HBEGF | ENSG00000113070 | NCBI 1839

Details for: HBEGF

Gene ID: 1839

Symbol: HBEGF

Ensembl ID: ENSG00000113070

Description: heparin binding EGF like growth factor

Associated with

Bacterial infection pathways
(R-HSA-9824439)
Cargo recognition for clathrin-mediated endocytosis
(R-HSA-8856825)
Clathrin-mediated endocytosis
(R-HSA-8856828)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downregulation of erbb2 signaling
(R-HSA-8863795)
Egfr downregulation
(R-HSA-182971)
Egfr interacts with phospholipase c-gamma
(R-HSA-212718)
Egfr transactivation by gastrin
(R-HSA-2179392)
Erbb2 activates ptk6 signaling
(R-HSA-8847993)
Erbb2 regulates cell motility
(R-HSA-6785631)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent nuclear events downstream of esr-membrane signaling
(R-HSA-9634638)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
Gab1 signalosome
(R-HSA-180292)
G alpha (q) signalling events
(R-HSA-416476)
Gastrin-creb signalling pathway via pkc and mapk
(R-HSA-881907)
Gpcr downstream signalling
(R-HSA-388396)
Grb2 events in egfr signaling
(R-HSA-179812)
Grb2 events in erbb2 signaling
(R-HSA-1963640)
Infectious disease
(R-HSA-5663205)
Inhibition of signaling by overexpressed egfr
(R-HSA-5638303)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Membrane trafficking
(R-HSA-199991)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Nuclear signaling by erbb4
(R-HSA-1251985)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi3k events in erbb2 signaling
(R-HSA-1963642)
Pi3k events in erbb4 signaling
(R-HSA-1250342)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Ptk6 promotes hif1a stabilization
(R-HSA-8857538)
Raf/map kinase cascade
(R-HSA-5673001)
Shc1 events in egfr signaling
(R-HSA-180336)
Shc1 events in erbb2 signaling
(R-HSA-1250196)
Shc1 events in erbb4 signaling
(R-HSA-1250347)
Signaling by egfr
(R-HSA-177929)
Signaling by egfr in cancer
(R-HSA-1643713)
Signaling by erbb2
(R-HSA-1227986)
Signaling by erbb2 in cancer
(R-HSA-1227990)
Signaling by erbb2 kd mutants
(R-HSA-9664565)
Signaling by erbb2 tmd/jmd mutants
(R-HSA-9665686)
Signaling by erbb4
(R-HSA-1236394)
Signaling by gpcr
(R-HSA-372790)
Signaling by non-receptor tyrosine kinases
(R-HSA-9006927)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by overexpressed wild-type egfr in cancer
(R-HSA-5638302)
Signaling by ptk6
(R-HSA-8848021)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Uptake and actions of bacterial toxins
(R-HSA-5339562)
Uptake and function of diphtheria toxin
(R-HSA-5336415)
Vesicle-mediated transport
(R-HSA-5653656)
Cell chemotaxis
(GO:0060326)
Cell surface
(GO:0009986)
Clathrin-coated endocytic vesicle membrane
(GO:0030669)
Endocytic vesicle membrane
(GO:0030666)
Epidermal growth factor receptor binding
(GO:0005154)
Epidermal growth factor receptor signaling pathway
(GO:0007173)
Erbb2-egfr signaling pathway
(GO:0038134)
Erbb2-erbb4 signaling pathway
(GO:0038135)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Growth factor activity
(GO:0008083)
Heparin binding
(GO:0008201)
Muscle organ development
(GO:0007517)
Negative regulation of elastin biosynthetic process
(GO:0051545)
Plasma membrane
(GO:0005886)
Positive regulation of cell growth
(GO:0030307)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of keratinocyte migration
(GO:0051549)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of smooth muscle cell proliferation
(GO:0048661)
Positive regulation of wound healing
(GO:0090303)
Protein binding
(GO:0005515)
Receptor ligand activity
(GO:0048018)
Regulation of heart contraction
(GO:0008016)
Signal transduction
(GO:0007165)
Transmembrane receptor protein tyrosine kinase activator activity
(GO:0030297)
Wound healing, spreading of epidermal cells
(GO:0035313)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 134.6232
Cell Significance Index: -20.9400
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 79.4817
Cell Significance Index: -20.1600
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 44.2567
Cell Significance Index: -22.7700
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 33.3223
Cell Significance Index: -22.3600
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 16.9998
Cell Significance Index: -20.9600
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 8.6305
Cell Significance Index: -23.1200
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 5.9852
Cell Significance Index: 17.8000
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 5.3522
Cell Significance Index: -21.1200
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.9701
Cell Significance Index: 154.2900
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 2.8150
Cell Significance Index: 42.1800
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 2.2612
Cell Significance Index: 65.1500
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 1.8881
Cell Significance Index: 13.5600
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.8142
Cell Significance Index: 49.3800
Cell Name: late promyelocyte (CL0002151)
Fold Change: 1.7169
Cell Significance Index: 11.3900
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.3494
Cell Significance Index: 29.2400
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.0961
Cell Significance Index: 19.3700
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.9374
Cell Significance Index: 27.5300
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.9103
Cell Significance Index: 24.3500
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 0.8427
Cell Significance Index: 5.2200
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.8176
Cell Significance Index: 12.6500
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.7652
Cell Significance Index: 10.4400
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.7411
Cell Significance Index: 10.5500
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.6130
Cell Significance Index: 11.3300
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.5389
Cell Significance Index: 102.5600
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.5266
Cell Significance Index: 23.8700
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.4903
Cell Significance Index: 216.7700
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.4522
Cell Significance Index: 15.8900
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.4387
Cell Significance Index: 28.3100
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.4230
Cell Significance Index: 19.8800
Cell Name: odontoblast (CL0000060)
Fold Change: 0.4034
Cell Significance Index: 51.7100
Cell Name: glomerular capillary endothelial cell (CL1001005)
Fold Change: 0.3810
Cell Significance Index: 1.4200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.2784
Cell Significance Index: 34.2300
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2076
Cell Significance Index: 187.4300
Cell Name: lactocyte (CL0002325)
Fold Change: 0.1946
Cell Significance Index: 25.1500
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.1807
Cell Significance Index: 5.1800
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1490
Cell Significance Index: 14.7400
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.1411
Cell Significance Index: 3.0900
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.1357
Cell Significance Index: 24.4600
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.0889
Cell Significance Index: 14.4600
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.0876
Cell Significance Index: 1.3200
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0566
Cell Significance Index: 2.6400
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0526
Cell Significance Index: 28.7000
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.0450
Cell Significance Index: 4.9000
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.0382
Cell Significance Index: 4.3600
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0372
Cell Significance Index: 23.2000
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.0361
Cell Significance Index: 0.4100
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0318
Cell Significance Index: 11.4000
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0231
Cell Significance Index: 4.6300
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.0070
Cell Significance Index: 0.7100
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0052
Cell Significance Index: 3.5700
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.0003
Cell Significance Index: -0.0200
Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.0012
Cell Significance Index: -0.0300
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.0033
Cell Significance Index: -0.0200
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0065
Cell Significance Index: -4.8500
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0095
Cell Significance Index: -17.9100
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0107
Cell Significance Index: -16.5000
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0125
Cell Significance Index: -22.9700
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0145
Cell Significance Index: -19.7300
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0151
Cell Significance Index: -11.4000
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0201
Cell Significance Index: -11.3500
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0208
Cell Significance Index: -1.5500
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0222
Cell Significance Index: -3.0500
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0239
Cell Significance Index: -17.5600
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0244
Cell Significance Index: -5.1400
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0318
Cell Significance Index: -20.2100
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0401
Cell Significance Index: -6.8400
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0470
Cell Significance Index: -21.3500
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0590
Cell Significance Index: -4.1700
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0612
Cell Significance Index: -17.6100
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0676
Cell Significance Index: -13.4100
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1012
Cell Significance Index: -3.2400
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1016
Cell Significance Index: -7.8000
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1328
Cell Significance Index: -19.3100
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1349
Cell Significance Index: -15.4500
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1628
Cell Significance Index: -4.5500
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.1647
Cell Significance Index: -8.3200
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.1774
Cell Significance Index: -12.2700
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.1867
Cell Significance Index: -7.6500
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1965
Cell Significance Index: -23.1700
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2011
Cell Significance Index: -20.9400
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.2101
Cell Significance Index: -5.4000
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2182
Cell Significance Index: -13.3800
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2566
Cell Significance Index: -13.4700
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2756
Cell Significance Index: -21.8300
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.2856
Cell Significance Index: -7.1400
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2881
Cell Significance Index: -19.3700
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.3094
Cell Significance Index: -19.0200
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3358
Cell Significance Index: -11.6700
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.3498
Cell Significance Index: -7.4500
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.3708
Cell Significance Index: -13.6100
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.3757
Cell Significance Index: -16.6200
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3897
Cell Significance Index: -21.8700
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.3937
Cell Significance Index: -3.2100
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.4269
Cell Significance Index: -11.4000
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.4551
Cell Significance Index: -17.2400
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.4633
Cell Significance Index: -9.6100
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.5077
Cell Significance Index: -13.3500
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.5098
Cell Significance Index: -4.7000
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.5437
Cell Significance Index: -13.5800
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.5766
Cell Significance Index: -20.2000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** HBEGF shares structural similarity with EGF and other members of the EGF family, which are characterized by the presence of a heparin-binding domain and a growth factor domain. The heparin-binding domain allows HBEGF to bind to heparan sulfate proteoglycans on the surface of target cells, facilitating its interaction with the EGF receptor. HBEGF also exhibits a high degree of homology with other EGF family members, such as HBEGF's ligand, HB-EGF, which is also involved in various cellular processes. HBEGF has been shown to exhibit a range of biological activities, including mitogenic, chemotactic, and motogenic effects, which are mediated through its interaction with the EGF receptor. The EGF receptor, also known as EGFR, is a transmembrane receptor tyrosine kinase that is involved in the regulation of various cellular processes, including cell growth, differentiation, and survival. **Pathways and Functions** HBEGF's biological activities are mediated through its interaction with the EGF receptor, which triggers a series of downstream signaling events. These events involve the activation of various kinases, including phosphatidylinositol 3-kinase (PI3K), mitogen-activated protein kinase (MAPK), and protein kinase B (Akt), which regulate a range of cellular processes, including cell growth, migration, and survival. HBEGF's signaling pathways are also involved in the regulation of various cellular processes, including cell migration, wound healing, and tissue remodeling. For example, HBEGF has been shown to promote cell migration and wound healing by activating the PI3K/Akt pathway, which regulates the expression of genes involved in cell migration and survival. **Clinical Significance** HBEGF's involvement in various diseases has been well established, including cancer, cardiovascular disease, and inflammatory disorders. In cancer, HBEGF's expression has been shown to be elevated in various types of cancer, including breast, lung, and colon cancer, and has been associated with tumor progression and metastasis. HBEGF's role in cardiovascular disease has also been established, where it has been shown to promote angiogenesis and tissue remodeling. In inflammatory disorders, HBEGF's expression has been shown to be elevated in various inflammatory conditions, including arthritis and asthma, and has been associated with disease progression and tissue damage. Overall, HBEGF's involvement in various diseases highlights its importance as a potential therapeutic target for the treatment of various diseases, including cancer, cardiovascular disease, and inflammatory disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Proheparin-binding EGF-like growth factor

Genular Protein ID: 2012311508

Symbol: HBEGF_HUMAN

Name: Proheparin-binding EGF-like growth factor

UniProtKB Accession Codes:

Q99075 B2R821

Database IDs:

Citations:

PubMed ID: 1840698

Title: A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF.

PubMed ID: 1840698

DOI: 10.1126/science.1840698

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1556128

Title: Structure of heparin-binding EGF-like growth factor. Multiple forms, primary structure, and glycosylation of the mature protein.

PubMed ID: 1556128

DOI: 10.1016/s0021-9258(18)42682-8

PubMed ID: 7836353

Title: Diphtheria toxin binds to the epidermal growth factor (EGF)-like domain of human heparin-binding EGF-like growth factor/diphtheria toxin receptor and inhibits specifically its mitogenic activity.

PubMed ID: 7836353

DOI: 10.1074/jbc.270.3.1015

PubMed ID: 9135143

Title: Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation.

PubMed ID: 9135143

DOI: 10.1093/emboj/16.6.1268

PubMed ID: 16508205

Title: ErbB and HB-EGF signaling in heart development and function.

PubMed ID: 16508205

DOI: 10.1247/csf.31.1

PubMed ID: 22171320

Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.

PubMed ID: 22171320

DOI: 10.1074/mcp.m111.013649

PubMed ID: 23234360

Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.

PubMed ID: 23234360

DOI: 10.1021/pr300963h

PubMed ID: 9659904

Title: Crystal structure of the complex of diphtheria toxin with an extracellular fragment of its receptor.

PubMed ID: 9659904

DOI: 10.1016/s1097-2765(00)80008-8

Sequence Information:

Length: 208
Mass: 23067
Checksum: 2C43C9D1D8291B51
Sequence:

MKLLPSVVLK LFLAAVLSAL VTGESLERLR RGLAAGTSNP DPPTVSTDQL LPLGGGRDRK 
VRDLQEADLD LLRVTLSSKP QALATPNKEE HGKRKKKGKG LGKKRDPCLR KYKDFCIHGE 
CKYVKELRAP SCICHPGYHG ERCHGLSLPV ENRLYTYDHT TILAVVAVVL SSVCLLVIVG 
LLMFRYHRRG GYDVENEEKV KLGMTNSH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: HBEGF

Associated with

Cells (max top 100)

Other Information

A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF. PubMed ID: 1840698

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 5. PubMed ID: 15372022

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Structure of heparin-binding EGF-like growth factor. Multiple forms, primary structure, and glycosylation of the mature protein. PubMed ID: 1556128

Diphtheria toxin binds to the epidermal growth factor (EGF)-like domain of human heparin-binding EGF-like growth factor/diphtheria toxin receptor and inhibits specifically its mitogenic activity. PubMed ID: 7836353

Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation. PubMed ID: 9135143

ErbB and HB-EGF signaling in heart development and function. PubMed ID: 16508205

Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD. PubMed ID: 22171320

LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins. PubMed ID: 23234360

Crystal structure of the complex of diphtheria toxin with an extracellular fragment of its receptor. PubMed ID: 9659904