Details for: DCAF5

Gene ID: 8816

Symbol: DCAF5

Ensembl ID: ENSG00000139990

Description: DDB1 and CUL4 associated factor 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 312.8029
    Cell Significance Index: -48.6600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 188.8872
    Cell Significance Index: -47.9100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 115.5487
    Cell Significance Index: -47.6000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 109.3572
    Cell Significance Index: -51.6300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 106.4843
    Cell Significance Index: -43.2600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 95.3371
    Cell Significance Index: -49.0400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 45.5411
    Cell Significance Index: -43.4800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 40.8490
    Cell Significance Index: -50.3700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.9143
    Cell Significance Index: -47.9900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.4036
    Cell Significance Index: -44.2400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.8559
    Cell Significance Index: -50.7300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.5515
    Cell Significance Index: -27.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.1641
    Cell Significance Index: 434.1100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.8279
    Cell Significance Index: 362.7500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.7698
    Cell Significance Index: 122.3900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.5850
    Cell Significance Index: 21.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.4434
    Cell Significance Index: 517.7200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.2919
    Cell Significance Index: 99.1400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.1761
    Cell Significance Index: 813.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.0302
    Cell Significance Index: 28.7900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.0042
    Cell Significance Index: 56.3500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.9262
    Cell Significance Index: 62.2800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.8900
    Cell Significance Index: 19.0300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.7312
    Cell Significance Index: 14.2700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.6501
    Cell Significance Index: 16.7100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6076
    Cell Significance Index: 31.6500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6007
    Cell Significance Index: 36.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5978
    Cell Significance Index: 73.5100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5783
    Cell Significance Index: 15.5000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5593
    Cell Significance Index: 25.3500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5477
    Cell Significance Index: 15.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5286
    Cell Significance Index: 95.2900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.5242
    Cell Significance Index: 14.9600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4518
    Cell Significance Index: 17.1100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4472
    Cell Significance Index: 19.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3626
    Cell Significance Index: 49.7900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3285
    Cell Significance Index: 179.3800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2467
    Cell Significance Index: 464.5500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2194
    Cell Significance Index: 11.4000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2107
    Cell Significance Index: 93.1600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1716
    Cell Significance Index: 77.8800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1679
    Cell Significance Index: 106.6300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1558
    Cell Significance Index: 2.6700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1433
    Cell Significance Index: 220.6800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1336
    Cell Significance Index: 6.2300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1079
    Cell Significance Index: 10.6800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0966
    Cell Significance Index: 131.3600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0893
    Cell Significance Index: 164.6100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0777
    Cell Significance Index: 13.2600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0697
    Cell Significance Index: 62.9700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0529
    Cell Significance Index: 1.8600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0486
    Cell Significance Index: 9.2400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0160
    Cell Significance Index: 0.2300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0128
    Cell Significance Index: -1.6400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0168
    Cell Significance Index: -12.4300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0333
    Cell Significance Index: -24.4200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0389
    Cell Significance Index: -24.2900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0513
    Cell Significance Index: -38.8000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0715
    Cell Significance Index: -40.3000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0876
    Cell Significance Index: -10.3300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1135
    Cell Significance Index: -7.3200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1192
    Cell Significance Index: -2.6100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1444
    Cell Significance Index: -9.1000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1447
    Cell Significance Index: -14.7800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1457
    Cell Significance Index: -30.6800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1554
    Cell Significance Index: -44.7200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1613
    Cell Significance Index: -23.4400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2075
    Cell Significance Index: -26.8100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2075
    Cell Significance Index: -5.5400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2204
    Cell Significance Index: -15.5900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2229
    Cell Significance Index: -16.6100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2317
    Cell Significance Index: -10.8900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2354
    Cell Significance Index: -8.1800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2446
    Cell Significance Index: -4.1200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2542
    Cell Significance Index: -29.6300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3029
    Cell Significance Index: -34.7000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3052
    Cell Significance Index: -31.7800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3741
    Cell Significance Index: -42.7000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.3773
    Cell Significance Index: -4.6800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3841
    Cell Significance Index: -5.6700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4171
    Cell Significance Index: -2.5200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4505
    Cell Significance Index: -9.7600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4870
    Cell Significance Index: -25.5700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5458
    Cell Significance Index: -17.4800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5559
    Cell Significance Index: -44.0300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.5717
    Cell Significance Index: -8.2100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6398
    Cell Significance Index: -13.6300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.6404
    Cell Significance Index: -17.4300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.6470
    Cell Significance Index: -9.5500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6861
    Cell Significance Index: -18.0400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.6928
    Cell Significance Index: -11.6000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.6988
    Cell Significance Index: -17.0500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.7214
    Cell Significance Index: -8.6000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7545
    Cell Significance Index: -46.2600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.7733
    Cell Significance Index: -47.5300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8173
    Cell Significance Index: -26.0300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.8311
    Cell Significance Index: -17.6400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.8367
    Cell Significance Index: -19.3300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8444
    Cell Significance Index: -27.6500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.8511
    Cell Significance Index: -6.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DCAF5 is a protein-coding gene that belongs to the Cul4-RING E3 ubiquitin ligase complex, a family of enzymes responsible for protein degradation and modification. It is characterized by its ability to interact with the DDB1 (DNA damage-binding protein 1) and CUL4 (Cullin 4) proteins, forming a complex that regulates the ubiquitination of target proteins. DCAF5 is highly expressed in neurons, particularly in GABAergic cortical interneurons, which are involved in regulating neural activity and synaptic transmission. **Pathways and Functions:** DCAF5 is involved in several key pathways, including: 1. **Cul4-RING E3 ubiquitin ligase complex:** This complex plays a crucial role in regulating protein degradation and modification, including the ubiquitination of target proteins. 2. **Neddylation:** DCAF5 is involved in the regulation of neddylation, a post-translational modification that involves the transfer of a ubiquitin-like protein (NEDD8) to target proteins. 3. **Negative regulation of fatty acid biosynthesis:** DCAF5 has been shown to regulate fatty acid biosynthesis by targeting key enzymes involved in this process. 4. **Protein binding and modification:** DCAF5 interacts with various proteins, including histones, to regulate chromatin structure and gene expression. **Clinical Significance:** DCAF5 has been implicated in several neurological disorders, including: 1. **Neurodegenerative diseases:** Mutations in the DCAF5 gene have been associated with neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 2. **Neuronal dysfunction:** Alterations in DCAF5 expression have been linked to neuronal dysfunction and synaptic transmission dysregulation. 3. **Cancer:** DCAF5 has been implicated in cancer development and progression, particularly in glioblastoma and other brain tumors. In conclusion, DCAF5 is a multifaceted gene that plays a crucial role in regulating various cellular processes, including protein degradation, modification, and metabolism. Its dysregulation has been implicated in several neurological disorders, highlighting the importance of further research into the mechanisms underlying DCAF5 function and its role in human disease.

Genular Protein ID: 2059340477

Symbol: DCAF5_HUMAN

Name: DDB1- and CUL4-associated factor 5

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11347906

Title: Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 11347906

DOI: 10.1093/dnares/8.2.85

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9740667

Title: Genomic and functional map of the chromosome 14 t(12;14) breakpoint cluster region in uterine leiomyoma.

PubMed ID: 9740667

DOI: 10.1006/geno.1998.5406

PubMed ID: 16949367

Title: A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1.

PubMed ID: 16949367

DOI: 10.1016/j.molcel.2006.08.010

PubMed ID: 16964240

Title: Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery.

PubMed ID: 16964240

DOI: 10.1038/nature05175

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29691401

Title: Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4-DCAF5 ubiquitin ligase.

PubMed ID: 29691401

DOI: 10.1038/s41467-018-04019-9

PubMed ID: 30442713

Title: Proteolysis of methylated SOX2 protein is regulated by L3MBTL3 and CRL4-DCAF5 ubiquitin ligase.

PubMed ID: 30442713

DOI: 10.1074/jbc.ra118.005336

Sequence Information:

  • Length: 942
  • Mass: 103963
  • Checksum: 3C627BA3FB2DC522
  • Sequence:
  • MKRRAGLGGS MRSVVGFLSQ RGLHGDPLLT QDFQRRRLRG CRNLYKKDLL GHFGCVNAIE 
    FSNNGGQWLV SGGDDRRVLL WHMEQAIHSR VKPIQLKGEH HSNIFCLAFN SGNTKVFSGG 
    NDEQVILHDV ESSETLDVFA HEDAVYGLSV SPVNDNIFAS SSDDGRVLIW DIRESPHGEP 
    FCLANYPSAF HSVMFNPVEP RLLATANSKE GVGLWDIRKP QSSLLRYGGN LSLQSAMSVR 
    FNSNGTQLLA LRRRLPPVLY DIHSRLPVFQ FDNQGYFNSC TMKSCCFAGD RDQYILSGSD 
    DFNLYMWRIP ADPEAGGIGR VVNGAFMVLK GHRSIVNQVR FNPHTYMICS SGVEKIIKIW 
    SPYKQPGCTG DLDGRIEDDS RCLYTHEEYI SLVLNSGSGL SHDYANQSVQ EDPRMMAFFD 
    SLVRREIEGW SSDSDSDLSE STILQLHAGV SERSGYTDSE SSASLPRSPP PTVDESADNA 
    FHLGPLRVTT TNTVASTPPT PTCEDAASRQ QRLSALRRYQ DKRLLALSNE SDSEENVCEV 
    ELDTDLFPRP RSPSPEDESS SSSSSSSSED EEELNERRAS TWQRNAMRRR QKTTREDKPS 
    APIKPTNTYI GEDNYDYPQI KVDDLSSSPT SSPERSTSTL EIQPSRASPT SDIESVERKI 
    YKAYKWLRYS YISYSNNKDG ETSLVTGEAD EGRAGTSHKD NPAPSSSKEA CLNIAMAQRN 
    QDLPPEGCSK DTFKEETPRT PSNGPGHEHS SHAWAEVPEG TSQDTGNSGS VEHPFETKKL 
    NGKALSSRAE EPPSPPVPKA SGSTLNSGSG NCPRTQSDDS EERSLETICA NHNNGRLHPR 
    PPHPHNNGQN LGELEVVAYS SPGHSDTDRD NSSLTGTLLH KDCCGSEMAC ETPNAGTRED 
    PTDTPATDSS RAVHGHSGLK RQRIELEDTD SENSSSEKKL KT

Genular Protein ID: 1899331210

Symbol: Q8TBB7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 326
  • Mass: 36590
  • Checksum: B56EF8095C053217
  • Sequence:
  • MKRRAGLGGS MRSVVGFLSQ RGLHGDPLLT QDFQRRRLRG CRNLYKKDLL GHFGCVNAIE 
    FSNNGGQWLV SGGDDRRVLL WHMEQAIHSR VKPIQLKGEH HSNIFCLAFN SGNTKVFSGG 
    NDEQVILHDV ESSETLDVFA HEDAVYGLSV SPVNDNIFAS SSDDGRVLIW DIRESPHGEP 
    FCLANYPSAF HSVMFNPVEP RLLATANSKE GVGLWDIRKP QSSLLRYGGN LSLQSAMSVR 
    FNSNGTQLLA LRRRLPPVLY DIHSRLPVFQ FDNQGYFNSC TMKSCCFAGD RDQHHNWKWR 
    AQAVSFQPFL SLTRNGDADV DLKLAV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.