Details for: KLK8

Gene ID: 11202

Symbol: KLK8

Ensembl ID: ENSG00000129455

Description: kallikrein related peptidase 8

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.69
    Marker Score: 8,279
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 5.52
    Marker Score: 35,585
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.2
    Marker Score: 1,517
  • Cell Name: monocyte (CL0000576)
    Fold Change: 1.55
    Marker Score: 2,010
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 874
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.37
    Marker Score: 10,729
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.37
    Marker Score: 488
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.31
    Marker Score: 11,249
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7,575
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3,653
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32,725
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,814
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,831
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,057
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,400
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.94
    Marker Score: 4,625
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,342
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.88
    Marker Score: 1,138
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.86
    Marker Score: 292
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 735
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1,236
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.71
    Marker Score: 597
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.66
    Marker Score: 303
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.66
    Marker Score: 824
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.64
    Marker Score: 425
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.56
    Marker Score: 179
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.56
    Marker Score: 339
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 435
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.5
    Marker Score: 884
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 477
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.49
    Marker Score: 204
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.38
    Marker Score: 258
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.37
    Marker Score: 1,383
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.37
    Marker Score: 212
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 373
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.34
    Marker Score: 3,819
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.33
    Marker Score: 133
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.33
    Marker Score: 1,414
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.29
    Marker Score: 605
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.27
    Marker Score: 66
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.23
    Marker Score: 331
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.22
    Marker Score: 246
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.22
    Marker Score: 54
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.21
    Marker Score: 219
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.21
    Marker Score: 254
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.2
    Marker Score: 211
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.19
    Marker Score: 71
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.19
    Marker Score: 192
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.19
    Marker Score: 102
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.19
    Marker Score: 2,491
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.18
    Marker Score: 348
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.18
    Marker Score: 228
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.15
    Marker Score: 267
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.15
    Marker Score: 71
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.14
    Marker Score: 224
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.13
    Marker Score: 202
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.12
    Marker Score: 275
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.12
    Marker Score: 245
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1
    Marker Score: 1,642
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.1
    Marker Score: 28
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.09
    Marker Score: 19
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.09
    Marker Score: 53
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.09
    Marker Score: 255
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.08
    Marker Score: 26
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.08
    Marker Score: 86
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.08
    Marker Score: 19
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.08
    Marker Score: 476
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.08
    Marker Score: 70
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.08
    Marker Score: 18
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.08
    Marker Score: 45
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.07
    Marker Score: 50
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.07
    Marker Score: 2,420
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.07
    Marker Score: 126
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.07
    Marker Score: 32
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.06
    Marker Score: 37
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.06
    Marker Score: 73
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.06
    Marker Score: 70
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.06
    Marker Score: 37
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.06
    Marker Score: 40
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.06
    Marker Score: 371
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.05
    Marker Score: 70
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.05
    Marker Score: 35
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.05
    Marker Score: 27
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.05
    Marker Score: 34
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.05
    Marker Score: 11
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.04
    Marker Score: 1,511
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.04
    Marker Score: 42

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KLK8 belongs to the kallikrein-related peptidase family, which consists of 15 members. These enzymes are characterized by their serine protease activity and ability to cleave a wide range of substrates, including growth factors, cytokines, and extracellular matrix proteins. KLK8 is specifically expressed in stratified epithelial cells, mammary gland epithelial cells, and epithelial cells of the esophagus, suggesting its involvement in tissue-specific functions. **Pathways and Functions:** KLK8 is involved in various signaling pathways that regulate epithelial cell proliferation, differentiation, and survival. Some of the notable pathways include: 1. **Keratinization and Epithelial Homeostasis:** KLK8 regulates the formation of the cornified envelope, a critical structure in stratified epithelial cells that provides mechanical strength and resistance to desiccation. By cleaving specific substrates, KLK8 promotes keratinocyte proliferation and differentiation. 2. **Proteolysis and Tissue Remodeling:** KLK8's serine protease activity enables it to degrade extracellular matrix proteins, facilitating tissue remodeling and repair processes. 3. **Immune Response:** KLK8 has been shown to regulate the activity of dendritic cells and other immune cells, influencing the initiation and progression of immune responses. 4. **Neurobiology:** KLK8 is involved in the regulation of synapse organization and neuron projection morphogenesis, highlighting its role in neural development and function. **Clinical Significance:** KLK8's dysregulation has been implicated in various diseases, including: 1. **Cancer:** Overexpression of KLK8 has been observed in several types of cancer, including breast, lung, and esophageal cancer. KLK8's role in tumor progression and metastasis is still under investigation. 2. **Neurological Disorders:** KLK8 has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, where its dysregulation may contribute to synapse dysfunction and neuronal loss. 3. **Inflammatory Diseases:** KLK8's involvement in immune regulation and tissue remodeling makes it a potential target for the treatment of inflammatory diseases, such as rheumatoid arthritis and psoriasis. In conclusion, KLK8 is a multifunctional serine protease that plays a critical role in maintaining epithelial homeostasis and regulating various physiological and pathological processes. Further research is needed to fully elucidate the mechanisms by which KLK8 contributes to disease pathogenesis and to explore its potential as a therapeutic target.

Genular Protein ID: 4032165380

Symbol: KLK8_HUMAN

Name: Kallikrein-8

UniProtKB Accession Codes:

O60259 Q5V9X1 Q5V9X2 Q8IW69 Q9HCB3 Q9NR68 Q9NR69 Q9UIL9 Q9UQ47

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChEMBL 1 DNASU 1 DisGeNET 1 EC 2 EMBL 43 EPD 1 Ensembl 6 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 5 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 neXtProt 1

Citations:

PubMed ID: 9714609

Title: Sequence analysis and expression of human neuropsin cDNA and gene.

PubMed ID: 9714609

DOI: 10.1016/s0378-1119(98)00232-7

PubMed ID: 10485494

Title: Cloning of tumor-associated differentially expressed gene-14, a novel serine protease overexpressed by ovarian carcinoma.

PubMed ID: 10485494

PubMed ID: 10102990

Title: A novel form of human neuropsin, a brain-related serine protease, is generated by alternative splicing and is expressed preferentially in human adult brain.

PubMed ID: 10102990

DOI: 10.1046/j.1432-1327.1999.00213.x

PubMed ID: 11054574

Title: Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region.

PubMed ID: 11054574

DOI: 10.1016/s0378-1119(00)00382-6

PubMed ID: 11309326

Title: The human KLK8 (neuropsin/ovasin) gene: identification of two novel splice variants and its prognostic value in ovarian cancer.

PubMed ID: 11309326

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15282331

Title: Recent origin of a hominoid-specific splice form of neuropsin, a gene involved in learning and memory.

PubMed ID: 15282331

DOI: 10.1093/molbev/msh220

PubMed ID: 11522960

Title: Expression of the kallikrein gene family in normal and Alzheimer's disease brain.

PubMed ID: 11522960

DOI: 10.1097/00001756-200108280-00031

PubMed ID: 12147714

Title: Epidermal expression of serine protease, neuropsin (KLK8) in normal and pathological skin samples.

PubMed ID: 12147714

DOI: 10.1136/mp.55.4.235

PubMed ID: 12782581

Title: Human kallikrein 8, a novel biomarker for ovarian carcinoma.

PubMed ID: 12782581

PubMed ID: 16337200

Title: Biochemical characterization of human kallikrein 8 and its possible involvement in the degradation of extracellular matrix proteins.

PubMed ID: 16337200

DOI: 10.1016/j.febslet.2005.11.039

PubMed ID: 17487847

Title: A human-specific mutation leads to the origin of a novel splice form of neuropsin (KLK8), a gene involved in learning and memory.

PubMed ID: 17487847

DOI: 10.1002/humu.20547

PubMed ID: 17761692

Title: SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes.

PubMed ID: 17761692

DOI: 10.1093/jb/mvm156

PubMed ID: 19194479

Title: SPINK9: a selective, skin-specific Kazal-type serine protease inhibitor.

PubMed ID: 19194479

DOI: 10.1038/jid.2008.448

Sequence Information:

  • Length: 260
  • Mass: 28048
  • Checksum: EF439E5B8C83E660
  • Sequence:
    • MGRPRPRAAK TWMFLLLLGG AWAGHSRAQE DKVLGGHECQ PHSQPWQAAL FQGQQLLCGG 
VLVGGNWVLT AAHCKKPKYT VRLGDHSLQN KDGPEQEIPV VQSIPHPCYN SSDVEDHNHD 
LMLLQLRDQA SLGSKVKPIS LADHCTQPGQ KCTVSGWGTV TSPRENFPDT LNCAEVKIFP 
QKKCEDAYPG QITDGMVCAG SSKGADTCQG DSGGPLVCDG ALQGITSWGS DPCGRSDKPG 
VYTNICRYLD WIKKIIGSKG

Genular Protein ID: 2252183893

Symbol: A0A0A0MQY9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MQY9

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PaxDb 1 PeptideAtlas 2 Pfam 1 Proteomes 2 RefSeq 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

Sequence Information:

  • Length: 139
  • Mass: 14715
  • Checksum: 5D49981310E7684A
  • Sequence:
    • MLLQLRDQAS LGSKVKPISL ADHCTQPGQK CTVSGWGTVT SPRENFPDTL NCAEVKIFPQ 
KKCEDAYPGQ ITDGMVCAGS SKGADTCQGD SGGPLVCDGA LQGITSWGSD PCGRSDKPGV 
YTNICRYLDW IKKIIGSKG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.