Gene DLX3 - ENSG00000064195 | NCBI Gene ID: 1747

Details for: DLX3

Gene ID: 1747

Symbol: DLX3

Ensembl ID: ENSG00000064195

Description: distal-less homeobox 3

Associated with

Blood vessel development
(GO:0001568)
Bmp signaling pathway
(GO:0030509)
Chromatin
(GO:0000785)
Chromatin binding
(GO:0003682)
Cytoplasm
(GO:0005737)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Embryo development
(GO:0009790)
Epithelial cell differentiation
(GO:0030855)
Gene expression
(GO:0010467)
Hair cell differentiation
(GO:0035315)
Hair follicle cell proliferation
(GO:0071335)
Hair follicle morphogenesis
(GO:0031069)
Nucleus
(GO:0005634)
Odontoblast differentiation
(GO:0071895)
Odontogenesis of dentin-containing tooth
(GO:0042475)
Placenta development
(GO:0001890)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific double-stranded dna binding
(GO:1990837)
Transcription cis-regulatory region binding
(GO:0000976)
Wnt signaling pathway
(GO:0016055)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: microglial cell (CL0000129)
Fold Change: 3.76
Marker Score: 6844
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 2.2
Marker Score: 1516
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 2.15
Marker Score: 2166
Cell Name: preosteoblast (CL0007010)
Fold Change: 1.58
Marker Score: 448
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.38
Marker Score: 874
Cell Name: monocyte (CL0000576)
Fold Change: 1.18
Marker Score: 1532
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.08
Marker Score: 2054
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.05
Marker Score: 800
Cell Name: osteoblast (CL0000062)
Fold Change: 1.03
Marker Score: 553.5
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71832
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48057.5
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30409
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.98
Marker Score: 2478
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5343
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2742
Cell Name: plasma cell (CL0000786)
Fold Change: 0.9
Marker Score: 1005
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.88
Marker Score: 279
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.88
Marker Score: 3448
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5292
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.85
Marker Score: 905.5
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.85
Marker Score: 13256
Cell Name: mast cell (CL0000097)
Fold Change: 0.82
Marker Score: 474
Cell Name: goblet cell (CL0000160)
Fold Change: 0.8
Marker Score: 5294
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 710
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1263
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 399
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.7
Marker Score: 180
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.65
Marker Score: 1316
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.63
Marker Score: 1312.5
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.61
Marker Score: 405
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.61
Marker Score: 291
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.57
Marker Score: 454
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.56
Marker Score: 149
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.56
Marker Score: 234
Cell Name: B cell (CL0000236)
Fold Change: 0.55
Marker Score: 527
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.5
Marker Score: 478
Cell Name: respiratory basal cell (CL0002633)
Fold Change: 0.5
Marker Score: 711
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.47
Marker Score: 279
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.45
Marker Score: 270
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.43
Marker Score: 685
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.4
Marker Score: 175
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.39
Marker Score: 217
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.37
Marker Score: 374
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.3
Marker Score: 254
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 0.27
Marker Score: 305
Cell Name: renal principal cell (CL0005009)
Fold Change: 0.26
Marker Score: 203
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 0.26
Marker Score: 210
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.22
Marker Score: 117
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.22
Marker Score: 118
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.21
Marker Score: 219
Cell Name: germ cell (CL0000586)
Fold Change: 0.21
Marker Score: 361
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.18
Marker Score: 429
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.18
Marker Score: 65
Cell Name: basal cell (CL0000646)
Fold Change: 0.17
Marker Score: 215
Cell Name: macrophage (CL0000235)
Fold Change: 0.16
Marker Score: 175
Cell Name: precursor cell (CL0011115)
Fold Change: 0.16
Marker Score: 38
Cell Name: male germ cell (CL0000015)
Fold Change: 0.16
Marker Score: 45
Cell Name: podocyte (CL0000653)
Fold Change: 0.15
Marker Score: 54
Cell Name: malignant cell (CL0001064)
Fold Change: 0.14
Marker Score: 1894
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.14
Marker Score: 36
Cell Name: tracheal goblet cell (CL1000329)
Fold Change: 0.13
Marker Score: 370
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.13
Marker Score: 25
Cell Name: trophoblast giant cell (CL0002488)
Fold Change: 0.12
Marker Score: 40
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.12
Marker Score: 636
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.12
Marker Score: 433
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.11
Marker Score: 36
Cell Name: neural cell (CL0002319)
Fold Change: 0.11
Marker Score: 53
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.11
Marker Score: 35
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 0.11
Marker Score: 51
Cell Name: oogonial cell (CL0000024)
Fold Change: 0.1
Marker Score: 142
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 0.1
Marker Score: 397.5
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.09
Marker Score: 22
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 0.09
Marker Score: 58
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.09
Marker Score: 52
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 0.09
Marker Score: 30
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.09
Marker Score: 31
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.09
Marker Score: 95
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.09
Marker Score: 76.5
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.08
Marker Score: 46
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 0.08
Marker Score: 147
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.08
Marker Score: 132
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.08
Marker Score: 688
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.08
Marker Score: 70
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.07
Marker Score: 116
Cell Name: taste receptor cell (CL0000209)
Fold Change: 0.07
Marker Score: 63
Cell Name: oocyte (CL0000023)
Fold Change: 0.07
Marker Score: 18
Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.07
Marker Score: 91
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.07
Marker Score: 75
Cell Name: ionocyte (CL0005006)
Fold Change: 0.07
Marker Score: 21
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.07
Marker Score: 69
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 0.07
Marker Score: 31
Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 0.07
Marker Score: 16
Cell Name: vasa recta descending limb cell (CL1001285)
Fold Change: 0.07
Marker Score: 18
Cell Name: endosteal cell (CL0002157)
Fold Change: 0.06
Marker Score: 21
Cell Name: epidermal cell (CL0000362)
Fold Change: 0.06
Marker Score: 17
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.06
Marker Score: 43
Cell Name: kidney cell (CL1000497)
Fold Change: 0.06
Marker Score: 40
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 0.06
Marker Score: 464.5
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: 0.06
Marker Score: 23
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.06
Marker Score: 27

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**Key characteristics:** * DLX3 is a homeobox gene, which are a group of genes that are involved in the development of the central nervous system. * It is expressed in a variety of cell types, including microglial cells, conventional dendritic cells, blood vessel endothelial cells, and preosteoblasts. * DLX3 is a key regulator of transcription, and its expression is upregulated in a number of cell types during development. * It is involved in the regulation of blood vessel development, epithelial cell differentiation, hair cell differentiation, and odontogenesis of dentin-containing tooth. **Pathways and functions:** * DLX3 is a key regulator of blood vessel development. It is expressed in endothelial cells of blood vessels, and its expression is upregulated in a number of mouse models of vascular development defects. * It is also involved in the regulation of epithelial cell differentiation. It is expressed in epithelial cells of the skin, and its expression is downregulated in a number of mouse models of skin disorders. * DLX3 is also involved in hair cell differentiation. It is expressed in hair cells, and its expression is upregulated in a number of mouse models of hair loss. * Finally, DLX3 is involved in the odontogenesis of dentin-containing tooth. It is expressed in cells of the dental lamina, and its expression is upregulated in a number of mouse models of dentinogenesis. **Clinical significance:** Mutations in the DLX3 gene have been linked to a number of human diseases, including cerebral palsy, epilepsy, and vascular abnormalities. These mutations can lead to a number of developmental disorders, including intellectual disability, seizures, and cardiovascular abnormalities. **Additional information:** * The DLX3 gene is located on chromosome 17q21. * It is a member of the DLX family of transcription factors. * It is a highly conserved gene, with a similar gene found in humans, mice, and zebrafish.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Homeobox protein DLX-3

Genular Protein ID: 988903442

Symbol: DLX3_HUMAN

Name: Homeobox protein DLX-3

UniProtKB Accession Codes:

O60479 B3KQL6

Database IDs:

Citations:

PubMed ID: 9467018

Title: Identification of a mutation in DLX3 associated with tricho-dento-osseous (TDO) syndrome.

PubMed ID: 9467018

DOI: 10.1093/hmg/7.3.563

PubMed ID: 11792834

Title: Genomic structure and functional control of the Dlx3-7 bigene cluster.

PubMed ID: 11792834

DOI: 10.1073/pnas.012584999

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15666299

Title: DLX3 mutation associated with autosomal dominant amelogenesis imperfecta with taurodontism.

PubMed ID: 15666299

DOI: 10.1002/ajmg.a.30521

PubMed ID: 26550823

Title: DNA-dependent formation of transcription factor pairs alters their binding specificity.

PubMed ID: 26550823

DOI: 10.1038/nature15518

Sequence Information:

Length: 287
Mass: 31738
Checksum: DCA9716E51D78DD1
Sequence:

MSGSFDRKLS SILTDISSSL SCHAGSKDSP TLPESSVTDL GYYSAPQHDY YSGQPYGQTV 
NPYTYHHQFN LNGLAGTGAY SPKSEYTYGA SYRQYGAYRE QPLPAQDPVS VKEEPEAEVR 
MVNGKPKKVR KPRTIYSSYQ LAALQRRFQK AQYLALPERA ELAAQLGLTQ TQVKIWFQNR 
RSKFKKLYKN GEVPLEHSPN NSDSMACNSP PSPALWDTSS HSTPAPARSQ LPPPLPYSAS 
PSYLDDPTNS WYHAQNLSGP HLQQQPPQPA TLHHASPGPP PNPGAVY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: DLX3

Associated with

Cells (max top 100)

Other Information

Identification of a mutation in DLX3 associated with tricho-dento-osseous (TDO) syndrome. PubMed ID: 9467018

Genomic structure and functional control of the Dlx3-7 bigene cluster. PubMed ID: 11792834

Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. PubMed ID: 16303743

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

DLX3 mutation associated with autosomal dominant amelogenesis imperfecta with taurodontism. PubMed ID: 15666299