Details for: NAPG

Gene ID: 8774

Symbol: NAPG

Ensembl ID: ENSG00000134265

Description: NSF attachment protein gamma

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 246.8735
    Cell Significance Index: -38.4000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 154.6660
    Cell Significance Index: -39.2300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 106.3606
    Cell Significance Index: -43.8200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 88.1762
    Cell Significance Index: -41.6300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 75.0508
    Cell Significance Index: -38.6100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 62.0546
    Cell Significance Index: -41.6400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 32.6532
    Cell Significance Index: -40.2600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.4726
    Cell Significance Index: -38.7700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.4739
    Cell Significance Index: -32.1700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.3851
    Cell Significance Index: -40.9800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.3244
    Cell Significance Index: -16.0300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.5594
    Cell Significance Index: 34.9200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.4672
    Cell Significance Index: 287.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7539
    Cell Significance Index: 351.8400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.3486
    Cell Significance Index: 90.6800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.1754
    Cell Significance Index: 9.0600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9739
    Cell Significance Index: 105.9400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.9384
    Cell Significance Index: 49.2700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9365
    Cell Significance Index: 185.8600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9348
    Cell Significance Index: 48.5600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.8224
    Cell Significance Index: 21.9600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8078
    Cell Significance Index: 61.9900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7785
    Cell Significance Index: 140.3400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6927
    Cell Significance Index: 248.4600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6661
    Cell Significance Index: 14.4300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.6360
    Cell Significance Index: 28.1300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6217
    Cell Significance Index: 28.1800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.6168
    Cell Significance Index: 9.9000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.5876
    Cell Significance Index: 22.2500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5394
    Cell Significance Index: 66.3200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5092
    Cell Significance Index: 14.6700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4822
    Cell Significance Index: 33.3500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4566
    Cell Significance Index: 10.5500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4463
    Cell Significance Index: 20.8100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3825
    Cell Significance Index: 208.8700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3712
    Cell Significance Index: 164.1000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3643
    Cell Significance Index: 3.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3558
    Cell Significance Index: 21.8700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3513
    Cell Significance Index: 242.9700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3119
    Cell Significance Index: 8.4900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3005
    Cell Significance Index: 18.9400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2989
    Cell Significance Index: 56.8800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.2989
    Cell Significance Index: 8.5300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2841
    Cell Significance Index: 39.0200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: 0.2694
    Cell Significance Index: 3.4000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2595
    Cell Significance Index: 42.2100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2090
    Cell Significance Index: 5.8400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1882
    Cell Significance Index: 10.5600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1598
    Cell Significance Index: 18.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1253
    Cell Significance Index: 5.8900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1158
    Cell Significance Index: 73.5700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0890
    Cell Significance Index: 15.2000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0683
    Cell Significance Index: 8.7600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0542
    Cell Significance Index: 3.8300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0478
    Cell Significance Index: 0.8200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0456
    Cell Significance Index: 84.1100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0301
    Cell Significance Index: 46.3400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0275
    Cell Significance Index: 51.8100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0226
    Cell Significance Index: 30.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0172
    Cell Significance Index: 2.2200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0150
    Cell Significance Index: 1.4800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0032
    Cell Significance Index: -0.2400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0035
    Cell Significance Index: -0.2200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0090
    Cell Significance Index: -6.6000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0103
    Cell Significance Index: -7.6300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0108
    Cell Significance Index: -4.9100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0153
    Cell Significance Index: -9.5300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0310
    Cell Significance Index: -17.4600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0311
    Cell Significance Index: -23.5600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0823
    Cell Significance Index: -8.4100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0926
    Cell Significance Index: -2.7200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0947
    Cell Significance Index: -1.1800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1035
    Cell Significance Index: -2.0200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1051
    Cell Significance Index: -22.1300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1160
    Cell Significance Index: -2.4700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1195
    Cell Significance Index: -34.3900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1282
    Cell Significance Index: -3.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1339
    Cell Significance Index: -15.3400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1368
    Cell Significance Index: -19.8900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1548
    Cell Significance Index: -3.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1591
    Cell Significance Index: -5.5900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1622
    Cell Significance Index: -3.8900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1738
    Cell Significance Index: -1.0500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2258
    Cell Significance Index: -6.0500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2734
    Cell Significance Index: -31.2100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2764
    Cell Significance Index: -3.3000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3793
    Cell Significance Index: -30.0400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3813
    Cell Significance Index: -39.7000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3898
    Cell Significance Index: -10.0200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4985
    Cell Significance Index: -10.6600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4999
    Cell Significance Index: -7.3800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.5384
    Cell Significance Index: -4.3900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5904
    Cell Significance Index: -12.5300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6534
    Cell Significance Index: -20.8100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6686
    Cell Significance Index: -40.9900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6988
    Cell Significance Index: -22.8800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7039
    Cell Significance Index: -18.8300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.7121
    Cell Significance Index: -10.6700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7153
    Cell Significance Index: -22.9100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7564
    Cell Significance Index: -26.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Protein Binding:** NAPG is known to interact with various proteins, including SNAG, syntaxin, and the SNARE complex, which are essential for vesicle-mediated transport and protein trafficking. 2. **Glycosylation:** NAPG is involved in the asparagine n-linked glycosylation pathway, which is critical for protein stability, folding, and function. 3. **Cellular Localization:** NAPG is predominantly expressed in germ cells, neurons, and specific types of neurons, highlighting its role in neural development and function. 4. **Expression Patterns:** NAPG is significantly expressed in bladder urothelial cells, suggesting its involvement in bladder function and disease. **Pathways and Functions:** 1. **Golgi-to-ER Retrograde Transport:** NAPG plays a crucial role in the retrograde transport of proteins from the Golgi apparatus to the endoplasmic reticulum (ER), ensuring proper protein folding and quality control. 2. **Anterograde Transport:** NAPG is involved in the anterograde transport of proteins from the ER to the Golgi apparatus, facilitating protein maturation and secretion. 3. **Intra-Golgi and Retrograde Golgi-to-ER Traffic:** NAPG regulates the intra-Golgi and retrograde Golgi-to-ER traffic of proteins, ensuring proper protein sorting and degradation. 4. **Protein Stabilization:** NAPG helps to stabilize proteins by facilitating their glycosylation and proper folding, which is essential for protein function and survival. **Clinical Significance:** 1. **Neurological Disorders:** Abnormalities in NAPG expression or function may contribute to neurological disorders, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Bladder Dysfunction:** Alterations in NAPG expression in bladder urothelial cells may lead to bladder dysfunction and disease, highlighting the importance of NAPG in bladder health. 3. **Immunological Disorders:** NAPG's role in protein trafficking and glycosylation may also contribute to immunological disorders, such as autoimmune diseases and cancer. In conclusion, the NAPG gene is a complex and multifaceted molecule that plays a crucial role in various cellular processes, including protein trafficking, glycosylation, and vesicle-mediated transport. Further research is necessary to fully elucidate the functions and clinical significance of NAPG, but it is clear that this gene has far-reaching implications for our understanding of immunology and disease.

Genular Protein ID: 2647090983

Symbol: SNAG_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q99747 B4DFC9 Q9BUV1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 5 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9269766

Title: Regulated secretion in platelets: identification of elements of the platelet exocytosis machinery.

PubMed ID: 9269766

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11278501

Title: Gaf-1, a gamma-SNAP-binding protein associated with the mitochondria.

PubMed ID: 11278501

DOI: 10.1074/jbc.m009424200

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 312
  • Mass: 34746
  • Checksum: C37D73C1AEFD48C8
  • Sequence:
    • MAAQKINEGL EHLAKAEKYL KTGFLKWKPD YDSAASEYGK AAVAFKNAKQ FEQAKDACLR 
EAVAHENNRA LFHAAKAYEQ AGMMLKEMQK LPEAVQLIEK ASMMYLENGT PDTAAMALER 
AGKLIENVDP EKAVQLYQQT ANVFENEERL RQAVELLGKA SRLLVRGRRF DEAALSIQKE 
KNIYKEIENY PTCYKKTIAQ VLVHLHRNDY VAAERCVRES YSIPGFNGSE DCAALEQLLE 
GYDQQDQDQV SDVCNSPLFK YMDNDYAKLG LSLVVPGGGI KKKSPATPQA KPDGVTATAA 
DEEEDEYSGG LC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.