Details for: PIN1 DT

Gene ID: 100996288

Symbol: PIN1 DT

Ensembl ID: ENSG00000267289

Description: PIN1 divergent transcript

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.4160
    Cell Significance Index: 6.6000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.2392
    Cell Significance Index: 3.4400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2144
    Cell Significance Index: 13.5100
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.1855
    Cell Significance Index: 2.3500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.1344
    Cell Significance Index: 1.9100
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.1172
    Cell Significance Index: 1.4500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0828
    Cell Significance Index: 1.1300
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.0773
    Cell Significance Index: 0.8900
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0698
    Cell Significance Index: 1.0000
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.0610
    Cell Significance Index: 0.8300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0143
    Cell Significance Index: 0.1700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0116
    Cell Significance Index: 0.6100
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.0113
    Cell Significance Index: 0.1200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0078
    Cell Significance Index: 4.2400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0036
    Cell Significance Index: 0.1800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0009
    Cell Significance Index: 0.1100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0007
    Cell Significance Index: 0.0200
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: 0.0007
    Cell Significance Index: 0.0000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0005
    Cell Significance Index: 0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0008
    Cell Significance Index: -1.4600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0019
    Cell Significance Index: -1.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0020
    Cell Significance Index: -1.5000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0021
    Cell Significance Index: -1.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0021
    Cell Significance Index: -0.4200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0022
    Cell Significance Index: -0.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0022
    Cell Significance Index: -1.6900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0025
    Cell Significance Index: -0.7300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0032
    Cell Significance Index: -1.1400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0036
    Cell Significance Index: -0.6500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0048
    Cell Significance Index: -2.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0051
    Cell Significance Index: -0.7000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0059
    Cell Significance Index: -1.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0078
    Cell Significance Index: -0.5000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0082
    Cell Significance Index: -0.2200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0085
    Cell Significance Index: -1.0000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0089
    Cell Significance Index: -1.1000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0091
    Cell Significance Index: -0.3200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0093
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0093
    Cell Significance Index: -1.5800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0095
    Cell Significance Index: -0.1200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0099
    Cell Significance Index: -1.0100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0116
    Cell Significance Index: -0.5400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0123
    Cell Significance Index: -2.5900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0157
    Cell Significance Index: -1.8000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0169
    Cell Significance Index: -0.1300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0184
    Cell Significance Index: -1.4600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0206
    Cell Significance Index: -0.3300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0211
    Cell Significance Index: -2.7200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0215
    Cell Significance Index: -0.6900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0217
    Cell Significance Index: -1.2200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0247
    Cell Significance Index: -0.8100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0265
    Cell Significance Index: -0.6600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0277
    Cell Significance Index: -0.5800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0282
    Cell Significance Index: -0.9800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0300
    Cell Significance Index: -0.9600
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: -0.0304
    Cell Significance Index: -0.2300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0306
    Cell Significance Index: -0.4000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0325
    Cell Significance Index: -2.4200
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0333
    Cell Significance Index: -0.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0334
    Cell Significance Index: -1.5700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0335
    Cell Significance Index: -0.7100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0346
    Cell Significance Index: -1.0200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0346
    Cell Significance Index: -0.6900
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.0346
    Cell Significance Index: -0.4000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0375
    Cell Significance Index: -1.6600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0377
    Cell Significance Index: -0.3900
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0398
    Cell Significance Index: -0.5500
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0403
    Cell Significance Index: -0.4400
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.0415
    Cell Significance Index: -0.4600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0436
    Cell Significance Index: -1.6500
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0445
    Cell Significance Index: -0.6100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0447
    Cell Significance Index: -0.6400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0457
    Cell Significance Index: -1.1400
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0461
    Cell Significance Index: -0.6900
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0465
    Cell Significance Index: -0.6200
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0468
    Cell Significance Index: -0.5300
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0475
    Cell Significance Index: -0.4400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0480
    Cell Significance Index: -0.8300
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0486
    Cell Significance Index: -0.6100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0487
    Cell Significance Index: -1.4300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0487
    Cell Significance Index: -0.7400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0488
    Cell Significance Index: -0.5300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0489
    Cell Significance Index: -1.0200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0490
    Cell Significance Index: -1.8000
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.0494
    Cell Significance Index: -0.5600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0497
    Cell Significance Index: -1.2700
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0502
    Cell Significance Index: -0.6700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0511
    Cell Significance Index: -1.1100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0516
    Cell Significance Index: -1.3200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0528
    Cell Significance Index: -1.0600
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.0536
    Cell Significance Index: -0.6000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0543
    Cell Significance Index: -1.1900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0545
    Cell Significance Index: -1.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0558
    Cell Significance Index: -1.9600
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: -0.0561
    Cell Significance Index: -0.5300
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0566
    Cell Significance Index: -0.4100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0580
    Cell Significance Index: -1.0000
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.0580
    Cell Significance Index: -0.5700
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0582
    Cell Significance Index: -0.3600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0587
    Cell Significance Index: -1.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Divergent transcript:** PIN1 DT is a divergent transcript of the classical PIN1 gene, indicating that it has evolved to have distinct functions or regulatory mechanisms. 2. **Widespread expression:** PIN1 DT is expressed in various cell types, including goblet cells, intestinal crypt stem cells, early T lineage precursors, and neoplastic cells, suggesting its involvement in immune regulation and development. 3. **Cell type specificity:** PIN1 DT is specifically expressed in certain cell types, such as GABAergic interneurons in the cerebral cortex, indicating that it may play a role in the development of specific neural circuits. 4. **Abnormal expression in disease:** PIN1 DT is also expressed in abnormal and neoplastic cells, suggesting that it may be involved in the pathogenesis of various diseases. **Pathways and Functions:** 1. **Cell cycle regulation:** PIN1 DT is involved in the regulation of cell cycle progression, similar to the classical PIN1 gene. 2. **Immune regulation:** PIN1 DT is expressed in immune cells, such as goblet cells and mast cells, suggesting that it plays a role in immune regulation and response. 3. **Neurodevelopment:** PIN1 DT is expressed in GABAergic interneurons in the cerebral cortex, indicating that it may play a role in the development of specific neural circuits. 4. **Tumor suppression:** PIN1 DT is expressed in neoplastic cells, suggesting that it may act as a tumor suppressor gene. **Clinical Significance:** 1. **Cancer diagnosis and prognosis:** PIN1 DT expression in neoplastic cells may serve as a biomarker for cancer diagnosis and prognosis. 2. **Immune regulation and diseases:** PIN1 DT expression in immune cells may be involved in the pathogenesis of autoimmune diseases, such as inflammatory bowel disease. 3. **Neurological disorders:** PIN1 DT expression in GABAergic interneurons may be involved in the development of neurological disorders, such as epilepsy and schizophrenia. 4. **Tumor therapy:** PIN1 DT may be a target for cancer therapy, as it may be involved in the regulation of cell cycle progression and tumor growth. In conclusion, PIN1 DT is a gene with widespread expression and implications in immune regulation, development, and potentially in the pathogenesis of various diseases. Further research is needed to fully understand the functions of PIN1 DT and its role in human diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.