RIPK2 | ENSG00000104312 | NCBI 8767

Details for: RIPK2

Gene ID: 8767

Symbol: RIPK2

Ensembl ID: ENSG00000104312

Description: receptor interacting serine/threonine kinase 2

Associated with

Activated tak1 mediates p38 mapk activation
(R-HSA-450302)
Adaptive immune system
(R-HSA-1280218)
Cytokine signaling in immune system
(R-HSA-1280215)
Death receptor signaling
(R-HSA-73887)
Deubiquitination
(R-HSA-5688426)
Disease
(R-HSA-1643685)
Downstream tcr signaling
(R-HSA-202424)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Interleukin-1 signaling
(R-HSA-9020702)
Interleukin-17 signaling
(R-HSA-448424)
Jnk (c-jun kinases) phosphorylation and activation mediated by activated human tak1
(R-HSA-450321)
Map kinase activation
(R-HSA-450294)
Metabolism of proteins
(R-HSA-392499)
Myd88 cascade initiated on plasma membrane
(R-HSA-975871)
Myd88 dependent cascade initiated on endosome
(R-HSA-975155)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Nod1/2 signaling pathway
(R-HSA-168638)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-HSA-168643)
Ovarian tumor domain proteases
(R-HSA-5689896)
P75 ntr receptor-mediated signalling
(R-HSA-193704)
P75ntr recruits signalling complexes
(R-HSA-209543)
P75ntr signals via nf-kb
(R-HSA-193639)
Post-translational protein modification
(R-HSA-597592)
Sars-cov-2 activates/modulates innate and adaptive immune responses
(R-HSA-9705671)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Signaling by interleukins
(R-HSA-449147)
Tak1-dependent ikk and nf-kappa-b activation
(R-HSA-445989)
Tcr signaling
(R-HSA-202403)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 5 (tlr5) cascade
(R-HSA-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor 10 (tlr10) cascade
(R-HSA-168142)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-HSA-975138)
Trif (ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
Apoptotic process
(GO:0006915)
Atp binding
(GO:0005524)
Canonical nf-kappab signal transduction
(GO:0007249)
Card domain binding
(GO:0050700)
Caspase binding
(GO:0089720)
Cd4-positive, alpha-beta t cell proliferation
(GO:0035739)
Chromatin remodeling
(GO:0006338)
Cytokine-mediated signaling pathway
(GO:0019221)
Defense response to bacterium
(GO:0042742)
Histone h2as1 kinase activity
(GO:0044024)
Identical protein binding
(GO:0042802)
Immature t cell proliferation in thymus
(GO:0033080)
Inflammatory response
(GO:0006954)
Jnk cascade
(GO:0007254)
Jun kinase kinase kinase activity
(GO:0004706)
Lim domain binding
(GO:0030274)
Lipopolysaccharide-mediated signaling pathway
(GO:0031663)
Non-membrane spanning protein tyrosine kinase activity
(GO:0004715)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of chemokine production
(GO:0032722)
Positive regulation of cytokine-mediated signaling pathway
(GO:0001961)
Positive regulation of immature t cell proliferation in thymus
(GO:0033092)
Positive regulation of interferon-alpha production
(GO:0032727)
Positive regulation of interferon-beta production
(GO:0032728)
Positive regulation of interleukin-1 beta production
(GO:0032731)
Positive regulation of interleukin-2 production
(GO:0032743)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of interleukin-12 production
(GO:0032735)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of peptidyl-threonine phosphorylation
(GO:0010800)
Positive regulation of protein binding
(GO:0032092)
Positive regulation of protein ubiquitination
(GO:0031398)
Positive regulation of stress-activated mapk cascade
(GO:0032874)
Positive regulation of t-helper 1 type immune response
(GO:0002827)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Positive regulation of type ii interferon production
(GO:0032729)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Response to exogenous dsrna
(GO:0043330)
Signaling adaptor activity
(GO:0035591)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
Toll-like receptor 2 signaling pathway
(GO:0034134)
Toll-like receptor 4 signaling pathway
(GO:0034142)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 138.5449
Cell Significance Index: -21.5500
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 72.2274
Cell Significance Index: -18.3200
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 61.3913
Cell Significance Index: -25.2900
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 55.8759
Cell Significance Index: -22.7000
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 48.5434
Cell Significance Index: -24.9700
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 19.2059
Cell Significance Index: -23.6800
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 8.9926
Cell Significance Index: -24.0900
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 6.1353
Cell Significance Index: -24.2100
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 3.6462
Cell Significance Index: -7.9800
Cell Name: decidual cell (CL2000002)
Fold Change: 1.9952
Cell Significance Index: 32.0100
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.6532
Cell Significance Index: 47.3900
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.5219
Cell Significance Index: 289.6400
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.4725
Cell Significance Index: 20.0900
Cell Name: lactocyte (CL0002325)
Fold Change: 1.1167
Cell Significance Index: 144.2700
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.9972
Cell Significance Index: 98.6500
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.9687
Cell Significance Index: 17.9100
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.7571
Cell Significance Index: 683.6000
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.7564
Cell Significance Index: 16.1100
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.7538
Cell Significance Index: 39.1600
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.6427
Cell Significance Index: 17.1600
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.5926
Cell Significance Index: 323.6500
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.5669
Cell Significance Index: 15.1700
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.5609
Cell Significance Index: 111.3100
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.4969
Cell Significance Index: 54.0500
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.4897
Cell Significance Index: 79.6400
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.4793
Cell Significance Index: 22.5300
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.4540
Cell Significance Index: 53.5400
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 0.4433
Cell Significance Index: 4.7100
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.4280
Cell Significance Index: 85.8600
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.4031
Cell Significance Index: 24.2000
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.3130
Cell Significance Index: 23.3300
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.2936
Cell Significance Index: 18.9400
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.2787
Cell Significance Index: 50.2400
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.2151
Cell Significance Index: 26.4500
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.2010
Cell Significance Index: 72.0900
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1980
Cell Significance Index: 13.7000
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.1827
Cell Significance Index: 26.5600
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1804
Cell Significance Index: 79.7800
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.1697
Cell Significance Index: 8.8400
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.1670
Cell Significance Index: 9.3700
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.1620
Cell Significance Index: 4.4100
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1107
Cell Significance Index: 15.2100
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.1034
Cell Significance Index: 2.2400
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.1004
Cell Significance Index: 154.6000
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0976
Cell Significance Index: 4.5500
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0676
Cell Significance Index: 1.6900
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0539
Cell Significance Index: 99.4100
Cell Name: preadipocyte (CL0002334)
Fold Change: 0.0528
Cell Significance Index: 1.0300
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0488
Cell Significance Index: 1.4100
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0238
Cell Significance Index: 3.0500
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0235
Cell Significance Index: 44.2900
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0213
Cell Significance Index: 14.7500
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0127
Cell Significance Index: 17.2100
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0091
Cell Significance Index: 0.7000
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0073
Cell Significance Index: -0.3700
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0141
Cell Significance Index: -8.9600
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0222
Cell Significance Index: -16.7800
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0277
Cell Significance Index: -2.8300
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0279
Cell Significance Index: -20.4800
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0285
Cell Significance Index: -21.1200
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0298
Cell Significance Index: -5.0800
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0338
Cell Significance Index: -2.3900
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0360
Cell Significance Index: -16.3600
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0423
Cell Significance Index: -23.8500
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0459
Cell Significance Index: -28.6900
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0488
Cell Significance Index: -2.2100
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.0679
Cell Significance Index: -1.0500
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.0706
Cell Significance Index: -0.6500
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0723
Cell Significance Index: -20.8100
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0945
Cell Significance Index: -11.0100
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1149
Cell Significance Index: -13.1600
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1271
Cell Significance Index: -26.7800
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.1377
Cell Significance Index: -4.8400
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1408
Cell Significance Index: -3.9400
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1497
Cell Significance Index: -3.8300
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1621
Cell Significance Index: -10.9000
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2123
Cell Significance Index: -22.1100
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.2317
Cell Significance Index: -1.4000
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.2360
Cell Significance Index: -3.9500
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2475
Cell Significance Index: -15.2100
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.2501
Cell Significance Index: -3.5600
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2615
Cell Significance Index: -16.0300
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2794
Cell Significance Index: -12.3600
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2943
Cell Significance Index: -23.3100
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.3366
Cell Significance Index: -5.9500
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.3409
Cell Significance Index: -17.9000
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.3687
Cell Significance Index: -11.8100
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.3702
Cell Significance Index: -14.0200
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.3981
Cell Significance Index: -11.3600
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.4041
Cell Significance Index: -25.4700
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.4227
Cell Significance Index: -14.6900
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.4329
Cell Significance Index: -12.7500
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.4453
Cell Significance Index: -9.3200
Cell Name: peg cell (CL4033014)
Fold Change: -0.4653
Cell Significance Index: -10.7500
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.4729
Cell Significance Index: -12.4400
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.5074
Cell Significance Index: -16.1600
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.5226
Cell Significance Index: -21.4100
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.5284
Cell Significance Index: -11.5700
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.5484
Cell Significance Index: -19.2100
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.5530
Cell Significance Index: -20.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** RIPK2 is a serine/threonine kinase that belongs to the receptor-interacting protein (RIP) family. It is characterized by its unique structure, which includes a death domain and a protein kinase domain. RIPK2 is highly expressed in various cell types, including immune cells, epithelial cells, and hematopoietic stem cells. Its expression is also detected in several types of cancer, suggesting a potential role in tumor progression. **Pathways and Functions** RIPK2 is involved in multiple signaling pathways, including: 1. **Apoptosis pathway**: RIPK2 interacts with death receptors, triggering a cascade of events that ultimately lead to apoptosis. 2. **Inflammatory response**: RIPK2 is activated by Toll-like receptors (TLRs) and NOD-like receptors (NLRs), leading to the production of pro-inflammatory cytokines. 3. **Cytokine signaling pathway**: RIPK2 interacts with cytokine receptors, modulating the production of cytokines and influencing immune responses. 4. **Cell survival pathway**: RIPK2 can also promote cell survival by activating anti-apoptotic signaling pathways. RIPK2 functions as a scaffold protein, interacting with various signaling molecules, including death receptors, TLRs, and NLRs. It also regulates the activity of downstream kinases, such as JNK and p38 MAPK. **Clinical Significance** RIPK2 has been implicated in various diseases, including: 1. **Autoimmune disorders**: RIPK2 has been associated with autoimmune diseases, such as rheumatoid arthritis and lupus, where it contributes to the production of pro-inflammatory cytokines. 2. **Cancer**: RIPK2 is overexpressed in several types of cancer, including melanoma, lung cancer, and breast cancer, where it promotes tumor progression and metastasis. 3. **Infectious diseases**: RIPK2 is involved in the regulation of innate immune responses, making it a potential target for the treatment of infectious diseases, such as COVID-19. 4. **Neurodegenerative diseases**: RIPK2 has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's, where it contributes to the production of neuroinflammatory cytokines. In conclusion, RIPK2 is a complex gene that plays a critical role in immune regulation, apoptosis, and inflammation. Its dysregulation has been implicated in various diseases, making it a promising target for the development of new therapeutic strategies. Further research is needed to fully understand the mechanisms by which RIPK2 regulates immune responses and to explore its potential as a therapeutic target.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Receptor-interacting serine/threonine-protein kinase 2

Genular Protein ID: 956715736

Symbol: RIPK2_HUMAN

Name: Receptor-interacting serine/threonine-protein kinase 2

UniProtKB Accession Codes:

O43353 B7Z748 Q6UWF0

Database IDs:

Citations:

PubMed ID: 9575181

Title: RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis.

PubMed ID: 9575181

DOI: 10.1074/jbc.273.20.12296

PubMed ID: 9642260

Title: RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase.

PubMed ID: 9642260

DOI: 10.1074/jbc.273.27.16968

PubMed ID: 9705938

Title: Identification of CARDIAK, a RIP-like kinase that associates with caspase-1.

PubMed ID: 9705938

DOI: 10.1016/s0960-9822(07)00352-1

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15044951

Title: Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition.

PubMed ID: 15044951

DOI: 10.1038/sj.emboj.7600175

PubMed ID: 14638696

Title: Rip2 participates in Bcl10 signaling and T-cell receptor-mediated NF-kappaB activation.

PubMed ID: 14638696

DOI: 10.1074/jbc.c300460200

PubMed ID: 16824733

Title: Identification of a regulatory autophosphorylation site in the serine-threonine kinase RIP2.

PubMed ID: 16824733

DOI: 10.1016/j.cellsig.2006.05.005

PubMed ID: 17355968

Title: The NOD2-RICK complex signals from the plasma membrane.

PubMed ID: 17355968

DOI: 10.1074/jbc.m606242200

PubMed ID: 17054981

Title: Solution structure of NOD1 CARD and mutational analysis of its interaction with the CARD of downstream kinase RICK.

PubMed ID: 17054981

DOI: 10.1016/j.jmb.2006.09.067

PubMed ID: 17562858

Title: Coordinated regulation of Toll-like receptor and NOD2 signaling by K63-linked polyubiquitin chains.

PubMed ID: 17562858

DOI: 10.1128/mcb.00270-07

PubMed ID: 18775659

Title: MEKK4 sequesters RIP2 to dictate NOD2 signal specificity.

PubMed ID: 18775659

DOI: 10.1016/j.cub.2008.07.084

PubMed ID: 18079694

Title: A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation.

PubMed ID: 18079694

DOI: 10.1038/sj.emboj.7601962

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19592251

Title: ITCH K63-ubiquitinates the NOD2 binding protein, RIP2, to influence inflammatory signaling pathways.

PubMed ID: 19592251

DOI: 10.1016/j.cub.2009.06.038

PubMed ID: 19464198

Title: Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2.

PubMed ID: 19464198

DOI: 10.1016/j.immuni.2009.04.011

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 21123652

Title: Inhibition of RIP2's tyrosine kinase activity limits NOD2-driven cytokine responses.

PubMed ID: 21123652

DOI: 10.1101/gad.1964410

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21931591

Title: cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4).

PubMed ID: 21931591

DOI: 10.1371/journal.pone.0022356

PubMed ID: 22520462

Title: Yersinia pseudotuberculosis effector YopJ subverts the Nod2/RICK/TAK1 pathway and activates caspase-1 to induce intestinal barrier dysfunction.

PubMed ID: 22520462

DOI: 10.1016/j.chom.2012.02.009

PubMed ID: 22672233

Title: NLRP10 enhances Shigella-induced pro-inflammatory responses.

PubMed ID: 22672233

DOI: 10.1111/j.1462-5822.2012.01822.x

PubMed ID: 21887730

Title: Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1.

PubMed ID: 21887730

DOI: 10.1002/ibd.21851

PubMed ID: 22607974

Title: The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity.

PubMed ID: 22607974

DOI: 10.1016/j.molcel.2012.04.014

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23806334

Title: OTULIN restricts Met1-linked ubiquitination to control innate immune signaling.

PubMed ID: 23806334

DOI: 10.1016/j.molcel.2013.06.004

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27812135

Title: Characterization and Genetic Analyses of New Genes Coding for NOD2 Interacting Proteins.

PubMed ID: 27812135

DOI: 10.1371/journal.pone.0165420

PubMed ID: 28436939

Title: An inflammatory bowel disease-risk variant in INAVA decreases pattern recognition receptor-induced outcomes.

PubMed ID: 28436939

DOI: 10.1172/jci86282

PubMed ID: 28656966

Title: E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP.

PubMed ID: 28656966

DOI: 10.1038/ncomms15865

PubMed ID: 27830463

Title: LRRK2 enhances Nod1/2-mediated inflammatory cytokine production by promoting Rip2 phosphorylation.

PubMed ID: 27830463

DOI: 10.1007/s13238-016-0326-x

PubMed ID: 29452636

Title: Disruption of XIAP-RIP2 association blocks NOD2-mediated inflammatory signaling.

PubMed ID: 29452636

DOI: 10.1016/j.molcel.2018.01.016

PubMed ID: 36221902

Title: Selective autophagy of RIPosomes maintains innate immune homeostasis during bacterial infection.

PubMed ID: 36221902

DOI: 10.15252/embj.2022111289

PubMed ID: 26646181

Title: Structural basis of death domain signaling in the p75 neurotrophin receptor.

PubMed ID: 26646181

DOI: 10.7554/elife.11692

PubMed ID: 28545134

Title: Structures of the inactive and active states of RIP2 kinase inform on the mechanism of activation.

PubMed ID: 28545134

DOI: 10.1371/journal.pone.0177161

PubMed ID: 30279485

Title: RIP2 filament formation is required for NOD2 dependent NF-kappaB signalling.

PubMed ID: 30279485

DOI: 10.1038/s41467-018-06451-3

PubMed ID: 30478312

Title: Structural basis of RIP2 activation and signaling.

PubMed ID: 30478312

DOI: 10.1038/s41467-018-07447-9

PubMed ID: 30026309

Title: Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling.

PubMed ID: 30026309

DOI: 10.15252/embj.201899372

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 540
Mass: 61195
Checksum: 575A692239505792
Sequence:

MNGEAICSAL PTIPYHKLAD LRYLSRGASG TVSSARHADW RVQVAVKHLH IHTPLLDSER 
KDVLREAEIL HKARFSYILP ILGICNEPEF LGIVTEYMPN GSLNELLHRK TEYPDVAWPL 
RFRILHEIAL GVNYLHNMTP PLLHHDLKTQ NILLDNEFHV KIADFGLSKW RMMSLSQSRS 
SKSAPEGGTI IYMPPENYEP GQKSRASIKH DIYSYAVITW EVLSRKQPFE DVTNPLQIMY 
SVSQGHRPVI NEESLPYDIP HRARMISLIE SGWAQNPDER PSFLKCLIEL EPVLRTFEEI 
TFLEAVIQLK KTKLQSVSSA IHLCDKKKME LSLNIPVNHG PQEESCGSSQ LHENSGSPET 
SRSLPAPQDN DFLSRKAQDC YFMKLHHCPG NHSWDSTISG SQRAAFCDHK TTPCSSAIIN 
PLSTAGNSER LQPGIAQQWI QSKREDIVNQ MTEACLNQSL DALLSRDLIM KEDYELVSTK 
PTRTSKVRQL LDTTDIQGEE FAKVIVQKLK DNKQMGLQPY PEILVVSRSP SLNLLQNKSM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RIPK2

Associated with

Cells (max top 100)

Other Information

RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis. PubMed ID: 9575181

RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase. PubMed ID: 9642260

Identification of CARDIAK, a RIP-like kinase that associates with caspase-1. PubMed ID: 9705938

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. PubMed ID: 12975309

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence and analysis of human chromosome 8. PubMed ID: 16421571

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition. PubMed ID: 15044951

Rip2 participates in Bcl10 signaling and T-cell receptor-mediated NF-kappaB activation. PubMed ID: 14638696

Identification of a regulatory autophosphorylation site in the serine-threonine kinase RIP2. PubMed ID: 16824733

The NOD2-RICK complex signals from the plasma membrane. PubMed ID: 17355968

Solution structure of NOD1 CARD and mutational analysis of its interaction with the CARD of downstream kinase RICK. PubMed ID: 17054981

Coordinated regulation of Toll-like receptor and NOD2 signaling by K63-linked polyubiquitin chains. PubMed ID: 17562858

MEKK4 sequesters RIP2 to dictate NOD2 signal specificity. PubMed ID: 18775659

A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation. PubMed ID: 18079694

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

ITCH K63-ubiquitinates the NOD2 binding protein, RIP2, to influence inflammatory signaling pathways. PubMed ID: 19592251

Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2. PubMed ID: 19464198

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Inhibition of RIP2's tyrosine kinase activity limits NOD2-driven cytokine responses. PubMed ID: 21123652

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4). PubMed ID: 21931591

Yersinia pseudotuberculosis effector YopJ subverts the Nod2/RICK/TAK1 pathway and activates caspase-1 to induce intestinal barrier dysfunction. PubMed ID: 22520462

NLRP10 enhances Shigella-induced pro-inflammatory responses. PubMed ID: 22672233

Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1. PubMed ID: 21887730

The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity. PubMed ID: 22607974

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

OTULIN restricts Met1-linked ubiquitination to control innate immune signaling. PubMed ID: 23806334

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Characterization and Genetic Analyses of New Genes Coding for NOD2 Interacting Proteins. PubMed ID: 27812135

An inflammatory bowel disease-risk variant in INAVA decreases pattern recognition receptor-induced outcomes. PubMed ID: 28436939

E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP. PubMed ID: 28656966

LRRK2 enhances Nod1/2-mediated inflammatory cytokine production by promoting Rip2 phosphorylation. PubMed ID: 27830463

Disruption of XIAP-RIP2 association blocks NOD2-mediated inflammatory signaling. PubMed ID: 29452636

Selective autophagy of RIPosomes maintains innate immune homeostasis during bacterial infection. PubMed ID: 36221902

Structural basis of death domain signaling in the p75 neurotrophin receptor. PubMed ID: 26646181

Structures of the inactive and active states of RIP2 kinase inform on the mechanism of activation. PubMed ID: 28545134

RIP2 filament formation is required for NOD2 dependent NF-kappaB signalling. PubMed ID: 30279485

Structural basis of RIP2 activation and signaling. PubMed ID: 30478312

Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling. PubMed ID: 30026309

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846