Details for: KLK8

Gene ID: 11202

Symbol: KLK8

Ensembl ID: ENSG00000129455

Description: kallikrein related peptidase 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thymocyte (CL0000893)
    Fold Change: 12.1824
    Cell Significance Index: 153.9300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.1262
    Cell Significance Index: -9.0300
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 2.5626
    Cell Significance Index: 22.0200
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: 2.2468
    Cell Significance Index: 30.3200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.7882
    Cell Significance Index: 18.2100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1883
    Cell Significance Index: 24.3300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1043
    Cell Significance Index: 46.1300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0550
    Cell Significance Index: 6.4100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0256
    Cell Significance Index: 17.6900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0036
    Cell Significance Index: 0.1500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0007
    Cell Significance Index: 0.0300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0152
    Cell Significance Index: -0.7700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0222
    Cell Significance Index: -12.1100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0261
    Cell Significance Index: -1.2300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0318
    Cell Significance Index: -2.2500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0369
    Cell Significance Index: -27.9100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0467
    Cell Significance Index: -1.1200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0470
    Cell Significance Index: -26.5000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0619
    Cell Significance Index: -7.9400
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0648
    Cell Significance Index: -0.4300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0721
    Cell Significance Index: -25.8700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0783
    Cell Significance Index: -10.7500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0944
    Cell Significance Index: -27.1500
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.1085
    Cell Significance Index: -1.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1099
    Cell Significance Index: -19.8200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1361
    Cell Significance Index: -27.3100
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.1393
    Cell Significance Index: -1.2300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1605
    Cell Significance Index: -19.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2206
    Cell Significance Index: -25.2700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2599
    Cell Significance Index: -19.3700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2983
    Cell Significance Index: -7.4500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3032
    Cell Significance Index: -11.1300
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.3178
    Cell Significance Index: -5.4600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3422
    Cell Significance Index: -20.9800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3530
    Cell Significance Index: -6.8900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4018
    Cell Significance Index: -11.2300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4304
    Cell Significance Index: -9.0100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4449
    Cell Significance Index: -15.4600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4451
    Cell Significance Index: -13.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4613
    Cell Significance Index: -21.5100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4830
    Cell Significance Index: -6.5900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.5114
    Cell Significance Index: -13.9200
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.5194
    Cell Significance Index: -6.1200
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.5196
    Cell Significance Index: -5.5200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.5253
    Cell Significance Index: -6.8700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5348
    Cell Significance Index: -28.0800
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: -0.5475
    Cell Significance Index: -5.2200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.6023
    Cell Significance Index: -6.9300
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.6233
    Cell Significance Index: -6.8300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.6310
    Cell Significance Index: -7.4500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6461
    Cell Significance Index: -18.5200
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.6958
    Cell Significance Index: -8.9900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.6984
    Cell Significance Index: -11.0800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7083
    Cell Significance Index: -26.8200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7513
    Cell Significance Index: -26.3200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.7682
    Cell Significance Index: -16.8200
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.7959
    Cell Significance Index: -9.0100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8253
    Cell Significance Index: -27.0200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.8279
    Cell Significance Index: -9.0000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.8441
    Cell Significance Index: -13.0600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8451
    Cell Significance Index: -26.9200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8569
    Cell Significance Index: -22.9600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.9003
    Cell Significance Index: -24.0400
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.9095
    Cell Significance Index: -7.7300
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.9175
    Cell Significance Index: -8.9800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.9212
    Cell Significance Index: -19.6900
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.9298
    Cell Significance Index: -9.0200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.9888
    Cell Significance Index: -26.4500
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.9997
    Cell Significance Index: -13.6000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.0230
    Cell Significance Index: -26.9000
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -1.0237
    Cell Significance Index: -2.3100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -1.0516
    Cell Significance Index: -13.2700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -1.0527
    Cell Significance Index: -26.8200
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -1.0642
    Cell Significance Index: -10.1800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -1.1131
    Cell Significance Index: -8.5800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.1241
    Cell Significance Index: -28.0400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -1.1252
    Cell Significance Index: -19.1100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.1522
    Cell Significance Index: -20.3600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -1.1732
    Cell Significance Index: -16.7000
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -1.1964
    Cell Significance Index: -17.5000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -1.2304
    Cell Significance Index: -19.7400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.2372
    Cell Significance Index: -26.7300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.2467
    Cell Significance Index: -26.4600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -1.2580
    Cell Significance Index: -26.2600
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -1.2602
    Cell Significance Index: -13.9200
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -1.2725
    Cell Significance Index: -13.8900
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -1.2804
    Cell Significance Index: -16.2000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -1.3223
    Cell Significance Index: -26.0300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -1.3540
    Cell Significance Index: -27.5500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -1.3630
    Cell Significance Index: -27.1800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.3641
    Cell Significance Index: -22.8300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.3767
    Cell Significance Index: -27.6400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.3802
    Cell Significance Index: -27.2900
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -1.3946
    Cell Significance Index: -17.9600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -1.4064
    Cell Significance Index: -24.0400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -1.4713
    Cell Significance Index: -23.8300
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -1.4725
    Cell Significance Index: -9.0200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.4815
    Cell Significance Index: -25.6200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -1.5346
    Cell Significance Index: -21.8100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -1.5423
    Cell Significance Index: -25.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KLK8 belongs to the kallikrein-related peptidase family, which consists of 15 members. These enzymes are characterized by their serine protease activity and ability to cleave a wide range of substrates, including growth factors, cytokines, and extracellular matrix proteins. KLK8 is specifically expressed in stratified epithelial cells, mammary gland epithelial cells, and epithelial cells of the esophagus, suggesting its involvement in tissue-specific functions. **Pathways and Functions:** KLK8 is involved in various signaling pathways that regulate epithelial cell proliferation, differentiation, and survival. Some of the notable pathways include: 1. **Keratinization and Epithelial Homeostasis:** KLK8 regulates the formation of the cornified envelope, a critical structure in stratified epithelial cells that provides mechanical strength and resistance to desiccation. By cleaving specific substrates, KLK8 promotes keratinocyte proliferation and differentiation. 2. **Proteolysis and Tissue Remodeling:** KLK8's serine protease activity enables it to degrade extracellular matrix proteins, facilitating tissue remodeling and repair processes. 3. **Immune Response:** KLK8 has been shown to regulate the activity of dendritic cells and other immune cells, influencing the initiation and progression of immune responses. 4. **Neurobiology:** KLK8 is involved in the regulation of synapse organization and neuron projection morphogenesis, highlighting its role in neural development and function. **Clinical Significance:** KLK8's dysregulation has been implicated in various diseases, including: 1. **Cancer:** Overexpression of KLK8 has been observed in several types of cancer, including breast, lung, and esophageal cancer. KLK8's role in tumor progression and metastasis is still under investigation. 2. **Neurological Disorders:** KLK8 has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, where its dysregulation may contribute to synapse dysfunction and neuronal loss. 3. **Inflammatory Diseases:** KLK8's involvement in immune regulation and tissue remodeling makes it a potential target for the treatment of inflammatory diseases, such as rheumatoid arthritis and psoriasis. In conclusion, KLK8 is a multifunctional serine protease that plays a critical role in maintaining epithelial homeostasis and regulating various physiological and pathological processes. Further research is needed to fully elucidate the mechanisms by which KLK8 contributes to disease pathogenesis and to explore its potential as a therapeutic target.

Genular Protein ID: 4032165380

Symbol: KLK8_HUMAN

Name: Kallikrein-8

UniProtKB Accession Codes:

O60259 Q5V9X1 Q5V9X2 Q8IW69 Q9HCB3 Q9NR68 Q9NR69 Q9UIL9 Q9UQ47

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChEMBL 1 DNASU 1 DisGeNET 1 EC 2 EMBL 43 Ensembl 6 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 5 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9714609

Title: Sequence analysis and expression of human neuropsin cDNA and gene.

PubMed ID: 9714609

DOI: 10.1016/s0378-1119(98)00232-7

PubMed ID: 10485494

Title: Cloning of tumor-associated differentially expressed gene-14, a novel serine protease overexpressed by ovarian carcinoma.

PubMed ID: 10485494

PubMed ID: 10102990

Title: A novel form of human neuropsin, a brain-related serine protease, is generated by alternative splicing and is expressed preferentially in human adult brain.

PubMed ID: 10102990

DOI: 10.1046/j.1432-1327.1999.00213.x

PubMed ID: 11054574

Title: Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region.

PubMed ID: 11054574

DOI: 10.1016/s0378-1119(00)00382-6

PubMed ID: 11309326

Title: The human KLK8 (neuropsin/ovasin) gene: identification of two novel splice variants and its prognostic value in ovarian cancer.

PubMed ID: 11309326

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15282331

Title: Recent origin of a hominoid-specific splice form of neuropsin, a gene involved in learning and memory.

PubMed ID: 15282331

DOI: 10.1093/molbev/msh220

PubMed ID: 11522960

Title: Expression of the kallikrein gene family in normal and Alzheimer's disease brain.

PubMed ID: 11522960

DOI: 10.1097/00001756-200108280-00031

PubMed ID: 12147714

Title: Epidermal expression of serine protease, neuropsin (KLK8) in normal and pathological skin samples.

PubMed ID: 12147714

DOI: 10.1136/mp.55.4.235

PubMed ID: 12782581

Title: Human kallikrein 8, a novel biomarker for ovarian carcinoma.

PubMed ID: 12782581

PubMed ID: 16337200

Title: Biochemical characterization of human kallikrein 8 and its possible involvement in the degradation of extracellular matrix proteins.

PubMed ID: 16337200

DOI: 10.1016/j.febslet.2005.11.039

PubMed ID: 17487847

Title: A human-specific mutation leads to the origin of a novel splice form of neuropsin (KLK8), a gene involved in learning and memory.

PubMed ID: 17487847

DOI: 10.1002/humu.20547

PubMed ID: 17761692

Title: SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes.

PubMed ID: 17761692

DOI: 10.1093/jb/mvm156

PubMed ID: 19194479

Title: SPINK9: a selective, skin-specific Kazal-type serine protease inhibitor.

PubMed ID: 19194479

DOI: 10.1038/jid.2008.448

Sequence Information:

  • Length: 260
  • Mass: 28048
  • Checksum: EF439E5B8C83E660
  • Sequence:
    • MGRPRPRAAK TWMFLLLLGG AWAGHSRAQE DKVLGGHECQ PHSQPWQAAL FQGQQLLCGG 
VLVGGNWVLT AAHCKKPKYT VRLGDHSLQN KDGPEQEIPV VQSIPHPCYN SSDVEDHNHD 
LMLLQLRDQA SLGSKVKPIS LADHCTQPGQ KCTVSGWGTV TSPRENFPDT LNCAEVKIFP 
QKKCEDAYPG QITDGMVCAG SSKGADTCQG DSGGPLVCDG ALQGITSWGS DPCGRSDKPG 
VYTNICRYLD WIKKIIGSKG

Genular Protein ID: 2252183893

Symbol: A0A0A0MQY9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MQY9

Database IDs:

ARBA 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 HGNC 1 InterPro 5 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PaxDb 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 139
  • Mass: 14715
  • Checksum: 5D49981310E7684A
  • Sequence:
    • MLLQLRDQAS LGSKVKPISL ADHCTQPGQK CTVSGWGTVT SPRENFPDTL NCAEVKIFPQ 
KKCEDAYPGQ ITDGMVCAGS SKGADTCQGD SGGPLVCDGA LQGITSWGSD PCGRSDKPGV 
YTNICRYLDW IKKIIGSKG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.