Details for: DCC

Gene ID: 1630

Symbol: DCC

Ensembl ID: ENSG00000187323

Description: DCC netrin 1 receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 8.9197
    Cell Significance Index: 195.3100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 7.2176
    Cell Significance Index: 319.2500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 6.9184
    Cell Significance Index: 197.4300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 6.9094
    Cell Significance Index: 261.6400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 5.9152
    Cell Significance Index: 397.7400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.7976
    Cell Significance Index: -10.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 4.0520
    Cell Significance Index: 1453.3900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.1362
    Cell Significance Index: 428.5200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.8863
    Cell Significance Index: 1304.6500
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.6311
    Cell Significance Index: 24.8200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4223
    Cell Significance Index: 25.9600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2046
    Cell Significance Index: 11.4800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1173
    Cell Significance Index: 216.3100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0153
    Cell Significance Index: 28.8900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0176
    Cell Significance Index: -7.9900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0251
    Cell Significance Index: -38.7200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0326
    Cell Significance Index: -44.3800
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0462
    Cell Significance Index: -0.4400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0853
    Cell Significance Index: -54.1500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0888
    Cell Significance Index: -65.7500
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0900
    Cell Significance Index: -1.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1092
    Cell Significance Index: -82.6300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.1263
    Cell Significance Index: -68.9500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1340
    Cell Significance Index: -1.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1440
    Cell Significance Index: -81.2200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1489
    Cell Significance Index: -92.9600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1672
    Cell Significance Index: -4.0100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1871
    Cell Significance Index: -5.2300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2054
    Cell Significance Index: -59.0900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.2883
    Cell Significance Index: -57.2200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.2898
    Cell Significance Index: -52.2400
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.3213
    Cell Significance Index: -2.0900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4075
    Cell Significance Index: -85.8400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.4254
    Cell Significance Index: -54.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4668
    Cell Significance Index: -67.8500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.4772
    Cell Significance Index: -58.6700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.4852
    Cell Significance Index: -5.6600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.5169
    Cell Significance Index: -88.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.5228
    Cell Significance Index: -71.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.5611
    Cell Significance Index: -72.4900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6403
    Cell Significance Index: -66.6700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.6796
    Cell Significance Index: -69.4300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.7222
    Cell Significance Index: -84.1700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.7238
    Cell Significance Index: -10.3700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.7490
    Cell Significance Index: -14.8100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.7762
    Cell Significance Index: -88.9300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.8492
    Cell Significance Index: -8.0500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.9117
    Cell Significance Index: -69.9700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.9740
    Cell Significance Index: -72.5900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.0140
    Cell Significance Index: -33.2000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.0276
    Cell Significance Index: -25.6300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.1269
    Cell Significance Index: -35.8900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.1765
    Cell Significance Index: -23.6200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.1822
    Cell Significance Index: -20.2600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.3020
    Cell Significance Index: -67.8200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.3372
    Cell Significance Index: -28.8900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.3442
    Cell Significance Index: -28.5300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.3546
    Cell Significance Index: -71.1200
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -1.4169
    Cell Significance Index: -14.7600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.4593
    Cell Significance Index: -50.7100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.4655
    Cell Significance Index: -37.6700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -1.4905
    Cell Significance Index: -70.0500
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -1.5377
    Cell Significance Index: -12.0600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -1.5541
    Cell Significance Index: -10.5300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -1.5956
    Cell Significance Index: -19.7900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.6230
    Cell Significance Index: -75.6700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.6471
    Cell Significance Index: -57.7000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.8184
    Cell Significance Index: -35.4900
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -1.8767
    Cell Significance Index: -17.0600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -1.8964
    Cell Significance Index: -23.9300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.9330
    Cell Significance Index: -121.8300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -1.9413
    Cell Significance Index: -11.5200
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -2.0627
    Cell Significance Index: -26.7500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -2.2000
    Cell Significance Index: -43.3000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.2416
    Cell Significance Index: -66.0300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -2.2500
    Cell Significance Index: -46.9600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -2.2735
    Cell Significance Index: -55.0700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -2.2801
    Cell Significance Index: -80.1200
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -2.3408
    Cell Significance Index: -30.5500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -2.4794
    Cell Significance Index: -128.8000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -2.4843
    Cell Significance Index: -52.0000
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -2.4998
    Cell Significance Index: -27.5800
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -2.5142
    Cell Significance Index: -37.6100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -2.5162
    Cell Significance Index: -72.1300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -2.5331
    Cell Significance Index: -54.1500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -2.5453
    Cell Significance Index: -50.7600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -2.5502
    Cell Significance Index: -63.6000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -2.6082
    Cell Significance Index: -29.6300
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: -2.6571
    Cell Significance Index: -20.3800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -2.6799
    Cell Significance Index: -84.7600
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -2.7461
    Cell Significance Index: -32.8400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -2.7589
    Cell Significance Index: -79.4900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -2.7748
    Cell Significance Index: -74.0900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -2.7871
    Cell Significance Index: -48.1900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -2.7880
    Cell Significance Index: -56.7300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -2.8727
    Cell Significance Index: -71.7500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -2.9227
    Cell Significance Index: -74.4700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -2.9516
    Cell Significance Index: -80.3400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -3.0079
    Cell Significance Index: -32.2500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -3.0561
    Cell Significance Index: -81.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Receptor for Netrin 1**: DCC acts as a receptor for netrin 1, a secreted protein that guides axons during development. 2. **Transmembrane Signaling Receptor**: DCC is a transmembrane receptor that undergoes conformational changes upon binding to netrin 1, triggering a signaling cascade. 3. **Regulation of Axon Guidance**: DCC plays a critical role in regulating axon guidance, particularly in the formation of the anterior/posterior and dorsal/ventral axon guidance. 4. **Apoptosis and Cell Death**: DCC is involved in regulating programmed cell death, particularly in the context of axonal guidance and neuronal development. 5. **Expression in Neuronal Cells**: DCC is expressed in various neuronal cell types, including Purkinje cells, retinal ganglion cells, and cerebral cortex neurons. **Pathways and Functions:** 1. **Anterior/Posterior Axon Guidance**: DCC regulates the guidance of axons from the dorsal to the ventral region during development. 2. **Dorsal/Ventral Axon Guidance**: DCC plays a role in regulating the guidance of axons from the ventral to the dorsal region during development. 3. **Apoptosis**: DCC is involved in regulating programmed cell death, particularly in the context of axonal guidance and neuronal development. 4. **Neuron Migration**: DCC regulates the migration of neurons during development. 5. **Synaptic Transmission**: DCC is involved in regulating synaptic transmission, particularly in the context of the Schaffer collateral-ca1 synapse. **Clinical Significance:** 1. **Autism Spectrum Disorder**: Abnormal expression of DCC has been implicated in autism spectrum disorder, a neurodevelopmental disorder characterized by impaired social interaction and communication. 2. **Schizophrenia**: DCC has been associated with schizophrenia, a psychiatric disorder characterized by impaired cognitive and social functioning. 3. **Cerebellar Ataxia**: Abnormal expression of DCC has been implicated in cerebellar ataxia, a neurological disorder characterized by impaired motor coordination and balance. 4. **Neurodevelopmental Disorders**: DCC plays a critical role in regulating neuronal development and axon guidance, and abnormalities in DCC have been implicated in various neurodevelopmental disorders. In conclusion, the DCC gene is a critical regulator of axon guidance and development in the nervous system. Abnormal expression or function of DCC has been implicated in various neurological disorders, highlighting the importance of this gene in maintaining normal neuronal development and function.

Genular Protein ID: 885260022

Symbol: DCC_HUMAN

Name: Netrin receptor DCC

UniProtKB Accession Codes:

P43146

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 21 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 7 RefSeq 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7926722

Title: The DCC gene product in cellular differentiation and colorectal tumorigenesis.

PubMed ID: 7926722

DOI: 10.1101/gad.8.10.1174

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 2294591

Title: Identification of a chromosome 18q gene that is altered in colorectal cancers.

PubMed ID: 2294591

DOI: 10.1126/science.2294591

PubMed ID: 1991322

Title: Scrambled exons.

PubMed ID: 1991322

DOI: 10.1016/0092-8674(91)90244-s

PubMed ID: 8188295

Title: The DCC gene: structural analysis and mutations in colorectal carcinomas.

PubMed ID: 8188295

DOI: 10.1006/geno.1994.1102

PubMed ID: 8861902

Title: Deleted in colorectal cancer (DCC) encodes a netrin receptor.

PubMed ID: 8861902

DOI: 10.1016/s0092-8674(00)81336-7

PubMed ID: 9334332

Title: Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway.

PubMed ID: 9334332

DOI: 10.1101/gad.11.20.2701

PubMed ID: 20431009

Title: Mutations in DCC cause congenital mirror movements.

PubMed ID: 20431009

DOI: 10.1126/science.1186463

PubMed ID: 28250454

Title: Mutations in DCC cause isolated agenesis of the corpus callosum with incomplete penetrance.

PubMed ID: 28250454

DOI: 10.1038/ng.3794

PubMed ID: 21642953

Title: Structural basis of cargo recognition by the myosin-X MyTH4-FERM domain.

PubMed ID: 21642953

DOI: 10.1038/emboj.2011.177

PubMed ID: 8187090

Title: Point mutations and allelic deletion of tumor suppressor gene DCC in human esophageal squamous cell carcinomas and their relation to metastasis.

PubMed ID: 8187090

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 28250456

Title: Biallelic mutations in human DCC cause developmental split-brain syndrome.

PubMed ID: 28250456

DOI: 10.1038/ng.3804

Sequence Information:

  • Length: 1447
  • Mass: 158457
  • Checksum: BC17EA0E93DE8768
  • Sequence:
    • MENSLRCVWV PKLAFVLFGA SLFSAHLQVT GFQIKAFTAL RFLSEPSDAV TMRGGNVLLD 
CSAESDRGVP VIKWKKDGIH LALGMDERKQ QLSNGSLLIQ NILHSRHHKP DEGLYQCEAS 
LGDSGSIISR TAKVAVAGPL RFLSQTESVT AFMGDTVLLK CEVIGEPMPT IHWQKNQQDL 
TPIPGDSRVV VLPSGALQIS RLQPGDIGIY RCSARNPASS RTGNEAEVRI LSDPGLHRQL 
YFLQRPSNVV AIEGKDAVLE CCVSGYPPPS FTWLRGEEVI QLRSKKYSLL GGSNLLISNV 
TDDDSGMYTC VVTYKNENIS ASAELTVLVP PWFLNHPSNL YAYESMDIEF ECTVSGKPVP 
TVNWMKNGDV VIPSDYFQIV GGSNLRILGV VKSDEGFYQC VAENEAGNAQ TSAQLIVPKP 
AIPSSSVLPS APRDVVPVLV SSRFVRLSWR PPAEAKGNIQ TFTVFFSREG DNRERALNTT 
QPGSLQLTVG NLKPEAMYTF RVVAYNEWGP GESSQPIKVA TQPELQVPGP VENLQAVSTS 
PTSILITWEP PAYANGPVQG YRLFCTEVST GKEQNIEVDG LSYKLEGLKK FTEYSLRFLA 
YNRYGPGVST DDITVVTLSD VPSAPPQNVS LEVVNSRSIK VSWLPPPSGT QNGFITGYKI 
RHRKTTRRGE METLEPNNLW YLFTGLEKGS QYSFQVSAMT VNGTGPPSNW YTAETPENDL 
DESQVPDQPS SLHVRPQTNC IIMSWTPPLN PNIVVRGYII GYGVGSPYAE TVRVDSKQRY 
YSIERLESSS HYVISLKAFN NAGEGVPLYE SATTRSITDP TDPVDYYPLL DDFPTSVPDL 
STPMLPPVGV QAVALTHDAV RVSWADNSVP KNQKTSEVRL YTVRWRTSFS ASAKYKSEDT 
TSLSYTATGL KPNTMYEFSV MVTKNRRSST WSMTAHATTY EAAPTSAPKD LTVITREGKP 
RAVIVSWQPP LEANGKITAY ILFYTLDKNI PIDDWIMETI SGDRLTHQIM DLNLDTMYYF 
RIQARNSKGV GPLSDPILFR TLKVEHPDKM ANDQGRHGDG GYWPVDTNLI DRSTLNEPPI 
GQMHPPHGSV TPQKNSNLLV IIVVTVGVIT VLVVVIVAVI CTRRSSAQQR KKRATHSAGK 
RKGSQKDLRP PDLWIHHEEM EMKNIEKPSG TDPAGRDSPI QSCQDLTPVS HSQSETQLGS 
KSTSHSGQDT EEAGSSMSTL ERSLAARRAP RAKLMIPMDA QSNNPAVVSA IPVPTLESAQ 
YPGILPSPTC GYPHPQFTLR PVPFPTLSVD RGFGAGRSQS VSEGPTTQQP PMLPPSQPEH 
SSSEEAPSRT IPTACVRPTH PLRSFANPLL PPPMSAIEPK VPYTPLLSQP GPTLPKTHVK 
TASLGLAGKA RSPLLPVSVP TAPEVSEESH KPTEDSANVY EQDDLSEQMA SLEGLMKQLN 
AITGSAF

Genular Protein ID: 656546381

Symbol: Q49AK4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q49AK4

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 1 InterPro 8 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SMART 3 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 772
  • Mass: 84992
  • Checksum: E444052269F016DC
  • Sequence:
    • SGVPVIKWKK DGIHLALGMD ERKQQLSNGS LLIQNILHSR HHKPDEGLYQ CEASLGDSGS 
IISRTAKVAV AGPLRFLSQT ESVTAFMGDT VLLKCEVIGE PMPTIHWQKN QQDLTPIPGD 
SRVVVLPSGA LQISRLQPGD IGIYRCSARN PASSRTGNEA EVRILSDPGL HRQLYFLQRP 
SNVVAIEGKD AVLEGCVSGY PPPSFTWLRG EEVIQLRSKK YSLLGGSNLL ISNVTDDDSG 
MYTCVVTYKN ENISASAELT VLVPPWFLNH PSNLYAYESM DIEFECTVSG KPVPTVNWMK 
NGDVVIPSDY FQIVGGSNLR ILGVVKSDEG FYQCVAENEA GNAQTSAQLI VPKPAIPSSS 
VLPSAPRDVV PVLVSSRFVR LSWRPPAEAK GNIQTFTVFF SREGDNRERA LNTTQPGSLQ 
LTVGNLKPEA MYTFRVVAYN EWGPGESSQP IKVATQPELQ VPGPVENLQA VSTSPTSILI 
TWEPPAYANG PVQGYRLFCT EVSTGKEQNI EVDGLSYKLE GLKKFTEYSL RFLAYNRYGP 
GVSTDDITVV TLSDVPSAPP QNVSLEVVNS RSIKVSWLPP PSGTQNGFIT GYKIRHRKTT 
RRGEMETLEP NNLWYLFTGL EKGSQYSFQV SAMTVNGTGP PSNWYTAETP ENDLDESQVP 
DQPSSLHVRP QTNCIIMSWT PPLNPNIVVR GYIIGYGVGS PYAETVRVDS KQRYYSIERL 
ESSSHYVISL KAFNNAGEGV PLYESATTRS ITVRRHNISK LHSNRPQTKH NV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.