Details for: IL18RAP

Gene ID: 8807

Symbol: IL18RAP

Ensembl ID: ENSG00000115607

Description: interleukin 18 receptor accessory protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 9.1568
    Cell Significance Index: -3.7200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 2.5004
    Cell Significance Index: 87.8600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 2.0497
    Cell Significance Index: 42.5200
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 1.5865
    Cell Significance Index: 4.2500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.5624
    Cell Significance Index: 45.0200
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.1297
    Cell Significance Index: 12.0200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.7817
    Cell Significance Index: 19.5400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.5666
    Cell Significance Index: -1.2400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3785
    Cell Significance Index: 17.1600
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.2498
    Cell Significance Index: 2.5900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2265
    Cell Significance Index: 7.2600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2088
    Cell Significance Index: 188.5100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2082
    Cell Significance Index: 4.5100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2032
    Cell Significance Index: 20.1100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1432
    Cell Significance Index: 23.2900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1298
    Cell Significance Index: 24.7100
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: 0.1250
    Cell Significance Index: 0.3200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0330
    Cell Significance Index: 3.5900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0237
    Cell Significance Index: 0.3400
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: 0.0059
    Cell Significance Index: 0.0800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0046
    Cell Significance Index: 0.2900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0014
    Cell Significance Index: -2.6400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0017
    Cell Significance Index: -3.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0021
    Cell Significance Index: -3.3000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0023
    Cell Significance Index: -3.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0037
    Cell Significance Index: -2.8200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0041
    Cell Significance Index: -0.5200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0044
    Cell Significance Index: -3.2900
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0056
    Cell Significance Index: -0.0400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0057
    Cell Significance Index: -3.5900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0062
    Cell Significance Index: -3.4800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0062
    Cell Significance Index: -3.4000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0073
    Cell Significance Index: -3.3000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0077
    Cell Significance Index: -0.5400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0089
    Cell Significance Index: -3.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0090
    Cell Significance Index: -2.5800
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0103
    Cell Significance Index: -0.1000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0108
    Cell Significance Index: -2.1500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0119
    Cell Significance Index: -2.3900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0150
    Cell Significance Index: -0.2200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0159
    Cell Significance Index: -2.8800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0165
    Cell Significance Index: -3.4900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0167
    Cell Significance Index: -2.8600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0169
    Cell Significance Index: -0.3600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0221
    Cell Significance Index: -3.2100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0232
    Cell Significance Index: -2.8500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0250
    Cell Significance Index: -3.4300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0253
    Cell Significance Index: -1.1000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0266
    Cell Significance Index: -3.0500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0286
    Cell Significance Index: -3.3800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0298
    Cell Significance Index: -1.5100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0311
    Cell Significance Index: -4.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0339
    Cell Significance Index: -3.4600
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0348
    Cell Significance Index: -0.3100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0368
    Cell Significance Index: -0.5000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: -0.0392
    Cell Significance Index: 0.1100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0429
    Cell Significance Index: -1.7600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0430
    Cell Significance Index: -0.7300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0444
    Cell Significance Index: -2.0700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0451
    Cell Significance Index: -0.5700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0453
    Cell Significance Index: -1.2700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0483
    Cell Significance Index: -3.7100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0521
    Cell Significance Index: -3.5000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0533
    Cell Significance Index: -3.9700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0547
    Cell Significance Index: -2.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0553
    Cell Significance Index: -3.4000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0572
    Cell Significance Index: -2.9800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0578
    Cell Significance Index: -3.7300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0706
    Cell Significance Index: -3.6700
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0715
    Cell Significance Index: -0.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0715
    Cell Significance Index: -4.0100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0718
    Cell Significance Index: -1.0200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0741
    Cell Significance Index: -1.0400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0790
    Cell Significance Index: -2.3200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0799
    Cell Significance Index: -1.5600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0802
    Cell Significance Index: -2.0000
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0835
    Cell Significance Index: -0.8700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0840
    Cell Significance Index: -2.1500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0842
    Cell Significance Index: -2.9500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0842
    Cell Significance Index: -2.1700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0888
    Cell Significance Index: -3.9300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0956
    Cell Significance Index: -3.1300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0974
    Cell Significance Index: -2.3600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0977
    Cell Significance Index: -2.6600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0980
    Cell Significance Index: -3.1200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1011
    Cell Significance Index: -3.7100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1043
    Cell Significance Index: -3.9500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1090
    Cell Significance Index: -2.9200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1091
    Cell Significance Index: -3.4500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1101
    Cell Significance Index: -1.3000
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1103
    Cell Significance Index: -0.9400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1147
    Cell Significance Index: -2.4000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1152
    Cell Significance Index: -2.3500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1195
    Cell Significance Index: -3.1900
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1201
    Cell Significance Index: -1.3300
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.1208
    Cell Significance Index: -1.2500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1213
    Cell Significance Index: -3.0900
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.1213
    Cell Significance Index: -1.3300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1224
    Cell Significance Index: -2.1100
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.1232
    Cell Significance Index: -0.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** IL18RAP exhibits several key characteristics that enable its function in the IL-18 signaling pathway: 1. **Cellular localization**: IL18RAP is primarily expressed in immune cells, including enterocytes, goblet cells, intestinal crypt stem cells, and various subsets of T cells and natural killer cells. 2. **Molecular structure**: IL18RAP is a transmembrane protein with an extracellular domain that interacts with the IL-18 receptor complex, facilitating the activation of downstream signaling pathways. 3. **Expression levels**: IL18RAP expression is tightly regulated, with varying levels observed in different cell types and tissues. 4. **Function**: IL18RAP is essential for the activation of IL-18 receptor complex, leading to the induction of pro-inflammatory cytokines and chemokines. **Pathways and Functions** IL18RAP is involved in various signaling pathways, including: 1. **IL-18 receptor activity**: IL18RAP facilitates the activation of the IL-18 receptor complex, leading to the induction of pro-inflammatory cytokines and chemokines. 2. **Cytokine signaling in immune system**: IL18RAP is involved in the regulation of immune responses, including the activation of natural killer cells and T cells. 3. **Inflammatory response**: IL18RAP contributes to the induction of pro-inflammatory cytokines and chemokines, playing a key role in the defense against pathogens. 4. **Neutrophil activation**: IL18RAP is essential for the activation of neutrophils, a crucial component of the innate immune response. **Clinical Significance** IL18RAP has significant implications in various diseases, including: 1. **Autoimmune disorders**: Dysregulation of IL18RAP expression has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Inflammatory bowel disease**: IL18RAP expression is altered in patients with inflammatory bowel disease, highlighting its potential role in disease pathogenesis. 3. **Cancer**: IL18RAP has been implicated in the regulation of immune responses in cancer, with potential therapeutic applications in cancer immunotherapy. 4. **Neurological disorders**: IL18RAP expression is altered in patients with neurological disorders, such as Alzheimer's disease and Parkinson's disease, highlighting its potential role in disease pathogenesis. In conclusion, IL18RAP is a critical component of the IL-18 signaling pathway, playing a pivotal role in the regulation of immune responses. Its dysregulation has significant implications in various diseases, highlighting the need for further research into its role in human health and disease.

Genular Protein ID: 1977742504

Symbol: I18RA_HUMAN

Name: Interleukin-18 receptor accessory protein

UniProtKB Accession Codes:

O95256 B2RPJ3 Q2QDE5 Q3KPE7 Q3KPE8 Q53TT4 Q53TU5

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 5 ChEMBL 1 DNASU 1 DisGeNET 1 EC 1 EMBL 11 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 3 Rhea 2 SASBDB 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9792649

Title: Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling.

PubMed ID: 9792649

DOI: 10.1074/jbc.273.45.29445

PubMed ID: 17897836

Title: Identification of IL-18RAP mRNA truncated splice variants in human testis and the other human tissues.

PubMed ID: 17897836

DOI: 10.1016/j.cyto.2007.07.186

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10653850

Title: IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells.

PubMed ID: 10653850

DOI: 10.1093/intimm/12.2.151

PubMed ID: 10925275

Title: IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cells.

PubMed ID: 10925275

DOI: 10.4049/jimmunol.165.4.1933

PubMed ID: 11046021

Title: IL-18 receptors, their role in ligand binding and function: anti-IL-1RAcPL antibody, a potent antagonist of IL-18.

PubMed ID: 11046021

DOI: 10.4049/jimmunol.165.9.4950

PubMed ID: 14528293

Title: The structure and binding mode of interleukin-18.

PubMed ID: 14528293

DOI: 10.1038/nsb993

PubMed ID: 25500532

Title: The structural basis for receptor recognition of human interleukin-18.

PubMed ID: 25500532

DOI: 10.1038/ncomms6340

Sequence Information:

  • Length: 599
  • Mass: 68310
  • Checksum: 54807DA3E05462F1
  • Sequence:
    • MLCLGWIFLW LVAGERIKGF NISGCSTKKL LWTYSTRSEE EFVLFCDLPE PQKSHFCHRN 
RLSPKQVPEH LPFMGSNDLS DVQWYQQPSN GDPLEDIRKS YPHIIQDKCT LHFLTPGVNN 
SGSYICRPKM IKSPYDVACC VKMILEVKPQ TNASCEYSAS HKQDLLLGST GSISCPSLSC 
QSDAQSPAVT WYKNGKLLSV ERSNRIVVDE VYDYHQGTYV CDYTQSDTVS SWTVRAVVQV 
RTIVGDTKLK PDILDPVEDT LEVELGKPLT ISCKARFGFE RVFNPVIKWY IKDSDLEWEV 
SVPEAKSIKS TLKDEIIERN IILEKVTQRD LRRKFVCFVQ NSIGNTTQSV QLKEKRGVVL 
LYILLGTIGT LVAVLAASAL LYRHWIEIVL LYRTYQSKDQ TLGDKKDFDA FVSYAKWSSF 
PSEATSSLSE EHLALSLFPD VLENKYGYSL CLLERDVAPG GVYAEDIVSI IKRSRRGIFI 
LSPNYVNGPS IFELQAAVNL ALDDQTLKLI LIKFCYFQEP ESLPHLVKKA LRVLPTVTWR 
GLKSVPPNSR FWAKMRYHMP VKNSQGFTWN QLRITSRIFQ WKGLSRTETT GRSSQPKEW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.