Details for: DLX3

Gene ID: 1747

Symbol: DLX3

Ensembl ID: ENSG00000064195

Description: distal-less homeobox 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granular cell of epidermis (CL0002189)
    Fold Change: 12.8477
    Cell Significance Index: 14.7900
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 2.4676
    Cell Significance Index: 22.4000
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.5343
    Cell Significance Index: 3.4600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6001
    Cell Significance Index: 76.9300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3329
    Cell Significance Index: 8.8900
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.2459
    Cell Significance Index: 2.0900
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.2237
    Cell Significance Index: 1.3900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1854
    Cell Significance Index: 2.5300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1704
    Cell Significance Index: 75.3200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1632
    Cell Significance Index: 8.4800
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.1596
    Cell Significance Index: 1.8600
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.0774
    Cell Significance Index: 0.8700
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.0768
    Cell Significance Index: 0.5100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0089
    Cell Significance Index: 0.6300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0014
    Cell Significance Index: 0.0700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0007
    Cell Significance Index: 0.0100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0001
    Cell Significance Index: -0.0100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0017
    Cell Significance Index: -0.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0018
    Cell Significance Index: -3.4300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0021
    Cell Significance Index: -0.0900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0033
    Cell Significance Index: -0.6500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0041
    Cell Significance Index: -0.1200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0042
    Cell Significance Index: -3.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0046
    Cell Significance Index: -2.5100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0048
    Cell Significance Index: -3.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0048
    Cell Significance Index: -3.6200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0052
    Cell Significance Index: -3.8600
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0063
    Cell Significance Index: -0.0600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0071
    Cell Significance Index: -0.8300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0078
    Cell Significance Index: -3.5600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0082
    Cell Significance Index: -4.6200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0094
    Cell Significance Index: -1.1500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0095
    Cell Significance Index: -0.1500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0128
    Cell Significance Index: -0.5800
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: -0.0139
    Cell Significance Index: -0.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0168
    Cell Significance Index: -3.3800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0207
    Cell Significance Index: -2.3700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0208
    Cell Significance Index: -3.0200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0223
    Cell Significance Index: -3.8000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0228
    Cell Significance Index: -2.9500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0240
    Cell Significance Index: -3.2900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0243
    Cell Significance Index: -1.8100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0271
    Cell Significance Index: -0.2500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0302
    Cell Significance Index: -3.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0369
    Cell Significance Index: -1.7200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0411
    Cell Significance Index: -1.1200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0433
    Cell Significance Index: -4.5100
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.0460
    Cell Significance Index: -0.5300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0494
    Cell Significance Index: -2.3200
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: -0.0534
    Cell Significance Index: -0.3200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0555
    Cell Significance Index: -2.8900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0607
    Cell Significance Index: -2.1100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0608
    Cell Significance Index: -0.8700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0636
    Cell Significance Index: -1.5900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0678
    Cell Significance Index: -1.1700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0707
    Cell Significance Index: -0.8000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0788
    Cell Significance Index: -2.7600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0799
    Cell Significance Index: -2.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0807
    Cell Significance Index: -4.5300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0831
    Cell Significance Index: -1.7400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0876
    Cell Significance Index: -4.6000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0876
    Cell Significance Index: -1.2600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0930
    Cell Significance Index: -2.7400
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.0959
    Cell Significance Index: -0.9300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0989
    Cell Significance Index: -3.6300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1012
    Cell Significance Index: -2.6600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1046
    Cell Significance Index: -3.3500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1060
    Cell Significance Index: -3.4700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1140
    Cell Significance Index: -3.6300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1183
    Cell Significance Index: -2.5900
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1219
    Cell Significance Index: -1.4400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1243
    Cell Significance Index: -3.1000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1284
    Cell Significance Index: -3.4400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1333
    Cell Significance Index: -3.2300
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.1351
    Cell Significance Index: -1.7500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1362
    Cell Significance Index: -3.6500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1363
    Cell Significance Index: -3.2700
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1367
    Cell Significance Index: -1.7600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1369
    Cell Significance Index: -2.7300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1378
    Cell Significance Index: -3.9700
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.1392
    Cell Significance Index: -1.6400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1414
    Cell Significance Index: -2.7600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1417
    Cell Significance Index: -1.7900
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.1429
    Cell Significance Index: -1.5300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1438
    Cell Significance Index: -2.3700
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1446
    Cell Significance Index: -1.9500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1459
    Cell Significance Index: -3.6400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1463
    Cell Significance Index: -5.1400
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.1486
    Cell Significance Index: -2.0400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1552
    Cell Significance Index: -3.2400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1585
    Cell Significance Index: -2.9300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1587
    Cell Significance Index: -4.5300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1591
    Cell Significance Index: -2.2600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1616
    Cell Significance Index: -3.1800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1619
    Cell Significance Index: -1.6800
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.1628
    Cell Significance Index: -1.7300
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.1633
    Cell Significance Index: -2.2200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1658
    Cell Significance Index: -2.9300
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.1660
    Cell Significance Index: -1.7000
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.1747
    Cell Significance Index: -1.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** DLX3 is a type of homeobox gene, which belongs to the distal-less (DLX) family of transcription factors. Homeobox genes are essential for the regulation of embryonic development, tissue patterning, and cell differentiation. DLX3 is specifically involved in the regulation of gene expression through DNA binding and transcriptional activation. It exhibits a high degree of sequence specificity, binding to specific DNA sequences and regulating the expression of target genes. **Pathways and Functions** DLX3 is involved in various signaling pathways, including the BMP (Bone Morphogenetic Protein) signaling pathway, Wnt signaling pathway, and the regulation of transcription by RNA polymerase II. These pathways are essential for the development and maintenance of various tissues, including the nervous system, epithelial tissues, and the immune system. DLX3's involvement in these pathways suggests its role in regulating cell proliferation, differentiation, and survival. In the context of the immune system, DLX3 is expressed in microglial cells, conventional dendritic cells, and other immune cells, where it regulates the expression of genes involved in immune responses, such as cytokine production and antigen presentation. DLX3 also plays a role in the regulation of blood vessel development, which is essential for the proper functioning of the immune system. **Clinical Significance** Dysregulation of DLX3 has been implicated in various diseases, including cancer, neurological disorders, and immune-related disorders. For example, alterations in DLX3 expression have been observed in certain types of leukemia, where it is thought to contribute to tumorigenesis. Additionally, DLX3 has been implicated in the regulation of immune responses in autoimmune diseases, such as multiple sclerosis. Furthermore, DLX3 has been identified as a potential therapeutic target for the treatment of cancer and immune-related disorders. For instance, inhibition of DLX3 has been shown to suppress tumor growth and immune cell proliferation in certain types of cancer. In conclusion, DLX3 is a transcription factor that plays a crucial role in the regulation of various developmental processes, including blood vessel development, epithelial cell differentiation, and hair follicle morphogenesis. Its involvement in the regulation of immune responses, particularly in microglial cells and conventional dendritic cells, highlights its significance in the context of immune system development and function. Further research is needed to fully elucidate the role of DLX3 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 988903442

Symbol: DLX3_HUMAN

Name: Homeobox protein DLX-3

UniProtKB Accession Codes:

O60479 B3KQL6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 24 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 2 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9467018

Title: Identification of a mutation in DLX3 associated with tricho-dento-osseous (TDO) syndrome.

PubMed ID: 9467018

DOI: 10.1093/hmg/7.3.563

PubMed ID: 11792834

Title: Genomic structure and functional control of the Dlx3-7 bigene cluster.

PubMed ID: 11792834

DOI: 10.1073/pnas.012584999

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15666299

Title: DLX3 mutation associated with autosomal dominant amelogenesis imperfecta with taurodontism.

PubMed ID: 15666299

DOI: 10.1002/ajmg.a.30521

PubMed ID: 26550823

Title: DNA-dependent formation of transcription factor pairs alters their binding specificity.

PubMed ID: 26550823

DOI: 10.1038/nature15518

Sequence Information:

  • Length: 287
  • Mass: 31738
  • Checksum: DCA9716E51D78DD1
  • Sequence:
    • MSGSFDRKLS SILTDISSSL SCHAGSKDSP TLPESSVTDL GYYSAPQHDY YSGQPYGQTV 
NPYTYHHQFN LNGLAGTGAY SPKSEYTYGA SYRQYGAYRE QPLPAQDPVS VKEEPEAEVR 
MVNGKPKKVR KPRTIYSSYQ LAALQRRFQK AQYLALPERA ELAAQLGLTQ TQVKIWFQNR 
RSKFKKLYKN GEVPLEHSPN NSDSMACNSP PSPALWDTSS HSTPAPARSQ LPPPLPYSAS 
PSYLDDPTNS WYHAQNLSGP HLQQQPPQPA TLHHASPGPP PNPGAVY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.