Details for: DDB2

Gene ID: 1643

Symbol: DDB2

Ensembl ID: ENSG00000134574

Description: damage specific DNA binding protein 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.99
    Marker Score: 1157
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.56
    Marker Score: 1766
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168108
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.25
    Marker Score: 1386
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.23
    Marker Score: 1649
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.18
    Marker Score: 18437
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.08
    Marker Score: 1396
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.06
    Marker Score: 6757
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1
    Marker Score: 7457
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71691
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47915
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.98
    Marker Score: 2669
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30394
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.97
    Marker Score: 9235
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.97
    Marker Score: 2121
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.96
    Marker Score: 1280
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.95
    Marker Score: 995
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2398
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 478
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 435
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.92
    Marker Score: 910
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2702
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.89
    Marker Score: 2449
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.85
    Marker Score: 3562.5
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.85
    Marker Score: 8423
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.84
    Marker Score: 4808
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.84
    Marker Score: 611
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.8
    Marker Score: 1001
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8
    Marker Score: 1180
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.79
    Marker Score: 1302
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.79
    Marker Score: 570
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.78
    Marker Score: 2315
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.78
    Marker Score: 16630
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 311
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 588.5
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.74
    Marker Score: 324
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.74
    Marker Score: 1505
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.74
    Marker Score: 238
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.73
    Marker Score: 232
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.73
    Marker Score: 6311
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.73
    Marker Score: 363
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 373
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.72
    Marker Score: 357
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.71
    Marker Score: 1369
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.7
    Marker Score: 4187
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2920
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.69
    Marker Score: 331
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.69
    Marker Score: 1632
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.68
    Marker Score: 2521
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.68
    Marker Score: 408
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 614
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.67
    Marker Score: 272
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.67
    Marker Score: 162
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.67
    Marker Score: 590
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.66
    Marker Score: 663
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.66
    Marker Score: 229
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.66
    Marker Score: 11631
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.65
    Marker Score: 34597
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.65
    Marker Score: 373
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.64
    Marker Score: 7412
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.64
    Marker Score: 770
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.64
    Marker Score: 1110
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.63
    Marker Score: 39010
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.63
    Marker Score: 789
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.63
    Marker Score: 141
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.63
    Marker Score: 155
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.63
    Marker Score: 416
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.63
    Marker Score: 218
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.62
    Marker Score: 231
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.62
    Marker Score: 141
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.62
    Marker Score: 303
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.62
    Marker Score: 345
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.62
    Marker Score: 1095
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.61
    Marker Score: 134
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.61
    Marker Score: 133
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.61
    Marker Score: 146
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.61
    Marker Score: 355
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.61
    Marker Score: 660
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.61
    Marker Score: 557
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.6
    Marker Score: 412
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.6
    Marker Score: 154
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.6
    Marker Score: 5650
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.6
    Marker Score: 562
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.6
    Marker Score: 152
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.6
    Marker Score: 139
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.6
    Marker Score: 685
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.59
    Marker Score: 157
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.59
    Marker Score: 1076
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.59
    Marker Score: 429
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.58
    Marker Score: 1139
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.58
    Marker Score: 236
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.58
    Marker Score: 144
  • Cell Name: parietal cell (CL0000162)
    Fold Change: 0.58
    Marker Score: 161
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.58
    Marker Score: 2362
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.58
    Marker Score: 990
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.58
    Marker Score: 282.5

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Other Information

**Key characteristics**: - DDB2 is a large protein with a molecular weight of approximately 120 kDa. - It is a member of the DNA damage binding protein family. - DDB2 is highly expressed in cells that are involved in DNA repair, such as corneal endothelial cells, basal epithelial cells of the tracheobronchial tree, mural cells, and corneal epithelial cells. - It is also expressed in cells that are involved in cell cycle regulation and apoptosis. **Pathways and functions:** - DDB2 is involved in the initiation of the gg-ner pathway, a DNA repair pathway that is triggered by DNA damage. - It binds to DNA damage response proteins, such as DNA repair proteins and cell cycle proteins, and recruits them to the site of DNA damage. - DDB2 also plays a role in the regulation of cell cycle progression and apoptosis. - It inhibits the activation of the DNA repair protein ATM, which is a key regulator of the cell cycle. - By binding to ATM and preventing its activation, DDB2 allows cells to repair DNA damage without compromising cell cycle progression. **Clinical significance:** - Mutations in DDB2 have been linked to an increased risk of certain types of cancer, including lung cancer, colorectal cancer, and breast cancer. - Targeting DDB2 has been explored as a therapeutic strategy for cancer treatment. - DDB2 is a promising target for cancer immunotherapy because it is highly expressed in cancer cells and is involved in DNA repair and cell cycle regulation.

Genular Protein ID: 3511850902

Symbol: DDB2_HUMAN

Name: DNA damage-binding protein 2

UniProtKB Accession Codes:

Q92466 B2R875 Q76E54 Q76E55 Q76E56 Q76E57

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 5 EPD 1 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 9 PIR 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 6 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8530102

Title: Chromosomal localization and cDNA cloning of the genes (DDB1 and DDB2) for the p127 and p48 subunits of a human damage-specific DNA binding protein.

PubMed ID: 8530102

DOI: 10.1006/geno.1995.1215

PubMed ID: 14751237

Title: Human DDB2 splicing variants are dominant negative inhibitors of UV-damaged DNA repair.

PubMed ID: 14751237

DOI: 10.1016/j.bbrc.2004.01.003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9632823

Title: p48 Activates a UV-damaged-DNA binding factor and is defective in xeroderma pigmentosum group E cells that lack binding activity.

PubMed ID: 9632823

DOI: 10.1128/mcb.18.7.4391

PubMed ID: 9892649

Title: Expression of the p48 xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair.

PubMed ID: 9892649

DOI: 10.1073/pnas.96.2.424

PubMed ID: 10777490

Title: Human damage-specific DNA-binding protein p48. Characterization of XPE mutations and regulation following UV irradiation.

PubMed ID: 10777490

DOI: 10.1074/jbc.m000960200

PubMed ID: 10777491

Title: Nuclear transport of human DDB protein induced by ultraviolet light.

PubMed ID: 10777491

DOI: 10.1074/jbc.m000961200

PubMed ID: 10882109

Title: Xeroderma pigmentosum p48 gene enhances global genomic repair and suppresses UV-induced mutagenesis.

PubMed ID: 10882109

DOI: 10.1016/s1097-2765(00)80252-x

PubMed ID: 11278856

Title: Damaged DNA-binding protein DDB stimulates the excision of cyclobutane pyrimidine dimers in vitro in concert with XPA and replication protein A.

PubMed ID: 11278856

DOI: 10.1074/jbc.m011177200

PubMed ID: 11673459

Title: UV-damaged DNA-binding proteins are targets of CUL-4A-mediated ubiquitination and degradation.

PubMed ID: 11673459

DOI: 10.1074/jbc.m106808200

PubMed ID: 11705987

Title: DDB accumulates at DNA damage sites immediately after UV irradiation and directly stimulates nucleotide excision repair.

PubMed ID: 11705987

DOI: 10.1074/jbc.c100610200

PubMed ID: 12732143

Title: The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage.

PubMed ID: 12732143

DOI: 10.1016/s0092-8674(03)00316-7

PubMed ID: 12944386

Title: In vivo recruitment of XPC to UV-induced cyclobutane pyrimidine dimers by the DDB2 gene product.

PubMed ID: 12944386

DOI: 10.1074/jbc.m307254200

PubMed ID: 15882621

Title: UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex.

PubMed ID: 15882621

DOI: 10.1016/j.cell.2005.02.035

PubMed ID: 16223728

Title: DDB1-DDB2 (xeroderma pigmentosum group E) protein complex recognizes a cyclobutane pyrimidine dimer, mismatches, apurinic/apyrimidinic sites, and compound lesions in DNA.

PubMed ID: 16223728

DOI: 10.1074/jbc.m507854200

PubMed ID: 16260596

Title: Xeroderma pigmentosum complementation group E protein (XPE/DDB2): purification of various complexes of XPE and analyses of their damaged DNA binding and putative DNA repair properties.

PubMed ID: 16260596

DOI: 10.1128/mcb.25.22.9784-9792.2005

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17079684

Title: DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases.

PubMed ID: 17079684

DOI: 10.1101/gad.1483206

PubMed ID: 16527807

Title: Cullin 4A-mediated proteolysis of DDB2 protein at DNA damage sites regulates in vivo lesion recognition by XPC.

PubMed ID: 16527807

DOI: 10.1074/jbc.m511834200

PubMed ID: 16678110

Title: Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage.

PubMed ID: 16678110

DOI: 10.1016/j.molcel.2006.03.035

PubMed ID: 16713579

Title: A kinase-independent function of c-Abl in promoting proteolytic destruction of damaged DNA binding proteins.

PubMed ID: 16713579

DOI: 10.1016/j.molcel.2006.04.021

PubMed ID: 16949367

Title: A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1.

PubMed ID: 16949367

DOI: 10.1016/j.molcel.2006.08.010

PubMed ID: 16964240

Title: Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery.

PubMed ID: 16964240

DOI: 10.1038/nature05175

PubMed ID: 17041588

Title: CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation.

PubMed ID: 17041588

DOI: 10.1038/ncb1490

PubMed ID: 16473935

Title: The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites.

PubMed ID: 16473935

DOI: 10.1073/pnas.0511160103

PubMed ID: 17635991

Title: Dynamic in vivo interaction of DDB2 E3 ubiquitin ligase with UV-damaged DNA is independent of damage-recognition protein XPC.

PubMed ID: 17635991

DOI: 10.1242/jcs.008367

PubMed ID: 18593899

Title: The cullin 4B-based UV-damaged DNA-binding protein ligase binds to UV-damaged chromatin and ubiquitinates histone H2A.

PubMed ID: 18593899

DOI: 10.1158/0008-5472.can-07-6162

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23159851

Title: The deubiquitinating protein USP24 interacts with DDB2 and regulates DDB2 stability.

PubMed ID: 23159851

DOI: 10.4161/cc.22688

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26572825

Title: UV damage-induced phosphorylation of HBO1 triggers CRL4DDB2-mediated degradation to regulate cell proliferation.

PubMed ID: 26572825

DOI: 10.1128/mcb.00809-15

PubMed ID: 32789493

Title: The deacetylase SIRT6 promotes the repair of UV-induced DNA damage by targeting DDB2.

PubMed ID: 32789493

DOI: 10.1093/nar/gkaa661

PubMed ID: 19109893

Title: Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex.

PubMed ID: 19109893

DOI: 10.1016/j.cell.2008.10.045

PubMed ID: 19966799

Title: A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery.

PubMed ID: 19966799

DOI: 10.1038/nsmb.1719

PubMed ID: 22822215

Title: Damaged DNA induced UV-damaged DNA-binding protein (UV-DDB) dimerization and its roles in chromatinized DNA repair.

PubMed ID: 22822215

DOI: 10.1073/pnas.1110067109

PubMed ID: 8798680

Title: Mutations specific to the xeroderma pigmentosum group E Ddb-phenotype.

PubMed ID: 8798680

DOI: 10.1074/jbc.271.40.24317

Sequence Information:

  • Length: 427
  • Mass: 47864
  • Checksum: E881F21242CA44D2
  • Sequence:
    • MAPKKRPETQ KTSEIVLRPR NKRSRSPLEL EPEAKKLCAK GSGPSRRCDS DCLWVGLAGP 
QILPPCRSIV RTLHQHKLGR ASWPSVQQGL QQSFLHTLDS YRILQKAAPF DRRATSLAWH 
PTHPSTVAVG SKGGDIMLWN FGIKDKPTFI KGIGAGGSIT GLKFNPLNTN QFYASSMEGT 
TRLQDFKGNI LRVFASSDTI NIWFCSLDVS ASSRMVVTGD NVGNVILLNM DGKELWNLRM 
HKKKVTHVAL NPCCDWFLAT ASVDQTVKIW DLRQVRGKAS FLYSLPHRHP VNAACFSPDG 
ARLLTTDQKS EIRVYSASQW DCPLGLIPHP HRHFQHLTPI KAAWHPRYNL IVVGRYPDPN 
FKSCTPYELR TIDVFDGNSG KMMCQLYDPE SSGISSLNEF NPMGDTLASA MGYHILIWSQ 
EEARTRK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.