Details for: EIF2B4

Gene ID: 8890

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: EIF2B4

Ensembl ID: ENSG00000115211

Description: eukaryotic translation initiation factor 2B subunit delta

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • mucus secreting cell CL0000319
    CSI 10.79
    rCSI 17.13%
    PRS 91.41
  • granulocyte CL0000094
    CSI 8.84
    rCSI 13.51%
    PRS 90.58
  • mature B cell CL0000785
    CSI 5.92
    rCSI 5.14%
    PRS 92.41
  • rod bipolar cell CL0000751
    CSI 5.88
    rCSI 10.56%
    PRS 78.95
  • ionocyte CL0005006
    CSI 5.58
    rCSI 5.98%
    PRS 86.77
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 5.49
    rCSI 4.95%
    PRS 83.44
  • placental villous trophoblast CL2000060
    CSI 5.48
    rCSI 8.47%
    PRS 83.67
  • type B pancreatic cell CL0000169
    CSI 4.82
    rCSI 10.67%
    PRS 84.63
  • CD4-positive, alpha-beta thymocyte CL0000810
    CSI 4.28
    rCSI 3.43%
    PRS 93.94
  • neural progenitor cell CL0011020
    CSI 4.17
    rCSI 18.34%
    PRS 73.5
  • cytotoxic T cell CL0000910
    CSI 4.07
    rCSI 23.34%
    PRS 86.47
  • interstitial cell of Cajal CL0002088
    CSI 3.61
    rCSI 4.59%
    PRS 89.28
  • CD4-positive, alpha-beta memory T cell CL0000897
    CSI 3.4
    rCSI 2.44%
    PRS 94.95
  • dendritic cell, human CL0001056
    CSI 3.35
    rCSI 5.15%
    PRS 91.75
  • naive T cell CL0000898
    CSI 3.31
    rCSI 2.3%
    PRS 95.48
  • cerebral cortex endothelial cell CL1001602
    CSI 3.19
    rCSI 5.52%
    PRS 77.44
  • forebrain radial glial cell CL0013000
    CSI 3.11
    rCSI 9.99%
    PRS 85.51
  • CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792
    CSI 3.08
    rCSI 3.02%
    PRS 95.02
  • precursor B cell CL0000817
    CSI 2.93
    rCSI 2.57%
    PRS 90.52
  • cerebral cortex GABAergic interneuron CL0010011
    CSI 2.85
    rCSI 8.41%
    PRS 85.54
  • pro-B cell CL0000826
    CSI 2.81
    rCSI 2.33%
    PRS 86.98
  • fibroblast of lung CL0002553
    CSI 2.8
    rCSI 2.6%
    PRS 85.79
  • plasmacytoid dendritic cell, human CL0001058
    CSI 2.73
    rCSI 1.9%
    PRS 88.25
  • hematopoietic stem cell CL0000037
    CSI 2.69
    rCSI 1.79%
    PRS 87
  • myeloid leukocyte CL0000766
    CSI 2.69
    rCSI 2.48%
    PRS 86.14
  • extravillous trophoblast CL0008036
    CSI 2.68
    rCSI 3.31%
    PRS 83.23
  • myoepithelial cell CL0000185
    CSI 2.65
    rCSI 6.7%
    PRS 88.6
  • CD4-positive helper T cell CL0000492
    CSI 2.63
    rCSI 1.99%
    PRS 94.48
  • double-positive, alpha-beta thymocyte CL0000809
    CSI 2.43
    rCSI 2.48%
    PRS 92.22
  • epithelial cell of lower respiratory tract CL0002632
    CSI 2.38
    rCSI 1.84%
    PRS 88.08
  • lung pericyte CL0009089
    CSI 2.36
    rCSI 6.23%
    PRS 90.05
  • epithelial cell of lung CL0000082
    CSI 2.32
    rCSI 1.92%
    PRS 85.91
  • retina horizontal cell CL0000745
    CSI 2.3
    rCSI 3.51%
    PRS 81.89
  • neural crest cell CL0011012
    CSI 2.29
    rCSI 1.81%
    PRS 75.44
  • common myeloid progenitor CL0000049
    CSI 2.2
    rCSI 1.78%
    PRS 86.95
  • stem cell CL0000034
    CSI 2.19
    rCSI 2.11%
    PRS 79.55
  • lung neuroendocrine cell CL1000223
    CSI 2.11
    rCSI 3.13%
    PRS 87.69
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 2.1
    rCSI 2.42%
    PRS 77.33
  • ependymal cell CL0000065
    CSI 2.08
    rCSI 4.22%
    PRS 65.03
  • goblet cell CL0000160
    CSI 2.05
    rCSI 1.93%
    PRS 83.07
  • enteric smooth muscle cell CL0002504
    CSI 1.98
    rCSI 2.83%
    PRS 85.49
  • peripheral nervous system neuron CL2000032
    CSI 1.96
    rCSI 2.67%
    PRS 77.35
  • mature alpha-beta T cell CL0000791
    CSI 1.9
    rCSI 6.86%
    PRS 96.58
  • alveolar adventitial fibroblast CL4028006
    CSI 1.79
    rCSI 2.83%
    PRS 85.98
  • ciliated epithelial cell CL0000067
    CSI 1.79
    rCSI 1.57%
    PRS 75
  • mesodermal cell CL0000222
    CSI 1.79
    rCSI 2.15%
    PRS 83.19
  • radial glial cell CL0000681
    CSI 1.78
    rCSI 2.48%
    PRS 83.23
  • promyelocyte CL0000836
    CSI 1.76
    rCSI 2.54%
    PRS 89.17
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 1.76
    rCSI 2.26%
    PRS 81.2
  • respiratory basal cell CL0002633
    CSI 1.75
    rCSI 1.81%
    PRS 87.82
  • chondrocyte CL0000138
    CSI 1.74
    rCSI 2.76%
    PRS 78.67
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 1.7
    rCSI 2.86%
    PRS 68.62
  • lung ciliated cell CL1000271
    CSI 1.7
    rCSI 1.96%
    PRS 78.18
  • granulocyte monocyte progenitor cell CL0000557
    CSI 1.68
    rCSI 1.45%
    PRS 88.08
  • group 3 innate lymphoid cell CL0001071
    CSI 1.67
    rCSI 1.26%
    PRS 89.61
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 1.66
    rCSI 2.93%
    PRS 68.18
  • basal cell of epidermis CL0002187
    CSI 1.61
    rCSI 2.85%
    PRS 54.22
  • glioblast CL0000030
    CSI 1.5
    rCSI 2.39%
    PRS 76.72
  • mesenchymal cell CL0008019
    CSI 1.49
    rCSI 3.78%
    PRS 78.73
  • intermediate monocyte CL0002393
    CSI 1.47
    rCSI 2.22%
    PRS 89.66
  • amacrine cell CL0000561
    CSI 1.3
    rCSI 3.77%
    PRS 75.08
  • retinal cone cell CL0000573
    CSI 1.25
    rCSI 2.02%
    PRS 75.91
  • astrocyte of the cerebral cortex CL0002605
    CSI 1.23
    rCSI 2.75%
    PRS 69.54
  • memory T cell CL0000813
    CSI 1.07
    rCSI 2.05%
    PRS 96.84
  • helper T cell CL0000912
    CSI 1.05
    rCSI 1.49%
    PRS 82.57
  • melanocyte of skin CL1000458
    CSI 1.01
    rCSI 1.38%
    PRS 52.79
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 0.96
    rCSI 2.33%
    PRS 66.48
  • microcirculation associated smooth muscle cell CL0008035
    CSI 0.88
    rCSI 2.55%
    PRS 83.94
  • suprabasal keratinocyte CL4033013
    CSI 0.88
    rCSI 1.44%
    PRS 52.92
  • L6b glutamatergic cortical neuron CL4023038
    CSI 0.83
    rCSI 2.59%
    PRS 70.13
  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI 0.76
    rCSI 0.93%
    PRS 65.35
  • erythroid progenitor cell CL0000038
    CSI 0.3
    rCSI 1.73%
    PRS 88.69

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [EIF2B4](/details-gene/8890) (eukaryotic translation initiation factor 2B subunit delta) encodes the delta subunit of the eIF2B complex, a critical guanyl-nucleotide exchange factor that regulates global protein synthesis. The primary function of this complex is to recycle the translation initiation factor eIF2 from its inactive GDP-bound form to its active GTP-bound state, a rate-limiting step in translational initiation. Expression data suggests that [EIF2B4](/details-gene/8890) plays a fundamental role in a wide variety of cell types, particularly those with high metabolic and secretory demands. Its significance is most pronounced in cells such as [mucus secreting cells](/details-cell/CL0000319), [granulocytes](/details-cell/CL0000094), and [mature B cells](/details-cell/CL0000785), underscoring its importance in maintaining high rates of protein production for functions like secretion and immune response. ## Cellular Roles and Expression Landscape The expression profile of [EIF2B4](/details-gene/8890) highlights its role as a key component of the cellular machinery in translationally active cells across diverse lineages. **Overall**, its high significance in secretory cell types, including [mucus secreting cells](/details-cell/CL0000319) (CSI: 10.79) and [type B pancreatic cells](/details-cell/CL0000169) (CSI: 4.82), is consistent with its essential function in supporting the large-scale synthesis of secreted proteins like mucins and insulin. Furthermore, [EIF2B4](/details-gene/8890) appears to be a crucial factor in the immune system. It shows high significance in both the innate and adaptive immune compartments, including [granulocytes](/details-cell/CL0000094) (CSI: 8.84), [mature B cells](/details-cell/CL0000785) (CSI: 5.92), [cytotoxic T cells](/details-cell/CL0000910) (CSI: 4.07), and [dendritic cells](/details-cell/CL0001056) (CSI: 3.35). This suggests that robust translational capacity, managed in part by [EIF2B4](/details-gene/8890), is required for the rapid production of cytokines, antibodies, and other effector molecules upon immune activation. Its presence in progenitor populations like [megakaryocyte-erythroid progenitor cells](/details-cell/CL0000050) (CSI: 5.49) and [neural progenitor cells](/details-cell/CL0011020) (CSI: 4.17) also points to a fundamental role in supporting the protein synthesis necessary for cellular proliferation and differentiation. ## Pathways and Molecular Function Functionally, [EIF2B4](/details-gene/8890) is integral to the process of protein synthesis. As a subunit of the eIF2B complex ([GO:0005851](https://www.ebi.ac.uk/QuickGO/term/GO:0005851)), its primary molecular function is 'guanyl-nucleotide exchange factor activity' ([GO:0005085](https://www.ebi.ac.uk/QuickGO/term/GO:0005085)) specific to the eIF2 complex. This activity is a central event in 'Cytoplasmic translational initiation' ([GO:0002183](https://www.ebi.ac.uk/QuickGO/term/GO:0002183)) and is detailed in Reactome pathways such as 'Cap-dependent translation initiation' ([R-HSA-72737](https://reactome.org/content/detail/R-HSA-72737)) and 'Recycling of eif2:gdp' ([R-HSA-72731](https://reactome.org/content/detail/R-HSA-72731)). Beyond this core role, functional annotations link [EIF2B4](/details-gene/8890) to specific physiological processes. Its involvement in the 'T cell receptor signaling pathway' ([GO:0050852](https://www.ebi.ac.uk/QuickGO/term/GO:0050852)) is consistent with its high expression in T cell subsets and is supported by quantitative phosphoproteomic studies that map signaling events following T cell activation [Link](https://doi.org/10.1126/scisignal.2000007). Additionally, annotations for 'Myelination' ([GO:0042552](https://www.ebi.ac.uk/QuickGO/term/GO:0042552)) and 'Oligodendrocyte development' ([GO:0014003](https://www.ebi.ac.uk/QuickGO/term/GO:0014003)) suggest a specialized requirement for precise translational control in the central nervous system, which warrants further investigation. ## Research Directions Based on its central role in translational regulation and its cell-specific expression patterns, several testable hypotheses can be proposed for [EIF2B4](/details-gene/8890). 1. **Hypothesis 1:** The high significance of [EIF2B4](/details-gene/8890) in professional secretory cells suggests that its activity is a rate-limiting step for the synthesis and secretion of high-abundance proteins (e.g., insulin in [type B pancreatic cells](/details-cell/CL0000169)). Dysregulation of [EIF2B4](/details-gene/8890) could therefore contribute to pathologies associated with secretory stress, such as certain forms of diabetes. 2. **Hypothesis 2:** Given its linkage to the 'T cell receptor signaling pathway' ([GO:0050852](https://www.ebi.ac.uk/QuickGO/term/GO:0050852)), the activity of the eIF2B complex containing [EIF2B4](/details-gene/8890) is critical for mediating the translational burst required for T cell activation, proliferation, and effector function. Fine-tuning this activity may represent a mechanism for controlling the magnitude of an adaptive immune response. **Experimental Approach for Hypothesis 2:** To test the role of [EIF2B4](/details-gene/8890) in T cell activation, one could utilize a targeted knockdown approach (e.g., shRNA or CRISPRi) in primary human CD4+ T cells. Following knockdown, these cells would be stimulated *in vitro* using anti-CD3/CD28 antibodies. The functional consequences could be assessed by measuring key activation readouts: proliferation via a cell trace dilution assay (flow cytometry), cytokine production (e.g., IL-2, IFN-gamma) by ELISA, and the global rate of protein synthesis using a puromycin incorporation assay (SUnSET). A significant reduction in these readouts in knockdown cells compared to controls would confirm the essential role of [EIF2B4](/details-gene/8890) in the T cell activation program. **Therapeutic Potential:** As an essential component of the general translation machinery, [EIF2B4](/details-gene/8890) presents a challenging therapeutic target. Global inhibition would likely induce significant cellular toxicity due to the universal requirement for protein synthesis. However, targeted modulation, rather than complete inhibition, may hold promise. For instance, research has identified the eIF2B complex as the target of a memory-enhancing compound, suggesting that specific activation could be beneficial in neurological contexts [Link](https://doi.org/10.1126/science.aaa6986). In oncology, where cancer cells are often highly dependent on protein synthesis, developing selective small-molecule inhibitors that target specific regulatory states of the eIF2B complex could be a viable strategy, though achieving a therapeutic window would be a major challenge.

Genular Protein ID: 1209781372

Symbol: EI2BD_HUMAN

Name: Translation initiation factor eIF2B subunit delta

UniProtKB Accession Codes:

Q9UI10 Q53RY7 Q5BJF4 Q9BUV9 Q9UBG4 Q9UIQ9 Q9UJ95

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 EMDB 22 Ensembl 3 ExpressionAtlas 1 GO 16 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 5 OrthoDB 1 PANTHER 2 PDB 22 PDBsum 22 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 7 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28169297

Title: Comparative influenza protein interactomes identify the role of plakophilin 2 in virus restriction.

PubMed ID: 28169297

DOI: 10.1038/ncomms13876

PubMed ID: 25858979

Title: Stress responses. Mutations in a translation initiation factor identify the target of a memory-enhancing compound.

PubMed ID: 25858979

DOI: 10.1126/science.aaa6986

PubMed ID: 27023709

Title: Expression, purification, and crystallization of Schizosaccharomyces pombe eIF2B.

PubMed ID: 27023709

DOI: 10.1007/s10969-016-9203-3

PubMed ID: 31048492

Title: Structural basis for eIF2B inhibition in integrated stress response.

PubMed ID: 31048492

DOI: 10.1126/science.aaw4104

PubMed ID: 11835386

Title: Mutations in each of the five subunits of translation initiation factor eIF2B can cause leukoencephalopathy with vanishing white matter.

PubMed ID: 11835386

DOI: 10.1002/ana.10112

PubMed ID: 12707859

Title: Ovarian failure related to eukaryotic initiation factor 2B mutations.

PubMed ID: 12707859

DOI: 10.1086/375404

PubMed ID: 15776425

Title: Identification of ten novel mutations in patients with eIF2B-related disorders.

PubMed ID: 15776425

DOI: 10.1002/humu.9325

Sequence Information:

  • Length: 523
  • Mass: 57557
  • Checksum: 5F38CF10CAD5A45E
  • Sequence:
    • MAAVAVAVRE DSGSGMKAEL PPGPGAVGRE MTKEEKLQLR KEKKQQKKKR KEEKGAEPET 
GSAVSAAQCQ VGPTRELPES GIQLGTPREK VPAGRSKAEL RAERRAKQEA ERALKQARKG 
EQGGPPPKAS PSTAGETPSG VKRLPEYPQV DDLLLRRLVK KPERQQVPTR KDYGSKVSLF 
SHLPQYSRQN SLTQFMSIPS SVIHPAMVRL GLQYSQGLVS GSNARCIALL RALQQVIQDY 
TTPPNEELSR DLVNKLKPYM SFLTQCRPLS ASMHNAIKFL NKEITSVGSS KREEEAKSEL 
RAAIDRYVQE KIVLAAQAIS RFAYQKISNG DVILVYGCSS LVSRILQEAW TEGRRFRVVV 
VDSRPWLEGR HTLRSLVHAG VPASYLLIPA ASYVLPEVSK VLLGAHALLA NGSVMSRVGT 
AQLALVARAH NVPVLVCCET YKFCERVQTD AFVSNELDDP DDLQCKRGEH VALANWQNHA 
SLRLLNLVYD VTPPELVDLV ITELGMIPCS SVPVVLRVKS SDQ

Genular Protein ID: 2012007295

Symbol: E7ERK9_HUMAN

Name: N/A

UniProtKB Accession Codes:

E7ERK9

Database IDs:

ARBA 7 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 2 GeneTree 1 HGNC 1 IntAct 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 2 Pfam 1 PhylomeDB 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 544
  • Mass: 59715
  • Checksum: 80573AA59A7458CB
  • Sequence:
    • MPTQQPAAPS TRAPKPSRSL SGSLCALFSD ADSGSGMKAE LPPGPGAVGR EMTKEEKLQL 
RKEKKQQKKK RKEEKGAEPE TGSAVSAAQC QVGPTRELPE SGIQLGTPRE KVPAGRSKAE 
LRAERRAKQE AERALKQARK GEQGGPPPKA SPSTAGETPS GVKRLPEYPQ VDDLLLRRLV 
KKPERQQVPT RKDYGSKVSL FSHLPQYSRQ NSLTQFMSIP SSVIHPAMVR LGLQYSQGLV 
SGSNARCIAL LRALQQVIQD YTTPPNEELS RDLVNKLKPY MSFLTQCRPL SASMHNAIKF 
LNKEITSVGS SKREEEAKSE LRAAIDRYVQ EKIVLAAQAI SRFAYQKISN GDVILVYGCS 
SLVSRILQEA WTEGRRFRVV VVDSRPWLEG RHTLRSLVHA GVPASYLLIP AASYVLPEVS 
KVLLGAHALL ANGSVMSRVG TAQLALVARA HNVPVLVCCE TYKFCERVQT DAFVSNELDD 
PDDLQCKRGE HVALANWQNH ASLRLLNLVY DVTPPELVDL VITELGMIPC SSVPVVLRVK 
SSDQ

Genular Protein ID: 3282434288

Symbol: Q9HBP7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9HBP7

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Google 1 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 RefSeq 1 SAM 1 SUPFAM 1

Sequence Information:

  • Length: 229
  • Mass: 25208
  • Checksum: 5FF5D040883554F6
  • Sequence:
    • MKAELPPGPG AVGREMTKEE KLQLRKEKKQ QKKKRKEEKG AEPETGSAVS AAQCQVGPTR 
ELPESGIQLG TPREKVPAGR SKAELRAERR AKQEAERALK QARKGEQGGP PPKASPSTAG 
ETPSGVKRLP EYPQVDDLLL RRLVKKPERQ QVPTRKDYGS KVSLFSHLPQ YSRQNSLTQF 
MSIPSSVIHP AMVRLGLQYS QGLVSGSNAR CIALLRALQQ VIQDYTTPA

Genular Protein ID: 4110477445

Symbol: F8W8L6_HUMAN

Name: N/A

UniProtKB Accession Codes:

F8W8L6

Database IDs:

Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 1 GeneTree 1 HGNC 1 HOGENOM 1 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 235
  • Mass: 25389
  • Checksum: 470492A86957AC9A
  • Sequence:
    • MAAVAVAVRE DSGSGMKAEL PPGPGAVGRE MTKEEKLQLR KEKKQQKKKR KEEKGAEPET 
GSAVSAAQCQ VGPTRELPES GIQLGTPREK VPAGRSKAEL RAERRAKQEA ERALKQARKG 
EQGGPPPKAS PSTAGETPSG VKRLPEYPQV DDLLLRRLVK KPERQQVPTR KDYGSKVSLF 
SHLPQYSRQN SLTQFMSHGA TRPAVLPGPG QWLQCPVYCP ASCLAAGDSG LHNTA

Genular Protein ID: 1714936127

Symbol: Q71US4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q71US4

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 1 RuleBase 1 SAM 1 SUPFAM 1 iPTMnet 1

Sequence Information:

  • Length: 520
  • Mass: 57554
  • Checksum: 6CBF93DDFAD511BC
  • Sequence:
    • MAAVAVAVRE DSGSGMKADS PWAWVGREMT KEEKLQLRKE KKQQKKKRKE EKGAEPETGS 
AVSAAQCQGP TRELPESGIQ LGTPREKVPA GRSKAELRAE RRAKQEAERA LKQARKGEQG 
GPPPKASPST AEETPSGVKR LPEYPQVDDL LLRRLVKKPE RQQVPTRKDY GSKVSLFSHL 
PQYSRQNSLT QFMSIPSSVI HPAMVRLGLQ YSQGLVSGSN ARCIALLRAL QQVIQDYTTP 
PNEELSRDLV NKLKPYMSFL TQCRPLSASM HNAIKFLNKE ITSVGSSKRE EEAKSELRAA 
IDRYVQEKIV LAAQAISRFA YQKISNGDVI LVYGCSSLVS RILQEAWTEG RRFRVVVVDS 
RPWLEGRHTL RSLVHAGVPA SYLLIPAASY VLPEVSKVLL GAHALLANGS VMSRVGTAQL 
ALVARAHNVP VLVCCETYKF CERVQTDAFV SNELDDPDDL QCKRGEHVAL ANWQNHASLR 
LLNLVYDVTP PELVDLVITE LGMIPCSSVP VVLRVKSSDQ

Genular Protein ID: 3501305960

Symbol: B4DUP5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DUP5

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 1 RuleBase 1 SAM 1 SUPFAM 1

Sequence Information:

  • Length: 312
  • Mass: 34797
  • Checksum: 4FD32AF402B32CD8
  • Sequence:
    • MKAELPPGPG AVGREMTKEE KLQLRKEKKQ QKKKRKEEKG AEPETGSAVS AAQCQGPTRE 
LPESGIQLGT PREKVPAGRS KAELRAERRA KQEAERALKQ ARKGEQGGPP PKASPSTAGE 
TPSGVKRLPE YPQVDDLLLR RLVKKPERQQ VPTRKDYGSK VSLFSHLPQY SRQNSLTQFM 
SIPSSVIHPA MVRLGLQYSQ GLVSGSNARC IALLRALQQV IQDYTTPPNE ELSRDLVNKL 
KPYMSFLTQC RPLSASMHNA IKFLNKEITS VGSSKREEEV MSMRNKEGMH LWVKLRNMLK 
TPGKANVSLF LP