CDC23 | ENSG00000094880 | NCBI 8697

Details for: CDC23

Gene ID: 8697

Symbol: CDC23

Ensembl ID: ENSG00000094880

Description: cell division cycle 23

Associated with

Aberrant regulation of mitotic cell cycle due to rb1 defects
(R-HSA-9687139)
Aberrant regulation of mitotic exit in cancer due to rb1 defects
(R-HSA-9687136)
Activation of apc/c and apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176814)
Adaptive immune system
(R-HSA-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-HSA-983168)
Apc-cdc20 mediated degradation of nek2a
(R-HSA-179409)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apc/c:cdc20 mediated degradation of cyclin b
(R-HSA-174048)
Apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176409)
Apc/c:cdc20 mediated degradation of securin
(R-HSA-174154)
Apc/c:cdh1 mediated degradation of cdc20 and other apc/c:cdh1 targeted proteins in late mitosis/early g1
(R-HSA-174178)
Apc:cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
(R-HSA-179419)
Assembly of the pre-replicative complex
(R-HSA-68867)
Autodegradation of cdh1 by cdh1:apc/c
(R-HSA-174084)
Cdc20:phospho-apc/c mediated degradation of cyclin a
(R-HSA-174184)
Cdk-mediated phosphorylation and removal of cdc6
(R-HSA-69017)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Conversion from apc/c:cdc20 to apc/c:cdh1 in late anaphase
(R-HSA-176407)
Disease
(R-HSA-1643685)
Diseases of mitotic cell cycle
(R-HSA-9675126)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Inactivation of apc/c via direct inhibition of the apc/c complex
(R-HSA-141430)
Inhibition of the proteolytic activity of apc/c required for the onset of anaphase by mitotic spindle checkpoint components
(R-HSA-141405)
Mitotic anaphase
(R-HSA-68882)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic spindle checkpoint
(R-HSA-69618)
M phase
(R-HSA-68886)
Phosphorylation of the apc/c
(R-HSA-176412)
Regulation of apc/c activators between g1/s and early anaphase
(R-HSA-176408)
Rna polymerase ii transcription
(R-HSA-73857)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Separation of sister chromatids
(R-HSA-2467813)
S phase
(R-HSA-69242)
Switching of origins to a post-replicative state
(R-HSA-69052)
Synthesis of dna
(R-HSA-69239)
Transcriptional regulation by ventx
(R-HSA-8853884)
Anaphase-promoting complex
(GO:0005680)
Anaphase-promoting complex-dependent catabolic process
(GO:0031145)
Cell division
(GO:0051301)
Cytosol
(GO:0005829)
Metaphase/anaphase transition of mitotic cell cycle
(GO:0007091)
Mitotic cell cycle
(GO:0000278)
Mitotic metaphase chromosome alignment
(GO:0007080)
Nucleoplasm
(GO:0005654)
Positive regulation of mitotic metaphase/anaphase transition
(GO:0045842)
Protein binding
(GO:0005515)
Protein branched polyubiquitination
(GO:0141198)
Protein k11-linked ubiquitination
(GO:0070979)
Protein k48-linked ubiquitination
(GO:0070936)
Protein ubiquitination
(GO:0016567)
Regulation of exit from mitosis
(GO:0007096)
Regulation of meiotic cell cycle
(GO:0051445)
Regulation of mitotic cell cycle
(GO:0007346)
Regulation of mitotic metaphase/anaphase transition
(GO:0030071)
Ubiquitin-dependent protein catabolic process
(GO:0006511)
Ubiquitin-protein transferase activity
(GO:0004842)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 108.9715
Cell Significance Index: -16.9500
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 70.2561
Cell Significance Index: -17.8200
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 41.0275
Cell Significance Index: -19.3700
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 39.4085
Cell Significance Index: -16.0100
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 16.8422
Cell Significance Index: -16.0800
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 15.2722
Cell Significance Index: -18.8300
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 6.4430
Cell Significance Index: -17.2600
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 4.8884
Cell Significance Index: -19.2900
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 2.9425
Cell Significance Index: -6.4400
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 2.7696
Cell Significance Index: 527.0800
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.5096
Cell Significance Index: 104.4000
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.3200
Cell Significance Index: 18.0100
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.8888
Cell Significance Index: 53.3600
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.8729
Cell Significance Index: 94.9400
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.7731
Cell Significance Index: 90.1000
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.7652
Cell Significance Index: 124.4600
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.7596
Cell Significance Index: 26.6900
Cell Name: decidual cell (CL2000002)
Fold Change: 0.6744
Cell Significance Index: 10.8200
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.5474
Cell Significance Index: 109.8100
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.4965
Cell Significance Index: 13.3100
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.4965
Cell Significance Index: 343.4300
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.4904
Cell Significance Index: 97.3300
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.4228
Cell Significance Index: 11.2900
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.4100
Cell Significance Index: 25.8400
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.3712
Cell Significance Index: 12.9000
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.3185
Cell Significance Index: 8.6700
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.3003
Cell Significance Index: 15.6000
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.2565
Cell Significance Index: 92.0100
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.2511
Cell Significance Index: 45.2700
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.2439
Cell Significance Index: 29.9900
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2249
Cell Significance Index: 22.2500
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.2213
Cell Significance Index: 4.7300
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2203
Cell Significance Index: 120.2900
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1915
Cell Significance Index: 26.3000
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1758
Cell Significance Index: 77.7300
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.1424
Cell Significance Index: 16.7900
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.1399
Cell Significance Index: 3.9100
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.1342
Cell Significance Index: 7.5300
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.1336
Cell Significance Index: 10.2600
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1201
Cell Significance Index: 3.4600
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.1064
Cell Significance Index: 6.5400
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0957
Cell Significance Index: 4.3400
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0920
Cell Significance Index: 4.2900
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0917
Cell Significance Index: 11.7500
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.0873
Cell Significance Index: 2.2900
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.0659
Cell Significance Index: 1.3800
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.0488
Cell Significance Index: 0.5300
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.0314
Cell Significance Index: 2.2200
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0208
Cell Significance Index: 0.4500
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0169
Cell Significance Index: 0.3600
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0148
Cell Significance Index: 27.9000
Cell Name: lactocyte (CL0002325)
Fold Change: 0.0039
Cell Significance Index: 0.5100
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0015
Cell Significance Index: 2.3800
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0001
Cell Significance Index: -0.0800
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0015
Cell Significance Index: -2.8400
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0029
Cell Significance Index: -0.1300
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0030
Cell Significance Index: -4.0200
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0070
Cell Significance Index: -5.1300
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0096
Cell Significance Index: -4.3400
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0124
Cell Significance Index: -9.3700
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0204
Cell Significance Index: -15.1100
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0235
Cell Significance Index: -3.4100
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0273
Cell Significance Index: -15.3700
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0341
Cell Significance Index: -3.4800
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0344
Cell Significance Index: -21.4800
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0353
Cell Significance Index: -1.8400
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0354
Cell Significance Index: -2.6400
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0357
Cell Significance Index: -6.1000
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0397
Cell Significance Index: -2.6700
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0439
Cell Significance Index: -0.9100
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0487
Cell Significance Index: -5.5800
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0508
Cell Significance Index: -0.8700
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0550
Cell Significance Index: -0.9200
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0557
Cell Significance Index: -16.0300
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0661
Cell Significance Index: -1.7000
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0669
Cell Significance Index: -3.5100
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0704
Cell Significance Index: -4.5500
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0834
Cell Significance Index: -3.6900
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0956
Cell Significance Index: -3.6200
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0996
Cell Significance Index: -20.9800
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1268
Cell Significance Index: -3.2400
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1666
Cell Significance Index: -17.3500
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.1685
Cell Significance Index: -3.6900
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1720
Cell Significance Index: -5.5100
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.1802
Cell Significance Index: -4.5100
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1871
Cell Significance Index: -14.8200
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: -0.2079
Cell Significance Index: -1.3800
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.2302
Cell Significance Index: -5.5200
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2558
Cell Significance Index: -15.6800
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.2690
Cell Significance Index: -7.9000
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.2743
Cell Significance Index: -4.0500
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.2748
Cell Significance Index: -7.3500
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.2886
Cell Significance Index: -3.4400
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.2989
Cell Significance Index: -8.5300
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.3307
Cell Significance Index: -9.4800
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.3381
Cell Significance Index: -4.3300
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.3425
Cell Significance Index: -6.6900
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3430
Cell Significance Index: -11.2300
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3496
Cell Significance Index: -11.1400
Cell Name: kidney cell (CL1000497)
Fold Change: -0.3782
Cell Significance Index: -3.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** CDC23 is a gene that encodes a protein involved in the regulation of the cell division cycle. It is part of the APC/CDK pathway, which is responsible for the degradation of mitotic proteins and the progression of cells through the cell cycle. CDC23 is also involved in the regulation of the adaptive immune system, particularly in the context of antigen processing and presentation. Its expression is widespread, with significant levels found in various cell types, including those involved in immune function. **Pathways and Functions:** CDC23 is involved in several key pathways, including: 1. **APC/CDK pathway:** CDC23 is part of the APC/CDK pathway, which regulates the degradation of mitotic proteins and the progression of cells through the cell cycle. 2. **Adaptive immune system:** CDC23 is involved in the regulation of the adaptive immune system, particularly in the context of antigen processing and presentation. 3. **Mitotic cell cycle regulation:** CDC23 regulates the progression of cells through the mitotic cell cycle, including the metaphase/anaphase transition and the regulation of mitotic metaphase/chromosome alignment. 4. **Antigen processing:** CDC23 is involved in the regulation of antigen processing, including the ubiquitination and proteasome degradation of mitotic proteins. **Functions:** 1. **Regulation of mitotic exit:** CDC23 regulates the exit from mitosis, including the regulation of the metaphase/anaphase transition and the regulation of mitotic metaphase/chromosome alignment. 2. **Degradation of mitotic proteins:** CDC23 is involved in the degradation of mitotic proteins, including the APC/CDK pathway. 3. **Regulation of adaptive immune system:** CDC23 regulates the adaptive immune system, particularly in the context of antigen processing and presentation. 4. **Regulation of cellular responses to stimuli:** CDC23 is involved in the regulation of cellular responses to stimuli, including the regulation of the cell division cycle. **Clinical Significance:** Dysregulation of CDC23 has been implicated in several diseases, including: 1. **Cancer:** CDC23 dysregulation has been implicated in several types of cancer, including breast, lung, and colon cancer. 2. **Cellular senescence:** CDC23 dysregulation has been implicated in the development of cellular senescence, a state of permanent cell cycle arrest. 3. **Immune system dysfunction:** CDC23 dysregulation has been implicated in immune system dysfunction, including the regulation of adaptive immune responses. In conclusion, CDC23 is a complex gene that plays a critical role in regulating the cell division cycle and the adaptive immune system. Its dysregulation has been implicated in several diseases, highlighting the importance of this gene in maintaining cellular homeostasis. Further research is needed to fully understand the role of CDC23 in human disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Cell division cycle protein 23 homolog

Genular Protein ID: 3891020282

Symbol: CDC23_HUMAN

Name: Cell division cycle protein 23 homolog

UniProtKB Accession Codes:

Q9UJX2 A8K6E5 B4E3A2 B7WP05 D3DQB7 O75433 Q53FN2 Q9BS73

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9790767

Title: Human CDC23: cDNA cloning, mapping to 5q31, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias.

PubMed ID: 9790767

DOI: 10.1006/geno.1998.5473

PubMed ID: 9469815

Title: Identification of a cullin homology region in a subunit of the anaphase-promoting complex.

PubMed ID: 9469815

DOI: 10.1126/science.279.5354.1219

PubMed ID: 14657031

Title: Mitotic regulation of the human anaphase-promoting complex by phosphorylation.

PubMed ID: 14657031

DOI: 10.1093/emboj/cdg627

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18485873

Title: Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex.

PubMed ID: 18485873

DOI: 10.1016/j.cell.2008.04.012

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21307936

Title: Structural basis for the subunit assembly of the anaphase-promoting complex.

PubMed ID: 21307936

DOI: 10.1038/nature09756

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 29033132

Title: Assembly and function of heterotypic ubiquitin chains in cell-cycle and protein quality control.

PubMed ID: 29033132

DOI: 10.1016/j.cell.2017.09.040

PubMed ID: 34595750

Title: A homozygous loss-of-function mutation in FBXO43 causes human non-obstructive azoospermia.

PubMed ID: 34595750

DOI: 10.1111/cge.14069

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 16364912

Title: Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C.

PubMed ID: 16364912

DOI: 10.1016/j.molcel.2005.11.008

PubMed ID: 25043029

Title: Molecular architecture and mechanism of the anaphase-promoting complex.

PubMed ID: 25043029

DOI: 10.1038/nature13543

PubMed ID: 26083744

Title: Atomic structure of the APC/C and its mechanism of protein ubiquitination.

PubMed ID: 26083744

DOI: 10.1038/nature14471

Sequence Information:

Length: 597
Mass: 68834
Checksum: 358F2B8745DB9D32
Sequence:

MAASTSMVPV AVTAAVAPVL SINSDFSDLR EIKKQLLLIA GLTRERGLLH SSKWSAELAF 
SLPALPLAEL QPPPPITEED AQDMDAYTLA KAYFDVKEYD RAAHFLHGCN SKKAYFLYMY 
SRYLSGEKKK DDETVDSLGP LEKGQVKNEA LRELRVELSK KHQARELDGF GLYLYGVVLR 
KLDLVKEAID VFVEATHVLP LHWGAWLELC NLITDKEMLK FLSLPDTWMK EFFLAHIYTE 
LQLIEEALQK YQNLIDVGFS KSSYIVSQIA VAYHNIRDID KALSIFNELR KQDPYRIENM 
DTFSNLLYVR SMKSELSYLA HNLCEIDKYR VETCCVIGNY YSLRSQHEKA ALYFQRALKL 
NPRYLGAWTL MGHEYMEMKN TSAAIQAYRH AIEVNKRDYR AWYGLGQTYE ILKMPFYCLY 
YYRRAHQLRP NDSRMLVALG ECYEKLNQLV EAKKCYWRAY AVGDVEKMAL VKLAKLHEQL 
TESEQAAQCY IKYIQDIYSC GEIVEHLEES TAFRYLAQYY FKCKLWDEAS TCAQKCCAFN 
DTREEGKALL RQILQLRNQG ETPTTEVPAP FFLPASLSAN NTPTRRVSPL NLSSVTP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CDC23

Associated with

Cells (max top 100)

Other Information

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 5. PubMed ID: 15372022

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Human CDC23: cDNA cloning, mapping to 5q31, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias. PubMed ID: 9790767

Identification of a cullin homology region in a subunit of the anaphase-promoting complex. PubMed ID: 9469815

Mitotic regulation of the human anaphase-promoting complex by phosphorylation. PubMed ID: 14657031

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. PubMed ID: 16964243

Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. PubMed ID: 18485873

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Structural basis for the subunit assembly of the anaphase-promoting complex. PubMed ID: 21307936

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Uncovering global SUMOylation signaling networks in a site-specific manner. PubMed ID: 25218447

Assembly and function of heterotypic ubiquitin chains in cell-cycle and protein quality control. PubMed ID: 29033132

A homozygous loss-of-function mutation in FBXO43 causes human non-obstructive azoospermia. PubMed ID: 34595750

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. PubMed ID: 16364912

Molecular architecture and mechanism of the anaphase-promoting complex. PubMed ID: 25043029

Atomic structure of the APC/C and its mechanism of protein ubiquitination. PubMed ID: 26083744