Details for: OR2T12

Gene ID: 127064

Symbol: OR2T12

Ensembl ID: ENSG00000177201

Description: olfactory receptor family 2 subfamily T member 12

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.3384
    Cell Significance Index: 32.4200
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.7136
    Cell Significance Index: 5.1900
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.5026
    Cell Significance Index: 6.6000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.4223
    Cell Significance Index: 6.1600
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 0.3607
    Cell Significance Index: 3.6100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.3353
    Cell Significance Index: 6.5600
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.2588
    Cell Significance Index: 1.9700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0657
    Cell Significance Index: 4.1400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0643
    Cell Significance Index: 0.9500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0449
    Cell Significance Index: 0.7700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0340
    Cell Significance Index: 0.7500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0243
    Cell Significance Index: 3.5300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0220
    Cell Significance Index: 0.1200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0195
    Cell Significance Index: 0.2700
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: 0.0168
    Cell Significance Index: 0.1700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0102
    Cell Significance Index: 0.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0101
    Cell Significance Index: 2.0000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0053
    Cell Significance Index: 0.2000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0034
    Cell Significance Index: 1.2100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0034
    Cell Significance Index: 5.2800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0030
    Cell Significance Index: 0.2000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0030
    Cell Significance Index: 0.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0027
    Cell Significance Index: 3.6400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0016
    Cell Significance Index: 0.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0012
    Cell Significance Index: 2.3100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0010
    Cell Significance Index: 1.9000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0002
    Cell Significance Index: -0.0400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0013
    Cell Significance Index: -0.8400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0021
    Cell Significance Index: -0.9700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0079
    Cell Significance Index: -0.2500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0080
    Cell Significance Index: -1.4400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0112
    Cell Significance Index: -1.1700
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0115
    Cell Significance Index: -0.1300
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0122
    Cell Significance Index: -0.1100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0136
    Cell Significance Index: -0.1700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0140
    Cell Significance Index: -0.4000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0173
    Cell Significance Index: -0.3200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0174
    Cell Significance Index: -0.1900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0179
    Cell Significance Index: -0.1700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0182
    Cell Significance Index: -0.2300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0184
    Cell Significance Index: -0.3900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0187
    Cell Significance Index: -0.8100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0191
    Cell Significance Index: -0.5500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0193
    Cell Significance Index: -0.4700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0207
    Cell Significance Index: -1.1600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0217
    Cell Significance Index: -0.5200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0223
    Cell Significance Index: -0.7100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0241
    Cell Significance Index: -0.7900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0248
    Cell Significance Index: -0.8700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0255
    Cell Significance Index: -0.3400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0274
    Cell Significance Index: -1.2900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0286
    Cell Significance Index: -0.3600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0303
    Cell Significance Index: -0.3200
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0303
    Cell Significance Index: -0.2900
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0317
    Cell Significance Index: -0.2200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0335
    Cell Significance Index: -0.4300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0337
    Cell Significance Index: -0.9000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0345
    Cell Significance Index: -0.4200
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0355
    Cell Significance Index: -0.4600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0369
    Cell Significance Index: -0.7400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0370
    Cell Significance Index: -0.8000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0373
    Cell Significance Index: -1.0700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0377
    Cell Significance Index: -0.9400
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0392
    Cell Significance Index: -0.4300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0397
    Cell Significance Index: -0.5700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0428
    Cell Significance Index: -1.0900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0436
    Cell Significance Index: -0.5700
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0444
    Cell Significance Index: -0.4300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0455
    Cell Significance Index: -0.9000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0457
    Cell Significance Index: -1.0600
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0468
    Cell Significance Index: -0.5600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0491
    Cell Significance Index: -0.6700
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0502
    Cell Significance Index: -0.8100
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0504
    Cell Significance Index: -0.6800
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0516
    Cell Significance Index: -0.6500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0517
    Cell Significance Index: -1.0800
  • Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
    Fold Change: -0.0523
    Cell Significance Index: -0.6200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0531
    Cell Significance Index: -0.6700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0534
    Cell Significance Index: -0.7600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0543
    Cell Significance Index: -1.0600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0544
    Cell Significance Index: -1.0700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0568
    Cell Significance Index: -0.9500
  • Cell Name: airway submucosal gland duct basal cell (CL4033024)
    Fold Change: -0.0582
    Cell Significance Index: -0.5100
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0586
    Cell Significance Index: -0.8200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0587
    Cell Significance Index: -1.1700
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0591
    Cell Significance Index: -0.7100
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0611
    Cell Significance Index: -0.9300
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0616
    Cell Significance Index: -0.7100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0627
    Cell Significance Index: -3.1700
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0647
    Cell Significance Index: -0.7000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0652
    Cell Significance Index: -0.7700
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0660
    Cell Significance Index: -0.8000
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0664
    Cell Significance Index: -0.7900
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0665
    Cell Significance Index: -0.7200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0666
    Cell Significance Index: -2.7300
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0673
    Cell Significance Index: -0.7600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0677
    Cell Significance Index: -1.1700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0679
    Cell Significance Index: -1.1000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0684
    Cell Significance Index: -1.0600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0700
    Cell Significance Index: -0.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** OR2T12 is a G protein-coupled receptor (GPCR) that belongs to the olfactory receptor family, which is responsible for detecting odorant molecules in the air. This receptor is specifically expressed in various cell types, including glutamatergic neurons, progenitor cells, endothelial cells, and immune cells such as CD8-positive, alpha-beta T cells. The OR2T12 gene is significantly expressed in the brain, particularly in the cerebral cortex, where it is involved in the processing of olfactory information. **Pathways and Functions:** The OR2T12 receptor is integrated into the G protein-coupled receptor signaling pathway, which is a critical mechanism for transducing signals from GPCRs to downstream effectors. Upon binding to its ligand, OR2T12 triggers a cascade of intracellular signaling events that ultimately lead to the activation of various cellular responses, including changes in gene expression, ion channel activity, and neurotransmitter release. These responses are essential for the perception of different odors and the integration of olfactory information with other sensory inputs. **Clinical Significance:** The OR2T12 gene has been implicated in various neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. Research has shown that OR2T12 is differentially expressed in the brains of individuals with these conditions, suggesting a potential role in the pathophysiology of these diseases. Furthermore, OR2T12 may also play a crucial role in the development of olfactory dysfunction, which is a common symptom in patients with neurodegenerative disorders. In addition to its clinical significance, OR2T12 has also been explored as a potential therapeutic target for the treatment of various diseases, including cancer and inflammatory disorders. The receptor's ability to detect specific odorant molecules makes it an attractive candidate for the development of novel therapeutic agents that can target specific disease-related pathways. **Conclusion:** In conclusion, OR2T12 is a novel olfactory receptor that plays a critical role in the detection of chemical stimuli involved in sensory perception of smell. Through its integration into the G protein-coupled receptor signaling pathway, OR2T12 triggers a cascade of intracellular signaling events that ultimately lead to the activation of various cellular responses. The gene's clinical significance is evident in its involvement in various neurological and psychiatric disorders, and its potential as a therapeutic target for the treatment of disease-related pathways makes it an exciting area of research. Further studies are necessary to fully elucidate the functions and implications of OR2T12, but the current evidence suggests that this gene is a crucial component of the complex olfactory system.

Genular Protein ID: 3041553016

Symbol: O2T12_HUMAN

Name: Olfactory receptor 2T12

UniProtKB Accession Codes:

Q8NG77

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

Sequence Information:

  • Length: 320
  • Mass: 35946
  • Checksum: DD6281B07E95F2EE
  • Sequence:
    • MEMRNTTPDF ILLGLFNHTR AHQVLFMMLL ATVLTSLFSN ALMILLIHWD HRLHRPMYFL 
LSQLSLMDMM LVSTTVPKMA ADYLTGNKAI SRAGCGVQIF FLPTLGGGEC FLLAAMAYDR 
YAAVCHPLRY PTLMSWQLCL RMTMSSWLLG AADGLLQAVA TLSFPYCGAH EIDHFFCEAP 
VLVRLACADT SVFENAMYIC CVLMLLVPFS LILSSYGLIL AAVLLMRSTE ARKKAFATCS 
SHVAVVGLFY GAGIFTYMRP KSHRSTNHDK VVSAFYTMFT PLLNPLIYSV RNSEVKEALK 
RWLGTCVNLK HQQNEAHRSR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.