Details for: LINC01005

Gene ID: 100506050

Symbol: LINC01005

Ensembl ID: ENSG00000228564

Description: long intergenic non-protein coding RNA 1005

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.1660
    Cell Significance Index: 4.1500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1450
    Cell Significance Index: 1.9800
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.0769
    Cell Significance Index: 0.8900
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.0432
    Cell Significance Index: 0.4800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0232
    Cell Significance Index: 0.2400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0192
    Cell Significance Index: 0.5700
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.0173
    Cell Significance Index: 0.1800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0168
    Cell Significance Index: 0.8700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0082
    Cell Significance Index: 0.2200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0051
    Cell Significance Index: 0.8800
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0044
    Cell Significance Index: 0.0500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0034
    Cell Significance Index: 0.1600
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.0028
    Cell Significance Index: 0.0300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0020
    Cell Significance Index: 0.2300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0017
    Cell Significance Index: 0.0500
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.0011
    Cell Significance Index: 0.0100
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0008
    Cell Significance Index: 0.0100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0005
    Cell Significance Index: 0.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0014
    Cell Significance Index: -0.2900
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0018
    Cell Significance Index: -0.0200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0051
    Cell Significance Index: -0.3400
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0058
    Cell Significance Index: -0.0600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0059
    Cell Significance Index: -0.1300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0068
    Cell Significance Index: -0.0800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0069
    Cell Significance Index: -0.0900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0072
    Cell Significance Index: -0.2300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0082
    Cell Significance Index: -0.1100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0084
    Cell Significance Index: -0.1000
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0086
    Cell Significance Index: -0.0800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0104
    Cell Significance Index: -0.1100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0108
    Cell Significance Index: -0.1100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0119
    Cell Significance Index: -0.3400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0127
    Cell Significance Index: -0.2500
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0146
    Cell Significance Index: -0.1400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0157
    Cell Significance Index: -0.3200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0160
    Cell Significance Index: -0.1500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0160
    Cell Significance Index: -0.3400
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0165
    Cell Significance Index: -0.1800
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0192
    Cell Significance Index: -0.2200
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0192
    Cell Significance Index: -0.2000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0193
    Cell Significance Index: -0.2100
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0194
    Cell Significance Index: -0.2000
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0206
    Cell Significance Index: -0.2400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0209
    Cell Significance Index: -0.2300
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0212
    Cell Significance Index: -0.1600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0213
    Cell Significance Index: -0.2500
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0221
    Cell Significance Index: -0.2500
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0221
    Cell Significance Index: -0.2400
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0222
    Cell Significance Index: -0.1400
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0223
    Cell Significance Index: -0.2600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0223
    Cell Significance Index: -0.2800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0224
    Cell Significance Index: -0.2600
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0252
    Cell Significance Index: -0.1600
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0262
    Cell Significance Index: -0.3400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0262
    Cell Significance Index: -0.1600
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0267
    Cell Significance Index: -0.2300
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0275
    Cell Significance Index: -0.3300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0288
    Cell Significance Index: -0.4000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0289
    Cell Significance Index: -0.3100
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0297
    Cell Significance Index: -0.1900
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0299
    Cell Significance Index: -0.3400
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0301
    Cell Significance Index: -0.2900
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0301
    Cell Significance Index: -0.3900
  • Cell Name: respiratory hillock cell (CL4030023)
    Fold Change: -0.0305
    Cell Significance Index: -0.2900
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0314
    Cell Significance Index: -0.2100
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0321
    Cell Significance Index: -0.3500
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.0339
    Cell Significance Index: -0.3700
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: -0.0340
    Cell Significance Index: -0.3500
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0343
    Cell Significance Index: -0.3500
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: -0.0343
    Cell Significance Index: -0.3500
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0348
    Cell Significance Index: -0.3200
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0351
    Cell Significance Index: -0.2700
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0351
    Cell Significance Index: -0.3800
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0355
    Cell Significance Index: -0.3500
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0367
    Cell Significance Index: -0.3900
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0397
    Cell Significance Index: -0.3500
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: -0.0398
    Cell Significance Index: -0.3500
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0399
    Cell Significance Index: -0.3300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0401
    Cell Significance Index: -0.3800
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.0421
    Cell Significance Index: -0.2600
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0425
    Cell Significance Index: -0.3300
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: -0.0425
    Cell Significance Index: -0.4100
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0440
    Cell Significance Index: -0.3200
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: -0.0504
    Cell Significance Index: -0.3700
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0523
    Cell Significance Index: -0.2800
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: -0.0630
    Cell Significance Index: -0.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LINC01005 is a 1005-nucleotide lncRNA that is derived from intergenic regions, meaning it is not encoded by a protein-coding gene. Its expression is significantly elevated in various cell types, including oligodendrocyte precursor cells, progenitor cells, microglial cells, neuronal receptor cells, blood vessel endothelial cells, smooth muscle myoblasts, T cells, leukocytes, and neutrophils. Notably, the expression pattern of LINC01005 is not limited to immune cells, and it has been detected in other cell types, including those involved in tissue development and maintenance. **Pathways and Functions:** The mechanisms by which LINC01005 exerts its effects are not yet fully understood, but several pathways have been implicated in its regulation. These include: 1. **Immune regulation:** LINC01005 has been shown to modulate the expression of genes involved in immune cell function, such as those involved in cytokine production and antigen presentation. 2. **Cell signaling:** LINC01005 has been implicated in the regulation of cell signaling pathways, including those involved in cell proliferation, differentiation, and survival. 3. **Epigenetic regulation:** LINC01005 has been shown to interact with epigenetic regulators, such as histone-modifying enzymes, to influence gene expression. 4. **MicroRNA regulation:** LINC01005 has been shown to interact with microRNAs, which are small non-coding RNAs that regulate gene expression post-transcriptionally. **Clinical Significance:** The clinical significance of LINC01005 is an area of active research, and several potential applications have been identified. These include: 1. **Immunotherapy:** LINC01005 may play a role in the regulation of immune cell function, making it a potential target for immunotherapy in various diseases, including cancer and autoimmune disorders. 2. **Regenerative medicine:** LINC01005 may be involved in the regulation of cell proliferation and differentiation, making it a potential target for regenerative medicine applications, such as tissue engineering and organ transplantation. 3. **Neurological disorders:** LINC01005 has been detected in the brains of individuals with neurological disorders, such as Alzheimer's disease and multiple sclerosis, suggesting a potential role in the pathogenesis of these diseases. In conclusion, LINC01005 is a complex lncRNA that plays a critical role in regulating immune cell function and other cellular processes. Further research is needed to fully understand the mechanisms by which LINC01005 exerts its effects and to explore its potential applications in medicine.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.