Gene HBEGF - ENSG00000113070 | NCBI Gene ID: 1839

Details for: HBEGF

Gene ID: 1839

Symbol: HBEGF

Ensembl ID: ENSG00000113070

Description: heparin binding EGF like growth factor

Associated with

Bacterial infection pathways
(R-HSA-9824439)
Cargo recognition for clathrin-mediated endocytosis
(R-HSA-8856825)
Clathrin-mediated endocytosis
(R-HSA-8856828)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downregulation of erbb2 signaling
(R-HSA-8863795)
Egfr downregulation
(R-HSA-182971)
Egfr interacts with phospholipase c-gamma
(R-HSA-212718)
Egfr transactivation by gastrin
(R-HSA-2179392)
Erbb2 activates ptk6 signaling
(R-HSA-8847993)
Erbb2 regulates cell motility
(R-HSA-6785631)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent nuclear events downstream of esr-membrane signaling
(R-HSA-9634638)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
Gab1 signalosome
(R-HSA-180292)
G alpha (q) signalling events
(R-HSA-416476)
Gastrin-creb signalling pathway via pkc and mapk
(R-HSA-881907)
Gpcr downstream signalling
(R-HSA-388396)
Grb2 events in egfr signaling
(R-HSA-179812)
Grb2 events in erbb2 signaling
(R-HSA-1963640)
Infectious disease
(R-HSA-5663205)
Inhibition of signaling by overexpressed egfr
(R-HSA-5638303)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Membrane trafficking
(R-HSA-199991)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Nuclear signaling by erbb4
(R-HSA-1251985)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi3k events in erbb2 signaling
(R-HSA-1963642)
Pi3k events in erbb4 signaling
(R-HSA-1250342)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Ptk6 promotes hif1a stabilization
(R-HSA-8857538)
Raf/map kinase cascade
(R-HSA-5673001)
Shc1 events in egfr signaling
(R-HSA-180336)
Shc1 events in erbb2 signaling
(R-HSA-1250196)
Shc1 events in erbb4 signaling
(R-HSA-1250347)
Signaling by egfr
(R-HSA-177929)
Signaling by egfr in cancer
(R-HSA-1643713)
Signaling by erbb2
(R-HSA-1227986)
Signaling by erbb2 in cancer
(R-HSA-1227990)
Signaling by erbb2 kd mutants
(R-HSA-9664565)
Signaling by erbb2 tmd/jmd mutants
(R-HSA-9665686)
Signaling by erbb4
(R-HSA-1236394)
Signaling by gpcr
(R-HSA-372790)
Signaling by non-receptor tyrosine kinases
(R-HSA-9006927)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by overexpressed wild-type egfr in cancer
(R-HSA-5638302)
Signaling by ptk6
(R-HSA-8848021)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Uptake and actions of bacterial toxins
(R-HSA-5339562)
Uptake and function of diphtheria toxin
(R-HSA-5336415)
Vesicle-mediated transport
(R-HSA-5653656)
Cell chemotaxis
(GO:0060326)
Cell surface
(GO:0009986)
Clathrin-coated endocytic vesicle membrane
(GO:0030669)
Endocytic vesicle membrane
(GO:0030666)
Epidermal growth factor receptor binding
(GO:0005154)
Epidermal growth factor receptor signaling pathway
(GO:0007173)
Erbb2-egfr signaling pathway
(GO:0038134)
Erbb2-erbb4 signaling pathway
(GO:0038135)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Growth factor activity
(GO:0008083)
Heparin binding
(GO:0008201)
Muscle organ development
(GO:0007517)
Negative regulation of elastin biosynthetic process
(GO:0051545)
Plasma membrane
(GO:0005886)
Positive regulation of cell growth
(GO:0030307)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of keratinocyte migration
(GO:0051549)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of smooth muscle cell proliferation
(GO:0048661)
Positive regulation of wound healing
(GO:0090303)
Protein binding
(GO:0005515)
Receptor ligand activity
(GO:0048018)
Regulation of heart contraction
(GO:0008016)
Signal transduction
(GO:0007165)
Transmembrane receptor protein tyrosine kinase activator activity
(GO:0030297)
Wound healing, spreading of epidermal cells
(GO:0035313)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.48
Marker Score: 6065
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 2.3
Marker Score: 1810
Cell Name: lung macrophage (CL1001603)
Fold Change: 2.18
Marker Score: 2499
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.17
Marker Score: 2284
Cell Name: B-2 B cell (CL0000822)
Fold Change: 2.04
Marker Score: 2507
Cell Name: keratinocyte (CL0000312)
Fold Change: 1.94
Marker Score: 1623
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 1.9
Marker Score: 1488
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.8
Marker Score: 2658
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 1.62
Marker Score: 1380
Cell Name: mucous neck cell (CL0000651)
Fold Change: 1.61
Marker Score: 3647.5
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 1.57
Marker Score: 1893.5
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.56
Marker Score: 1557
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.56
Marker Score: 386
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 1.55
Marker Score: 39621
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 1.53
Marker Score: 11956
Cell Name: kidney loop of Henle epithelial cell (CL1000909)
Fold Change: 1.5
Marker Score: 938
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 1.49
Marker Score: 504
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.34
Marker Score: 2720
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 1.33
Marker Score: 3264
Cell Name: elicited macrophage (CL0000861)
Fold Change: 1.3
Marker Score: 7875
Cell Name: enterocyte (CL0000584)
Fold Change: 1.26
Marker Score: 6068
Cell Name: Kupffer cell (CL0000091)
Fold Change: 1.25
Marker Score: 1253.5
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.22
Marker Score: 2309.5
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 1.2
Marker Score: 3115
Cell Name: eurydendroid cell (CL0000253)
Fold Change: 1.2
Marker Score: 488
Cell Name: peptic cell (CL0000155)
Fold Change: 1.13
Marker Score: 473
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.11
Marker Score: 17367
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 1.06
Marker Score: 1633
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251735.5
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.03
Marker Score: 1136
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 1.02
Marker Score: 457
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71755
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47980
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0.98
Marker Score: 6283
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30401
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.98
Marker Score: 281
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 0.98
Marker Score: 1418
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 0.97
Marker Score: 839
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.96
Marker Score: 497
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 0.96
Marker Score: 3019.5
Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.96
Marker Score: 240
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.95
Marker Score: 451
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 0.95
Marker Score: 229
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.95
Marker Score: 524
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2406
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 0.95
Marker Score: 394
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 0.94
Marker Score: 364
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 0.92
Marker Score: 932.5
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2723
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.9
Marker Score: 5763
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 0.89
Marker Score: 371
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.88
Marker Score: 318
Cell Name: basal cell (CL0000646)
Fold Change: 0.88
Marker Score: 1141
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5265
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 0.87
Marker Score: 831
Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
Fold Change: 0.87
Marker Score: 250
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.86
Marker Score: 4921
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.85
Marker Score: 1444
Cell Name: macrophage (CL0000235)
Fold Change: 0.85
Marker Score: 940
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.84
Marker Score: 535
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 0.83
Marker Score: 4087
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.81
Marker Score: 617
Cell Name: classical monocyte (CL0000860)
Fold Change: 0.79
Marker Score: 3284
Cell Name: vasa recta ascending limb cell (CL1001131)
Fold Change: 0.79
Marker Score: 208
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 0.78
Marker Score: 1891
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.78
Marker Score: 736
Cell Name: malignant cell (CL0001064)
Fold Change: 0.78
Marker Score: 10462
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1258
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.77
Marker Score: 1224
Cell Name: stem cell (CL0000034)
Fold Change: 0.75
Marker Score: 1793
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.75
Marker Score: 300
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.75
Marker Score: 387
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 463
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.72
Marker Score: 233
Cell Name: monocyte (CL0000576)
Fold Change: 0.72
Marker Score: 937
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 0.71
Marker Score: 352
Cell Name: brush cell (CL0002204)
Fold Change: 0.7
Marker Score: 638
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.69
Marker Score: 323
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.68
Marker Score: 1365
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 175
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.66
Marker Score: 1503
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 0.66
Marker Score: 662
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.66
Marker Score: 2751.5
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.65
Marker Score: 6540.5
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 0.63
Marker Score: 218
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 0.63
Marker Score: 4102.5
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 0.62
Marker Score: 1211.5
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.62
Marker Score: 555
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.61
Marker Score: 20889.5
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 0.61
Marker Score: 658
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.61
Marker Score: 979
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 0.6
Marker Score: 727
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.6
Marker Score: 159
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.6
Marker Score: 224
Cell Name: Mueller cell (CL0000636)
Fold Change: 0.58
Marker Score: 808
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.58
Marker Score: 383
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.58
Marker Score: 32344
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 0.57
Marker Score: 606
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.57
Marker Score: 1331
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.56
Marker Score: 401

Hover over a box to see details here...

**Key characteristics**: - HBEGF is a glycoprotein with a molecular weight of approximately 120 kDa. - It is a member of the EGF family of growth factors. - HBEGF is known to have both pro-oncogenic and anti-oncogenic activities. - It is a key regulator of epithelial cell migration and invasion. - It is also involved in cell cycle regulation and apoptosis. **Pathways and functions**: - HBEGF signaling is initiated by binding to its receptor, EGF receptor (EGFR). - This binding activates the EGF receptor-mediated signaling pathway, which is a major pathway for cell growth, proliferation, and differentiation. - HBEGF also binds to other receptors, including EGFR, ERBB2, and ERBB4, which can activate different signaling pathways. - These pathways can lead to the activation of MAPK, PI3K/AKT, and other downstream signaling molecules, which are involved in cell growth, survival, and proliferation. - HBEGF also plays a role in cell migration and invasion by promoting epithelial cell migration and invasion through the activation of the MAPK pathway. **Clinical significance**: - HBEGF is a key target for cancer therapy. - Abnormalities in HBEGF signaling are associated with various cancers, including prostate cancer, breast cancer, and lung cancer. - Inhibition of HBEGF signaling has been shown to inhibit tumor growth and metastasis. - Therefore, HBEGF is a promising target for cancer treatment.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Proheparin-binding EGF-like growth factor

Genular Protein ID: 2012311508

Symbol: HBEGF_HUMAN

Name: Proheparin-binding EGF-like growth factor

UniProtKB Accession Codes:

Q99075 B2R821

Database IDs:

Citations:

PubMed ID: 1840698

Title: A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF.

PubMed ID: 1840698

DOI: 10.1126/science.1840698

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1556128

Title: Structure of heparin-binding EGF-like growth factor. Multiple forms, primary structure, and glycosylation of the mature protein.

PubMed ID: 1556128

DOI: 10.1016/s0021-9258(18)42682-8

PubMed ID: 7836353

Title: Diphtheria toxin binds to the epidermal growth factor (EGF)-like domain of human heparin-binding EGF-like growth factor/diphtheria toxin receptor and inhibits specifically its mitogenic activity.

PubMed ID: 7836353

DOI: 10.1074/jbc.270.3.1015

PubMed ID: 9135143

Title: Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation.

PubMed ID: 9135143

DOI: 10.1093/emboj/16.6.1268

PubMed ID: 16508205

Title: ErbB and HB-EGF signaling in heart development and function.

PubMed ID: 16508205

DOI: 10.1247/csf.31.1

PubMed ID: 22171320

Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.

PubMed ID: 22171320

DOI: 10.1074/mcp.m111.013649

PubMed ID: 23234360

Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.

PubMed ID: 23234360

DOI: 10.1021/pr300963h

PubMed ID: 9659904

Title: Crystal structure of the complex of diphtheria toxin with an extracellular fragment of its receptor.

PubMed ID: 9659904

DOI: 10.1016/s1097-2765(00)80008-8

Sequence Information:

Length: 208
Mass: 23067
Checksum: 2C43C9D1D8291B51
Sequence:

MKLLPSVVLK LFLAAVLSAL VTGESLERLR RGLAAGTSNP DPPTVSTDQL LPLGGGRDRK 
VRDLQEADLD LLRVTLSSKP QALATPNKEE HGKRKKKGKG LGKKRDPCLR KYKDFCIHGE 
CKYVKELRAP SCICHPGYHG ERCHGLSLPV ENRLYTYDHT TILAVVAVVL SSVCLLVIVG 
LLMFRYHRRG GYDVENEEKV KLGMTNSH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: HBEGF

Associated with

Cells (max top 100)

Other Information

A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF. PubMed ID: 1840698

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 5. PubMed ID: 15372022

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Structure of heparin-binding EGF-like growth factor. Multiple forms, primary structure, and glycosylation of the mature protein. PubMed ID: 1556128

Diphtheria toxin binds to the epidermal growth factor (EGF)-like domain of human heparin-binding EGF-like growth factor/diphtheria toxin receptor and inhibits specifically its mitogenic activity. PubMed ID: 7836353

Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation. PubMed ID: 9135143

ErbB and HB-EGF signaling in heart development and function. PubMed ID: 16508205

Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD. PubMed ID: 22171320

LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins. PubMed ID: 23234360

Crystal structure of the complex of diphtheria toxin with an extracellular fragment of its receptor. PubMed ID: 9659904