Details for: SNX4

Gene ID: 8723

Symbol: SNX4

Ensembl ID: ENSG00000114520

Description: sorting nexin 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 234.5299
    Cell Significance Index: -36.4800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 152.1427
    Cell Significance Index: -38.5900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 84.9144
    Cell Significance Index: -40.0900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 82.6201
    Cell Significance Index: -33.5700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 59.9086
    Cell Significance Index: -40.2000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 35.5541
    Cell Significance Index: -33.9500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 33.0507
    Cell Significance Index: -40.7500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.9309
    Cell Significance Index: -34.6400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.5865
    Cell Significance Index: -41.7800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.0561
    Cell Significance Index: -19.8200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7016
    Cell Significance Index: 341.3300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.5370
    Cell Significance Index: 41.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4372
    Cell Significance Index: 285.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9033
    Cell Significance Index: 324.0100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8950
    Cell Significance Index: 68.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.8579
    Cell Significance Index: 48.1400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8562
    Cell Significance Index: 59.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.8130
    Cell Significance Index: 49.9700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.5826
    Cell Significance Index: 11.3700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5652
    Cell Significance Index: 101.8900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5412
    Cell Significance Index: 25.2400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5231
    Cell Significance Index: 23.7100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4566
    Cell Significance Index: 249.3400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4226
    Cell Significance Index: 12.1800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.4078
    Cell Significance Index: 9.7800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3755
    Cell Significance Index: 46.1700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3490
    Cell Significance Index: 23.4700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3183
    Cell Significance Index: 16.5800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3158
    Cell Significance Index: 43.3700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.3007
    Cell Significance Index: 7.7300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2768
    Cell Significance Index: 6.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2660
    Cell Significance Index: 500.8600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2403
    Cell Significance Index: 10.6300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2070
    Cell Significance Index: 20.4800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2049
    Cell Significance Index: 90.6000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2044
    Cell Significance Index: 34.9100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2044
    Cell Significance Index: 7.7400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2026
    Cell Significance Index: 38.5600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1825
    Cell Significance Index: 5.1000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1734
    Cell Significance Index: 4.5600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1684
    Cell Significance Index: 3.6000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1565
    Cell Significance Index: 20.0600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1466
    Cell Significance Index: 6.8900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0740
    Cell Significance Index: 136.3900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0729
    Cell Significance Index: 112.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0710
    Cell Significance Index: 45.1000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0703
    Cell Significance Index: 9.0900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0592
    Cell Significance Index: 2.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0562
    Cell Significance Index: 25.5200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0292
    Cell Significance Index: 39.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0243
    Cell Significance Index: 1.8100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0193
    Cell Significance Index: 2.2800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0183
    Cell Significance Index: 0.9500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0175
    Cell Significance Index: 0.3000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0163
    Cell Significance Index: 2.6500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0010
    Cell Significance Index: -0.0600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0087
    Cell Significance Index: -6.3700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0100
    Cell Significance Index: -7.4400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0256
    Cell Significance Index: -3.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0257
    Cell Significance Index: -19.4800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0258
    Cell Significance Index: -16.1300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0504
    Cell Significance Index: -28.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0622
    Cell Significance Index: -6.3600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0811
    Cell Significance Index: -0.8400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0950
    Cell Significance Index: -6.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0957
    Cell Significance Index: -20.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1095
    Cell Significance Index: -12.5500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1114
    Cell Significance Index: -1.8700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1175
    Cell Significance Index: -0.7100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1229
    Cell Significance Index: -35.3700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1766
    Cell Significance Index: -5.0400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1927
    Cell Significance Index: -22.4600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1974
    Cell Significance Index: -3.3300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2032
    Cell Significance Index: -2.5200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2101
    Cell Significance Index: -1.9400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2418
    Cell Significance Index: -15.2400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2734
    Cell Significance Index: -9.5000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2737
    Cell Significance Index: -28.5000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2940
    Cell Significance Index: -33.5600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3116
    Cell Significance Index: -4.6000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3468
    Cell Significance Index: -27.4700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3636
    Cell Significance Index: -19.0900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3826
    Cell Significance Index: -5.2200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4750
    Cell Significance Index: -10.2900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4763
    Cell Significance Index: -14.0300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5053
    Cell Significance Index: -14.8400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5787
    Cell Significance Index: -12.3300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.5968
    Cell Significance Index: -8.5700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.6392
    Cell Significance Index: -13.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6425
    Cell Significance Index: -39.3900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.6508
    Cell Significance Index: -17.7200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6534
    Cell Significance Index: -20.8100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6557
    Cell Significance Index: -16.3900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6565
    Cell Significance Index: -18.8200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6678
    Cell Significance Index: -21.3900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6772
    Cell Significance Index: -22.1700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6858
    Cell Significance Index: -18.3800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7036
    Cell Significance Index: -18.8200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.7136
    Cell Significance Index: -18.2300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7416
    Cell Significance Index: -15.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SNX4 is a small, cytoplasmic protein that belongs to the sorting nexin family. It is characterized by its ability to bind to phosphatidylinositol-3-phosphate (PI3P) and phosphatidylinositol (PI) lipids, which are essential for regulating membrane trafficking and transport. SNX4 is also a positive regulator of autophagosome assembly and histamine secretion in mast cells. Its expression is highly regulated, with significant expression in cells involved in neurotransmission, immune responses, and development. **Pathways and Functions:** SNX4 is involved in several cellular pathways, including: 1. **Endocytic Recycling:** SNX4 regulates the endocytic recycling of receptors and proteins, ensuring proper membrane trafficking and transport. 2. **Autophagy:** SNX4 is a positive regulator of autophagosome assembly, which is essential for cellular homeostasis and survival. 3. **Neurotransmission:** SNX4 is highly expressed in neurons and plays a crucial role in regulating neurotransmitter release and synaptic plasticity. 4. **Immune Responses:** SNX4 is involved in regulating immune responses, including histamine secretion in mast cells and the interaction with the leptin receptor. 5. **Epidermal Growth Factor Receptor (EGFR) Signaling:** SNX4 regulates the endocytic recycling of EGFR, which is essential for cell growth and survival. **Clinical Significance:** SNX4 has been implicated in various diseases, including: 1. **Neurodegenerative Disorders:** SNX4 dysregulation has been linked to neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 2. **Cancer:** SNX4 expression is altered in various types of cancer, including breast cancer and lung cancer. 3. **Immunological Disorders:** SNX4 is involved in regulating immune responses, and its dysregulation has been implicated in autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis. 4. **Neurodevelopmental Disorders:** SNX4 expression is altered in neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. In conclusion, SNX4 is a multifunctional protein that plays a crucial role in various cellular processes, including endocytosis, autophagy, and neurotransmission. Its dysregulation has been implicated in various diseases, highlighting the importance of SNX4 in maintaining cellular homeostasis and overall health. Further research is necessary to fully understand the role of SNX4 in human disease and to develop therapeutic strategies targeting this protein.

Genular Protein ID: 2926436119

Symbol: SNX4_HUMAN

Name: N/A

UniProtKB Accession Codes:

O95219 B3KMH0 B4DQV4 D3DNA3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEBI 4 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 1 ExpressionAtlas 1 GO 19 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9819414

Title: Identification of a family of sorting nexin molecules and characterization of their association with receptors.

PubMed ID: 9819414

DOI: 10.1128/mcb.18.12.7278

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12668730

Title: Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking.

PubMed ID: 12668730

DOI: 10.1242/jcs.00403

PubMed ID: 17994011

Title: SNX4 coordinates endosomal sorting of TfnR with dynein-mediated transport into the endocytic recycling compartment.

PubMed ID: 17994011

DOI: 10.1038/ncb1656

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 32513819

Title: A heterodimeric SNX4--SNX7 SNX-BAR autophagy complex coordinates ATG9A trafficking for efficient autophagosome assembly.

PubMed ID: 32513819

DOI: 10.1242/jcs.246306

PubMed ID: 33468622

Title: The phosphatidylinositol 3-phosphate-binding protein SNX4 controls ATG9A recycling and autophagy.

PubMed ID: 33468622

DOI: 10.1242/jcs.250670

Sequence Information:

  • Length: 450
  • Mass: 51909
  • Checksum: 3D5B52AC52A07686
  • Sequence:
    • MEQAPPDPER QLQPAPLEPL GSPDAGLGAA VGKEAEGAGE ESSGVDTMTH NNFWLKKIEI 
SVSEAEKRTG RNAMNMQETY TAYLIETRSV EHTDGQSVLT DSLWRRYSEF ELLRSYLLVY 
YPHIVVPPLP EKRAEFVWHK LSADNMDPDF VERRRIGLEN FLLRIASHPI LCRDKIFYLF 
LTQEGNWKET VNETGFQLKA DSRLKALNAT FRVKNPDKRF TDLKHYSDEL QSVISHLLRV 
RARVADRLYG VYKVHGNYGR VFSEWSAIEK EMGDGLQSAG HHMDVYASSI DDILEDEEHY 
ADQLKEYLFY AEALRAVCRK HELMQYDLEM AAQDLASKKQ QCEELVTGTV RTFSLKGMTT 
KLFGQETPEQ REARIKVLEE QINEGEQQLK SKNLEGREFV KNAWADIERF KEQKNRDLKE 
ALISYAVMQI SMCKKGIQVW TNAKECFSKM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.