Details for: DFFB

Gene ID: 1677

Symbol: DFFB

Ensembl ID: ENSG00000169598

Description: DNA fragmentation factor subunit beta

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.2
    Marker Score: 11298
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.15
    Marker Score: 10895
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.12
    Marker Score: 1730
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.09
    Marker Score: 2578
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.04
    Marker Score: 38352
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.02
    Marker Score: 8729
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71801
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48024
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.99
    Marker Score: 3813
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.99
    Marker Score: 60616
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 491
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 445
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2732
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5178
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.88
    Marker Score: 33275
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.87
    Marker Score: 17313
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5275
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 312
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.86
    Marker Score: 12891
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.85
    Marker Score: 640
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.84
    Marker Score: 3500
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.8
    Marker Score: 737
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1244
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.76
    Marker Score: 5818
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 561
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 380
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 663
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.71
    Marker Score: 11125
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.69
    Marker Score: 277
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2858
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.67
    Marker Score: 6887
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.57
    Marker Score: 1086
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.55
    Marker Score: 2289
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.52
    Marker Score: 1061
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.52
    Marker Score: 310.5
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5
    Marker Score: 320
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.46
    Marker Score: 1296
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.45
    Marker Score: 767
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.45
    Marker Score: 2690
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.43
    Marker Score: 1755
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.43
    Marker Score: 137
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.39
    Marker Score: 162
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.37
    Marker Score: 253
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.36
    Marker Score: 236
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.33
    Marker Score: 721
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.33
    Marker Score: 377
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.32
    Marker Score: 87
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.31
    Marker Score: 6715
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.31
    Marker Score: 122
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.31
    Marker Score: 208
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.31
    Marker Score: 97
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.3
    Marker Score: 105
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.3
    Marker Score: 368
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.3
    Marker Score: 136
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.3
    Marker Score: 177
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.29
    Marker Score: 92
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.29
    Marker Score: 309
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.29
    Marker Score: 690
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.28
    Marker Score: 176
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.28
    Marker Score: 84
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.28
    Marker Score: 82
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.28
    Marker Score: 73
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.27
    Marker Score: 111
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.27
    Marker Score: 86
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.27
    Marker Score: 110
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.27
    Marker Score: 287
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.26
    Marker Score: 444
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.26
    Marker Score: 228
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.26
    Marker Score: 749
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.26
    Marker Score: 68
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.26
    Marker Score: 209
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.26
    Marker Score: 124
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.25
    Marker Score: 74
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.25
    Marker Score: 224
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.25
    Marker Score: 142
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.24
    Marker Score: 238
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.24
    Marker Score: 264
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.24
    Marker Score: 183
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.24
    Marker Score: 229
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.24
    Marker Score: 414
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.24
    Marker Score: 431
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.24
    Marker Score: 455
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.23
    Marker Score: 46
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.23
    Marker Score: 74
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.23
    Marker Score: 12676
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.23
    Marker Score: 51
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.22
    Marker Score: 111
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.22
    Marker Score: 49
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.22
    Marker Score: 152
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.22
    Marker Score: 82
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.22
    Marker Score: 109
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.21
    Marker Score: 49
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.21
    Marker Score: 74
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.21
    Marker Score: 94
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 71

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Other Information

**Key characteristics:** * DFFB is a protein of the DNA repair and recombination family. * It is a key component of the DNA damage response pathway. * It is also involved in the regulation of cell cycle progression and apoptosis. **Pathways and functions:** * DFFB is involved in a variety of cellular processes, including apoptosis, cell cycle progression, and DNA repair. * In apoptosis, DFFB is a key regulator of the decision of a cell to undergo apoptosis or to survive. * It is activated by DNA damage and binds to DNA break sites, promoting the recruitment of other DNA repair proteins to the site. * DFFB also regulates the expression of other genes involved in apoptosis. **Clinical significance:** * Mutations in the DFFB gene have been linked to a number of human diseases, including autism, schizophrenia, and Alzheimer's disease. * Understanding the role of DFFB in apoptosis could lead to the development of new treatments for these diseases. **Additional information:** * The DFFB gene is located on chromosome 15q21.1. * It is a highly conserved gene, with a similar gene found in mice and rats. * DFFB is a ubiquitin-dependent protein, meaning that it is targeted for degradation by the proteasome when it is no longer needed.

Genular Protein ID: 2790884205

Symbol: DFFB_HUMAN

Name: DNA fragmentation factor subunit beta

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9671700

Title: The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis.

PubMed ID: 9671700

DOI: 10.1073/pnas.95.15.8461

PubMed ID: 9689044

Title: Molecular cloning and characterization of human caspase-activated DNase.

PubMed ID: 9689044

DOI: 10.1073/pnas.95.16.9123

PubMed ID: 9560346

Title: CPAN, a human nuclease regulated by the caspase-sensitive inhibitor DFF45.

PubMed ID: 9560346

DOI: 10.1016/s0960-9822(98)79298-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 19882353

Title: Histone H1 subtype preferences of DFF40 and possible nuclear localization of DFF40/45 in normal and trichostatin A-treated NB4 leukemic cells.

PubMed ID: 19882353

DOI: 10.1007/s10495-009-0418-7

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 11371636

Title: Solution structure of DFF40 and DFF45 N-terminal domain complex and mutual chaperone activity of DFF40 and DFF45.

PubMed ID: 11371636

DOI: 10.1073/pnas.111145098

PubMed ID: 10830907

Title: Structure and mutation analysis of the gene encoding DNA fragmentation factor 40 (caspase-activated nuclease), a candidate neuroblastoma tumour suppressor gene.

PubMed ID: 10830907

DOI: 10.1007/s004390000257

Sequence Information:

  • Length: 338
  • Mass: 39110
  • Checksum: 0B0F3F8D91209389
  • Sequence:
  • MLQKPKSVKL RALRSPRKFG VAGRSCQEVL RKGCLRFQLP ERGSRLCLYE DGTELTEDYF 
    PSVPDNAELV LLTLGQAWQG YVSDIRRFLS AFHEPQVGLI QAAQQLLCDE QAPQRQRLLA 
    DLLHNVSQNI AAETRAEDPP WFEGLESRFQ SKSGYLRYSC ESRIRSYLRE VSSYPSTVGA 
    EAQEEFLRVL GSMCQRLRSM QYNGSYFDRG AKGGSRLCTP EGWFSCQGPF DMDSCLSRHS 
    INPYSNRESR ILFSTWNLDH IIEKKRTIIP TLVEAIKEQD GREVDWEYFY GLLFTSENLK 
    LVHIVCHKKT THKLNCDPSR IYKPQTRLKR KQPVRKRQ

Genular Protein ID: 2419879726

Symbol: B4DZS0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 362
  • Mass: 41956
  • Checksum: 4CC54106A612393B
  • Sequence:
  • MLQKPKSVKL RALRSPRKFG VAGRSCQEVL RKGCLRFQLP ERGSRLCLYE DGTELTEDYF 
    PSVPDNAELV LLTLGQAWQG CEWQGLWRMC LLLDRHLLFV PLVADVSDIR RFLSAFHEPQ 
    VGLIQAAQQL LCDEQAPQRQ RLLADLLHNV SQNIAAETRA EDPPWFEGLE SRFQSKSGYL 
    RYSCESRIRS YLREVSSYPS TVGAEAQEEF LRVLGSMCQR LRSMQYNGSY FDRGAKGGSR 
    LCTPEGWFSC QGPFDMDSCL SRHSINPYSN RESRILFSTW NLDHIIEKKR TIIPTLVEAI 
    KEQDGREVDW EYFYGLLFTS ENLKLVHIVC HKKTTHKLNC DPSRIYKPQT RLKRKQPVRK 
    RQ

Genular Protein ID: 1709566851

Symbol: Q96P72_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15147901

Title: Characterization of splice variants of human caspase-activated DNase with CIDE-N structure and function.

PubMed ID: 15147901

DOI: 10.1016/j.febslet.2004.04.050

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 80
  • Mass: 9053
  • Checksum: 9EB6C9C0B35AE529
  • Sequence:
  • MLQKPKSVKL RALRSPRKFG VAGRSCQEVL RKGCLRFQLP ERGSRLCLYE DGTELTEDYF 
    PSVPDNAELV LLTLGQAWQG

Genular Protein ID: 1468370969

Symbol: Q96P73_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15147901

Title: Characterization of splice variants of human caspase-activated DNase with CIDE-N structure and function.

PubMed ID: 15147901

DOI: 10.1016/j.febslet.2004.04.050

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 115
  • Mass: 12849
  • Checksum: 4D59BFEE32424142
  • Sequence:
  • MLQKPKSVKL RALRSPRKFG VAGRSCQEVL RKGCLRFQLP ERGSRLCLYE DGTELTEDYF 
    PSVPDNAELV LLTLGQAWQG CEWQGLWRCE RHQALPQCIS RATGGAHPGR PAAAV

Genular Protein ID: 420974129

Symbol: Q96P74_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15147901

Title: Characterization of splice variants of human caspase-activated DNase with CIDE-N structure and function.

PubMed ID: 15147901

DOI: 10.1016/j.febslet.2004.04.050

Sequence Information:

  • Length: 110
  • Mass: 12106
  • Checksum: 34E72888A0F3B909
  • Sequence:
  • MLQKPKSVKL RALRSPRKFG VAGRSCQEVL RKGCLRFQLP ERGSRLCLYE DGTELTEDYF 
    PSVPDNAELV LLTLGQAWQG CGRCERHQAL PQCISRATGG AHPGRPAAAV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.