NAPG | ENSG00000134265 | NCBI 8774

Details for: NAPG

Associated with

Asparagine n-linked glycosylation
(R-HSA-446203)
Copi-dependent golgi-to-er retrograde traffic
(R-HSA-6811434)
Copi-mediated anterograde transport
(R-HSA-6807878)
Copii-mediated vesicle transport
(R-HSA-204005)
Er to golgi anterograde transport
(R-HSA-199977)
Golgi-to-er retrograde transport
(R-HSA-8856688)
Intra-golgi and retrograde golgi-to-er traffic
(R-HSA-6811442)
Intra-golgi traffic
(R-HSA-6811438)
Membrane trafficking
(R-HSA-199991)
Metabolism of proteins
(R-HSA-392499)
Post-translational protein modification
(R-HSA-597592)
Retrograde transport at the trans-golgi-network
(R-HSA-6811440)
Transport to the golgi and subsequent modification
(R-HSA-948021)
Vesicle-mediated transport
(R-HSA-5653656)
Extracellular exosome
(GO:0070062)
Golgi apparatus
(GO:0005794)
Intra-golgi vesicle-mediated transport
(GO:0006891)
Intracellular protein transport
(GO:0006886)
Lysosomal membrane
(GO:0005765)
Membrane fusion
(GO:0061025)
Mitochondrion
(GO:0005739)
Protein-containing complex assembly
(GO:0065003)
Protein binding
(GO:0005515)
Protein stabilization
(GO:0050821)
Snare complex
(GO:0031201)
Soluble nsf attachment protein activity
(GO:0005483)
Syntaxin binding
(GO:0019905)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 13.69

rCSI 49.28%

PRS 31.69
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 6.75

rCSI 16.4%

PRS 31.83
class switched memory B cell CL0000972

CSI 5.45

rCSI 4.07%

PRS 67.33
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 3.79

rCSI 22.31%

PRS 34.33
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 3.22

rCSI 2.17%

PRS 60.76
effector CD8-positive, alpha-beta T cell CL0001050

CSI 3.11

rCSI 2.36%

PRS 61.35
GABAergic neuron CL0000617

CSI 2.96

rCSI 9.93%

PRS 36.55
T-helper 17 cell CL0000899

CSI 2.93

rCSI 2.32%

PRS 71.88
myoepithelial cell CL0000185

CSI 2.9

rCSI 7.34%

PRS 57.52
pancreatic D cell CL0000173

CSI 2.89

rCSI 2.84%

PRS 51.88
direct pathway medium spiny neuron CL4023026

CSI 2.74

rCSI 65.56%

PRS 32.35
indirect pathway medium spiny neuron CL4023029

CSI 2.69

rCSI 65.01%

PRS 33.25
CD14-low, CD16-positive monocyte CL0002396

CSI 2.6

rCSI 2%

PRS 48.45
CD4-positive helper T cell CL0000492

CSI 2.6

rCSI 1.96%

PRS 62.63
common myeloid progenitor CL0000049

CSI 2.59

rCSI 2.1%

PRS 50.11
cerebellar granule cell CL0001031

CSI 2.48

rCSI 3.64%

PRS 44.25
squamous epithelial cell CL0000076

CSI 2.46

rCSI 5.83%

PRS 54.67
multi-ciliated epithelial cell CL0005012

CSI 2.36

rCSI 2.36%

PRS 43.27
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 2.36

rCSI 1.39%

PRS 65.49
alveolar type 1 fibroblast cell CL4028004

CSI 2.29

rCSI 2.51%

PRS 53.12
Cajal-Retzius cell CL0000695

CSI 2.29

rCSI 17.91%

PRS 64.44
mature B cell CL0000785

CSI 2.24

rCSI 1.95%

PRS 59.39
double negative thymocyte CL0002489

CSI 2.24

rCSI 1.56%

PRS 58.89
retinal ganglion cell CL0000740

CSI 2.21

rCSI 4.88%

PRS 36.99
lung ciliated cell CL1000271

CSI 2.19

rCSI 2.53%

PRS 39.4
hepatocyte CL0000182

CSI 2.13

rCSI 3.81%

PRS 47.8
cerebral cortex endothelial cell CL1001602

CSI 2.13

rCSI 3.68%

PRS 39.84
ON-bipolar cell CL0000749

CSI 2.09

rCSI 3.11%

PRS 51.55
interstitial cell of Cajal CL0002088

CSI 2.06

rCSI 2.63%

PRS 55.07
L6b glutamatergic cortical neuron CL4023038

CSI 2.06

rCSI 6.45%

PRS 34.24
ionocyte CL0005006

CSI 2.06

rCSI 2.21%

PRS 47.51
choroid plexus epithelial cell CL0000706

CSI 2.04

rCSI 3.35%

PRS 39.48
fallopian tube secretory epithelial cell CL4030006

CSI 1.98

rCSI 1.9%

PRS 49.58
T follicular helper cell CL0002038

CSI 1.96

rCSI 1.47%

PRS 64.28
neural crest cell CL0011012

CSI 1.96

rCSI 1.55%

PRS 36.78
perivascular cell CL4033054

CSI 1.96

rCSI 2.68%

PRS 54.43
pro-B cell CL0000826

CSI 1.95

rCSI 1.62%

PRS 50.65
plasmacytoid dendritic cell, human CL0001058

CSI 1.94

rCSI 1.35%

PRS 51.43
retinal rod cell CL0000604

CSI 1.92

rCSI 3.39%

PRS 47.08
plasmablast CL0000980

CSI 1.87

rCSI 1.47%

PRS 55.91
lymphoid lineage restricted progenitor cell CL0000838

CSI 1.86

rCSI 7.23%

PRS 70.02
neuroblast (sensu Vertebrata) CL0000031

CSI 1.85

rCSI 2.37%

PRS 47.27
megakaryocyte-erythroid progenitor cell CL0000050

CSI 1.84

rCSI 1.66%

PRS 46.06
interneuron CL0000099

CSI 1.84

rCSI 3.69%

PRS 38.91
enteric smooth muscle cell CL0002504

CSI 1.83

rCSI 2.61%

PRS 51.88
secretory cell CL0000151

CSI 1.83

rCSI 1.91%

PRS 49.85
nasal mucosa goblet cell CL0002480

CSI 1.81

rCSI 2.1%

PRS 59.01
Kupffer cell CL0000091

CSI 1.79

rCSI 4.09%

PRS 48.71
precursor B cell CL0000817

CSI 1.78

rCSI 1.56%

PRS 59.32
renal alpha-intercalated cell CL0005011

CSI 1.76

rCSI 2.35%

PRS 57.81
ciliated epithelial cell CL0000067

CSI 1.76

rCSI 1.54%

PRS 38.18
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 1.75

rCSI 3.08%

PRS 31.89
epithelial cell of lower respiratory tract CL0002632

CSI 1.73

rCSI 1.34%

PRS 49.94
Mueller cell CL0000636

CSI 1.72

rCSI 3.92%

PRS 42.24
hepatic stellate cell CL0000632

CSI 1.68

rCSI 6.29%

PRS 41.97
hematopoietic stem cell CL0000037

CSI 1.68

rCSI 1.11%

PRS 53.05
goblet cell CL0000160

CSI 1.65

rCSI 1.56%

PRS 49.94
basal cell CL0000646

CSI 1.64

rCSI 2.2%

PRS 50.54
group 3 innate lymphoid cell CL0001071

CSI 1.63

rCSI 1.23%

PRS 53.28
pulmonary ionocyte CL0017000

CSI 1.61

rCSI 1.96%

PRS 57.07
inhibitory interneuron CL0000498

CSI 1.57

rCSI 3.63%

PRS 40.07
Bergmann glial cell CL0000644

CSI 1.56

rCSI 2.14%

PRS 44.74
parietal epithelial cell CL1000452

CSI 1.55

rCSI 4.13%

PRS 41.49
rod bipolar cell CL0000751

CSI 1.54

rCSI 2.77%

PRS 42.62
colon epithelial cell CL0011108

CSI 1.54

rCSI 1.61%

PRS 46.27
CD14-positive monocyte CL0001054

CSI 1.53

rCSI 1.9%

PRS 60.49
naive T cell CL0000898

CSI 1.51

rCSI 1.05%

PRS 62.9
lung secretory cell CL1000272

CSI 1.51

rCSI 3.74%

PRS 47.21
fibroblast of cardiac tissue CL0002548

CSI 1.5

rCSI 7.21%

PRS 48.06
chondrocyte CL0000138

CSI 1.5

rCSI 2.38%

PRS 41.97
vascular leptomeningeal cell CL4023051

CSI 1.47

rCSI 2.59%

PRS 41.47
granulocyte CL0000094

CSI 1.46

rCSI 2.23%

PRS 58.82
cardiac endothelial cell CL0010008

CSI 1.46

rCSI 5.89%

PRS 47.72
intestine goblet cell CL0019031

CSI 1.44

rCSI 1.28%

PRS 48.01
effector CD4-positive, alpha-beta T cell CL0001044

CSI 1.44

rCSI 4.12%

PRS 67.92
common dendritic progenitor CL0001029

CSI 1.42

rCSI 1.78%

PRS 59.34
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 1.42

rCSI 1.64%

PRS 43.37
club cell CL0000158

CSI 1.41

rCSI 2.07%

PRS 47.88
extravillous trophoblast CL0008036

CSI 1.41

rCSI 1.75%

PRS 45.14
blood vessel endothelial cell CL0000071

CSI 1.41

rCSI 2.93%

PRS 46.99
stem cell CL0000034

CSI 1.41

rCSI 1.36%

PRS 39.92
keratinocyte CL0000312

CSI 1.4

rCSI 1.17%

PRS 54.25
cerebral cortex neuron CL0010012

CSI 1.37

rCSI 5.6%

PRS 45.87
transit amplifying cell of colon CL0009011

CSI 1.37

rCSI 1.61%

PRS 52.42
erythrocyte CL0000232

CSI 1.37

rCSI 3.1%

PRS 54.63
small intestine goblet cell CL1000495

CSI 1.37

rCSI 2.99%

PRS 58.83
epithelial cell of lung CL0000082

CSI 1.36

rCSI 1.13%

PRS 48.02
pancreatic A cell CL0000171

CSI 1.35

rCSI 1.42%

PRS 52.52
cerebral cortex GABAergic interneuron CL0010011

CSI 1.34

rCSI 3.96%

PRS 53.37
pvalb GABAergic cortical interneuron CL4023018

CSI 1.33

rCSI 1.66%

PRS 31.21
sncg GABAergic cortical interneuron CL4023015

CSI 1.33

rCSI 2.14%

PRS 35.03
ependymal cell CL0000065

CSI 1.3

rCSI 2.64%

PRS 31.07
dendritic cell, human CL0001056

CSI 1.28

rCSI 1.97%

PRS 56.87
acinar cell CL0000622

CSI 1.28

rCSI 1.87%

PRS 60.69
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 1.26

rCSI 3.26%

PRS 45.04
pancreatic ductal cell CL0002079

CSI 1.25

rCSI 2.43%

PRS 51.54
glioblast CL0000030

CSI 1.25

rCSI 1.99%

PRS 42.87
BEST4+ enteroycte CL4030026

CSI 1.25

rCSI 1.55%

PRS 51.76
retinal bipolar neuron CL0000748

CSI 1.22

rCSI 2.28%

PRS 38.6
regular atrial cardiac myocyte CL0002129

CSI 1.21

rCSI 3.91%

PRS 48.12

acinar cell of salivary gland CL0002623

CSI 0.1

rCSI 1.6%

PRS 71.7%
regular ventricular cardiac myocyte CL0002131

CSI 0.2

rCSI 1.2%

PRS 41.5%
medium spiny neuron CL1001474

CSI 0.3

rCSI 2.3%

PRS 36.6%
blood vessel smooth muscle cell CL0019018

CSI 0.3

rCSI 2.4%

PRS 43.3%
central nervous system neuron CL2000029

CSI 0.4

rCSI 2.6%

PRS 36.9%
dopaminergic neuron CL0000700

CSI 0.4

rCSI 2.3%

PRS 35.3%
ON midget ganglion cell CL4033046

CSI 0.4

rCSI 8.6%

PRS 41.1%
near-projecting glutamatergic cortical neuron CL4023012

CSI 0.4

rCSI 1.7%

PRS 33.8%
megakaryocyte CL0000556

CSI 0.5

rCSI 2.1%

PRS 64.9%
microcirculation associated smooth muscle cell CL0008035

CSI 0.5

rCSI 1.4%

PRS 51.5%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 0.6

rCSI 1.7%

PRS 36.6%
OFF midget ganglion cell CL4033047

CSI 0.6

rCSI 11.7%

PRS 42.4%
type B pancreatic cell CL0000169

CSI 0.6

rCSI 1.3%

PRS 46.8%
retina horizontal cell CL0000745

CSI 0.6

rCSI 0.9%

PRS 45.8%
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 0.6

rCSI 3.2%

PRS 60.9%
neural progenitor cell CL0011020

CSI 0.7

rCSI 3.1%

PRS 42.0%
cardiac neuron CL0010022

CSI 0.7

rCSI 2.3%

PRS 46.0%
amacrine cell CL0000561

CSI 0.7

rCSI 2.1%

PRS 40.3%
endothelial cell of placenta CL0009092

CSI 0.7

rCSI 3.6%

PRS 61.1%
placental villous trophoblast CL2000060

CSI 0.8

rCSI 1.2%

PRS 47.1%
helper T cell CL0000912

CSI 0.8

rCSI 1.1%

PRS 57.2%
L5/6 near-projecting glutamatergic neuron CL4030067

CSI 0.8

rCSI 2.5%

PRS 37.5%
kidney connecting tubule epithelial cell CL1000768

CSI 0.8

rCSI 2.0%

PRS 39.4%
lung macrophage CL1001603

CSI 0.8

rCSI 1.8%

PRS 56.2%
GABAergic amacrine cell CL4030027

CSI 0.8

rCSI 2.9%

PRS 39.8%
intermediate monocyte CL0002393

CSI 0.8

rCSI 1.3%

PRS 51.9%
OFF-bipolar cell CL0000750

CSI 0.9

rCSI 1.2%

PRS 58.6%
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 0.9

rCSI 1.1%

PRS 42.2%
CD1c-positive myeloid dendritic cell CL0002399

CSI 0.9

rCSI 1.1%

PRS 57.4%
tracheal goblet cell CL1000329

CSI 0.9

rCSI 2.1%

PRS 67.5%
lamp5 GABAergic cortical interneuron CL4023011

CSI 1.0

rCSI 1.7%

PRS 32.8%
sst GABAergic cortical interneuron CL4023017

CSI 1.0

rCSI 1.3%

PRS 33.9%
Hofbauer cell CL3000001

CSI 1.0

rCSI 1.9%

PRS 59.7%
cardiac muscle cell CL0000746

CSI 1.0

rCSI 1.4%

PRS 40.0%
vascular associated smooth muscle cell CL0000359

CSI 1.0

rCSI 3.3%

PRS 51.7%
respiratory basal cell CL0002633

CSI 1.0

rCSI 1.1%

PRS 55.2%
VIP GABAergic cortical interneuron CL4023016

CSI 1.0

rCSI 1.2%

PRS 32.7%
conjunctival epithelial cell CL1000432

CSI 1.0

rCSI 1.6%

PRS 49.9%
neuron CL0000540

CSI 1.1

rCSI 2.8%

PRS 40.6%
CD14-positive, CD16-positive monocyte CL0002397

CSI 1.1

rCSI 1.4%

PRS 62.8%
granulocyte monocyte progenitor cell CL0000557

CSI 1.1

rCSI 0.9%

PRS 53.4%
respiratory suprabasal cell CL4033048

CSI 1.1

rCSI 1.4%

PRS 54.1%
alveolar macrophage CL0000583

CSI 1.1

rCSI 1.8%

PRS 54.8%
enterocyte CL0000584

CSI 1.1

rCSI 1.8%

PRS 56.8%
enteroendocrine cell CL0000164

CSI 1.1

rCSI 1.5%

PRS 51.8%
duct epithelial cell CL0000068

CSI 1.1

rCSI 1.7%

PRS 52.6%
differentiation-committed oligodendrocyte precursor CL4023059

CSI 1.1

rCSI 2.1%

PRS 42.4%
intrahepatic cholangiocyte CL0002538

CSI 1.2

rCSI 2.8%

PRS 63.7%
retinal cone cell CL0000573

CSI 1.2

rCSI 1.9%

PRS 39.7%
pancreatic acinar cell CL0002064

CSI 1.2

rCSI 1.6%

PRS 54.5%
retinal pigment epithelial cell CL0002586

CSI 1.2

rCSI 2.4%

PRS 47.9%
astrocyte of the cerebral cortex CL0002605

CSI 1.2

rCSI 2.7%

PRS 33.7%
platelet CL0000233

CSI 1.2

rCSI 4.9%

PRS 58.2%
regular atrial cardiac myocyte CL0002129

CSI 1.2

rCSI 3.9%

PRS 48.1%
retinal bipolar neuron CL0000748

CSI 1.2

rCSI 2.3%

PRS 38.6%
BEST4+ enteroycte CL4030026

CSI 1.3

rCSI 1.6%

PRS 51.8%
glioblast CL0000030

CSI 1.3

rCSI 2.0%

PRS 42.9%
pancreatic ductal cell CL0002079

CSI 1.3

rCSI 2.4%

PRS 51.5%
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 1.3

rCSI 3.3%

PRS 45.0%
acinar cell CL0000622

CSI 1.3

rCSI 1.9%

PRS 60.7%
dendritic cell, human CL0001056

CSI 1.3

rCSI 2.0%

PRS 56.9%
ependymal cell CL0000065

CSI 1.3

rCSI 2.6%

PRS 31.1%
sncg GABAergic cortical interneuron CL4023015

CSI 1.3

rCSI 2.1%

PRS 35.0%
pvalb GABAergic cortical interneuron CL4023018

CSI 1.3

rCSI 1.7%

PRS 31.2%
cerebral cortex GABAergic interneuron CL0010011

CSI 1.3

rCSI 4.0%

PRS 53.4%
pancreatic A cell CL0000171

CSI 1.4

rCSI 1.4%

PRS 52.5%
epithelial cell of lung CL0000082

CSI 1.4

rCSI 1.1%

PRS 48.0%
small intestine goblet cell CL1000495

CSI 1.4

rCSI 3.0%

PRS 58.8%
erythrocyte CL0000232

CSI 1.4

rCSI 3.1%

PRS 54.6%
transit amplifying cell of colon CL0009011

CSI 1.4

rCSI 1.6%

PRS 52.4%
cerebral cortex neuron CL0010012

CSI 1.4

rCSI 5.6%

PRS 45.9%
keratinocyte CL0000312

CSI 1.4

rCSI 1.2%

PRS 54.3%
stem cell CL0000034

CSI 1.4

rCSI 1.4%

PRS 39.9%
blood vessel endothelial cell CL0000071

CSI 1.4

rCSI 2.9%

PRS 47.0%
extravillous trophoblast CL0008036

CSI 1.4

rCSI 1.8%

PRS 45.1%
club cell CL0000158

CSI 1.4

rCSI 2.1%

PRS 47.9%
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 1.4

rCSI 1.6%

PRS 43.4%
common dendritic progenitor CL0001029

CSI 1.4

rCSI 1.8%

PRS 59.3%
effector CD4-positive, alpha-beta T cell CL0001044

CSI 1.4

rCSI 4.1%

PRS 67.9%
intestine goblet cell CL0019031

CSI 1.4

rCSI 1.3%

PRS 48.0%
cardiac endothelial cell CL0010008

CSI 1.5

rCSI 5.9%

PRS 47.7%
granulocyte CL0000094

CSI 1.5

rCSI 2.2%

PRS 58.8%
vascular leptomeningeal cell CL4023051

CSI 1.5

rCSI 2.6%

PRS 41.5%
chondrocyte CL0000138

CSI 1.5

rCSI 2.4%

PRS 42.0%
fibroblast of cardiac tissue CL0002548

CSI 1.5

rCSI 7.2%

PRS 48.1%
lung secretory cell CL1000272

CSI 1.5

rCSI 3.7%

PRS 47.2%
naive T cell CL0000898

CSI 1.5

rCSI 1.1%

PRS 62.9%
CD14-positive monocyte CL0001054

CSI 1.5

rCSI 1.9%

PRS 60.5%
colon epithelial cell CL0011108

CSI 1.5

rCSI 1.6%

PRS 46.3%
rod bipolar cell CL0000751

CSI 1.5

rCSI 2.8%

PRS 42.6%
parietal epithelial cell CL1000452

CSI 1.6

rCSI 4.1%

PRS 41.5%
Bergmann glial cell CL0000644

CSI 1.6

rCSI 2.1%

PRS 44.7%
inhibitory interneuron CL0000498

CSI 1.6

rCSI 3.6%

PRS 40.1%
pulmonary ionocyte CL0017000

CSI 1.6

rCSI 2.0%

PRS 57.1%
group 3 innate lymphoid cell CL0001071

CSI 1.6

rCSI 1.2%

PRS 53.3%
basal cell CL0000646

CSI 1.6

rCSI 2.2%

PRS 50.5%
goblet cell CL0000160

CSI 1.7

rCSI 1.6%

PRS 49.9%
hematopoietic stem cell CL0000037

CSI 1.7

rCSI 1.1%

PRS 53.1%
hepatic stellate cell CL0000632

CSI 1.7

rCSI 6.3%

PRS 42.0%
Mueller cell CL0000636

CSI 1.7

rCSI 3.9%

PRS 42.2%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

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Node Color (Target Cell CSI, relative to current network):
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- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [NAPG](/details-gene/8774) (N-ethylmaleimide-sensitive factor attachment protein gamma) is a protein-coding gene that functions as a core component of the intracellular membrane trafficking machinery. As a soluble NSF attachment protein (SNAP), it plays a pivotal role in the assembly and function of SNARE complexes, which are essential for vesicle fusion events. Its functions are central to biological processes such as [intra-golgi vesicle-mediated transport](/details-go/GO:0006891), [membrane fusion](/details-go/GO:0061025), and general protein transport. Expression data indicates that **Overall**, [NAPG](/details-gene/8774) is most significant in cell types with high secretory or membrane trafficking demands, particularly neuronal subtypes like the [L5 extratelencephalic projecting glutamatergic cortical neuron](/details-cell/CL4023041) and various immune cells, including [class switched memory B cell](/details-cell/CL0000972) and memory T cell populations. ## Cellular Roles and Expression Landscape The expression profile of [NAPG](/details-gene/8774) underscores its fundamental role in cellular logistics, with particularly high significance in metabolically active and secretory cells. **Overall**, the gene's most prominent expression is within the central nervous system. It shows the highest cell significance index in [L5 extratelencephalic projecting glutamatergic cortical neuron](/details-cell/CL4023041) (CSI: 13.69), followed by other neuronal populations such as [L2/3-6 intratelencephalic projecting glutamatergic neuron](/details-cell/CL4023040) and [GABAergic neuron](/details-cell/CL0000617). This pattern suggests a critical function in supporting the intense vesicle trafficking required for synaptic transmission and neuronal maintenance. Beyond the nervous system, [NAPG](/details-gene/8774) is also highly significant within the immune system, particularly in cells associated with immunological memory and effector functions. It is a key marker in [class switched memory B cell](/details-cell/CL0000972), [central memory CD8-positive, alpha-beta T cell](/details-cell/CL0000907), and [effector CD8-positive, alpha-beta T cell](/details-cell/CL0001050). This is consistent with a role in facilitating the rapid secretion of antibodies and cytokines, which is a hallmark of an effective immune response. The gene's importance is further highlighted by its expression in other secretory cell types, such as [myoepithelial cell](/details-cell/CL0000185) and [pancreatic D cell](/details-cell/CL0000173), reinforcing its broad role in protein and vesicle transport across diverse tissues. ## Pathways and Molecular Function Functional annotations for [NAPG](/details-gene/8774) confirm its identity as a key facilitator of intracellular transport. At the molecular level, it exhibits [soluble nsf attachment protein activity](/details-go/GO:0005483) and [syntaxin binding](/details-go/GO:0019905) capabilities, which are essential for its role within the [Snare complex](/details-go/GO:0031201). This complex mediates the fusion of vesicles with target membranes, a fundamental step in transport pathways. The gene is extensively involved in numerous Reactome pathways related to [Vesicle-mediated transport](/details-pathway/R-HSA-5653656) and [Metabolism of proteins](/details-pathway/R-HSA-392499). Specifically, it participates in both anterograde and retrograde trafficking between the endoplasmic reticulum and the Golgi apparatus, as evidenced by its association with pathways like [Er to golgi anterograde transport](/details-pathway/R-HSA-199977) and [Golgi-to-er retrograde transport](/details-pathway/R-HSA-8856688). Its central role in [Intra-golgi traffic](/details-pathway/R-HSA-6811438) is crucial for protein modification and sorting. This function is vital for the physiological activities of the highly expressing neuronal and immune cells, which depend on precise and efficient protein secretion and membrane management. Early research has indeed implicated NAPG (gamma-SNAP) in regulated secretion in platelets, further supporting its role in exocytosis ([Link](https://pubmed.ncbi.nlm.nih.gov/9269766)). ## Research Directions Given that [NAPG](/details-gene/8774) is a ubiquitous and essential component of the cellular trafficking machinery, future research should focus on its context-specific roles and potential contribution to diseases characterized by trafficking defects. ### Proposed Hypotheses 1. **Neurological Function:** The exceptionally high significance of [NAPG](/details-gene/8774) in specific long-projection neurons, such as the [L5 extratelencephalic projecting glutamatergic cortical neuron](/details-cell/CL4023041), suggests that its expression level is rate-limiting for maintaining neuronal health and connectivity. It is hypothesized that subtle reductions in [NAPG](/details-gene/8774) function could disproportionately affect these high-demand neurons, contributing to the etiology of synaptopathies or neurodegenerative diseases associated with impaired axonal transport. 2. **Immunological Memory:** The high significance of [NAPG](/details-gene/8774) in memory lymphocyte populations, including [class switched memory B cell](/details-cell/CL0000972) and [central memory CD8-positive, alpha-beta T cell](/details-cell/CL0000907), suggests a specialized role in preparing these cells for a rapid recall response. We hypothesize that [NAPG](/details-gene/8774) is critical for pre-establishing and maintaining the robust secretory infrastructure required for the swift deployment of antibodies or cytotoxic molecules upon secondary antigen exposure. ### Experimental Approach To test the role of [NAPG](/details-gene/8774) in the immunological memory response (Hypothesis 2), a conditional knockout mouse model could be employed. `Napg`-floxed mice could be crossed with mice expressing Cre recombinase under the control of a B-cell-specific (e.g., `CD19-Cre`) or T-cell-specific (e.g., `CD4-Cre`) promoter. Following immunization and subsequent antigen re-challenge, the magnitude and kinetics of the secondary immune response could be assessed. Key readouts would include serum antibody titers (for B-cell knockout) and effector cytokine production or target cell lysis (for T-cell knockout) compared to wild-type controls. A failure to mount an efficient recall response in the knockout animals would confirm the critical role of [NAPG](/details-gene/8774) in memory cell function. ### Therapeutic Potential As a core and ubiquitous component of the membrane trafficking machinery, systemic inhibition of [NAPG](/details-gene/8774) would likely result in significant, widespread cellular toxicity, making it a poor therapeutic target for systemic therapies. However, its role in supporting high rates of secretion could potentially be exploited in specific pathological contexts. In cancers characterized by hypersecretion of growth factors or extracellular matrix components, targeted **inhibition** of [NAPG](/details-gene/8774) activity specifically in tumor cells could be a viable strategy. This would require a sophisticated delivery mechanism, such as an antibody-drug conjugate or a tumor-homing nanoparticle, to limit off-target effects.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

SNAG_HUMAN

Genular Protein ID: 2647090983

Symbol: SNAG_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q99747 B4DFC9 Q9BUV1

Database IDs:

Citations:

PubMed ID: 9269766

Title: Regulated secretion in platelets: identification of elements of the platelet exocytosis machinery.

PubMed ID: 9269766

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11278501

Title: Gaf-1, a gamma-SNAP-binding protein associated with the mitochondria.

PubMed ID: 11278501

DOI: 10.1074/jbc.m009424200

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

Length: 312
Mass: 34746
Checksum: C37D73C1AEFD48C8
Sequence:

MAAQKINEGL EHLAKAEKYL KTGFLKWKPD YDSAASEYGK AAVAFKNAKQ FEQAKDACLR 
EAVAHENNRA LFHAAKAYEQ AGMMLKEMQK LPEAVQLIEK ASMMYLENGT PDTAAMALER 
AGKLIENVDP EKAVQLYQQT ANVFENEERL RQAVELLGKA SRLLVRGRRF DEAALSIQKE 
KNIYKEIENY PTCYKKTIAQ VLVHLHRNDY VAAERCVRES YSIPGFNGSE DCAALEQLLE 
GYDQQDQDQV SDVCNSPLFK YMDNDYAKLG LSLVVPGGGI KKKSPATPQA KPDGVTATAA 
DEEEDEYSGG LC

	Overall overall
	Acute kidney failure MONDO0002492
	Alzheimer disease MONDO0004975
	Amyotrophic lateral sclerosis MONDO0004976
	Basal cell carcinoma MONDO0020804
	Bipolar disorder MONDO0004985
	Bipolar I disorder MONDO0001866
	Blood UBERON0000178
	\|— Blood COVID-19 UBERON0000178_MONDO0100096
	\|— Blood Healthy UBERON0000178_PATO0000461
	Bone marrow UBERON0002371
	Brain UBERON0000955
	Breast UBERON0000310
	\|— Breast cancer MONDO0007254
	Bronchus UBERON0002185
	Cerebellum UBERON0002037
	\|— Cerebellum Healthy UBERON0002037_PATO0000461
	Cerebral cortex UBERON0000956
	\|— Cerebral cortex Healthy UBERON0000956_PATO0000461
	Choroid plexus UBERON0001886
	Colon UBERON0001155
	Cortex of kidney UBERON0001225
	\|— Cortex of kidney Healthy UBERON0001225_PATO0000461
	COVID-19 MONDO0100096
	Crohn disease MONDO0005011
	Dementia MONDO0001627
	Dorsolateral prefrontal cortex UBERON0009834
	\|— Dorsolateral prefrontal cortex Bipolar disorder UBERON0009834_MONDO0004985
	\|— Dorsolateral prefrontal cortex Bipolar I disorder UBERON0009834_MONDO0001866
	\|— Dorsolateral prefrontal cortex Dementia UBERON0009834_MONDO0001627
	\|— Dorsolateral prefrontal cortex Healthy UBERON0009834_PATO0000461
	\|— Dorsolateral prefrontal cortex Schizophrenia UBERON0009834_MONDO0005090
	\|— Dorsolateral prefrontal cortex Vascular dementia UBERON0009834_MONDO0004648
	Fovea centralis UBERON0001786
	\|— Fovea centralis Healthy UBERON0001786_PATO0000461
	Frontal cortex UBERON0001870
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Heart left ventricle UBERON0002084
	\|— Heart left ventricle Healthy UBERON0002084_PATO0000461
	Heart right ventricle UBERON0002080
	\|— Heart right ventricle Healthy UBERON0002080_PATO0000461
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Hypothalamus UBERON0001898
	\|— Hypothalamus Healthy UBERON0001898_PATO0000461
	Ileum UBERON0002116
	Interventricular septum UBERON0002094
	Islet of Langerhans UBERON0000006
	Isolated focal cortical dysplasia type II MONDO0011818
	Kidney UBERON0002113
	\|— Kidney Healthy UBERON0002113_PATO0000461
	Leukoencephalopathy, diffuse hereditary, with spheroids 1 MONDO0800027
	Liver UBERON0002107
	\|— Liver Healthy UBERON0002107_PATO0000461
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	\|— Lung adenocarcinoma MONDO0005061
	Lymph node UBERON0000029
	Malignant ovarian serous tumor MONDO0024885
	Medial orbital frontal cortex UBERON0022352
	Midbrain UBERON0001891
	\|— Midbrain Healthy UBERON0001891_PATO0000461
	Nasopharynx UBERON0001728
	Neocortex UBERON0001950
	\|— Neocortex Healthy UBERON0001950_PATO0000461
	Neuroblastoma MONDO0005072
	Occipital cortex UBERON0016540
	Parkinson disease MONDO0005180
	Peripheral region of retina UBERON0013682
	\|— Peripheral region of retina Healthy UBERON0013682_PATO0000461
	Placenta UBERON0001987
	Pons UBERON0000988
	\|— Pons Healthy UBERON0000988_PATO0000461
	Prefrontal cortex UBERON0000451
	Primary motor cortex UBERON0001384
	Renal medulla UBERON0000362
	Respiratory airway UBERON0001005
	\|— Respiratory airway COVID-19 UBERON0001005_MONDO0100096
	Retina UBERON0000966
	\|— Retina Healthy UBERON0000966_PATO0000461
	Right atrium auricular region UBERON0006631
	Schizophrenia MONDO0005090
	Small cell lung carcinoma MONDO0008433
	Substantia nigra pars compacta UBERON0001965
	Telencephalon UBERON0001893
	\|— Telencephalon Healthy UBERON0001893_PATO0000461
	Thalamic complex UBERON0010225
	\|— Thalamic complex Healthy UBERON0010225_PATO0000461
	UBERON0005290 UBERON0005290
	\|— UBERON0005290 Healthy UBERON0005290_PATO0000461
	UBERON8440012 UBERON8440012
	\|— UBERON8440012 Healthy UBERON8440012_PATO0000461
	Vascular dementia MONDO0004648

Details for: NAPG

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Regulated secretion in platelets: identification of elements of the platelet exocytosis machinery. PubMed ID: 9269766

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence and analysis of human chromosome 18. PubMed ID: 16177791

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Gaf-1, a gamma-SNAP-binding protein associated with the mitochondria. PubMed ID: 11278501

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. PubMed ID: 15592455

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Initial characterization of the human central proteome. PubMed ID: 21269460

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712