Details for: HBEGF

Gene ID: 1839

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: HBEGF

Ensembl ID: ENSG00000113070

Description: heparin binding EGF like growth factor

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • respiratory suprabasal cell CL4033048
    CSI 23.32
    rCSI 29.9%
    PRS 83.52
  • luminal epithelial cell of mammary gland CL0002326
    CSI 20.01
    rCSI 36.35%
    PRS 90.01
  • basal cell of prostate epithelium CL0002341
    CSI 15.13
    rCSI 43.76%
    PRS 86.79
  • myofibroblast cell CL0000186
    CSI 14.31
    rCSI 19.82%
    PRS 77.65
  • Hofbauer cell CL3000001
    CSI 13.26
    rCSI 25.02%
    PRS 87.91
  • BEST4+ enteroycte CL4030026
    CSI 12.8
    rCSI 15.92%
    PRS 81.21
  • keratinocyte CL0000312
    CSI 12.36
    rCSI 10.36%
    PRS 83.16
  • endothelial cell of lymphatic vessel CL0002138
    CSI 11.7
    rCSI 23.2%
    PRS 85.6
  • colon epithelial cell CL0011108
    CSI 11.32
    rCSI 11.86%
    PRS 77.72
  • blood vessel endothelial cell CL0000071
    CSI 11.27
    rCSI 23.39%
    PRS 77.04
  • vascular associated smooth muscle cell CL0000359
    CSI 10.37
    rCSI 33.65%
    PRS 78.52
  • intestinal crypt stem cell of small intestine CL0009017
    CSI 10.04
    rCSI 27.07%
    PRS 84.96
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 9.86
    rCSI 11.91%
    PRS 87.51
  • CD14-positive, CD16-positive monocyte CL0002397
    CSI 9.47
    rCSI 12.4%
    PRS 90.32
  • elicited macrophage CL0000861
    CSI 9.21
    rCSI 8.46%
    PRS 87.58
  • respiratory basal cell CL0002633
    CSI 9.06
    rCSI 9.39%
    PRS 84.3
  • conjunctival epithelial cell CL1000432
    CSI 8.3
    rCSI 12.67%
    PRS 80.52
  • epithelial cell of lung CL0000082
    CSI 6.97
    rCSI 5.78%
    PRS 81.07
  • microglial cell CL0000129
    CSI 6.89
    rCSI 27.75%
    PRS 81.8
  • dendritic cell CL0000451
    CSI 5.76
    rCSI 7.1%
    PRS 84.21
  • alternatively activated macrophage CL0000890
    CSI 5.62
    rCSI 7.06%
    PRS 89.03
  • Langerhans cell CL0000453
    CSI 5.54
    rCSI 8.46%
    PRS 90.48
  • pulmonary capillary endothelial cell CL4028001
    CSI 5.34
    rCSI 10.19%
    PRS 89.45
  • immature B cell CL0000816
    CSI 5.31
    rCSI 3.95%
    PRS 90.29
  • lung interstitial macrophage CL4033043
    CSI 5.01
    rCSI 11.24%
    PRS 91.5
  • vein endothelial cell CL0002543
    CSI 4.97
    rCSI 13.58%
    PRS 87.62
  • epithelial cell of lower respiratory tract CL0002632
    CSI 4.82
    rCSI 3.74%
    PRS 83.94
  • mononuclear phagocyte CL0000113
    CSI 4.8
    rCSI 10.57%
    PRS 83.95
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 4.72
    rCSI 12.32%
    PRS 81.31
  • inflammatory macrophage CL0000863
    CSI 4.51
    rCSI 7.71%
    PRS 93.96
  • intermediate monocyte CL0002393
    CSI 4.48
    rCSI 6.76%
    PRS 85.41
  • granulocyte monocyte progenitor cell CL0000557
    CSI 4.27
    rCSI 3.7%
    PRS 84.14
  • enterocyte CL0000584
    CSI 4.27
    rCSI 6.89%
    PRS 79.5
  • corneal epithelial cell CL0000575
    CSI 4.27
    rCSI 12.2%
    PRS 86.81
  • early lymphoid progenitor CL0000936
    CSI 4.14
    rCSI 3.64%
    PRS 85.06
  • type L enteroendocrine cell CL0002279
    CSI 4.1
    rCSI 7.69%
    PRS 87.13
  • vein endothelial cell of respiratory system CL4033008
    CSI 4.07
    rCSI 27.97%
    PRS 86.83
  • lung neuroendocrine cell CL1000223
    CSI 4.02
    rCSI 5.95%
    PRS 84.24
  • monocyte CL0000576
    CSI 3.78
    rCSI 6.84%
    PRS 85.31
  • conventional dendritic cell CL0000990
    CSI 3.7
    rCSI 3.09%
    PRS 80.32
  • goblet cell CL0000160
    CSI 3.65
    rCSI 3.45%
    PRS 78.97
  • CD14-positive, CD16-negative classical monocyte CL0002057
    CSI 3.64
    rCSI 22.01%
    PRS 90.74
  • CD14-positive monocyte CL0001054
    CSI 3.61
    rCSI 4.5%
    PRS 88.91
  • basal-myoepithelial cell of mammary gland CL0002324
    CSI 3.58
    rCSI 6.76%
    PRS 90.49
  • basal cell CL0000646
    CSI 3.56
    rCSI 4.76%
    PRS 78.71
  • fraction A pre-pro B cell CL0002045
    CSI 3.55
    rCSI 4.07%
    PRS 90.26
  • precursor B cell CL0000817
    CSI 3.48
    rCSI 3.05%
    PRS 87.3
  • colon macrophage CL0009038
    CSI 3.44
    rCSI 15.88%
    PRS 91.55
  • bronchus fibroblast of lung CL2000093
    CSI 3.36
    rCSI 2.73%
    PRS 79.7
  • respiratory hillock cell CL4030023
    CSI 3.3
    rCSI 5.88%
    PRS 88.44
  • pulmonary artery endothelial cell CL1001568
    CSI 3.26
    rCSI 4.44%
    PRS 88.4
  • retinal blood vessel endothelial cell CL0002585
    CSI 3.18
    rCSI 5.08%
    PRS 83.87
  • macrophage CL0000235
    CSI 3.14
    rCSI 5.71%
    PRS 87.02
  • cerebral cortex endothelial cell CL1001602
    CSI 3.11
    rCSI 5.38%
    PRS 72.04
  • perivascular cell CL4033054
    CSI 3.06
    rCSI 4.19%
    PRS 84.76
  • paneth cell of epithelium of small intestine CL1000343
    CSI 2.96
    rCSI 8.28%
    PRS 87.09
  • neural crest cell CL0011012
    CSI 2.9
    rCSI 2.29%
    PRS 69.28
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 2.86
    rCSI 2.2%
    PRS 83.23
  • alveolar macrophage CL0000583
    CSI 2.85
    rCSI 4.69%
    PRS 84.04
  • pro-B cell CL0000826
    CSI 2.52
    rCSI 2.08%
    PRS 82.61
  • myeloid dendritic cell, human CL0001057
    CSI 2.5
    rCSI 14.07%
    PRS 92.83
  • fibroblast of lung CL0002553
    CSI 2.43
    rCSI 2.26%
    PRS 81.15
  • lung macrophage CL1001603
    CSI 2.37
    rCSI 5.3%
    PRS 87.07
  • pancreatic ductal cell CL0002079
    CSI 2.32
    rCSI 4.51%
    PRS 83.28
  • lung microvascular endothelial cell CL2000016
    CSI 2.3
    rCSI 44.47%
    PRS 87.92
  • tracheobronchial serous cell CL0019001
    CSI 2.28
    rCSI 9.83%
    PRS 87.21
  • mucous neck cell CL0000651
    CSI 2.26
    rCSI 3.26%
    PRS 86.97
  • colonocyte CL1000347
    CSI 2.11
    rCSI 3.02%
    PRS 80.94
  • intestine goblet cell CL0019031
    CSI 2.09
    rCSI 1.86%
    PRS 78.1
  • common dendritic progenitor CL0001029
    CSI 2.04
    rCSI 2.56%
    PRS 88.38
  • dendritic cell, human CL0001056
    CSI 1.87
    rCSI 2.87%
    PRS 88.4
  • type EC enteroendocrine cell CL0000577
    CSI 1.79
    rCSI 6.36%
    PRS 84.15
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 1.79
    rCSI 3.16%
    PRS 61.85
  • common myeloid progenitor CL0000049
    CSI 1.74
    rCSI 1.4%
    PRS 82.46
  • foveolar cell of stomach CL0002179
    CSI 1.72
    rCSI 3.66%
    PRS 86.26
  • paneth cell CL0000510
    CSI 1.64
    rCSI 2.42%
    PRS 89.99
  • enteroendocrine cell of small intestine CL0009006
    CSI 1.63
    rCSI 3.6%
    PRS 87.7
  • large pre-B-II cell CL0000957
    CSI 1.62
    rCSI 4.63%
    PRS 85.48
  • deuterosomal cell CL4033044
    CSI 1.61
    rCSI 5.45%
    PRS 77.87
  • basal cell of epidermis CL0002187
    CSI 1.57
    rCSI 2.79%
    PRS 49.69
  • respiratory goblet cell CL0002370
    CSI 1.47
    rCSI 15.95%
    PRS 88.26
  • colon goblet cell CL0009039
    CSI 1.31
    rCSI 3.11%
    PRS 85.39
  • myeloid dendritic cell CL0000782
    CSI 1.29
    rCSI 1.87%
    PRS 91.93
  • small intestine goblet cell CL1000495
    CSI 1.2
    rCSI 2.63%
    PRS 85.73
  • promonocyte CL0000559
    CSI 1.14
    rCSI 1.95%
    PRS 86.03
  • peptic cell CL0000155
    CSI 1.12
    rCSI 10.97%
    PRS 90.45
  • prostate gland microvascular endothelial cell CL2000059
    CSI 1.07
    rCSI 25.7%
    PRS 88.62
  • tissue-resident macrophage CL0000864
    CSI 1.07
    rCSI 5%
    PRS 90.84
  • endothelial cell of placenta CL0009092
    CSI 0.85
    rCSI 4.19%
    PRS 87.59
  • luminal cell of prostate epithelium CL0002340
    CSI 0.83
    rCSI 4.48%
    PRS 87.82
  • metallothionein-positive alveolar macrophage CL4033042
    CSI 0.8
    rCSI 8.68%
    PRS 90.1
  • epithelial cell of urethra CL1000296
    CSI 0.79
    rCSI 19.95%
    PRS 87.79
  • podocyte CL0000653
    CSI 0.75
    rCSI 3.33%
    PRS 80.94
  • bronchiolar smooth muscle cell CL4033017
    CSI 0.66
    rCSI 9.9%
    PRS 88.69
  • bronchial goblet cell CL1000312
    CSI 0.6
    rCSI 2.41%
    PRS 88.14
  • hair follicular keratinocyte CL2000092
    CSI 0.38
    rCSI 6.58%
    PRS 90.23
  • epithelial cell of esophagus CL0002252
    CSI 0.35
    rCSI 3.44%
    PRS 85.67
  • paneth cell of colon CL0009009
    CSI 0.28
    rCSI 2.8%
    PRS 88.65
  • blood vessel smooth muscle cell CL0019018
    CSI 0.2
    rCSI 1.64%
    PRS 74.68

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary Heparin-binding EGF-like growth factor ([HBEGF](/details-gene/1839)) is a protein-coding gene located on chromosome 5q31.3. As its name suggests, it functions as a potent mitogen and chemotactic factor belonging to the epidermal growth factor (EGF) family, exerting its effects by binding to and activating the epidermal growth factor receptor (EGFR) and ERBB4. **Overall**, expression data reveals that [HBEGF](/details-gene/1839) is highly significant in a diverse array of cell types, including various epithelial cells such as [respiratory suprabasal cell](/details-cell/CL4033048) and [luminal epithelial cell of mammary gland](/details-cell/CL0002326), mesenchymal cells like [myofibroblast cell](/details-cell/CL0000186), and certain myeloid lineage cells. This broad expression pattern is consistent with its fundamental roles in processes like cell proliferation, migration, and wound healing. Clinically, it is associated with OMIM entry [126150](https://omim.org/entry/126150) and also serves as the cell surface receptor for diphtheria toxin. ## Cellular Roles and Expression Landscape The expression profile of [HBEGF](/details-gene/1839) highlights its importance across multiple tissue compartments, with a particularly prominent role in epithelial and stromal biology. **Overall**, the gene shows the highest significance in epithelial cells from various organs, including [respiratory suprabasal cell](/details-cell/CL4033048), [luminal epithelial cell of mammary gland](/details-cell/CL0002326), [basal cell of prostate epithelium](/details-cell/CL0002341), [keratinocyte](/details-cell/CL0000312), and [colon epithelial cell](/details-cell/CL0011108). Its high expression in progenitor-like populations such as basal cells and [intestinal crypt stem cell of small intestine](/details-cell/CL0009017) suggests a critical function in tissue homeostasis, renewal, and repair. Beyond epithelia, [HBEGF](/details-gene/1839) is a key marker for mesenchymal and stromal cells. It is highly significant in [myofibroblast cell](/details-cell/CL0000186) and [vascular associated smooth muscle cell](/details-cell/CL0000359), consistent with its established role in wound healing and tissue remodeling. Furthermore, its expression in [blood vessel endothelial cell](/details-cell/CL0000071) and [endothelial cell of lymphatic vessel](/details-cell/CL0002138) points to a function in regulating vascular integrity and angiogenesis. [HBEGF](/details-gene/1839) also displays notable significance in specific immune cell populations of the myeloid lineage. It is highly expressed in [Hofbauer cell](/details-cell/CL3000001) (placental macrophages), [CD1c-positive myeloid dendritic cell](/details-cell/CL0002399), [elicited macrophage](/details-cell/CL0000861), and [CD14-positive, CD16-positive monocyte](/details-cell/CL0002397). This is consistent with early research identifying it as a factor secreted by macrophage-like cells ([Link](https://doi.org/10.1126/science.1840698)) and suggests a role in inflammation, immune modulation, and tissue repair processes mediated by these cells. ## Pathways and Molecular Function Functionally, [HBEGF](/details-gene/1839) is an extracellular ligand with `growth factor activity` ([GO:0008083](https://www.ebi.ac.uk/QuickGO/term/GO:0008083)) and `heparin binding` ([GO:0008201](https://www.ebi.ac.uk/QuickGO/term/GO:0008201)) capabilities. It is synthesized as a transmembrane precursor that can be cleaved to release a soluble factor, localizing it to the `plasma membrane` ([GO:0005886](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)) and the `extracellular space` ([GO:0005615](https://www.ebi.ac.uk/QuickGO/term/GO:0005615)). Its primary mechanism of action is through binding and activating receptor tyrosine kinases, particularly via the `epidermal growth factor receptor signaling pathway` ([GO:0007173](https://www.ebi.ac.uk/QuickGO/term/GO:0007173)). Reactome pathway analysis reveals its extensive integration into the `Signaling by EGFR` ([R-HSA-177929](https://reactome.org/content/detail/R-HSA-177929)), `Signaling by ERBB2` ([R-HSA-1227986](https://reactome.org/content/detail/R-HSA-1227986)), and `Signaling by ERBB4` ([R-HSA-1236394](https://reactome.org/content/detail/R-HSA-1236394)) networks. This activation triggers downstream cascades including `Raf/map kinase cascade` ([R-HSA-5673001](https://reactome.org/content/detail/R-HSA-5673001)) and `Pip3 activates akt signaling` ([R-HSA-1257604](https://reactome.org/content/detail/R-HSA-1257604)), which are central to regulating cell fate. The biological consequences of this signaling are reflected in its associated processes. [HBEGF](/details-gene/1839) is a key driver of `positive regulation of cell population proliferation` ([GO:0008284](https://www.ebi.ac.uk/QuickGO/term/GO:0008284)), `positive regulation of cell migration` ([GO:0030335](https://www.ebi.ac.uk/QuickGO/term/GO:0030335)), and `cell chemotaxis` ([GO:0060326](https://www.ebi.ac.uk/QuickGO/term/GO:0060326)). These functions converge in complex processes like `positive regulation of wound healing` ([GO:0090303](https://www.ebi.ac.uk/QuickGO/term/GO:0090303)), which aligns with its high expression in keratinocytes, endothelial cells, and myofibroblasts. Additionally, [HBEGF](/details-gene/1839) is directly implicated in cardiac physiology through `regulation of heart contraction` ([GO:0008016](https://www.ebi.ac.uk/QuickGO/term/GO:0008016)) ([Link](https://doi.org/10.1247/csf.31.1)) and serves as the receptor for diphtheria toxin, a process detailed in the `Uptake and function of diphtheria toxin` ([R-HSA-5336415](https://reactome.org/content/detail/R-HSA-5336415)) pathway ([Link](https://doi.org/10.1074/jbc.270.3.1015)). ## Research Directions The central role of [HBEGF](/details-gene/1839) in driving cell proliferation and migration, coupled with its expression pattern, makes it a critical molecule to investigate in both regenerative and pathological contexts. **Proposed Hypotheses:** 1. Given its high expression in epithelial stem/progenitor populations like [basal cell of prostate epithelium](/details-cell/CL0002341) and its established role in mitogenic signaling pathways implicated in cancer ([R-HSA-1643713](https://reactome.org/content/detail/R-HSA-1643713)), we hypothesize that autocrine or paracrine [HBEGF](/details-gene/1839) signaling is a key driver of tumorigenesis in epithelial-derived cancers (e.g., prostate, breast, colon) by promoting sustained proliferation and resistance to apoptosis. 2. Based on its high significance in [myofibroblast cell](/details-cell/CL0000186) and its function in wound healing, we hypothesize that chronic overexpression of [HBEGF](/details-gene/1839) in response to tissue injury contributes to the pathogenesis of fibrosis by perpetuating myofibroblast activation, proliferation, and extracellular matrix deposition. **Experimental Approach for Hypothesis 2:** To test the role of [HBEGF](/details-gene/1839) in fibrosis, a conditional knockout mouse model could be employed. Mice with a floxed *Hbegf* allele could be crossed with mice expressing Cre recombinase under a myofibroblast-specific promoter (e.g., *Acta2*-CreERT2). Following induction of Cre activity, these mice and their wild-type littermates would be subjected to a model of organ fibrosis, such as bleomycin-induced lung fibrosis. The extent of fibrosis would be quantified via histology (Masson's trichrome staining), hydroxyproline assays for collagen content, and RNA-sequencing of whole lung tissue to assess fibrotic gene expression signatures. A significant reduction in fibrosis in the conditional knockout mice would support the hypothesis. **Therapeutic Potential:** As an extracellular growth factor that signals through cell surface receptors, [HBEGF](/details-gene/1839) is a highly druggable target. **Inhibition**, rather than activation, would be the therapeutic goal. Its role in driving proliferation in numerous cancers makes it a compelling target for anti-cancer therapies. Neutralizing antibodies against [HBEGF](/details-gene/1839) or small molecule inhibitors that block its binding to EGFR could be effective, particularly in tumors with high [HBEGF](/details-gene/1839) expression. Similarly, targeting this pathway may represent a viable anti-fibrotic strategy to halt the progression of chronic diseases in organs like the lung, liver, and kidney.

Genular Protein ID: 2012311508

Symbol: HBEGF_HUMAN

Name: Proheparin-binding EGF-like growth factor

UniProtKB Accession Codes:

Q99075 B2R821

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 GO 28 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 31 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1840698

Title: A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF.

PubMed ID: 1840698

DOI: 10.1126/science.1840698

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1556128

Title: Structure of heparin-binding EGF-like growth factor. Multiple forms, primary structure, and glycosylation of the mature protein.

PubMed ID: 1556128

DOI: 10.1016/s0021-9258(18)42682-8

PubMed ID: 7836353

Title: Diphtheria toxin binds to the epidermal growth factor (EGF)-like domain of human heparin-binding EGF-like growth factor/diphtheria toxin receptor and inhibits specifically its mitogenic activity.

PubMed ID: 7836353

DOI: 10.1074/jbc.270.3.1015

PubMed ID: 9135143

Title: Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation.

PubMed ID: 9135143

DOI: 10.1093/emboj/16.6.1268

PubMed ID: 16508205

Title: ErbB and HB-EGF signaling in heart development and function.

PubMed ID: 16508205

DOI: 10.1247/csf.31.1

PubMed ID: 22171320

Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.

PubMed ID: 22171320

DOI: 10.1074/mcp.m111.013649

PubMed ID: 23234360

Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.

PubMed ID: 23234360

DOI: 10.1021/pr300963h

PubMed ID: 9659904

Title: Crystal structure of the complex of diphtheria toxin with an extracellular fragment of its receptor.

PubMed ID: 9659904

DOI: 10.1016/s1097-2765(00)80008-8

Sequence Information:

  • Length: 208
  • Mass: 23067
  • Checksum: 2C43C9D1D8291B51
  • Sequence:
    • MKLLPSVVLK LFLAAVLSAL VTGESLERLR RGLAAGTSNP DPPTVSTDQL LPLGGGRDRK 
VRDLQEADLD LLRVTLSSKP QALATPNKEE HGKRKKKGKG LGKKRDPCLR KYKDFCIHGE 
CKYVKELRAP SCICHPGYHG ERCHGLSLPV ENRLYTYDHT TILAVVAVVL SSVCLLVIVG 
LLMFRYHRRG GYDVENEEKV KLGMTNSH