSQHEKA ALYFQRALKL 
NPRYLGAWTL MGHEYMEMKN TSAAIQAYRH AIEVNKRDYR AWYGLGQTYE ILKMPFYCLY 
YYRRAHQLRP NDSRMLVALG ECYEKLNQLV EAKKCYWRAY AVGDVEKMAL VKLAKLHEQL 
TESEQAAQCY IKYIQDIYSC GEIVEHLEES TAFRYLAQYY FKCKLWDEAS TCAQKCCAFN 
DTREEGKALL RQILQLRNQG ETPTTEVPAP FFLPASLSAN NTPTRRVSPL NLSSVTP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.