Details for: SNX4
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 12.76rCSI 18.48%PRS 69.5
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CSI 11.41rCSI 41.06%PRS 34.7
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CSI 10.39rCSI 10.2%PRS 69.25
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CSI 9.74rCSI 37.86%PRS 60.28
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CSI 8.43rCSI 28.24%PRS 39.63
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CSI 8.4rCSI 19.07%PRS 58.36
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CSI 7.39rCSI 10.09%PRS 55.57
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CSI 7.38rCSI 15.17%PRS 45.15
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CSI 6.96rCSI 9.47%PRS 65.59
-
CSI 6.58rCSI 7.89%PRS 51.35
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CSI 6.39rCSI 6.15%PRS 53.62
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CSI 6.07rCSI 14.75%PRS 34.83
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CSI 6.06rCSI 9.81%PRS 50.74
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CSI 5.92rCSI 4.91%PRS 52.08
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CSI 5.6rCSI 9.01%PRS 43.31
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CSI 5.43rCSI 6.72%PRS 49.11
-
CSI 5.41rCSI 21.83%PRS 51.55
-
CSI 5.24rCSI 12.52%PRS 41.31
-
CSI 5.03rCSI 7.99%PRS 64.33
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CSI 5rCSI 8.81%PRS 50.68
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CSI 4.61rCSI 3.22%PRS 55.79
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CSI 4.3rCSI 13.42%PRS 37.45
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CSI 4.26rCSI 5.83%PRS 47.87
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CSI 4.14rCSI 24.36%PRS 37.48
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CSI 3.81rCSI 9.04%PRS 58.04
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CSI 3.8rCSI 4.84%PRS 59.5
-
CSI 3.67rCSI 9.68%PRS 61.59
-
CSI 3.47rCSI 10.31%PRS 63.64
-
CSI 3.27rCSI 2.87%PRS 41.66
-
CSI 3.26rCSI 5.93%PRS 69.39
-
CSI 3.26rCSI 3.42%PRS 56.49
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CSI 3.22rCSI 2.54%PRS 40.38
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CSI 3.19rCSI 12.04%PRS 36.84
-
CSI 3.15rCSI 6.97%PRS 50.9
-
CSI 2.9rCSI 16.71%PRS 53.49
-
CSI 2.87rCSI 8.3%PRS 43.58
-
CSI 2.84rCSI 2.58%PRS 67.68
-
CSI 2.84rCSI 4.57%PRS 59.17
-
CSI 2.73rCSI 4.82%PRS 35.07
-
CSI 2.72rCSI 5.91%PRS 42.23
-
CSI 2.72rCSI 2.79%PRS 71.19
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CSI 2.71rCSI 3.62%PRS 62.04
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CSI 2.68rCSI 3.33%PRS 34.31
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CSI 2.66rCSI 2.07%PRS 54.22
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CSI 2.62rCSI 4.29%PRS 43
-
CSI 2.61rCSI 1.93%PRS 45.96
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CSI 2.55rCSI 2.66%PRS 53.56
-
CSI 2.5rCSI 3.21%PRS 58.08
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CSI 2.42rCSI 12.42%PRS 57.22
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CSI 2.41rCSI 5.57%PRS 43.31
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CSI 2.41rCSI 6.18%PRS 53.89
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CSI 2.4rCSI 3.82%PRS 46.49
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CSI 2.37rCSI 5.04%PRS 54.74
-
CSI 2.34rCSI 3.72%PRS 45.7
-
CSI 2.33rCSI 7.46%PRS 50.19
-
CSI 2.3rCSI 2.17%PRS 53.42
-
CSI 2.29rCSI 2.95%PRS 47.06
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CSI 2.28rCSI 3.94%PRS 43.4
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CSI 2.27rCSI 6.7%PRS 57.05
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CSI 2.26rCSI 1.83%PRS 54.46
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CSI 2.25rCSI 4.53%PRS 42.53
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CSI 2.23rCSI 2.78%PRS 64.29
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CSI 2.23rCSI 3.19%PRS 58.78
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CSI 2.22rCSI 1.5%PRS 65.41
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CSI 2.19rCSI 5%PRS 45.6
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CSI 2.19rCSI 4.1%PRS 42.11
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CSI 2.15rCSI 5.32%PRS 51.17
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CSI 2.13rCSI 1.68%PRS 59.94
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CSI 2.11rCSI 5.51%PRS 52.42
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CSI 2.1rCSI 50.18%PRS 35.42
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CSI 2.09rCSI 1.61%PRS 52.76
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CSI 2.07rCSI 3.53%PRS 78.37
-
CSI 2.05rCSI 49.41%PRS 36.39
-
CSI 2.04rCSI 3.02%PRS 58.6
-
CSI 2rCSI 2.74%PRS 58.7
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CSI 2rCSI 5.67%PRS 51.73
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CSI 1.98rCSI 4.37%PRS 40.32
-
CSI 1.97rCSI 4.5%PRS 52.64
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CSI 1.96rCSI 2.46%PRS 63.6
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CSI 1.92rCSI 3.82%PRS 51.31
-
CSI 1.86rCSI 2.59%PRS 52.48
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CSI 1.84rCSI 4.1%PRS 60.55
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CSI 1.81rCSI 1.78%PRS 55.78
-
CSI 1.79rCSI 2.54%PRS 49.6
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CSI 1.77rCSI 1.86%PRS 52.02
-
CSI 1.75rCSI 2.25%PRS 50.98
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CSI 1.75rCSI 1.69%PRS 43.79
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CSI 1.74rCSI 1.62%PRS 52.93
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CSI 1.74rCSI 4.15%PRS 54.52
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CSI 1.74rCSI 1.59%PRS 61.67
-
CSI 1.7rCSI 3.53%PRS 50.47
-
CSI 1.69rCSI 6.32%PRS 45.49
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CSI 1.68rCSI 6.56%PRS 73.87
-
CSI 1.66rCSI 1.82%PRS 56.89
-
CSI 1.66rCSI 1.5%PRS 50.07
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CSI 1.65rCSI 4.18%PRS 61.68
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CSI 1.64rCSI 2.92%PRS 67.96
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CSI 1.64rCSI 1.75%PRS 51.68
-
CSI 1.63rCSI 1.63%PRS 46.9
-
CSI 1.63rCSI 5.03%PRS 63.47
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CSI 0.1rCSI 3.2%PRS 74.7%
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CSI 0.3rCSI 2.6%PRS 67.2%
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CSI 0.4rCSI 1.0%PRS 66.1%
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CSI 0.4rCSI 2.5%PRS 45.2%
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CSI 0.4rCSI 3.0%PRS 40.4%
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CSI 0.4rCSI 1.1%PRS 48.3%
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CSI 0.5rCSI 2.7%PRS 63.7%
-
CSI 0.5rCSI 3.7%PRS 71.2%
-
CSI 0.5rCSI 3.5%PRS 49.8%
-
CSI 0.5rCSI 1.7%PRS 39.9%
-
CSI 0.6rCSI 1.1%PRS 63.7%
-
CSI 0.6rCSI 2.0%PRS 43.1%
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CSI 0.6rCSI 3.6%PRS 38.8%
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CSI 0.7rCSI 2.2%PRS 41.1%
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CSI 0.7rCSI 2.2%PRS 59.5%
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CSI 0.8rCSI 3.7%PRS 73.6%
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CSI 0.8rCSI 1.7%PRS 62.1%
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CSI 0.8rCSI 3.3%PRS 64.8%
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CSI 0.8rCSI 1.2%PRS 56.3%
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CSI 0.8rCSI 1.0%PRS 61.6%
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CSI 0.9rCSI 2.2%PRS 42.9%
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CSI 0.9rCSI 2.4%PRS 61.3%
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CSI 0.9rCSI 1.9%PRS 74.2%
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CSI 0.9rCSI 2.3%PRS 61.9%
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CSI 1.0rCSI 1.3%PRS 58.8%
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CSI 1.0rCSI 2.3%PRS 63.8%
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CSI 1.0rCSI 1.6%PRS 36.1%
-
CSI 1.0rCSI 2.1%PRS 66.8%
-
CSI 1.0rCSI 4.4%PRS 52.4%
-
CSI 1.0rCSI 2.6%PRS 51.6%
-
CSI 1.0rCSI 1.5%PRS 64.8%
-
CSI 1.0rCSI 3.9%PRS 45.1%
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CSI 1.1rCSI 1.7%PRS 38.2%
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CSI 1.1rCSI 5.3%PRS 64.7%
-
CSI 1.1rCSI 1.6%PRS 70.1%
-
CSI 1.1rCSI 2.6%PRS 62.6%
-
CSI 1.1rCSI 1.6%PRS 43.5%
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CSI 1.1rCSI 3.6%PRS 54.4%
-
CSI 1.1rCSI 3.0%PRS 44.9%
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CSI 1.1rCSI 1.7%PRS 57.8%
-
CSI 1.1rCSI 16.1%PRS 44.8%
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CSI 1.1rCSI 1.7%PRS 53.8%
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CSI 1.1rCSI 3.1%PRS 49.1%
-
CSI 1.2rCSI 24.0%PRS 46.0%
-
CSI 1.2rCSI 2.1%PRS 51.8%
-
CSI 1.2rCSI 2.7%PRS 36.8%
-
CSI 1.2rCSI 2.0%PRS 58.7%
-
CSI 1.2rCSI 1.5%PRS 55.3%
-
CSI 1.2rCSI 1.4%PRS 56.4%
-
CSI 1.2rCSI 1.8%PRS 47.5%
-
CSI 1.3rCSI 1.4%PRS 43.1%
-
CSI 1.3rCSI 2.0%PRS 51.2%
-
CSI 1.3rCSI 3.1%PRS 66.4%
-
CSI 1.3rCSI 5.7%PRS 45.0%
-
CSI 1.3rCSI 1.5%PRS 62.3%
-
CSI 1.3rCSI 2.0%PRS 61.7%
-
CSI 1.3rCSI 1.2%PRS 51.6%
-
CSI 1.3rCSI 26.7%PRS 44.6%
-
CSI 1.3rCSI 3.7%PRS 66.3%
-
CSI 1.3rCSI 3.4%PRS 57.5%
-
CSI 1.3rCSI 3.5%PRS 48.6%
-
CSI 1.4rCSI 14.3%PRS 52.6%
-
CSI 1.4rCSI 1.4%PRS 50.0%
-
CSI 1.4rCSI 1.7%PRS 61.0%
-
CSI 1.4rCSI 1.6%PRS 47.1%
-
CSI 1.4rCSI 1.7%PRS 35.9%
-
CSI 1.4rCSI 2.5%PRS 46.4%
-
CSI 1.4rCSI 1.2%PRS 54.8%
-
CSI 1.4rCSI 1.1%PRS 71.2%
-
CSI 1.4rCSI 2.2%PRS 49.7%
-
CSI 1.4rCSI 2.2%PRS 54.7%
-
CSI 1.4rCSI 3.5%PRS 47.6%
-
CSI 1.4rCSI 2.5%PRS 45.3%
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CSI 1.5rCSI 2.3%PRS 57.0%
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CSI 1.5rCSI 4.7%PRS 52.0%
-
CSI 1.5rCSI 7.1%PRS 52.4%
-
CSI 1.5rCSI 1.4%PRS 54.3%
-
CSI 1.5rCSI 2.9%PRS 55.7%
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CSI 1.6rCSI 2.1%PRS 66.8%
-
CSI 1.6rCSI 2.1%PRS 37.1%
-
CSI 1.6rCSI 1.3%PRS 53.7%
-
CSI 1.6rCSI 2.4%PRS 56.8%
-
CSI 1.6rCSI 2.2%PRS 45.9%
-
CSI 1.6rCSI 5.0%PRS 63.5%
-
CSI 1.6rCSI 1.6%PRS 46.9%
-
CSI 1.6rCSI 1.8%PRS 51.7%
-
CSI 1.6rCSI 2.9%PRS 68.0%
-
CSI 1.7rCSI 4.2%PRS 61.7%
-
CSI 1.7rCSI 1.5%PRS 50.1%
-
CSI 1.7rCSI 1.8%PRS 56.9%
-
CSI 1.7rCSI 6.6%PRS 73.9%
-
CSI 1.7rCSI 6.3%PRS 45.5%
-
CSI 1.7rCSI 3.5%PRS 50.5%
-
CSI 1.7rCSI 1.6%PRS 61.7%
-
CSI 1.7rCSI 4.2%PRS 54.5%
-
CSI 1.7rCSI 1.6%PRS 52.9%
-
CSI 1.8rCSI 1.7%PRS 43.8%
-
CSI 1.8rCSI 2.3%PRS 51.0%
-
CSI 1.8rCSI 1.9%PRS 52.0%
-
CSI 1.8rCSI 2.5%PRS 49.6%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2926436119
Symbol: SNX4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9819414
Title: Identification of a family of sorting nexin molecules and characterization of their association with receptors.
PubMed ID: 9819414
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12668730
Title: Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking.
PubMed ID: 12668730
DOI: 10.1242/jcs.00403
PubMed ID: 17994011
Title: SNX4 coordinates endosomal sorting of TfnR with dynein-mediated transport into the endocytic recycling compartment.
PubMed ID: 17994011
DOI: 10.1038/ncb1656
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 32513819
Title: A heterodimeric SNX4--SNX7 SNX-BAR autophagy complex coordinates ATG9A trafficking for efficient autophagosome assembly.
PubMed ID: 32513819
DOI: 10.1242/jcs.246306
PubMed ID: 33468622
Title: The phosphatidylinositol 3-phosphate-binding protein SNX4 controls ATG9A recycling and autophagy.
PubMed ID: 33468622
DOI: 10.1242/jcs.250670
Sequence Information:
- Length: 450
- Mass: 51909
- Checksum: 3D5B52AC52A07686
- Sequence:
MEQAPPDPER QLQPAPLEPL GSPDAGLGAA VGKEAEGAGE ESSGVDTMTH NNFWLKKIEI SVSEAEKRTG RNAMNMQETY TAYLIETRSV EHTDGQSVLT DSLWRRYSEF ELLRSYLLVY YPHIVVPPLP EKRAEFVWHK LSADNMDPDF VERRRIGLEN FLLRIASHPI LCRDKIFYLF LTQEGNWKET VNETGFQLKA DSRLKALNAT FRVKNPDKRF TDLKHYSDEL QSVISHLLRV RARVADRLYG VYKVHGNYGR VFSEWSAIEK EMGDGLQSAG HHMDVYASSI DDILEDEEHY ADQLKEYLFY AEALRAVCRK HELMQYDLEM AAQDLASKKQ QCEELVTGTV RTFSLKGMTT KLFGQETPEQ REARIKVLEE QINEGEQQLK SKNLEGREFV KNAWADIERF KEQKNRDLKE ALISYAVMQI SMCKKGIQVW TNAKECFSKM