Details for: CHRM5

Gene ID: 1133

Symbol: CHRM5

Ensembl ID: ENSG00000184984

Description: cholinergic receptor muscarinic 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 4.6565
    Cell Significance Index: 68.7300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.7552
    Cell Significance Index: -6.0300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.4546
    Cell Significance Index: 37.3900
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.1136
    Cell Significance Index: 5.8600
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 1.0035
    Cell Significance Index: 8.2200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6433
    Cell Significance Index: 127.6600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.5631
    Cell Significance Index: 11.6800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.4416
    Cell Significance Index: 4.5700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3198
    Cell Significance Index: 221.2100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2273
    Cell Significance Index: 36.9700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1812
    Cell Significance Index: 10.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1808
    Cell Significance Index: 36.2700
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.1726
    Cell Significance Index: 0.6500
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.1526
    Cell Significance Index: 1.5900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.1232
    Cell Significance Index: 0.8400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1189
    Cell Significance Index: 2.3200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1172
    Cell Significance Index: 8.1100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1064
    Cell Significance Index: 5.9700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1056
    Cell Significance Index: 3.0100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1006
    Cell Significance Index: 14.6200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0923
    Cell Significance Index: 2.5800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0766
    Cell Significance Index: 1.0900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0689
    Cell Significance Index: 24.7200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0593
    Cell Significance Index: 91.3500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0589
    Cell Significance Index: 11.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0567
    Cell Significance Index: 77.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0510
    Cell Significance Index: 3.9200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0486
    Cell Significance Index: 89.5500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0195
    Cell Significance Index: 36.8100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0142
    Cell Significance Index: 2.5700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0041
    Cell Significance Index: 0.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0016
    Cell Significance Index: 1.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0068
    Cell Significance Index: -3.0700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0102
    Cell Significance Index: -4.5000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0140
    Cell Significance Index: -4.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0151
    Cell Significance Index: -11.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0183
    Cell Significance Index: -13.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0229
    Cell Significance Index: -12.9200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0231
    Cell Significance Index: -12.6400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0256
    Cell Significance Index: -3.1500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0274
    Cell Significance Index: -17.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0329
    Cell Significance Index: -5.6100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0712
    Cell Significance Index: -15.0000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0718
    Cell Significance Index: -5.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0827
    Cell Significance Index: -4.3400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0838
    Cell Significance Index: -1.2000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0855
    Cell Significance Index: -9.3100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0905
    Cell Significance Index: -12.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1198
    Cell Significance Index: -12.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1212
    Cell Significance Index: -13.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1350
    Cell Significance Index: -13.7900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1406
    Cell Significance Index: -9.4600
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.1538
    Cell Significance Index: -2.1600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1549
    Cell Significance Index: -2.3400
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1559
    Cell Significance Index: -1.8900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1608
    Cell Significance Index: -5.1500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1687
    Cell Significance Index: -4.8600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1847
    Cell Significance Index: -8.1700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1867
    Cell Significance Index: -1.7700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1894
    Cell Significance Index: -6.2000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1955
    Cell Significance Index: -4.7700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1977
    Cell Significance Index: -2.1200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2013
    Cell Significance Index: -5.3800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2034
    Cell Significance Index: -9.5600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2062
    Cell Significance Index: -5.1500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2146
    Cell Significance Index: -4.6500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2170
    Cell Significance Index: -7.6300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2171
    Cell Significance Index: -10.1200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2177
    Cell Significance Index: -4.3700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2228
    Cell Significance Index: -4.7500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2235
    Cell Significance Index: -3.2100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2253
    Cell Significance Index: -14.2000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2305
    Cell Significance Index: -8.7300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2366
    Cell Significance Index: -2.7600
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.2382
    Cell Significance Index: -2.0600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.2387
    Cell Significance Index: -1.9700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2398
    Cell Significance Index: -5.0200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2410
    Cell Significance Index: -14.8100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2514
    Cell Significance Index: -10.9300
  • Cell Name: bipolar neuron (CL0000103)
    Fold Change: -0.2515
    Cell Significance Index: -1.4100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2592
    Cell Significance Index: -9.0800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2620
    Cell Significance Index: -5.1800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2772
    Cell Significance Index: -8.8300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2799
    Cell Significance Index: -3.4900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2946
    Cell Significance Index: -4.3500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3005
    Cell Significance Index: -13.6200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.3028
    Cell Significance Index: -5.2200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3144
    Cell Significance Index: -16.3300
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.3149
    Cell Significance Index: -4.2500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3284
    Cell Significance Index: -8.9400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3302
    Cell Significance Index: -12.1200
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.3406
    Cell Significance Index: -4.8500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.3451
    Cell Significance Index: -2.6600
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -0.3467
    Cell Significance Index: -4.3100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3486
    Cell Significance Index: -4.1600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3590
    Cell Significance Index: -7.6200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3731
    Cell Significance Index: -11.8000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3763
    Cell Significance Index: -4.7500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3884
    Cell Significance Index: -9.7100
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.3923
    Cell Significance Index: -4.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CHRM5 is a G-protein coupled receptor (GPCR) that belongs to the muscarinic receptor family. It is characterized by its unique structure, which consists of seven transmembrane helices and an intracellular domain. The M5 receptor is specifically expressed in various tissues, including the retina, lung, liver, and gastrointestinal tract. Its expression is also notable in dopaminergic neurons, indicating a potential role in modulating neurotransmitter release. **Pathways and Functions:** CHRM5 functions as a ligand-activated receptor, binding to the neurotransmitter acetylcholine (ACh) and other muscarinic agonists. Upon binding, the receptor triggers a cascade of signaling events involving G-proteins, which modulate downstream effectors. The primary signaling pathways activated by CHRM5 include: 1. **Adenylate cyclase inhibition**: CHRM5 inhibits adenylate cyclase activity, leading to a decrease in cAMP levels and subsequent suppression of downstream signaling. 2. **Phosphatidylinositol phospholipase C (PLC) activity**: CHRM5 activates PLC, which generates inositol trisphosphate (IP3) and diacylglycerol (DAG), modulating calcium and phospholipid metabolism. 3. **Gαq signaling**: CHRM5 activates Gαq, which stimulates phospholipase C and modulates calcium release from intracellular stores. These signaling pathways are involved in various physiological processes, including: 1. **Gastric acid secretion**: CHRM5 modulates gastric acid secretion by inhibiting adenylate cyclase and reducing cAMP levels. 2. **Smooth muscle contraction**: CHRM5 activates PLC and Gαq, leading to smooth muscle contraction in the gastrointestinal tract. 3. **Neurotransmitter release**: CHRM5 modulates neurotransmitter release in dopaminergic neurons, influencing dopamine signaling. **Clinical Significance:** CHRM5 plays a significant role in various diseases, including: 1. **Gastrointestinal disorders**: CHRM5 dysregulation contributes to gastrointestinal motility disorders, such as gastroparesis and irritable bowel syndrome (IBS). 2. **Neurodegenerative diseases**: CHRM5 is implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's, where its dysregulation affects neurotransmitter release and synaptic plasticity. 3. **Cancer**: CHRM5 expression is altered in various cancers, including lung and colon cancer, where it influences cell proliferation and survival. In conclusion, CHRM5 is a critical component of the cholinergic system, playing a vital role in modulating various physiological and pathological processes. Further research is necessary to elucidate the intricacies of CHRM5 signaling and its implications in human disease. As an expert immunologist, it is essential to recognize the significance of CHRM5 in the immune system and its potential therapeutic applications in the management of immune-related disorders.

Genular Protein ID: 2673201551

Symbol: ACM5_HUMAN

Name: Muscarinic acetylcholine receptor M5

UniProtKB Accession Codes:

P08912 Q96RG7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 53 DrugCentral 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3272174

Title: Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes.

PubMed ID: 3272174

DOI: 10.1016/0896-6273(88)90190-0

Sequence Information:

  • Length: 532
  • Mass: 60074
  • Checksum: EE846186F645DD9B
  • Sequence:
    • MEGDSYHNAT TVNGTPVNHQ PLERHRLWEV ITIAAVTAVV SLITIVGNVL VMISFKVNSQ 
LKTVNNYYLL SLACADLIIG IFSMNLYTTY ILMGRWALGS LACDLWLALD YVASNASVMN 
LLVISFDRYF SITRPLTYRA KRTPKRAGIM IGLAWLISFI LWAPAILCWQ YLVGKRTVPL 
DECQIQFLSE PTITFGTAIA AFYIPVSVMT ILYCRIYRET EKRTKDLADL QGSDSVTKAE 
KRKPAHRALF RSCLRCPRPT LAQRERNQAS WSSSRRSTST TGKPSQATGP SANWAKAEQL 
TTCSSYPSSE DEDKPATDPV LQVVYKSQGK ESPGEEFSAE ETEETFVKAE TEKSDYDTPN 
YLLSPAAAHR PKSQKCVAYK FRLVVKADGN QETNNGCHKV KIMPCPFPVA KEPSTKGLNP 
NPSHQMTKRK RVVLVKERKA AQTLSAILLA FIITWTPYNI MVLVSTFCDK CVPVTLWHLG 
YWLCYVNSTV NPICYALCNR TFRKTFKMLL LCRWKKKKVE EKLYWQGNSK LP

Genular Protein ID: 2222444973

Symbol: Q8IVW0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8IVW0

Database IDs:

ARBA 14 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 7 Gene3D 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 3 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 RuleBase 2 SAM 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 532
  • Mass: 60086
  • Checksum: 6674707A1B493C67
  • Sequence:
    • MEGDSYHNAT TVNGTPVNHQ PLERHRLWEV ITIAAVTAVV SLITIVGNVL VMISFKVNSQ 
LKTVNNYYLL SLACADLIIG IFSMNLYTTY ILMGRWALGS LACDLWLALD YVASNASVMN 
LLVISFDRYF SITRPLTYRA KRTPKRAGIM IGLAWLISFI LWAPAILCWQ YLVGKRTVPL 
DECQIQFLSE PTITFGTAIA AFYIPVSVMT ILYCRIYRET EKRTKDLADL QGSDSVTKAE 
KRKPAHRALF RSCLRCPRPT LAQRERNQAS WSSSRRSTST TGKPSQATGP SANWAKAEQL 
TTCSSYPSSE DEDKPATDPV LQVVYKSQGK ESPGEEFSAE ETEEIFVKAE TEKSDYDTPN 
YLLSPAAAHR PKSQKCVAYK FRLVVKADGN QETNNGCHKV KIMPCPFPVA KEPSTKGLNP 
NPSHQMTKRK RVVLVKERKA AQTLSAILLA FIITWTPYNI MVLVSTFCDK CVPVTLWHLG 
YWLCYVNSTV NPICYALCNR TFRKTFKMLL LCRWKKKKVE EKLYWQGNSK LP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.