Details for: ANGPTL1
Gene ID: 9068
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: ANGPTL1
Ensembl ID: ENSG00000116194
Description: angiopoietin like 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 13.93rCSI 12.01%PRS 85.53
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CSI 12.87rCSI 37.25%PRS 85.03
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CSI 10.89rCSI 19.56%PRS 80.03
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CSI 6.32rCSI 15.07%PRS 85.69
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CSI 6.31rCSI 20.33%PRS 82.63
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CSI 4.75rCSI 9.64%PRS 66.28
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CSI 4.43rCSI 12.17%PRS 90.26
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CSI 4.4rCSI 3.67%PRS 82.95
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CSI 4.29rCSI 9.91%PRS 75.2
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CSI 4.24rCSI 24.65%PRS 88.21
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CSI 4.06rCSI 3.3%PRS 85.28
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CSI 3.82rCSI 4.19%PRS 87.55
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CSI 3.8rCSI 5.43%PRS 86.38
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CSI 3.69rCSI 16.24%PRS 80.47
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CSI 3.66rCSI 20.98%PRS 87.02
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CSI 3.5rCSI 18.42%PRS 86.62
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CSI 3.43rCSI 9.75%PRS 81.6
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CSI 3.32rCSI 7.57%PRS 78.31
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CSI 3.27rCSI 10.48%PRS 83.7
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CSI 3.27rCSI 5.77%PRS 81.36
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CSI 3.21rCSI 3.89%PRS 66.27
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CSI 3.2rCSI 7.68%PRS 87.84
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CSI 3.2rCSI 6.42%PRS 78.04
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CSI 3.15rCSI 4.29%PRS 54.09
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CSI 3.11rCSI 4.58%PRS 79.6
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CSI 2.96rCSI 11.09%PRS 79.67
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CSI 2.92rCSI 4.04%PRS 82.28
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CSI 2.79rCSI 4.44%PRS 79.96
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CSI 2.74rCSI 5.14%PRS 75.83
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CSI 2.7rCSI 7.6%PRS 81.25
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CSI 2.69rCSI 3.74%PRS 84.21
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CSI 2.62rCSI 3.5%PRS 90.45
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CSI 2.61rCSI 11.48%PRS 74.51
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CSI 2.53rCSI 3.04%PRS 84.1
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CSI 2.51rCSI 4%PRS 77.86
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CSI 2.41rCSI 10.12%PRS 88.94
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CSI 2.24rCSI 2.59%PRS 78.34
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CSI 2.2rCSI 3.58%PRS 54.28
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CSI 2.19rCSI 2.82%PRS 71.23
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CSI 2.05rCSI 4.89%PRS 88.73
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CSI 1.96rCSI 10.9%PRS 87.35
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CSI 1.91rCSI 2.29%PRS 70.21
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CSI 1.89rCSI 3.38%PRS 84.96
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CSI 1.73rCSI 2.91%PRS 70.02
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CSI 1.73rCSI 2.73%PRS 86.98
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CSI 1.7rCSI 3.51%PRS 81.32
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CSI 1.66rCSI 2.92%PRS 89.6
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CSI 1.64rCSI 2.64%PRS 77.03
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CSI 1.57rCSI 2.78%PRS 69.62
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CSI 1.56rCSI 4.06%PRS 90.42
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CSI 1.55rCSI 1.99%PRS 76.73
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CSI 1.51rCSI 4.89%PRS 83.9
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CSI 1.5rCSI 3.09%PRS 91.39
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CSI 1.44rCSI 2.56%PRS 55.46
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CSI 1.36rCSI 3.28%PRS 87.69
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CSI 1.35rCSI 2.16%PRS 71.45
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CSI 1.33rCSI 8.3%PRS 78.6
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CSI 1.3rCSI 7.63%PRS 70.55
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CSI 1.25rCSI 2.77%PRS 73.33
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CSI 1.21rCSI 4.57%PRS 70.4
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CSI 1.2rCSI 3.48%PRS 76.36
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CSI 1.1rCSI 1.56%PRS 83.07
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CSI 1.02rCSI 2.48%PRS 67.88
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CSI 1.01rCSI 2.57%PRS 79.78
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CSI 1rCSI 3.13%PRS 73.71
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CSI 0.91rCSI 2.93%PRS 86.28
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CSI 0.81rCSI 2.53%PRS 71.53
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CSI 0.78rCSI 18.8%PRS 68.33
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CSI 0.63rCSI 2.28%PRS 68.02
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CSI 0.41rCSI 6.19%PRS 91.74
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CSI 0.37rCSI 4.03%PRS 89.13
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CSI 0.3rCSI 2.44%PRS 81.51
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CSI 0.23rCSI 5.6%PRS 67.87
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
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Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 31671777
Symbol: ANGL1_HUMAN
Name: Angiopoietin-related protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10025962
Title: Molecular cloning and characterization of a novel angiopoietin family protein, angiopoietin-3.
PubMed ID: 10025962
PubMed ID: 12975309
Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
PubMed ID: 12975309
DOI: 10.1101/gr.1293003
PubMed ID: 16303743
Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.
PubMed ID: 16303743
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 491
- Mass: 56720
- Checksum: 3C4DB8DEF6CF7E99
- Sequence:
MKTFTWTLGV LFFLLVDTGH CRGGQFKIKK INQRRYPRAT DGKEEAKKCA YTFLVPEQRI TGPICVNTKG QDASTIKDMI TRMDLENLKD VLSRQKREID VLQLVVDVDG NIVNEVKLLR KESRNMNSRV TQLYMQLLHE IIRKRDNSLE LSQLENKILN VTTEMLKMAT RYRELEVKYA SLTDLVNNQS VMITLLEEQC LRIFSRQDTH VSPPLVQVVP QHIPNSQQYT PGLLGGNEIQ RDPGYPRDLM PPPDLATSPT KSPFKIPPVT FINEGPFKDC QQAKEAGHSV SGIYMIKPEN SNGPMQLWCE NSLDPGGWTV IQKRTDGSVN FFRNWENYKK GFGNIDGEYW LGLENIYMLS NQDNYKLLIE LEDWSDKKVY AEYSSFRLEP ESEFYRLRLG TYQGNAGDSM MWHNGKQFTT LDRDKDMYAG NCAHFHKGGW WYNACAHSNL NGVWYRGGHY RSKHQDGIFW AEYRGGSYSL RAVQMMIKPI D