Details for: PABPC4

Gene ID: 8761

Symbol: PABPC4

Ensembl ID: ENSG00000090621

Description: poly(A) binding protein cytoplasmic 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 306.4061
    Cell Significance Index: -47.6600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 195.9444
    Cell Significance Index: -49.7000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 124.1521
    Cell Significance Index: -58.6200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 123.1855
    Cell Significance Index: -50.0500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 110.8022
    Cell Significance Index: -57.0000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 52.8153
    Cell Significance Index: -50.4300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 43.8296
    Cell Significance Index: -54.0400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 19.4224
    Cell Significance Index: -52.0300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.0976
    Cell Significance Index: -55.6300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.4729
    Cell Significance Index: -38.3100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.0371
    Cell Significance Index: -17.5900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 3.2137
    Cell Significance Index: 548.7700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.2088
    Cell Significance Index: 43.7800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.6093
    Cell Significance Index: 118.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.3566
    Cell Significance Index: 289.7700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.3204
    Cell Significance Index: 418.3000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.0304
    Cell Significance Index: 58.5000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.0225
    Cell Significance Index: 18.6300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.9064
    Cell Significance Index: 51.8900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.8093
    Cell Significance Index: 93.9900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.7564
    Cell Significance Index: 241.2000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.6979
    Cell Significance Index: 336.9500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.6392
    Cell Significance Index: 178.2900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.4934
    Cell Significance Index: 70.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.3789
    Cell Significance Index: 36.8200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.2850
    Cell Significance Index: 27.8400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.2451
    Cell Significance Index: 679.9900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1491
    Cell Significance Index: 1037.5400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.0235
    Cell Significance Index: 131.2100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.9498
    Cell Significance Index: 27.2300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7745
    Cell Significance Index: 100.0600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7408
    Cell Significance Index: 34.5400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.7240
    Cell Significance Index: 8.6300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7164
    Cell Significance Index: 46.2200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6744
    Cell Significance Index: 18.0700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6000
    Cell Significance Index: 70.7600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.5459
    Cell Significance Index: 18.9700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.5050
    Cell Significance Index: 5.4900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4734
    Cell Significance Index: 35.2900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4650
    Cell Significance Index: 13.0000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4529
    Cell Significance Index: 28.5500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4201
    Cell Significance Index: 185.7500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4000
    Cell Significance Index: 76.1200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3980
    Cell Significance Index: 13.9900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3869
    Cell Significance Index: 38.2700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3524
    Cell Significance Index: 24.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3517
    Cell Significance Index: 70.5600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3131
    Cell Significance Index: 21.6600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3077
    Cell Significance Index: 212.8000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2476
    Cell Significance Index: 19.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2174
    Cell Significance Index: 77.9600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1913
    Cell Significance Index: 5.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1322
    Cell Significance Index: 248.9900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0734
    Cell Significance Index: 112.9200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0526
    Cell Significance Index: 96.9500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0298
    Cell Significance Index: 40.5000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0045
    Cell Significance Index: 2.8300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0093
    Cell Significance Index: -7.0200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0143
    Cell Significance Index: -0.3300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0241
    Cell Significance Index: -17.8700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0244
    Cell Significance Index: -3.9700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0271
    Cell Significance Index: -19.8400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0409
    Cell Significance Index: -25.5700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0435
    Cell Significance Index: -4.4400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0478
    Cell Significance Index: -0.8000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0497
    Cell Significance Index: -1.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0637
    Cell Significance Index: -28.9300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0680
    Cell Significance Index: -38.3500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1123
    Cell Significance Index: -2.0800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1359
    Cell Significance Index: -28.6300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1479
    Cell Significance Index: -16.9500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1575
    Cell Significance Index: -45.3300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1729
    Cell Significance Index: -25.1400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1873
    Cell Significance Index: -21.8300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2058
    Cell Significance Index: -11.5500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2529
    Cell Significance Index: -6.1700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2573
    Cell Significance Index: -29.3700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2809
    Cell Significance Index: -14.6300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4536
    Cell Significance Index: -11.3400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4584
    Cell Significance Index: -47.7300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4836
    Cell Significance Index: -12.4300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4987
    Cell Significance Index: -30.6600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5626
    Cell Significance Index: -18.0200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5890
    Cell Significance Index: -46.6500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5987
    Cell Significance Index: -12.7500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.6193
    Cell Significance Index: -9.2800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6504
    Cell Significance Index: -39.8800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6557
    Cell Significance Index: -17.5400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.6598
    Cell Significance Index: -33.3400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6658
    Cell Significance Index: -9.8300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6896
    Cell Significance Index: -46.3700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7001
    Cell Significance Index: -36.7600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8713
    Cell Significance Index: -22.2600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.9199
    Cell Significance Index: -10.4500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.9238
    Cell Significance Index: -18.0300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.9496
    Cell Significance Index: -38.9100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.9577
    Cell Significance Index: -42.3600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.9876
    Cell Significance Index: -15.2800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.9979
    Cell Significance Index: -16.8100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.0424
    Cell Significance Index: -17.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PABPC4 is a cytoplasmic poly(A) binding protein that binds to the 3'-untranslated region (UTR) of mRNAs, thereby regulating their stability and translation. This gene is highly expressed in various cell types, including immune cells, such as IgA plasma cells, lung macrophages, and alveolar macrophages. The PABPC4 protein is also involved in the formation of stress granules, a cytoplasmic structure that plays a role in responding to cellular stress. **Pathways and Functions:** The PABPC4 gene is involved in several key pathways, including: 1. **Regulation of mRNA stability:** PABPC4 binds to the 3'-UTR of mRNAs, preventing their degradation and promoting their translation. 2. **Translation:** PABPC4 regulates the translation of mRNAs by binding to ribosomes and promoting the initiation of protein synthesis. 3. **RNA processing:** PABPC4 is involved in the processing of pre-mRNAs, including splicing, capping, and polyadenylation. 4. **Cytoplasmic stress granule formation:** PABPC4 is a key component of stress granules, which form in response to cellular stress and play a role in regulating protein synthesis and cellular homeostasis. **Clinical Significance:** The PABPC4 gene has been implicated in various diseases, including: 1. **Immunological disorders:** PABPC4 has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus, where it plays a role in regulating the translation of immune-related mRNAs. 2. **Cancer:** PABPC4 has been found to be overexpressed in various types of cancer, including lung, breast, and colon cancer, where it promotes tumor growth and metastasis. 3. **Neurological disorders:** PABPC4 has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's, where it regulates the translation of neuronal mRNAs. In conclusion, the PABPC4 gene is a multifaceted gene involved in various cellular processes, including mRNA stability, translation, and RNA processing. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its role in maintaining cellular homeostasis and preventing disease.

Genular Protein ID: 1582722472

Symbol: PABP4_HUMAN

Name: Polyadenylate-binding protein 4

UniProtKB Accession Codes:

Q13310 B1ANQ8 Q4VC03 Q6P0N3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 4 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 8 Ensembl 3 ExpressionAtlas 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 3 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8524242

Title: iPABP, an inducible poly(A)-binding protein detected in activated human T cells.

PubMed ID: 8524242

DOI: 10.1128/mcb.15.12.6770

PubMed ID: 9030741

Title: Identification and structure of activated-platelet protein-1, a protein with RNA-binding domain motifs that is expressed by activated platelets.

PubMed ID: 9030741

DOI: 10.1111/j.1432-1033.1997.0209a.x

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17267499

Title: NFX1-123 and poly(A) binding proteins synergistically augment activation of telomerase in human papillomavirus type 16 E6-expressing cells.

PubMed ID: 17267499

DOI: 10.1128/jvi.02007-06

PubMed ID: 17289661

Title: Molecular composition of IMP1 ribonucleoprotein granules.

PubMed ID: 17289661

DOI: 10.1074/mcp.m600346-mcp200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 27871484

Title: Identification of a nuclear exosome decay pathway for processed transcripts.

PubMed ID: 27871484

DOI: 10.1016/j.molcel.2016.09.025

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 37009826

Title: LINC00493-encoded microprotein SMIM26 exerts anti-metastatic activity in renal cell carcinoma.

PubMed ID: 37009826

DOI: 10.15252/embr.202256282

Sequence Information:

  • Length: 644
  • Mass: 70783
  • Checksum: A761488F0B10DF5A
  • Sequence:
    • MNAAASSYPM ASLYVGDLHS DVTEAMLYEK FSPAGPVLSI RVCRDMITRR SLGYAYVNFQ 
QPADAERALD TMNFDVIKGK PIRIMWSQRD PSLRKSGVGN VFIKNLDKSI DNKALYDTFS 
AFGNILSCKV VCDENGSKGY AFVHFETQEA ADKAIEKMNG MLLNDRKVFV GRFKSRKERE 
AELGAKAKEF TNVYIKNFGE EVDDESLKEL FSQFGKTLSV KVMRDPNGKS KGFGFVSYEK 
HEDANKAVEE MNGKEISGKI IFVGRAQKKV ERQAELKRKF EQLKQERISR YQGVNLYIKN 
LDDTIDDEKL RKEFSPFGSI TSAKVMLEDG RSKGFGFVCF SSPEEATKAV TEMNGRIVGS 
KPLYVALAQR KEERKAHLTN QYMQRVAGMR ALPANAILNQ FQPAAGGYFV PAVPQAQGRP 
PYYTPNQLAQ MRPNPRWQQG GRPQGFQGMP SAIRQSGPRP TLRHLAPTGS ECPDRLAMDF 
GGAGAAQQGL TDSCQSGGVP TAVQNLAPRA AVAAAAPRAV APYKYASSVR SPHPAIQPLQ 
APQPAVHVQG QEPLTASMLA AAPPQEQKQM LGERLFPLIQ TMHSNLAGKI TGMLLEIDNS 
ELLHMLESPE SLRSKVDEAV AVLQAHHAKK EAAQKVGAVA AATS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.