Details for: MAP3K14

Gene ID: 9020

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: MAP3K14

Ensembl ID: ENSG00000006062

Description: mitogen-activated protein kinase kinase kinase 14

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • plasmablast CL0000980
    CSI 12.15
    rCSI 9.56%
    PRS 74.76
  • effector memory CD8-positive, alpha-beta T cell CL0000913
    CSI 10.75
    rCSI 9.79%
    PRS 82.28
  • mononuclear phagocyte CL0000113
    CSI 5.85
    rCSI 12.88%
    PRS 72.55
  • mucosal invariant T cell CL0000940
    CSI 5.82
    rCSI 4.7%
    PRS 78.61
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 5.02
    rCSI 6.06%
    PRS 77.36
  • ependymal cell CL0000065
    CSI 4.07
    rCSI 8.25%
    PRS 46.78
  • Kupffer cell CL0000091
    CSI 3.99
    rCSI 9.12%
    PRS 68.87
  • unswitched memory B cell CL0000970
    CSI 3.93
    rCSI 3.31%
    PRS 84.04
  • melanocyte CL0000148
    CSI 3.5
    rCSI 2.59%
    PRS 61.19
  • group 3 innate lymphoid cell CL0001071
    CSI 3.41
    rCSI 2.57%
    PRS 74.07
  • pulmonary artery endothelial cell CL1001568
    CSI 3.23
    rCSI 4.39%
    PRS 79.14
  • cerebellar granule cell CL0001031
    CSI 3.14
    rCSI 4.61%
    PRS 61.49
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 3.12
    rCSI 8.13%
    PRS 68.62
  • class switched memory B cell CL0000972
    CSI 2.93
    rCSI 2.19%
    PRS 83.57
  • cardiac endothelial cell CL0010008
    CSI 2.88
    rCSI 11.63%
    PRS 67.55
  • hepatic stellate cell CL0000632
    CSI 2.62
    rCSI 9.83%
    PRS 60.26
  • mesothelial cell CL0000077
    CSI 2.59
    rCSI 10.14%
    PRS 45.64
  • interneuron CL0000099
    CSI 2.58
    rCSI 5.18%
    PRS 57.59
  • vascular leptomeningeal cell CL4023051
    CSI 2.55
    rCSI 4.46%
    PRS 60.87
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 2.46
    rCSI 7.68%
    PRS 53.87
  • choroid plexus epithelial cell CL0000706
    CSI 2.43
    rCSI 3.98%
    PRS 57.45
  • renal beta-intercalated cell CL0002201
    CSI 2.34
    rCSI 5.58%
    PRS 68.83
  • pulmonary alveolar type 1 cell CL0002062
    CSI 2.3
    rCSI 13.29%
    PRS 66.37
  • neural crest cell CL0011012
    CSI 2.09
    rCSI 1.65%
    PRS 55.48
  • conjunctival epithelial cell CL1000432
    CSI 2.06
    rCSI 3.14%
    PRS 69.16
  • intrahepatic cholangiocyte CL0002538
    CSI 2.05
    rCSI 4.91%
    PRS 76.6
  • blood vessel endothelial cell CL0000071
    CSI 2.02
    rCSI 4.18%
    PRS 65.42
  • cerebral cortex endothelial cell CL1001602
    CSI 1.99
    rCSI 3.44%
    PRS 58.76
  • Langerhans cell CL0000453
    CSI 1.97
    rCSI 3%
    PRS 82.72
  • sst GABAergic cortical interneuron CL4023017
    CSI 1.94
    rCSI 2.5%
    PRS 50.91
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 1.94
    rCSI 2.75%
    PRS 64.69
  • colon epithelial cell CL0011108
    CSI 1.88
    rCSI 1.96%
    PRS 65.15
  • CD14-positive monocyte CL0001054
    CSI 1.83
    rCSI 2.28%
    PRS 79.08
  • myeloid dendritic cell CL0000782
    CSI 1.75
    rCSI 2.54%
    PRS 83.51
  • lung secretory cell CL1000272
    CSI 1.75
    rCSI 4.32%
    PRS 67.18
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 1.74
    rCSI 2.16%
    PRS 47.67
  • BEST4+ enteroycte CL4030026
    CSI 1.74
    rCSI 2.16%
    PRS 70.16
  • astrocyte of the cerebral cortex CL0002605
    CSI 1.73
    rCSI 3.89%
    PRS 50.26
  • paneth cell of epithelium of small intestine CL1000343
    CSI 1.73
    rCSI 4.85%
    PRS 78.25
  • fibroblast of cardiac tissue CL0002548
    CSI 1.63
    rCSI 7.82%
    PRS 68.32
  • retinal ganglion cell CL0000740
    CSI 1.62
    rCSI 3.59%
    PRS 54.31
  • Hofbauer cell CL3000001
    CSI 1.59
    rCSI 3.01%
    PRS 78.47
  • cardiac muscle cell CL0000746
    CSI 1.59
    rCSI 2.28%
    PRS 57.91
  • epithelial cell of proximal tubule CL0002306
    CSI 1.59
    rCSI 3.88%
    PRS 61.53
  • renal principal cell CL0005009
    CSI 1.52
    rCSI 3.96%
    PRS 71.35
  • small intestine goblet cell CL1000495
    CSI 1.51
    rCSI 3.31%
    PRS 75.46
  • lymphoid lineage restricted progenitor cell CL0000838
    CSI 1.48
    rCSI 5.76%
    PRS 86.71
  • dendritic cell, human CL0001056
    CSI 1.43
    rCSI 2.2%
    PRS 77.69
  • extravillous trophoblast CL0008036
    CSI 1.36
    rCSI 1.68%
    PRS 65.27
  • renal interstitial pericyte CL1001318
    CSI 1.33
    rCSI 3.67%
    PRS 63.51
  • regular atrial cardiac myocyte CL0002129
    CSI 1.29
    rCSI 4.16%
    PRS 66.04
  • cardiac neuron CL0010022
    CSI 1.27
    rCSI 4.07%
    PRS 65.64
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 1.25
    rCSI 3.23%
    PRS 63.35
  • intestinal crypt stem cell of small intestine CL0009017
    CSI 1.18
    rCSI 3.18%
    PRS 74.69
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 1.13
    rCSI 0.87%
    PRS 69.9
  • kidney connecting tubule epithelial cell CL1000768
    CSI 1.07
    rCSI 2.7%
    PRS 57.97
  • parietal epithelial cell CL1000452
    CSI 0.87
    rCSI 2.34%
    PRS 59.38
  • regular ventricular cardiac myocyte CL0002131
    CSI 0.87
    rCSI 5.44%
    PRS 59.9
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 0.86
    rCSI 2.1%
    PRS 48.01
  • indirect pathway medium spiny neuron CL4023029
    CSI 0.85
    rCSI 20.59%
    PRS 49.43
  • ON midget ganglion cell CL4033046
    CSI 0.73
    rCSI 14.88%
    PRS 58.78
  • direct pathway medium spiny neuron CL4023026
    CSI 0.69
    rCSI 16.44%
    PRS 48.76
  • luminal cell of prostate epithelium CL0002340
    CSI 0.67
    rCSI 3.62%
    PRS 78.67
  • L6b glutamatergic cortical neuron CL4023038
    CSI 0.65
    rCSI 2.02%
    PRS 51.33
  • kidney distal convoluted tubule epithelial cell CL1000849
    CSI 0.63
    rCSI 6.72%
    PRS 65.99
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 0.63
    rCSI 3.69%
    PRS 50.76
  • OFF midget ganglion cell CL4033047
    CSI 0.43
    rCSI 8.81%
    PRS 60.31
  • medium spiny neuron CL1001474
    CSI 0.23
    rCSI 1.97%
    PRS 55.53

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [MAP3K14](/details-gene/9020), also known as NF-κB-inducing kinase (NIK), is a protein-coding gene located on chromosome 17q21.31. It functions as a serine/threonine protein kinase and is a central upstream regulator of the non-canonical NF-κB signaling pathway. This pathway is critical for various aspects of the immune system, including lymphoid organ development, B-cell maturation, and inflammatory responses. Consistent with this role, **Overall**, [MAP3K14](/details-gene/9020) shows high significance in mature, activated immune cells, most notably [plasmablasts](/details-cell/CL0000980) and [effector memory CD8-positive, alpha-beta T cells](/details-cell/CL0000913), suggesting a crucial function in the terminal differentiation and long-term function of both the humoral and cellular arms of the adaptive immune system. ## Cellular Roles and Expression Landscape The expression profile of [MAP3K14](/details-gene/9020) highlights its profound importance within the immune system, spanning both lymphoid and myeloid lineages. **Overall**, the gene exhibits its highest significance in highly differentiated lymphocyte populations. It is a top marker for [plasmablasts](/details-cell/CL0000980) (CSI: 12.15), the terminally differentiated antibody-secreting B cells, and various T cell subsets, including [effector memory CD8-positive, alpha-beta T cells](/details-cell/CL0000913) (CSI: 10.75) and [mucosal invariant T cells](/details-cell/CL0000940) (CSI: 5.82). Its high significance extends to different stages of B cell maturation, including [unswitched memory B cells](/details-cell/CL0000970) and [class switched memory B cells](/details-cell/CL0000972), underscoring a continuous role in B cell biology. In the myeloid compartment, [MAP3K14](/details-gene/9020) is significant in antigen-presenting cells such as [mononuclear phagocytes](/details-cell/CL0000113), [CD1c-positive myeloid dendritic cells](/details-cell/CL0002399), and tissue-resident macrophages like [Kupffer cells](/details-cell/CL0000091). This expression pattern is consistent with its role in integrating signals from innate immune receptors and cytokines. Beyond the immune system, [MAP3K14](/details-gene/9020) also shows relevance in select other cell types, including [ependymal cells](/details-cell/CL0000065) and endothelial cells like [pulmonary artery endothelial cells](/details-cell/CL1001568), which may suggest a role in inflammation or cell signaling within these specific tissue contexts. ## Pathways and Molecular Function Functionally, [MAP3K14](/details-gene/9020) is a protein kinase ([GO:0004672](https://www.ebi.ac.uk/QuickGO/term/GO:0004672)) with specific MAP kinase kinase kinase activity ([GO:0004709](https://www.ebi.ac.uk/QuickGO/term/GO:0004709)). Its primary and most well-characterized function is as the apical kinase in the non-canonical NF-κB signaling pathway ([GO:0038061](https://www.ebi.ac.uk/QuickGO/term/GO:0038061)). This is supported by its involvement in Reactome pathways such as `Nik-->noncanonical nf-kb signaling` ([R-HSA-5676590](https://reactome.org/content/detail/R-HSA-5676590)) and signaling downstream of `Tnf receptor superfamily (tnfsf) members` ([R-HSA-5676594](https://reactome.org/content/detail/R-HSA-5676594)). Early research established its involvement in NF-κB induction by stimuli such as TNF and IL-1 ([Link](https://doi.org/10.1038/385540a0)). The non-canonical NF-κB pathway is essential for the activation and survival of B cells, the generation of secondary lymphoid organs, and the function of T cells and dendritic cells. The kinase activity of [MAP3K14](/details-gene/9020) leads to the phosphorylation and activation of IKKα, which in turn processes the NF-κB2 precursor protein p100 into its active p52 form. This role places [MAP3K14](/details-gene/9020) as a critical node within the broader `Immune system` ([R-HSA-168256](https://reactome.org/content/detail/R-HSA-168256)), influencing both the `Innate immune system` ([R-HSA-168249](https://reactome.org/content/detail/R-HSA-168249)) via pathways like `Clec7a (dectin-1) signaling` ([R-HSA-5607764](https://reactome.org/content/detail/R-HSA-5607764)), and the `Adaptive immune system` ([R-HSA-1280218](https://reactome.org/content/detail/R-HSA-1280218)) through processes such as `Cd28 co-stimulation` ([R-HSA-389356](https://reactome.org/content/detail/R-HSA-389356)). ## Research Directions The specific and high significance of [MAP3K14](/details-gene/9020) in terminally differentiated immune cells, coupled with its central role as a signaling kinase, opens several avenues for investigation into its function in health and disease. **Proposed Hypotheses:** 1. Given its peak significance in [plasmablasts](/details-cell/CL0000980), [MAP3K14](/details-gene/9020) may be an essential checkpoint for the survival and secretory function of antibody-producing cells. Its constitutive activation or overexpression could be a key driver in plasma cell dyscrasias like multiple myeloma. 2. The high significance of [MAP3K14](/details-gene/9020) in [effector memory CD8-positive, alpha-beta T cells](/details-cell/CL0000913) suggests it plays a critical, non-redundant role in integrating co-stimulatory and cytokine signals required for the long-term maintenance and recall potential of these memory cells. **Suggested Experiment:** To test the hypothesis regarding its role in plasma cell biology, a loss-of-function study could be performed. Human primary B cells could be isolated and transduced with lentiviral vectors expressing either a [MAP3K14](/details-gene/9020)-targeting shRNA or a non-targeting control. These cells would then be cultured under conditions that promote differentiation into plasmablasts (e.g., stimulation with IL-21 and CD40L). The impact of [MAP3K14](/details-gene/9020) knockdown would be assessed by measuring the efficiency of plasmablast generation (via flow cytometry for CD38 and CD138), the quantity of secreted immunoglobulin (via ELISA), and the rate of apoptosis (via Annexin V staining). **Therapeutic Potential:** As a protein kinase, [MAP3K14](/details-gene/9020) is a highly druggable target. The non-canonical NF-κB pathway is frequently found to be constitutively active in various B-cell malignancies (e.g., multiple myeloma, marginal zone lymphoma) and autoimmune diseases. Therefore, [MAP3K14](/details-gene/9020) represents a promising therapeutic target for **inhibition**. The development of selective small molecule inhibitors against the kinase domain of [MAP3K14](/details-gene/9020) could provide a targeted therapy to suppress the pro-survival signaling in these pathological contexts. However, its broad importance in immune cell function suggests that systemic inhibition could lead to immunosuppressive side effects, requiring careful consideration of therapeutic windows and patient populations.

Genular Protein ID: 2905303571

Symbol: M3K14_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q99558 A8K2D8 D3DX67 Q8IYN1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 3 EMBL 6 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PIRSF 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 5 RefSeq 2 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9020361

Title: MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1.

PubMed ID: 9020361

DOI: 10.1038/385540a0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12874243

Title: Pellino3, a novel member of the Pellino protein family, promotes activation of c-Jun and Elk-1 and may act as a scaffolding protein.

PubMed ID: 12874243

DOI: 10.4049/jimmunol.171.3.1500

PubMed ID: 12853971

Title: NIK is a component of the EGF/heregulin receptor signaling complexes.

PubMed ID: 12853971

DOI: 10.1038/sj.onc.1206532

PubMed ID: 15084608

Title: Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation.

PubMed ID: 15084608

DOI: 10.1074/jbc.m403286200

PubMed ID: 15173580

Title: beta-Arrestin inhibits NF-kappaB activity by means of its interaction with the NF-kappaB inhibitor IkappaBalpha.

PubMed ID: 15173580

DOI: 10.1073/pnas.0402851101

PubMed ID: 15951441

Title: NIBP, a novel NIK and IKK(beta)-binding protein that enhances NF-(kappa)B activation.

PubMed ID: 15951441

DOI: 10.1074/jbc.m501670200

PubMed ID: 17237370

Title: Monarch-1 suppresses non-canonical NF-kappaB activation and p52-dependent chemokine expression in monocytes.

PubMed ID: 17237370

DOI: 10.4049/jimmunol.178.3.1256

PubMed ID: 20501937

Title: Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylation.

PubMed ID: 20501937

DOI: 10.1126/scisignal.2000778

PubMed ID: 30341167

Title: DDX3 directly facilitates IKKalpha activation and regulates downstream signalling pathways.

PubMed ID: 30341167

DOI: 10.1042/bcj20180163

PubMed ID: 22718757

Title: Structure of the nuclear factor kappaB-inducing kinase (NIK) kinase domain reveals a constitutively active conformation.

PubMed ID: 22718757

DOI: 10.1074/jbc.m112.366658

PubMed ID: 22921830

Title: The crystal structure of the catalytic domain of the NF-kappaB inducing kinase reveals a narrow but flexible active site.

PubMed ID: 22921830

DOI: 10.1016/j.str.2012.07.013

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 20682767

Title: An atypical E3 ligase zinc finger protein 91 stabilizes and activates NF-kappaB-inducing kinase via Lys63-linked ubiquitination.

PubMed ID: 20682767

DOI: 10.1074/jbc.m110.129551

PubMed ID: 25406581

Title: Biallelic loss-of-function mutation in NIK causes a primary immunodeficiency with multifaceted aberrant lymphoid immunity.

PubMed ID: 25406581

DOI: 10.1038/ncomms6360

PubMed ID: 29230214

Title: Exome Sequencing Identifies a Novel MAP3K14 Mutation in Recessive Atypical Combined Immunodeficiency.

PubMed ID: 29230214

DOI: 10.3389/fimmu.2017.01624

Sequence Information:

  • Length: 947
  • Mass: 104042
  • Checksum: C9D10F67FF7F48AC
  • Sequence:
    • MAVMEMACPG APGSAVGQQK ELPKAKEKTP PLGKKQSSVY KLEAVEKSPV FCGKWEILND 
VITKGTAKEG SEAGPAAISI IAQAECENSQ EFSPTFSERI FIAGSKQYSQ SESLDQIPNN 
VAHATEGKMA RVCWKGKRRS KARKKRKKKS SKSLAHAGVA LAKPLPRTPE QESCTIPVQE 
DESPLGAPYV RNTPQFTKPL KEPGLGQLCF KQLGEGLRPA LPRSELHKLI SPLQCLNHVW 
KLHHPQDGGP LPLPTHPFPY SRLPHPFPFH PLQPWKPHPL ESFLGKLACV DSQKPLPDPH 
LSKLACVDSP KPLPGPHLEP SCLSRGAHEK FSVEEYLVHA LQGSVSSGQA HSLTSLAKTW 
AARGSRSREP SPKTEDNEGV LLTEKLKPVD YEYREEVHWA THQLRLGRGS FGEVHRMEDK 
QTGFQCAVKK VRLEVFRAEE LMACAGLTSP RIVPLYGAVR EGPWVNIFME LLEGGSLGQL 
VKEQGCLPED RALYYLGQAL EGLEYLHSRR ILHGDVKADN VLLSSDGSHA ALCDFGHAVC 
LQPDGLGKSL LTGDYIPGTE THMAPEVVLG RSCDAKVDVW SSCCMMLHML NGCHPWTQFF 
RGPLCLKIAS EPPPVREIPP SCAPLTAQAI QEGLRKEPIH RVSAAELGGK VNRALQQVGG 
LKSPWRGEYK EPRHPPPNQA NYHQTLHAQP RELSPRAPGP RPAEETTGRA PKLQPPLPPE 
PPEPNKSPPL TLSKEESGMW EPLPLSSLEP APARNPSSPE RKATVPEQEL QQLEIELFLN 
SLSQPFSLEE QEQILSCLSI DSLSLSDDSE KNPSKASQSS RDTLSSGVHS WSSQAEARSS 
SWNMVLARGR PTDTPSYFNG VKVQIQSLNG EHLHIREFHR VKVGDIATGI SSQIPAAAFS 
LVTKDGQPVR YDMEVPDSGI DLQCTLAPDG SFAWSWRVKH GQLENRP

Genular Protein ID: 238365066

Symbol: Q68D39_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q68D39

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 1 RuleBase 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 433
  • Mass: 47220
  • Checksum: F9A8E975968AA0CA
  • Sequence:
    • CFKQLGEGLR PALPRSELHK LISPLQCLNH VWKLHHPQDG GPLPLPTHPF PFHPLQPWKP 
HPLESFLGKL ACVDSQKPLP DPHLSKLACV DSPKPLPGPH LEPSCLSRGA HEKFSVEEYL 
VHALQGSVSS GQAHSLTSLA KTWAARGSRS RGPSPKTEDN EGVLLTEKLK PVDYEYREEV 
HWATHQLRLG RGSFGEVHRM EDKQTGFQCA VKKVRLEVFR AEELMACAGL TSPRIVPLYG 
AVREGPWVNI FMELLEGGSL GQLVKEQGCL PEDRALYYLG QALEGLEYLH SRRILHGDVK 
ADNVLLSSDG SHAALCDFGH AVCLQPDGLG KSLLTGDYIP GTETHMAPEV VLGRSCDAKV 
DVWSSCCMML HMLNGCHPWT QFFRGPLCLK VGDGTQHGQQ GELQGPGAQA AGWRGCSAVA 
DGARGGLVIH VGS