Gene DNA2 - ENSG00000138346 | NCBI Gene ID: 1763

Details for: DNA2

Gene ID: 1763

Symbol: DNA2

Ensembl ID: ENSG00000138346

Description: DNA replication helicase/nuclease 2

Associated with

Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Chromosome maintenance
(R-HSA-73886)
Defective hdr through homologous recombination repair (hrr) due to palb2 loss of brca1 binding function
(R-HSA-9704331)
Defective hdr through homologous recombination repair (hrr) due to palb2 loss of brca2/rad51/rad51c binding function
(R-HSA-9704646)
Defective homologous recombination repair (hrr) due to brca1 loss of function
(R-HSA-9701192)
Defective homologous recombination repair (hrr) due to brca2 loss of function
(R-HSA-9701190)
Defective homologous recombination repair (hrr) due to palb2 loss of function
(R-HSA-9701193)
Disease
(R-HSA-1643685)
Diseases of dna double-strand break repair
(R-HSA-9675136)
Diseases of dna repair
(R-HSA-9675135)
Dna double-strand break repair
(R-HSA-5693532)
Dna repair
(R-HSA-73894)
Dna strand elongation
(R-HSA-69190)
Extension of telomeres
(R-HSA-180786)
G2/m checkpoints
(R-HSA-69481)
G2/m dna damage checkpoint
(R-HSA-69473)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Hdr through homologous recombination (hrr)
(R-HSA-5685942)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-HSA-5693567)
Hdr through single strand annealing (ssa)
(R-HSA-5685938)
Homologous dna pairing and strand exchange
(R-HSA-5693579)
Homology directed repair
(R-HSA-5693538)
Impaired brca2 binding to palb2
(R-HSA-9709603)
Impaired brca2 binding to rad51
(R-HSA-9709570)
Lagging strand synthesis
(R-HSA-69186)
Presynaptic phase of homologous dna pairing and strand exchange
(R-HSA-5693616)
Processing of dna double-strand break ends
(R-HSA-5693607)
Processive synthesis on the c-strand of the telomere
(R-HSA-174414)
Processive synthesis on the lagging strand
(R-HSA-69183)
Regulation of tp53 activity
(R-HSA-5633007)
Regulation of tp53 activity through phosphorylation
(R-HSA-6804756)
Removal of the flap intermediate
(R-HSA-69166)
Removal of the flap intermediate from the c-strand
(R-HSA-174437)
Resolution of d-loop structures
(R-HSA-5693537)
Resolution of d-loop structures through holliday junction intermediates
(R-HSA-5693568)
Resolution of d-loop structures through synthesis-dependent strand annealing (sdsa)
(R-HSA-5693554)
Rna polymerase ii transcription
(R-HSA-73857)
S phase
(R-HSA-69242)
Synthesis of dna
(R-HSA-69239)
Telomere c-strand (lagging strand) synthesis
(R-HSA-174417)
Transcriptional regulation by tp53
(R-HSA-3700989)
4 iron, 4 sulfur cluster binding
(GO:0051539)
5'-3' dna helicase activity
(GO:0043139)
5'-flap endonuclease activity
(GO:0017108)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Base-excision repair
(GO:0006284)
Chromosome, telomeric region
(GO:0000781)
Cytoplasm
(GO:0005737)
Dna binding
(GO:0003677)
Dna double-strand break processing
(GO:0000729)
Dna duplex unwinding
(GO:0032508)
Dna helicase activity
(GO:0003678)
Dna replication
(GO:0006260)
Dna replication, okazaki fragment processing
(GO:0033567)
Dna replication, removal of rna primer
(GO:0043137)
Dna replication checkpoint signaling
(GO:0000076)
G-quadruplex dna unwinding
(GO:0044806)
Gamma dna polymerase complex
(GO:0005760)
Helicase activity
(GO:0004386)
Metal ion binding
(GO:0046872)
Mitochondrial dna repair
(GO:0043504)
Mitochondrial dna replication
(GO:0006264)
Mitochondrial nucleoid
(GO:0042645)
Mitochondrion
(GO:0005739)
Mitotic telomere maintenance via semi-conservative replication
(GO:1902990)
Nuclease activity
(GO:0004518)
Nucleic acid metabolic process
(GO:0090304)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of dna replication
(GO:0045740)
Protein binding
(GO:0005515)
Replication fork reversal
(GO:0071932)
Rna binding
(GO:0003723)
Single-stranded dna helicase activity
(GO:0017116)
Site-specific endodeoxyribonuclease activity, specific for altered base
(GO:0016890)
T-circle formation
(GO:0090656)
Telomere maintenance
(GO:0000723)
Telomere maintenance via semi-conservative replication
(GO:0032201)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.01
Marker Score: 1563
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71809
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48033
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.99
Marker Score: 60929
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.97
Marker Score: 9207
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 499
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.96
Marker Score: 454
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2411
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.94
Marker Score: 8090
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2735
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.91
Marker Score: 5168
Cell Name: germ cell (CL0000586)
Fold Change: 0.9
Marker Score: 1575
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.89
Marker Score: 32722
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.88
Marker Score: 318
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.88
Marker Score: 8250
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5296
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.86
Marker Score: 349
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.84
Marker Score: 8654
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 0.82
Marker Score: 2219.5
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1250
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.76
Marker Score: 11396
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.75
Marker Score: 3154
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.75
Marker Score: 389
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.74
Marker Score: 297
Cell Name: neuron (CL0000540)
Fold Change: 0.73
Marker Score: 2986
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.73
Marker Score: 554
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 0.72
Marker Score: 403
Cell Name: brush cell (CL0002204)
Fold Change: 0.71
Marker Score: 652
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.7
Marker Score: 2702
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 175
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.68
Marker Score: 5231
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.64
Marker Score: 24377
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.62
Marker Score: 2551
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.59
Marker Score: 11758
Cell Name: proerythroblast (CL0000547)
Fold Change: 0.58
Marker Score: 395
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 443
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.54
Marker Score: 347
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.52
Marker Score: 219
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.52
Marker Score: 8170
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.52
Marker Score: 216
Cell Name: gut endothelial cell (CL0000131)
Fold Change: 0.51
Marker Score: 181
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.49
Marker Score: 367
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 0.48
Marker Score: 454
Cell Name: mesangial cell (CL0000650)
Fold Change: 0.47
Marker Score: 571
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.47
Marker Score: 962
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.45
Marker Score: 9666
Cell Name: plasmablast (CL0000980)
Fold Change: 0.45
Marker Score: 599
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.44
Marker Score: 119
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.43
Marker Score: 435
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.43
Marker Score: 2592
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.42
Marker Score: 720
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.42
Marker Score: 112
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.42
Marker Score: 175
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 0.42
Marker Score: 205
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 0.41
Marker Score: 297
Cell Name: oogonial cell (CL0000024)
Fold Change: 0.4
Marker Score: 577
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.4
Marker Score: 382
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.39
Marker Score: 231
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.39
Marker Score: 444
Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.39
Marker Score: 485
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.38
Marker Score: 252
Cell Name: T-helper 17 cell (CL0000899)
Fold Change: 0.38
Marker Score: 247
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.37
Marker Score: 1108
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.37
Marker Score: 117
Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.37
Marker Score: 117
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.35
Marker Score: 208
Cell Name: taste receptor cell (CL0000209)
Fold Change: 0.34
Marker Score: 297
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.34
Marker Score: 847
Cell Name: neural crest cell (CL0011012)
Fold Change: 0.34
Marker Score: 360
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.33
Marker Score: 352
Cell Name: interneuron (CL0000099)
Fold Change: 0.32
Marker Score: 148
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 0.31
Marker Score: 1453
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 0.31
Marker Score: 749
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.31
Marker Score: 1099
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.31
Marker Score: 209
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.3
Marker Score: 277
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.3
Marker Score: 189
Cell Name: Unknown (CL0000548)
Fold Change: 0.3
Marker Score: 217
Cell Name: thymocyte (CL0000893)
Fold Change: 0.3
Marker Score: 309
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.29
Marker Score: 685
Cell Name: astrocyte (CL0000127)
Fold Change: 0.29
Marker Score: 249
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.29
Marker Score: 405
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 0.28
Marker Score: 293
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.28
Marker Score: 176
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.28
Marker Score: 1799
Cell Name: erythroblast (CL0000765)
Fold Change: 0.28
Marker Score: 174
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.28
Marker Score: 97
Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 0.28
Marker Score: 88
Cell Name: promyelocyte (CL0000836)
Fold Change: 0.28
Marker Score: 137
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.28
Marker Score: 577
Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 0.27
Marker Score: 1183
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.27
Marker Score: 9197
Cell Name: fat cell (CL0000136)
Fold Change: 0.27
Marker Score: 150
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.26
Marker Score: 128
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.26
Marker Score: 156
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.26
Marker Score: 1003
Cell Name: neural cell (CL0002319)
Fold Change: 0.26
Marker Score: 125
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.25
Marker Score: 98
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.25
Marker Score: 268

Hover over a box to see details here...

**Key characteristics** - DNA2 is a serine/threonine protein with a molecular weight of approximately 135 kDa. - It is a subunit of the DNA2 complex, which is responsible for the repair of double-strand breaks in DNA. - It is expressed in a variety of cell types, including neurons, epithelial cells, and stem cells. **Pathways and functions** - DNA2 is involved in the cell cycle checkpoints that ensure the proper replication of DNA. - It is activated by DNA damage and plays a role in repairing double-strand breaks in DNA. - It is also involved in the maintenance of telomeres, which are protective DNA sequences at the ends of chromosomes. - It is involved in the regulation of gene expression through the transcription of the tp53 tumor suppressor gene. **Clinical significance** - Mutations in DNA2 have been linked to a number of human diseases, including cancer and neurodegenerative diseases. - Targeting DNA2 has been explored as a therapeutic strategy for these diseases. **Other important facts** - DNA2 is a highly conserved protein, with a similar gene found in all eukaryotic organisms. - It is a key player in the maintenance of genomic integrity and the prevention of cancer.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

DNA replication ATP-dependent helicase/nuclease DNA2

Genular Protein ID: 1605576781

Symbol: DNA2_HUMAN

Name: DNA replication ATP-dependent helicase/nuclease DNA2

UniProtKB Accession Codes:

P51530 Q2NKM1 Q5TC49 Q5TC50 Q6P455 Q6PI80 Q7Z6H9 Q8N346

Database IDs:

Citations:

PubMed ID: 7788527

Title: Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 7788527

DOI: 10.1093/dnares/2.1.37

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16595799

Title: Isolation of human Dna2 endonuclease and characterization of its enzymatic properties.

PubMed ID: 16595799

DOI: 10.1093/nar/gkl102

PubMed ID: 16595800

Title: Biochemical analysis of human Dna2.

PubMed ID: 16595800

DOI: 10.1093/nar/gkl070

PubMed ID: 18995831

Title: Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates.

PubMed ID: 18995831

DOI: 10.1016/j.molcel.2008.09.024

PubMed ID: 19487465

Title: Human Dna2 is a nuclear and mitochondrial DNA maintenance protein.

PubMed ID: 19487465

DOI: 10.1128/mcb.01834-08

PubMed ID: 20019387

Title: Acetylation of Dna2 endonuclease/helicase and flap endonuclease 1 by p300 promotes DNA stability by creating long flap intermediates.

PubMed ID: 20019387

DOI: 10.1074/jbc.m109.086397

PubMed ID: 21325134

Title: BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair.

PubMed ID: 21325134

DOI: 10.1101/gad.2003811

PubMed ID: 21572043

Title: Characterization of the endonuclease and ATP-dependent flap endo/exonuclease of Dna2.

PubMed ID: 21572043

DOI: 10.1074/jbc.m111.243071

PubMed ID: 22570476

Title: Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication.

PubMed ID: 22570476

DOI: 10.1074/jbc.m112.359018

PubMed ID: 22570407

Title: Biochemical analyses indicate that binding and cleavage specificities define the ordered processing of human Okazaki fragments by Dna2 and FEN1.

PubMed ID: 22570407

DOI: 10.1093/nar/gks388

PubMed ID: 24389050

Title: Genomic analysis of primordial dwarfism reveals novel disease genes.

PubMed ID: 24389050

DOI: 10.1101/gr.160572.113

PubMed ID: 23352259

Title: Mutations in DNA2 link progressive myopathy to mitochondrial DNA instability.

PubMed ID: 23352259

DOI: 10.1016/j.ajhg.2012.12.014

Sequence Information:

Length: 1060
Mass: 120415
Checksum: 727D4B268FD75C5A
Sequence:

MEQLNELELL MEKSFWEEAE LPAELFQKKV VASFPRTVLS TGMDNRYLVL AVNTVQNKEG 
NCEKRLVITA SQSLENKELC ILRNDWCSVP VEPGDIIHLE GDCTSDTWII DKDFGYLILY 
PDMLISGTSI ASSIRCMRRA VLSETFRSSD PATRQMLIGT VLHEVFQKAI NNSFAPEKLQ 
ELAFQTIQEI RHLKEMYRLN LSQDEIKQEV EDYLPSFCKW AGDFMHKNTS TDFPQMQLSL 
PSDNSKDNST CNIEVVKPMD IEESIWSPRF GLKGKIDVTV GVKIHRGYKT KYKIMPLELK 
TGKESNSIEH RSQVVLYTLL SQERRADPEA GLLLYLKTGQ MYPVPANHLD KRELLKLRNQ 
MAFSLFHRIS KSATRQKTQL ASLPQIIEEE KTCKYCSQIG NCALYSRAVE QQMDCSSVPI 
VMLPKIEEET QHLKQTHLEY FSLWCLMLTL ESQSKDNKKN HQNIWLMPAS EMEKSGSCIG 
NLIRMEHVKI VCDGQYLHNF QCKHGAIPVT NLMAGDRVIV SGEERSLFAL SRGYVKEINM 
TTVTCLLDRN LSVLPESTLF RLDQEEKNCD IDTPLGNLSK LMENTFVSKK LRDLIIDFRE 
PQFISYLSSV LPHDAKDTVA CILKGLNKPQ RQAMKKVLLS KDYTLIVGMP GTGKTTTICT 
LVRILYACGF SVLLTSYTHS AVDNILLKLA KFKIGFLRLG QIQKVHPAIQ QFTEQEICRS 
KSIKSLALLE ELYNSQLIVA TTCMGINHPI FSRKIFDFCI VDEASQISQP ICLGPLFFSR 
RFVLVGDHQQ LPPLVLNREA RALGMSESLF KRLEQNKSAV VQLTVQYRMN SKIMSLSNKL 
TYEGKLECGS DKVANAVINL RHFKDVKLEL EFYADYSDNP WLMGVFEPNN PVCFLNTDKV 
PAPEQVEKGG VSNVTEAKLI VFLTSIFVKA GCSPSDIGII APYRQQLKII NDLLARSIGM 
VEVNTVDKYQ GRDKSIVLVS FVRSNKDGTV GELLKDWRRL NVAITRAKHK LILLGCVPSL 
NCYPPLEKLL NHLNSEKLII DLPSREHESL CHILGDFQRE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: DNA2

Associated with

Cells (max top 100)

Other Information

Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. PubMed ID: 7788527

The DNA sequence and comparative analysis of human chromosome 10. PubMed ID: 15164054

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Isolation of human Dna2 endonuclease and characterization of its enzymatic properties. PubMed ID: 16595799

Biochemical analysis of human Dna2. PubMed ID: 16595800

Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates. PubMed ID: 18995831

Human Dna2 is a nuclear and mitochondrial DNA maintenance protein. PubMed ID: 19487465

Acetylation of Dna2 endonuclease/helicase and flap endonuclease 1 by p300 promotes DNA stability by creating long flap intermediates. PubMed ID: 20019387

BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair. PubMed ID: 21325134

Characterization of the endonuclease and ATP-dependent flap endo/exonuclease of Dna2. PubMed ID: 21572043

Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication. PubMed ID: 22570476

Biochemical analyses indicate that binding and cleavage specificities define the ordered processing of human Okazaki fragments by Dna2 and FEN1. PubMed ID: 22570407

Genomic analysis of primordial dwarfism reveals novel disease genes. PubMed ID: 24389050

Mutations in DNA2 link progressive myopathy to mitochondrial DNA instability. PubMed ID: 23352259