Details for: DGKQ

Gene ID: 1609

Symbol: DGKQ

Ensembl ID: ENSG00000145214

Description: diacylglycerol kinase theta

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.04
    Marker Score: 2107
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71802
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48027
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.98
    Marker Score: 2297
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 493
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 447
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.93
    Marker Score: 1756
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2730
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5151
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5273
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.87
    Marker Score: 13587
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 312
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.81
    Marker Score: 259.5
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.8
    Marker Score: 1238
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 573.5
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 382
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 666
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.72
    Marker Score: 790
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.71
    Marker Score: 425
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.69
    Marker Score: 278
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2858
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.66
    Marker Score: 206
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.6
    Marker Score: 6144
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.59
    Marker Score: 5102
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 437
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.54
    Marker Score: 3271
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.54
    Marker Score: 33372
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.54
    Marker Score: 2569
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.53
    Marker Score: 229
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.52
    Marker Score: 4880
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.5
    Marker Score: 4736
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.49
    Marker Score: 18096
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.49
    Marker Score: 447
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.48
    Marker Score: 1520.5
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.44
    Marker Score: 436
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.44
    Marker Score: 291
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.43
    Marker Score: 727
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.43
    Marker Score: 415
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.43
    Marker Score: 1749
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.42
    Marker Score: 202
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.42
    Marker Score: 398
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.41
    Marker Score: 170
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.4
    Marker Score: 178
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.4
    Marker Score: 200
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.4
    Marker Score: 15015
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.4
    Marker Score: 1109
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.38
    Marker Score: 261
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.37
    Marker Score: 1448
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.37
    Marker Score: 7412
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.37
    Marker Score: 95
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.36
    Marker Score: 382
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.35
    Marker Score: 116
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.35
    Marker Score: 85
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.34
    Marker Score: 295
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.34
    Marker Score: 223
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.33
    Marker Score: 136
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.32
    Marker Score: 146
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.31
    Marker Score: 4623
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.3
    Marker Score: 2318
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.3
    Marker Score: 207.5
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.3
    Marker Score: 103
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.29
    Marker Score: 184
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.29
    Marker Score: 76
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.29
    Marker Score: 441
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.28
    Marker Score: 116
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.28
    Marker Score: 1050
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.28
    Marker Score: 69
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.28
    Marker Score: 188
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.27
    Marker Score: 5846
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.27
    Marker Score: 228
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.27
    Marker Score: 74
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.27
    Marker Score: 265
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.27
    Marker Score: 918
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.26
    Marker Score: 622
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.26
    Marker Score: 1077
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.26
    Marker Score: 1645
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.25
    Marker Score: 369
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.25
    Marker Score: 526
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.25
    Marker Score: 702
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.24
    Marker Score: 92
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.24
    Marker Score: 137
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.23
    Marker Score: 116
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.23
    Marker Score: 46
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.22
    Marker Score: 701
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.22
    Marker Score: 159
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.22
    Marker Score: 280
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.21
    Marker Score: 47
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.21
    Marker Score: 217
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.21
    Marker Score: 2096
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.2
    Marker Score: 45
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.2
    Marker Score: 204
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.2
    Marker Score: 70
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.2
    Marker Score: 118
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.2
    Marker Score: 43

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Other Information

**Key characteristics:** * DGKQ is a serine/threonine kinase that is highly expressed in various cell types. * It is a key regulator of lipid metabolism and is involved in the synthesis and degradation of diacylglycerol. * DGKQ is also involved in cell signaling, as it is a key regulator of the G alpha (q) signaling pathway. * It is a regulator of transcription, as it is involved in the regulation of gluconeogenesis and the expression of genes involved in inflammation. **Pathways and functions:** * DGKQ is involved in the regulation of lipid metabolism. * It is a key regulator of the G alpha (q) signaling pathway, which is involved in cell growth, proliferation, and differentiation. * It is also involved in the regulation of inflammation, as it is a key regulator of the production of inflammatory cytokines. **Clinical significance:** * Mutations in DGKQ have been linked to several human diseases, including cancer, cardiovascular disease, and metabolic disorders. * DGKQ inhibitors are being investigated as potential treatments for these diseases. **Additional notes:** * DGKQ is a multi-functional enzyme that can be divided into two isoforms: DGKQ1 and DGKQ2. * DGKQ2 is expressed in a variety of cell types, including immune cells. * DGKQ is a highly conserved enzyme that is found in organisms from yeast to humans.

Genular Protein ID: 1625584070

Symbol: DGKQ_HUMAN

Name: Diglyceride kinase theta

UniProtKB Accession Codes:

P52824 Q6P3W4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 5 CTD 1 ChEBI 35 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 3 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 46 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 4 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 14 SAM 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7607687

Title: Chromosomal localization of three mouse diacylglycerol kinase (DAGK) genes: genes sharing sequence homology to the Drosophila retinal degeneration A (rdgA) gene.

PubMed ID: 7607687

DOI: 10.1016/0888-7543(95)80182-l

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9099683

Title: Cloning of a novel human diacylglycerol kinase (DGKtheta) containing three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain.

PubMed ID: 9099683

DOI: 10.1074/jbc.272.16.10422

PubMed ID: 10066731

Title: Diacylglycerol kinase theta binds to and is negatively regulated by active RhoA.

PubMed ID: 10066731

DOI: 10.1074/jbc.274.11.6820

PubMed ID: 11309392

Title: Nuclear diacylglycerol kinase-theta is activated in response to alpha-thrombin.

PubMed ID: 11309392

DOI: 10.1074/jbc.m101501200

PubMed ID: 12799190

Title: Diacylglycerol kinase-theta is localized in the speckle domains of the nucleus.

PubMed ID: 12799190

DOI: 10.1016/s0014-4827(03)00115-0

PubMed ID: 15164764

Title: Structure-activity relationship of diacylglycerol kinase theta.

PubMed ID: 15164764

DOI: 10.1016/j.bbalip.2003.11.008

PubMed ID: 15632189

Title: Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C.

PubMed ID: 15632189

DOI: 10.1074/jbc.m409301200

PubMed ID: 17664281

Title: Cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17.

PubMed ID: 17664281

DOI: 10.1128/mcb.00355-07

PubMed ID: 22627129

Title: Biosynthesis of alkyl lysophosphatidic acid by diacylglycerol kinases.

PubMed ID: 22627129

DOI: 10.1016/j.bbrc.2012.05.077

PubMed ID: 23949095

Title: Evaluations of the selectivities of the diacylglycerol kinase inhibitors R59022 and R59949 among diacylglycerol kinase isozymes using a new non-radioactive assay method.

PubMed ID: 23949095

DOI: 10.1159/000351849

PubMed ID: 26748701

Title: DGKtheta Catalytic Activity Is Required for Efficient Recycling of Presynaptic Vesicles at Excitatory Synapses.

PubMed ID: 26748701

DOI: 10.1016/j.celrep.2015.12.022

Sequence Information:

  • Length: 942
  • Mass: 101155
  • Checksum: 836D4FCBC208A5B6
  • Sequence:
    • MAAAAEPGAR AWLGGGSPRP GSPACSPVLG SGGRARPGPG PGPGPERAGV RAPGPAAAPG 
HSFRKVTLTK PTFCHLCSDF IWGLAGFLCD VCNFMSHEKC LKHVRIPCTS VAPSLVRVPV 
AHCFGPRGLH KRKFCAVCRK VLEAPALHCE VCELHLHPDC VPFACSDCRQ CHQDGHQDHD 
THHHHWREGN LPSGARCEVC RKTCGSSDVL AGVRCEWCGV QAHSLCSAAL APECGFGRLR 
SLVLPPACVR LLPGGFSKTQ SFRIVEAAEP GEGGDGADGS AAVGPGRETQ ATPESGKQTL 
KIFDGDDAVR RSQFRLVTVS RLAGAEEVLE AALRAHHIPE DPGHLELCRL PPSSQACDAW 
AGGKAGSAVI SEEGRSPGSG EATPEAWVIR ALPRAQEVLK IYPGWLKVGV AYVSVRVTPK 
STARSVVLEV LPLLGRQAES PESFQLVEVA MGCRHVQRTM LMDEQPLLDR LQDIRQMSVR 
QVSQTRFYVA ESRDVAPHVS LFVGGLPPGL SPEEYSSLLH EAGATKATVV SVSHIYSSQG 
AVVLDVACFA EAERLYMLLK DMAVRGRLLT ALVLPDLLHA KLPPDSCPLL VFVNPKSGGL 
KGRDLLCSFR KLLNPHQVFD LTNGGPLPGL HLFSQVPCFR VLVCGGDGTV GWVLGALEET 
RYRLACPEPS VAILPLGTGN DLGRVLRWGA GYSGEDPFSV LLSVDEADAV LMDRWTILLD 
AHEAGSAEND TADAEPPKIV QMSNYCGIGI DAELSLDFHQ AREEEPGKFT SRLHNKGVYV 
RVGLQKISHS RSLHKQIRLQ VERQEVELPS IEGLIFINIP SWGSGADLWG SDSDTRFEKP 
RMDDGLLEVV GVTGVVHMGQ VQGGLRSGIR IAQGSYFRVT LLKATPVQVD GEPWVQAPGH 
MIISAAGPKV HMLRKAKQKP RRAGTTRDAR ADAAPAPESD PR

Genular Protein ID: 3096399434

Symbol: Q59FF7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59FF7

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 5 CTD 1 ChEBI 10 DNASU 1 EC 1 EMBL 2 GO 7 Gene3D 2 GenomeRNAi 1 InterPro 9 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 7 PeptideAtlas 1 Pfam 4 RefSeq 1 Rhea 3 RuleBase 1 SAM 1 SMART 4 SUPFAM 3 UniPathway 1

Sequence Information:

  • Length: 885
  • Mass: 95694
  • Checksum: 0427DD04A1114EAF
  • Sequence:
    • AAAPVPPACS PAAAPGHSFR KVTLTKPTFC HLCSDFIWGL AGFLCDVCNF MSHEKCLKHV 
RIPCTSVAPS LVRVPVAHCF GPRGLHKRKF CAVCRKVLEA PALHCEVCEL HLHPDCVPFA 
CSDCRQCHQD GHQDHDTHHH HWREGNLPSG ARCEVCRKTC GSSDVLAGVR CEWCGVQAHS 
LCSAALAPEC GFGRLRSLVL PPACVRLLPG GFSKTQSFRI VEAAEPGEGG DGADGSAAVG 
PGRETQATPE SGKQTLKIFD GDDAVRRSQF RLVTVSRLAG AEEVLEAALR AHHIPEDPGH 
LELCRLPPSS QACDAWAGGK AGSAVISEEG RSPGSGEATP EAWVIRALPR AQEVLKIYPG 
WLKVGVAYVS VRVTPKSTAR SVVLEVLPLL GRQAESPESF QLVEVAMGCR HVQRTMLMDE 
QPLLDRLQDI RQMSVRQVSQ TRFYVAESRD VAPHVSLFVG GLPPGLSPEE YSSLLHEAGA 
TKGAVVLDVA CFAEAERLYM LLKDMAVRGR LLTALVLPDL LHAKLPPDSC PLLVFVNPKS 
GGLKGRDLLC SFRKLLNPHQ VFDLTNGGPL PGLHLFSQVP CFRVLVCGGD GTVGWVLGAL 
EETRYRLACP EPSVAILPLG TGNDLGRVLR WGAGYSGEDP FSVLLSVDEA DAVLMDRWTI 
LLDAHEAGSA ENDTADAEPP KIVQMSNYCG IGIDAELSLD FHQAREEEPG KFTSRLHNKG 
VYVRVGLQKI SHSRSLHKQI RLQVERQEVE LPSIEGLIFI NIPSWGSGAD LWGSDSDTRF 
EKPRMDDGLL EVVGVTGVVH MGQVQGGLRS GIRIAQGSYF RVTLLKATPV QVDGEPWVQA 
PGHMIISAAG PKVHMLRKAK QKPRRAGTTR DARADAAPAP ESDPR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.