Genular: Defining Cellular Identity and Function

Details for: RIPK2

Gene ID: 8767

Symbol: RIPK2

Ensembl ID: ENSG00000104312

Description: receptor interacting serine/threonine kinase 2

Associated with

Activated tak1 mediates p38 mapk activation
(R-HSA-450302)
Adaptive immune system
(R-HSA-1280218)
Cytokine signaling in immune system
(R-HSA-1280215)
Death receptor signaling
(R-HSA-73887)
Deubiquitination
(R-HSA-5688426)
Disease
(R-HSA-1643685)
Downstream tcr signaling
(R-HSA-202424)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Interleukin-1 signaling
(R-HSA-9020702)
Interleukin-17 signaling
(R-HSA-448424)
Jnk (c-jun kinases) phosphorylation and activation mediated by activated human tak1
(R-HSA-450321)
Map kinase activation
(R-HSA-450294)
Metabolism of proteins
(R-HSA-392499)
Myd88 cascade initiated on plasma membrane
(R-HSA-975871)
Myd88 dependent cascade initiated on endosome
(R-HSA-975155)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Nod1/2 signaling pathway
(R-HSA-168638)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-HSA-168643)
Ovarian tumor domain proteases
(R-HSA-5689896)
P75 ntr receptor-mediated signalling
(R-HSA-193704)
P75ntr recruits signalling complexes
(R-HSA-209543)
P75ntr signals via nf-kb
(R-HSA-193639)
Post-translational protein modification
(R-HSA-597592)
Sars-cov-2 activates/modulates innate and adaptive immune responses
(R-HSA-9705671)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Signaling by interleukins
(R-HSA-449147)
Tak1-dependent ikk and nf-kappa-b activation
(R-HSA-445989)
Tcr signaling
(R-HSA-202403)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 5 (tlr5) cascade
(R-HSA-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor 10 (tlr10) cascade
(R-HSA-168142)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-HSA-975138)
Trif(ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
Apoptotic process
(GO:0006915)
Atp binding
(GO:0005524)
Canonical nf-kappab signal transduction
(GO:0007249)
Card domain binding
(GO:0050700)
Caspase binding
(GO:0089720)
Cd4-positive, alpha-beta t cell proliferation
(GO:0035739)
Cytokine-mediated signaling pathway
(GO:0019221)
Defense response to bacterium
(GO:0042742)
Identical protein binding
(GO:0042802)
Immature t cell proliferation in thymus
(GO:0033080)
Inflammatory response
(GO:0006954)
Innate immune response
(GO:0045087)
Jnk cascade
(GO:0007254)
Jun kinase kinase kinase activity
(GO:0004706)
Lim domain binding
(GO:0030274)
Lipopolysaccharide-mediated signaling pathway
(GO:0031663)
Non-membrane spanning protein tyrosine kinase activity
(GO:0004715)
Phosphorylation
(GO:0016310)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of chemokine production
(GO:0032722)
Positive regulation of cytokine-mediated signaling pathway
(GO:0001961)
Positive regulation of immature t cell proliferation in thymus
(GO:0033092)
Positive regulation of interferon-alpha production
(GO:0032727)
Positive regulation of interferon-beta production
(GO:0032728)
Positive regulation of interleukin-1 beta production
(GO:0032731)
Positive regulation of interleukin-2 production
(GO:0032743)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of interleukin-12 production
(GO:0032735)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of peptidyl-threonine phosphorylation
(GO:0010800)
Positive regulation of protein binding
(GO:0032092)
Positive regulation of protein ubiquitination
(GO:0031398)
Positive regulation of t-helper 1 cell differentiation
(GO:0045627)
Positive regulation of t-helper 1 type immune response
(GO:0002827)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Positive regulation of type ii interferon production
(GO:0032729)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Response to exogenous dsrna
(GO:0043330)
Signaling adaptor activity
(GO:0035591)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
Toll-like receptor 2 signaling pathway
(GO:0034134)
Toll-like receptor 4 signaling pathway
(GO:0034142)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 2.16
Marker Score: 4,560
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 2.01
Marker Score: 4,951
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.62
Marker Score: 55,015
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 1.51
Marker Score: 1,135
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 1.51
Marker Score: 3,649
Cell Name: mural cell (CL0008034)
Fold Change: 1.46
Marker Score: 167,952
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 1.28
Marker Score: 2,500
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 1.19
Marker Score: 899
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.16
Marker Score: 65,140
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.13
Marker Score: 1,666
Cell Name: germ cell (CL0000586)
Fold Change: 1.06
Marker Score: 1,853
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.06
Marker Score: 1,282
Cell Name: mononuclear cell (CL0000842)
Fold Change: 1.04
Marker Score: 336
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251,667
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 1.03
Marker Score: 2,677
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 1.02
Marker Score: 594
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.01
Marker Score: 640
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,691
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47,916
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.99
Marker Score: 682
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,391
Cell Name: B-1 B cell (CL0000819)
Fold Change: 0.98
Marker Score: 1,704
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 0.95
Marker Score: 1,676
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.94
Marker Score: 638
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2,395
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.94
Marker Score: 1,911
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.94
Marker Score: 32,545
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.94
Marker Score: 14,650
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.93
Marker Score: 480
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 0.92
Marker Score: 667
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.92
Marker Score: 435
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.91
Marker Score: 2,273
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.9
Marker Score: 2,700
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 0.89
Marker Score: 22,798
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,292
Cell Name: lung macrophage (CL1001603)
Fold Change: 0.86
Marker Score: 987
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.85
Marker Score: 542
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.85
Marker Score: 307
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 0.85
Marker Score: 512
Cell Name: elicited macrophage (CL0000861)
Fold Change: 0.85
Marker Score: 5,138
Cell Name: osteoclast (CL0000092)
Fold Change: 0.85
Marker Score: 421
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.84
Marker Score: 4,802
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.83
Marker Score: 1,274
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.82
Marker Score: 2,446
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.82
Marker Score: 434
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.82
Marker Score: 3,038
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 0.82
Marker Score: 831
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 0.81
Marker Score: 418
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.81
Marker Score: 323
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.8
Marker Score: 483
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 0.79
Marker Score: 276
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.79
Marker Score: 781
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 0.78
Marker Score: 269
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1,260
Cell Name: granulocyte (CL0000094)
Fold Change: 0.77
Marker Score: 345
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.77
Marker Score: 585
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.76
Marker Score: 379
Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 0.76
Marker Score: 243
Cell Name: stromal cell (CL0000499)
Fold Change: 0.76
Marker Score: 885
Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.75
Marker Score: 752
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.75
Marker Score: 262
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.75
Marker Score: 7,127
Cell Name: taste receptor cell (CL0000209)
Fold Change: 0.75
Marker Score: 644
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.74
Marker Score: 725
Cell Name: monocyte (CL0000576)
Fold Change: 0.73
Marker Score: 948
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.73
Marker Score: 979
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.73
Marker Score: 465
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.73
Marker Score: 501
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.72
Marker Score: 3,029
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 0.72
Marker Score: 869
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.72
Marker Score: 372
Cell Name: astrocyte (CL0000127)
Fold Change: 0.72
Marker Score: 622
Cell Name: classical monocyte (CL0000860)
Fold Change: 0.72
Marker Score: 2,974
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 0.72
Marker Score: 161
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.71
Marker Score: 655
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.71
Marker Score: 786
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.71
Marker Score: 4,256
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.7
Marker Score: 2,717
Cell Name: centrocyte (CL0009111)
Fold Change: 0.7
Marker Score: 168
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 0.7
Marker Score: 218
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.7
Marker Score: 1,598
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 0.7
Marker Score: 551
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.7
Marker Score: 153
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.7
Marker Score: 284
Cell Name: mature B cell (CL0000785)
Fold Change: 0.69
Marker Score: 509
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.69
Marker Score: 617
Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
Fold Change: 0.69
Marker Score: 313
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 0.69
Marker Score: 244
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.68
Marker Score: 711
Cell Name: group 3 innate lymphoid cell (CL0001071)
Fold Change: 0.68
Marker Score: 287
Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.68
Marker Score: 171
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 174
Cell Name: macrophage (CL0000235)
Fold Change: 0.68
Marker Score: 755
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 0.68
Marker Score: 735
Cell Name: brush cell (CL0002204)
Fold Change: 0.67
Marker Score: 616
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.67
Marker Score: 13,378
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.67
Marker Score: 5,774
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.67
Marker Score: 444
Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 0.67
Marker Score: 146
Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 0.67
Marker Score: 142

**Key Characteristics** RIPK2 is a serine/threonine kinase that belongs to the receptor-interacting protein (RIP) family. It is characterized by its unique structure, which includes a death domain and a protein kinase domain. RIPK2 is highly expressed in various cell types, including immune cells, epithelial cells, and hematopoietic stem cells. Its expression is also detected in several types of cancer, suggesting a potential role in tumor progression. **Pathways and Functions** RIPK2 is involved in multiple signaling pathways, including: 1. **Apoptosis pathway**: RIPK2 interacts with death receptors, triggering a cascade of events that ultimately lead to apoptosis. 2. **Inflammatory response**: RIPK2 is activated by Toll-like receptors (TLRs) and NOD-like receptors (NLRs), leading to the production of pro-inflammatory cytokines. 3. **Cytokine signaling pathway**: RIPK2 interacts with cytokine receptors, modulating the production of cytokines and influencing immune responses. 4. **Cell survival pathway**: RIPK2 can also promote cell survival by activating anti-apoptotic signaling pathways. RIPK2 functions as a scaffold protein, interacting with various signaling molecules, including death receptors, TLRs, and NLRs. It also regulates the activity of downstream kinases, such as JNK and p38 MAPK. **Clinical Significance** RIPK2 has been implicated in various diseases, including: 1. **Autoimmune disorders**: RIPK2 has been associated with autoimmune diseases, such as rheumatoid arthritis and lupus, where it contributes to the production of pro-inflammatory cytokines. 2. **Cancer**: RIPK2 is overexpressed in several types of cancer, including melanoma, lung cancer, and breast cancer, where it promotes tumor progression and metastasis. 3. **Infectious diseases**: RIPK2 is involved in the regulation of innate immune responses, making it a potential target for the treatment of infectious diseases, such as COVID-19. 4. **Neurodegenerative diseases**: RIPK2 has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's, where it contributes to the production of neuroinflammatory cytokines. In conclusion, RIPK2 is a complex gene that plays a critical role in immune regulation, apoptosis, and inflammation. Its dysregulation has been implicated in various diseases, making it a promising target for the development of new therapeutic strategies. Further research is needed to fully understand the mechanisms by which RIPK2 regulates immune responses and to explore its potential as a therapeutic target.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Receptor-interacting serine/threonine-protein kinase 2

Genular Protein ID: 956715736

Symbol: RIPK2_HUMAN

Name: Receptor-interacting serine/threonine-protein kinase 2

UniProtKB Accession Codes:

O43353 B7Z748 Q6UWF0

Database IDs:

Citations:

PubMed ID: 9575181

Title: RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis.

PubMed ID: 9575181

DOI: 10.1074/jbc.273.20.12296

PubMed ID: 9642260

Title: RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase.

PubMed ID: 9642260

DOI: 10.1074/jbc.273.27.16968

PubMed ID: 9705938

Title: Identification of CARDIAK, a RIP-like kinase that associates with caspase-1.

PubMed ID: 9705938

DOI: 10.1016/s0960-9822(07)00352-1

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15044951

Title: Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition.

PubMed ID: 15044951

DOI: 10.1038/sj.emboj.7600175

PubMed ID: 14638696

Title: Rip2 participates in Bcl10 signaling and T-cell receptor-mediated NF-kappaB activation.

PubMed ID: 14638696

DOI: 10.1074/jbc.c300460200

PubMed ID: 16824733

Title: Identification of a regulatory autophosphorylation site in the serine-threonine kinase RIP2.

PubMed ID: 16824733

DOI: 10.1016/j.cellsig.2006.05.005

PubMed ID: 17355968

Title: The NOD2-RICK complex signals from the plasma membrane.

PubMed ID: 17355968

DOI: 10.1074/jbc.m606242200

PubMed ID: 17054981

Title: Solution structure of NOD1 CARD and mutational analysis of its interaction with the CARD of downstream kinase RICK.

PubMed ID: 17054981

DOI: 10.1016/j.jmb.2006.09.067

PubMed ID: 17562858

Title: Coordinated regulation of Toll-like receptor and NOD2 signaling by K63-linked polyubiquitin chains.

PubMed ID: 17562858

DOI: 10.1128/mcb.00270-07

PubMed ID: 18775659

Title: MEKK4 sequesters RIP2 to dictate NOD2 signal specificity.

PubMed ID: 18775659

DOI: 10.1016/j.cub.2008.07.084

PubMed ID: 18079694

Title: A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation.

PubMed ID: 18079694

DOI: 10.1038/sj.emboj.7601962

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19592251

Title: ITCH K63-ubiquitinates the NOD2 binding protein, RIP2, to influence inflammatory signaling pathways.

PubMed ID: 19592251

DOI: 10.1016/j.cub.2009.06.038

PubMed ID: 19464198

Title: Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2.

PubMed ID: 19464198

DOI: 10.1016/j.immuni.2009.04.011

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 21123652

Title: Inhibition of RIP2's tyrosine kinase activity limits NOD2-driven cytokine responses.

PubMed ID: 21123652

DOI: 10.1101/gad.1964410

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21931591

Title: cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4).

PubMed ID: 21931591

DOI: 10.1371/journal.pone.0022356

PubMed ID: 22520462

Title: Yersinia pseudotuberculosis effector YopJ subverts the Nod2/RICK/TAK1 pathway and activates caspase-1 to induce intestinal barrier dysfunction.

PubMed ID: 22520462

DOI: 10.1016/j.chom.2012.02.009

PubMed ID: 22672233

Title: NLRP10 enhances Shigella-induced pro-inflammatory responses.

PubMed ID: 22672233

DOI: 10.1111/j.1462-5822.2012.01822.x

PubMed ID: 21887730

Title: Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1.

PubMed ID: 21887730

DOI: 10.1002/ibd.21851

PubMed ID: 22607974

Title: The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity.

PubMed ID: 22607974

DOI: 10.1016/j.molcel.2012.04.014

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23806334

Title: OTULIN restricts Met1-linked ubiquitination to control innate immune signaling.

PubMed ID: 23806334

DOI: 10.1016/j.molcel.2013.06.004

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27812135

Title: Characterization and Genetic Analyses of New Genes Coding for NOD2 Interacting Proteins.

PubMed ID: 27812135

DOI: 10.1371/journal.pone.0165420

PubMed ID: 28436939

Title: An inflammatory bowel disease-risk variant in INAVA decreases pattern recognition receptor-induced outcomes.

PubMed ID: 28436939

DOI: 10.1172/jci86282

PubMed ID: 28656966

Title: E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP.

PubMed ID: 28656966

DOI: 10.1038/ncomms15865

PubMed ID: 27830463

Title: LRRK2 enhances Nod1/2-mediated inflammatory cytokine production by promoting Rip2 phosphorylation.

PubMed ID: 27830463

DOI: 10.1007/s13238-016-0326-x

PubMed ID: 29452636

Title: Disruption of XIAP-RIP2 association blocks NOD2-mediated inflammatory signaling.

PubMed ID: 29452636

DOI: 10.1016/j.molcel.2018.01.016

PubMed ID: 36221902

Title: Selective autophagy of RIPosomes maintains innate immune homeostasis during bacterial infection.

PubMed ID: 36221902

DOI: 10.15252/embj.2022111289

PubMed ID: 26646181

Title: Structural basis of death domain signaling in the p75 neurotrophin receptor.

PubMed ID: 26646181

DOI: 10.7554/elife.11692

PubMed ID: 28545134

Title: Structures of the inactive and active states of RIP2 kinase inform on the mechanism of activation.

PubMed ID: 28545134

DOI: 10.1371/journal.pone.0177161

PubMed ID: 30279485

Title: RIP2 filament formation is required for NOD2 dependent NF-kappaB signalling.

PubMed ID: 30279485

DOI: 10.1038/s41467-018-06451-3

PubMed ID: 30478312

Title: Structural basis of RIP2 activation and signaling.

PubMed ID: 30478312

DOI: 10.1038/s41467-018-07447-9

PubMed ID: 30026309

Title: Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling.

PubMed ID: 30026309

DOI: 10.15252/embj.201899372

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 540
Mass: 61195
Checksum: 575A692239505792
Sequence:

MNGEAICSAL PTIPYHKLAD LRYLSRGASG TVSSARHADW RVQVAVKHLH IHTPLLDSER 
KDVLREAEIL HKARFSYILP ILGICNEPEF LGIVTEYMPN GSLNELLHRK TEYPDVAWPL 
RFRILHEIAL GVNYLHNMTP PLLHHDLKTQ NILLDNEFHV KIADFGLSKW RMMSLSQSRS 
SKSAPEGGTI IYMPPENYEP GQKSRASIKH DIYSYAVITW EVLSRKQPFE DVTNPLQIMY 
SVSQGHRPVI NEESLPYDIP HRARMISLIE SGWAQNPDER PSFLKCLIEL EPVLRTFEEI 
TFLEAVIQLK KTKLQSVSSA IHLCDKKKME LSLNIPVNHG PQEESCGSSQ LHENSGSPET 
SRSLPAPQDN DFLSRKAQDC YFMKLHHCPG NHSWDSTISG SQRAAFCDHK TTPCSSAIIN 
PLSTAGNSER LQPGIAQQWI QSKREDIVNQ MTEACLNQSL DALLSRDLIM KEDYELVSTK 
PTRTSKVRQL LDTTDIQGEE FAKVIVQKLK DNKQMGLQPY PEILVVSRSP SLNLLQNKSM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: RIPK2

Associated with

Cells (max top 100)

Other Information

RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis. PubMed ID: 9575181

RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase. PubMed ID: 9642260

Identification of CARDIAK, a RIP-like kinase that associates with caspase-1. PubMed ID: 9705938

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. PubMed ID: 12975309

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence and analysis of human chromosome 8. PubMed ID: 16421571

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition. PubMed ID: 15044951

Rip2 participates in Bcl10 signaling and T-cell receptor-mediated NF-kappaB activation. PubMed ID: 14638696

Identification of a regulatory autophosphorylation site in the serine-threonine kinase RIP2. PubMed ID: 16824733

The NOD2-RICK complex signals from the plasma membrane. PubMed ID: 17355968

Solution structure of NOD1 CARD and mutational analysis of its interaction with the CARD of downstream kinase RICK. PubMed ID: 17054981

Coordinated regulation of Toll-like receptor and NOD2 signaling by K63-linked polyubiquitin chains. PubMed ID: 17562858

MEKK4 sequesters RIP2 to dictate NOD2 signal specificity. PubMed ID: 18775659

A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation. PubMed ID: 18079694

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

ITCH K63-ubiquitinates the NOD2 binding protein, RIP2, to influence inflammatory signaling pathways. PubMed ID: 19592251

Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2. PubMed ID: 19464198

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Inhibition of RIP2's tyrosine kinase activity limits NOD2-driven cytokine responses. PubMed ID: 21123652

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4). PubMed ID: 21931591

Yersinia pseudotuberculosis effector YopJ subverts the Nod2/RICK/TAK1 pathway and activates caspase-1 to induce intestinal barrier dysfunction. PubMed ID: 22520462

NLRP10 enhances Shigella-induced pro-inflammatory responses. PubMed ID: 22672233

Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1. PubMed ID: 21887730

The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity. PubMed ID: 22607974

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

OTULIN restricts Met1-linked ubiquitination to control innate immune signaling. PubMed ID: 23806334

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Characterization and Genetic Analyses of New Genes Coding for NOD2 Interacting Proteins. PubMed ID: 27812135

An inflammatory bowel disease-risk variant in INAVA decreases pattern recognition receptor-induced outcomes. PubMed ID: 28436939

E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP. PubMed ID: 28656966

LRRK2 enhances Nod1/2-mediated inflammatory cytokine production by promoting Rip2 phosphorylation. PubMed ID: 27830463

Disruption of XIAP-RIP2 association blocks NOD2-mediated inflammatory signaling. PubMed ID: 29452636

Selective autophagy of RIPosomes maintains innate immune homeostasis during bacterial infection. PubMed ID: 36221902

Structural basis of death domain signaling in the p75 neurotrophin receptor. PubMed ID: 26646181

Structures of the inactive and active states of RIP2 kinase inform on the mechanism of activation. PubMed ID: 28545134

RIP2 filament formation is required for NOD2 dependent NF-kappaB signalling. PubMed ID: 30279485

Structural basis of RIP2 activation and signaling. PubMed ID: 30478312

Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling. PubMed ID: 30026309

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846