Details for: DDB2

Gene ID: 1643

Symbol: DDB2

Ensembl ID: ENSG00000134574

Description: damage specific DNA binding protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 150.5671
    Cell Significance Index: -23.4200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 93.7931
    Cell Significance Index: -23.7900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 54.2020
    Cell Significance Index: -25.5900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 47.9407
    Cell Significance Index: -24.6600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 38.1508
    Cell Significance Index: -25.6000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.1849
    Cell Significance Index: -26.1200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.1845
    Cell Significance Index: -21.9300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.9314
    Cell Significance Index: -15.1700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.7485
    Cell Significance Index: -26.6300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.6744
    Cell Significance Index: -20.5000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.2242
    Cell Significance Index: 423.2700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.0632
    Cell Significance Index: 57.6600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1.9746
    Cell Significance Index: 29.9900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.8007
    Cell Significance Index: 209.8500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.5311
    Cell Significance Index: 20.8900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.1217
    Cell Significance Index: 30.0600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0077
    Cell Significance Index: 199.9800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9548
    Cell Significance Index: 155.2900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8314
    Cell Significance Index: 750.7000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.8243
    Cell Significance Index: 24.2100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8014
    Cell Significance Index: 48.1100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7109
    Cell Significance Index: 19.3500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6192
    Cell Significance Index: 273.7600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5334
    Cell Significance Index: 27.7100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4836
    Cell Significance Index: 21.9200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4241
    Cell Significance Index: 52.1500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4221
    Cell Significance Index: 29.1900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3941
    Cell Significance Index: 46.4800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3931
    Cell Significance Index: 78.8600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3883
    Cell Significance Index: 27.4600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3655
    Cell Significance Index: 65.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3151
    Cell Significance Index: 24.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2745
    Cell Significance Index: 17.7100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2520
    Cell Significance Index: 5.4600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2400
    Cell Significance Index: 6.9200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2263
    Cell Significance Index: 10.5500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1967
    Cell Significance Index: 107.4100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1944
    Cell Significance Index: 19.2300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1716
    Cell Significance Index: 3.3500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1495
    Cell Significance Index: 7.5600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1267
    Cell Significance Index: 7.1100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1117
    Cell Significance Index: 1.5900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1071
    Cell Significance Index: 74.0500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1031
    Cell Significance Index: 13.2200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0945
    Cell Significance Index: 12.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0871
    Cell Significance Index: 160.7200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0845
    Cell Significance Index: 24.3200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0836
    Cell Significance Index: 11.4800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0764
    Cell Significance Index: 1.9100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0717
    Cell Significance Index: 2.5200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0653
    Cell Significance Index: 122.8800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0331
    Cell Significance Index: 50.9900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0306
    Cell Significance Index: 0.9800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0268
    Cell Significance Index: 12.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0115
    Cell Significance Index: 4.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0061
    Cell Significance Index: 8.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0077
    Cell Significance Index: -4.8700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0246
    Cell Significance Index: -18.6100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0268
    Cell Significance Index: -2.7400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0285
    Cell Significance Index: -4.1500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0288
    Cell Significance Index: -21.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0343
    Cell Significance Index: -25.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0402
    Cell Significance Index: -22.6800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0488
    Cell Significance Index: -30.4600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0492
    Cell Significance Index: -8.4000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0719
    Cell Significance Index: -4.4200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0751
    Cell Significance Index: -3.5300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0944
    Cell Significance Index: -7.0400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1343
    Cell Significance Index: -2.8600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1438
    Cell Significance Index: -30.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1737
    Cell Significance Index: -19.9000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1749
    Cell Significance Index: -18.2100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1973
    Cell Significance Index: -10.3600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2259
    Cell Significance Index: -5.7700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2582
    Cell Significance Index: -15.8300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2688
    Cell Significance Index: -16.9400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2932
    Cell Significance Index: -23.2200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3007
    Cell Significance Index: -7.7300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3266
    Cell Significance Index: -11.3500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3485
    Cell Significance Index: -23.4300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3554
    Cell Significance Index: -6.0900
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.3766
    Cell Significance Index: -5.7300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3986
    Cell Significance Index: -3.2500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4185
    Cell Significance Index: -11.2000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4393
    Cell Significance Index: -19.4300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4614
    Cell Significance Index: -10.6600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5187
    Cell Significance Index: -19.6400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5470
    Cell Significance Index: -17.4200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5500
    Cell Significance Index: -20.1900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5621
    Cell Significance Index: -19.6900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5743
    Cell Significance Index: -3.4700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5756
    Cell Significance Index: -15.3700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5826
    Cell Significance Index: -15.3200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5998
    Cell Significance Index: -17.2000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6135
    Cell Significance Index: -20.0900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.6248
    Cell Significance Index: -10.7700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.6259
    Cell Significance Index: -10.4800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6379
    Cell Significance Index: -11.7900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6740
    Cell Significance Index: -9.9500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.6799
    Cell Significance Index: -12.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structural Features:** DDB2 is a 74-kDa protein consisting of an N-terminal domain (NTD) and a C-terminal domain (CTD), which interact to form a heterodimeric complex with DDB1. 2. **Subcellular Localization:** DDB2 is primarily localized in the nucleus, where it interacts with other components of the NER pathway. 3. **Interaction Partners:** DDB2 forms complexes with DDB1, Cul4, and other E3 ubiquitin ligases to facilitate the ubiquitination and degradation of target proteins. 4. **Mutational Stability:** DDB2 has been shown to be a tumor suppressor gene, with mutations leading to loss of function and increased cancer risk. **Pathways and Functions:** 1. **DNA Damage Recognition:** DDB2, in complex with DDB1, recognizes UV-induced DNA lesions, such as cyclobutane pyrimidine dimers (CPDs) and 6-4 photoproducts (6-4PPs). 2. **NER Pathway Activation:** The DDB2-DDB1 complex recruits repair enzymes, including DNA polymerase epsilon, XPF, and ERCC1, to initiate the NER repair process. 3. **Incision Complex Formation:** DDB2 plays a critical role in the formation of the incision complex, which cleaves the DNA at the site of damage. 4. **DNA Repair:** DDB2 facilitates the repair of UV-induced DNA damage through the incision and excision steps of the NER pathway. **Clinical Significance:** 1. **Cancer Susceptibility:** Mutations in DDB2 have been associated with increased cancer risk, particularly in skin cancers, such as melanoma and basal cell carcinoma. 2. **Genetic Instability:** DDB2 dysfunction can lead to genetic instability, resulting in increased mutation rates and tumor progression. 3. **Neurological Disorders:** Recent studies have implicated DDB2 in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's, suggesting a potential role in maintaining genome stability in the central nervous system. 4. **Radiosensitization:** DDB2 has been identified as a target for radiosensitization, a strategy to enhance the efficacy of radiation therapy in cancer treatment. In conclusion, DDB2 is a crucial component of the NER pathway, playing a vital role in maintaining genomic stability and preventing cancer. Further research is needed to elucidate the molecular mechanisms underlying DDB2's functions and to explore its potential as a therapeutic target in cancer and other diseases.

Genular Protein ID: 3511850902

Symbol: DDB2_HUMAN

Name: DNA damage-binding protein 2

UniProtKB Accession Codes:

Q92466 B2R875 Q76E54 Q76E55 Q76E56 Q76E57

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 5 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 6 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8530102

Title: Chromosomal localization and cDNA cloning of the genes (DDB1 and DDB2) for the p127 and p48 subunits of a human damage-specific DNA binding protein.

PubMed ID: 8530102

DOI: 10.1006/geno.1995.1215

PubMed ID: 14751237

Title: Human DDB2 splicing variants are dominant negative inhibitors of UV-damaged DNA repair.

PubMed ID: 14751237

DOI: 10.1016/j.bbrc.2004.01.003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9632823

Title: p48 Activates a UV-damaged-DNA binding factor and is defective in xeroderma pigmentosum group E cells that lack binding activity.

PubMed ID: 9632823

DOI: 10.1128/mcb.18.7.4391

PubMed ID: 9892649

Title: Expression of the p48 xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair.

PubMed ID: 9892649

DOI: 10.1073/pnas.96.2.424

PubMed ID: 10777490

Title: Human damage-specific DNA-binding protein p48. Characterization of XPE mutations and regulation following UV irradiation.

PubMed ID: 10777490

DOI: 10.1074/jbc.m000960200

PubMed ID: 10777491

Title: Nuclear transport of human DDB protein induced by ultraviolet light.

PubMed ID: 10777491

DOI: 10.1074/jbc.m000961200

PubMed ID: 10882109

Title: Xeroderma pigmentosum p48 gene enhances global genomic repair and suppresses UV-induced mutagenesis.

PubMed ID: 10882109

DOI: 10.1016/s1097-2765(00)80252-x

PubMed ID: 11278856

Title: Damaged DNA-binding protein DDB stimulates the excision of cyclobutane pyrimidine dimers in vitro in concert with XPA and replication protein A.

PubMed ID: 11278856

DOI: 10.1074/jbc.m011177200

PubMed ID: 11673459

Title: UV-damaged DNA-binding proteins are targets of CUL-4A-mediated ubiquitination and degradation.

PubMed ID: 11673459

DOI: 10.1074/jbc.m106808200

PubMed ID: 11705987

Title: DDB accumulates at DNA damage sites immediately after UV irradiation and directly stimulates nucleotide excision repair.

PubMed ID: 11705987

DOI: 10.1074/jbc.c100610200

PubMed ID: 12732143

Title: The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage.

PubMed ID: 12732143

DOI: 10.1016/s0092-8674(03)00316-7

PubMed ID: 12944386

Title: In vivo recruitment of XPC to UV-induced cyclobutane pyrimidine dimers by the DDB2 gene product.

PubMed ID: 12944386

DOI: 10.1074/jbc.m307254200

PubMed ID: 15882621

Title: UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex.

PubMed ID: 15882621

DOI: 10.1016/j.cell.2005.02.035

PubMed ID: 16223728

Title: DDB1-DDB2 (xeroderma pigmentosum group E) protein complex recognizes a cyclobutane pyrimidine dimer, mismatches, apurinic/apyrimidinic sites, and compound lesions in DNA.

PubMed ID: 16223728

DOI: 10.1074/jbc.m507854200

PubMed ID: 16260596

Title: Xeroderma pigmentosum complementation group E protein (XPE/DDB2): purification of various complexes of XPE and analyses of their damaged DNA binding and putative DNA repair properties.

PubMed ID: 16260596

DOI: 10.1128/mcb.25.22.9784-9792.2005

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17079684

Title: DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases.

PubMed ID: 17079684

DOI: 10.1101/gad.1483206

PubMed ID: 16527807

Title: Cullin 4A-mediated proteolysis of DDB2 protein at DNA damage sites regulates in vivo lesion recognition by XPC.

PubMed ID: 16527807

DOI: 10.1074/jbc.m511834200

PubMed ID: 16678110

Title: Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage.

PubMed ID: 16678110

DOI: 10.1016/j.molcel.2006.03.035

PubMed ID: 16713579

Title: A kinase-independent function of c-Abl in promoting proteolytic destruction of damaged DNA binding proteins.

PubMed ID: 16713579

DOI: 10.1016/j.molcel.2006.04.021

PubMed ID: 16949367

Title: A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1.

PubMed ID: 16949367

DOI: 10.1016/j.molcel.2006.08.010

PubMed ID: 16964240

Title: Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery.

PubMed ID: 16964240

DOI: 10.1038/nature05175

PubMed ID: 17041588

Title: CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation.

PubMed ID: 17041588

DOI: 10.1038/ncb1490

PubMed ID: 16473935

Title: The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites.

PubMed ID: 16473935

DOI: 10.1073/pnas.0511160103

PubMed ID: 17635991

Title: Dynamic in vivo interaction of DDB2 E3 ubiquitin ligase with UV-damaged DNA is independent of damage-recognition protein XPC.

PubMed ID: 17635991

DOI: 10.1242/jcs.008367

PubMed ID: 18593899

Title: The cullin 4B-based UV-damaged DNA-binding protein ligase binds to UV-damaged chromatin and ubiquitinates histone H2A.

PubMed ID: 18593899

DOI: 10.1158/0008-5472.can-07-6162

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23159851

Title: The deubiquitinating protein USP24 interacts with DDB2 and regulates DDB2 stability.

PubMed ID: 23159851

DOI: 10.4161/cc.22688

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26572825

Title: UV damage-induced phosphorylation of HBO1 triggers CRL4DDB2-mediated degradation to regulate cell proliferation.

PubMed ID: 26572825

DOI: 10.1128/mcb.00809-15

PubMed ID: 32789493

Title: The deacetylase SIRT6 promotes the repair of UV-induced DNA damage by targeting DDB2.

PubMed ID: 32789493

DOI: 10.1093/nar/gkaa661

PubMed ID: 19109893

Title: Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex.

PubMed ID: 19109893

DOI: 10.1016/j.cell.2008.10.045

PubMed ID: 19966799

Title: A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery.

PubMed ID: 19966799

DOI: 10.1038/nsmb.1719

PubMed ID: 22822215

Title: Damaged DNA induced UV-damaged DNA-binding protein (UV-DDB) dimerization and its roles in chromatinized DNA repair.

PubMed ID: 22822215

DOI: 10.1073/pnas.1110067109

PubMed ID: 8798680

Title: Mutations specific to the xeroderma pigmentosum group E Ddb-phenotype.

PubMed ID: 8798680

DOI: 10.1074/jbc.271.40.24317

Sequence Information:

  • Length: 427
  • Mass: 47864
  • Checksum: E881F21242CA44D2
  • Sequence:
    • MAPKKRPETQ KTSEIVLRPR NKRSRSPLEL EPEAKKLCAK GSGPSRRCDS DCLWVGLAGP 
QILPPCRSIV RTLHQHKLGR ASWPSVQQGL QQSFLHTLDS YRILQKAAPF DRRATSLAWH 
PTHPSTVAVG SKGGDIMLWN FGIKDKPTFI KGIGAGGSIT GLKFNPLNTN QFYASSMEGT 
TRLQDFKGNI LRVFASSDTI NIWFCSLDVS ASSRMVVTGD NVGNVILLNM DGKELWNLRM 
HKKKVTHVAL NPCCDWFLAT ASVDQTVKIW DLRQVRGKAS FLYSLPHRHP VNAACFSPDG 
ARLLTTDQKS EIRVYSASQW DCPLGLIPHP HRHFQHLTPI KAAWHPRYNL IVVGRYPDPN 
FKSCTPYELR TIDVFDGNSG KMMCQLYDPE SSGISSLNEF NPMGDTLASA MGYHILIWSQ 
EEARTRK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.