Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 74.8335
Cell Significance Index: -11.6400 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 36.7445
Cell Significance Index: -9.3200 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 31.5687
Cell Significance Index: -12.8300 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 26.5365
Cell Significance Index: -13.6500 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 9.5624
Cell Significance Index: -11.7900 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 9.4049
Cell Significance Index: 195.1000 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 4.8479
Cell Significance Index: -10.6100 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 4.3367
Cell Significance Index: -13.3200 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 3.5239
Cell Significance Index: -9.4400 - Cell Name: late promyelocyte (CL0002151)
Fold Change: 1.7410
Cell Significance Index: 11.5500 - Cell Name: megakaryocyte progenitor cell (CL0000553)
Fold Change: 1.3452
Cell Significance Index: 9.6700 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.9283
Cell Significance Index: 7.5700 - Cell Name: early promyelocyte (CL0002154)
Fold Change: 0.8929
Cell Significance Index: 5.7000 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.8419
Cell Significance Index: 15.5600 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.6085
Cell Significance Index: 115.8100 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.5105
Cell Significance Index: 107.5300 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4742
Cell Significance Index: 46.9100 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.3529
Cell Significance Index: 9.4400 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3137
Cell Significance Index: 283.2400 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.3120
Cell Significance Index: 20.1300 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.2435
Cell Significance Index: 5.1900 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2345
Cell Significance Index: 38.1500 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.1864
Cell Significance Index: 20.2800 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.1433
Cell Significance Index: 89.5100 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.1136
Cell Significance Index: 13.4000 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.0926
Cell Significance Index: 5.5600 - Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 0.0821
Cell Significance Index: 0.6700 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0491
Cell Significance Index: 8.3800 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.0334
Cell Significance Index: 0.9800 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.0089
Cell Significance Index: 0.1300 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0006
Cell Significance Index: 0.0200 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.0001
Cell Significance Index: 0.1100 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0032
Cell Significance Index: -1.7800 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0042
Cell Significance Index: -0.2600 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0055
Cell Significance Index: -10.3700 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0076
Cell Significance Index: -14.0200 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0088
Cell Significance Index: -13.5800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0104
Cell Significance Index: -14.1600 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0141
Cell Significance Index: -1.4400 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0149
Cell Significance Index: -0.3800 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0158
Cell Significance Index: -11.9900 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0175
Cell Significance Index: -0.3800 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0181
Cell Significance Index: -13.2700 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0181
Cell Significance Index: -5.2100 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0188
Cell Significance Index: -0.4700 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0201
Cell Significance Index: -12.7700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0212
Cell Significance Index: -0.6100 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0212
Cell Significance Index: -11.5800 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.0222
Cell Significance Index: -0.3400 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0234
Cell Significance Index: -4.6500 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0244
Cell Significance Index: -10.7900 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0259
Cell Significance Index: -9.2900 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0282
Cell Significance Index: -12.8200 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0304
Cell Significance Index: -1.3800 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.0354
Cell Significance Index: -2.4500 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0408
Cell Significance Index: -4.6600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0472
Cell Significance Index: -9.4600 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0556
Cell Significance Index: -10.0300 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0562
Cell Significance Index: -1.8000 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0752
Cell Significance Index: -10.3300 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0777
Cell Significance Index: -3.3800 - Cell Name: DN3 thymocyte (CL0000807)
Fold Change: -0.0788
Cell Significance Index: -0.7900 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0830
Cell Significance Index: -12.0700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0861
Cell Significance Index: -9.8600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0917
Cell Significance Index: -11.2700 - Cell Name: leukocyte (CL0000738)
Fold Change: -0.0960
Cell Significance Index: -1.6300 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.1008
Cell Significance Index: -13.0200 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.1056
Cell Significance Index: -5.3400 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1091
Cell Significance Index: -11.3600 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1142
Cell Significance Index: -13.3100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1252
Cell Significance Index: -5.8900 - Cell Name: myeloid cell (CL0000763)
Fold Change: -0.1279
Cell Significance Index: -1.7000 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.1341
Cell Significance Index: -17.1900 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1474
Cell Significance Index: -11.3200 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1664
Cell Significance Index: -7.7600 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1702
Cell Significance Index: -10.7300 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1758
Cell Significance Index: -13.1000 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1850
Cell Significance Index: -11.3700 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1942
Cell Significance Index: -13.0600 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.2010
Cell Significance Index: -5.4700 - Cell Name: proerythroblast (CL0000547)
Fold Change: -0.2013
Cell Significance Index: -2.8900 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.2146
Cell Significance Index: -3.7000 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.2229
Cell Significance Index: -11.5800 - Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: -0.2237
Cell Significance Index: -1.2200 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.2288
Cell Significance Index: -9.3800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2392
Cell Significance Index: -13.4200 - Cell Name: macrophage (CL0000235)
Fold Change: -0.2395
Cell Significance Index: -2.4500 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.2473
Cell Significance Index: -12.8800 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2531
Cell Significance Index: -13.2900 - Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: -0.2691
Cell Significance Index: -2.7900 - Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.2829
Cell Significance Index: -3.9700 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2930
Cell Significance Index: -12.9600 - Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: -0.3141
Cell Significance Index: -2.6600 - Cell Name: microglial cell (CL0000129)
Fold Change: -0.3155
Cell Significance Index: -3.7100 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.3211
Cell Significance Index: -11.2500 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.3226
Cell Significance Index: -3.9900 - Cell Name: mononuclear cell (CL0000842)
Fold Change: -0.3292
Cell Significance Index: -1.3700 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.3299
Cell Significance Index: -4.1800 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.3403
Cell Significance Index: -12.8900 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3451
Cell Significance Index: -11.3000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3531925973
Symbol: SLAF5_HUMAN
Name: SLAM family member 5
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9310491
Title: CD84 leukocyte antigen is a new member of the Ig superfamily.
PubMed ID: 9310491
PubMed ID: 10698700
Title: Characterization of MAX.3 antigen, a glycoprotein expressed on mature macrophages, dendritic cells and blood platelets: identity with CD84.
PubMed ID: 10698700
DOI: 10.1042/bj3460729
PubMed ID: 10746783
Title: Genomic characterization of CD84 reveals the existence of five isoforms differing in their cytoplasmic domains.
PubMed ID: 10746783
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11389028
Title: Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP.
PubMed ID: 11389028
PubMed ID: 11414741
Title: Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family.
PubMed ID: 11414741
PubMed ID: 11313386
Title: CD150 association with either the SH2-containing inositol phosphatase or the SH2-containing protein tyrosine phosphatase is regulated by the adaptor protein SH2D1A.
PubMed ID: 11313386
PubMed ID: 11564780
Title: CD84 functions as a homophilic adhesion molecule and enhances IFN-gamma secretion: adhesion is mediated by Ig-like domain 1.
PubMed ID: 11564780
PubMed ID: 12115647
Title: CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2.
PubMed ID: 12115647
DOI: 10.1002/1521-4141(200206)32:6<1640::aid-immu1640>3.0.co;2-s
PubMed ID: 12458214
Title: Dual functional roles for the X-linked lymphoproliferative syndrome gene product SAP/SH2D1A in signaling through the signaling lymphocyte activation molecule (SLAM) family of immune receptors.
PubMed ID: 12458214
PubMed ID: 12928397
Title: Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation.
PubMed ID: 12928397
PubMed ID: 12962726
Title: CD84 expression on human hematopoietic progenitor cells.
PubMed ID: 12962726
PubMed ID: 15245368
Title: Differential expression of SAP and EAT-2-binding leukocyte cell-surface molecules CD84, CD150 (SLAM), CD229 (Ly9) and CD244 (2B4).
PubMed ID: 15245368
PubMed ID: 16037392
Title: Platelet aggregation induces platelet aggregate stability via SLAM family receptor signaling.
PubMed ID: 16037392
PubMed ID: 22068234
Title: CD84 negatively regulates IgE high-affinity receptor signaling in human mast cells.
PubMed ID: 22068234
PubMed ID: 29434592
Title: Signaling lymphocyte activation molecule family 5 enhances autophagy and fine-tunes cytokine response in monocyte-derived dendritic cells via stabilization of interferon regulatory factor 8.
PubMed ID: 29434592
PubMed ID: 17563375
Title: Structure of CD84 provides insight into SLAM family function.
PubMed ID: 17563375
Sequence Information:
- Length: 345
- Mass: 38782
- Checksum: DA06BC5A682E62DE
- Sequence:
MAQHHLWILL LCLQTWPEAA GKDSEIFTVN GILGESVTFP VNIQEPRQVK IIAWTSKTSV AYVTPGDSET APVVTVTHRN YYERIHALGP NYNLVISDLR MEDAGDYKAD INTQADPYTT TKRYNLQIYR RLGKPKITQS LMASVNSTCN VTLTCSVEKE EKNVTYNWSP LGEEGNVLQI FQTPEDQELT YTCTAQNPVS NNSDSISARQ LCADIAMGFR THHTGLLSVL AMFFLLVLIL SSVFLFRLFK RRQGRIFPEG SCLNTFTKNP YAASKKTIYT YIMASRNTQP AESRIYDEIL QSKVLPSKEE PVNTVYSEVQ FADKMGKAST QDSKPPGTSS YEIVI
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.