Details for: MEGF8
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 114.4362
Cell Significance Index: -17.8000 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 68.4031
Cell Significance Index: -17.3500 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 43.5007
Cell Significance Index: -17.9200 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 35.0763
Cell Significance Index: -14.2500 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 35.0333
Cell Significance Index: -16.5400 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 14.9150
Cell Significance Index: -14.2400 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 14.4815
Cell Significance Index: -17.8600 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 5.9727
Cell Significance Index: -16.0000 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 4.5514
Cell Significance Index: -17.9600 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 3.2784
Cell Significance Index: -7.1800 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.2153
Cell Significance Index: 243.7800 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.9833
Cell Significance Index: 97.2800 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.7512
Cell Significance Index: 678.2500 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.6102
Cell Significance Index: 218.8500 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.5392
Cell Significance Index: 58.6500 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5043
Cell Significance Index: 82.0200 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.4950
Cell Significance Index: 29.7200 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.4753
Cell Significance Index: 6.4900 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.4667
Cell Significance Index: 10.2200 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.4467
Cell Significance Index: 5.5400 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.4157
Cell Significance Index: 82.5000 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.3795
Cell Significance Index: 10.1700 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.3502
Cell Significance Index: 15.4900 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.3430
Cell Significance Index: 7.4300 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.3290
Cell Significance Index: 18.4600 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.3093
Cell Significance Index: 19.0100 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.2831
Cell Significance Index: 10.7200 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2662
Cell Significance Index: 18.4100 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2462
Cell Significance Index: 11.1600 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.2424
Cell Significance Index: 18.6000 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2241
Cell Significance Index: 122.4000 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.2173
Cell Significance Index: 6.2600 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.2076
Cell Significance Index: 13.0900 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.2068
Cell Significance Index: 5.1700 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.1976
Cell Significance Index: 5.6400 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.1876
Cell Significance Index: 4.5000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.1828
Cell Significance Index: 32.9500 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.1779
Cell Significance Index: 11.9600 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.1331
Cell Significance Index: 3.7200 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1322
Cell Significance Index: 18.1500 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.1032
Cell Significance Index: 4.8100 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0969
Cell Significance Index: 11.9100 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0857
Cell Significance Index: 10.9800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0825
Cell Significance Index: 15.7000 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0707
Cell Significance Index: 31.2700 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0705
Cell Significance Index: 3.6600 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0391
Cell Significance Index: 0.6700 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0276
Cell Significance Index: 0.9700 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0182
Cell Significance Index: 34.2100 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0123
Cell Significance Index: 22.6300 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.0110
Cell Significance Index: 0.5800 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0070
Cell Significance Index: 0.1500 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0060
Cell Significance Index: 9.2000 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0001
Cell Significance Index: 0.0500 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0001
Cell Significance Index: -0.0500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0044
Cell Significance Index: -5.9800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0090
Cell Significance Index: -4.1000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0148
Cell Significance Index: -2.1500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0175
Cell Significance Index: -12.9800 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0184
Cell Significance Index: -13.9400 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0221
Cell Significance Index: -0.3700 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0250
Cell Significance Index: -14.0900 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0301
Cell Significance Index: -18.8000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0496
Cell Significance Index: -14.2700 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0537
Cell Significance Index: -9.1800 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0565
Cell Significance Index: -1.4900 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0571
Cell Significance Index: -6.6600 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0583
Cell Significance Index: -5.9600 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0738
Cell Significance Index: -8.7000 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0792
Cell Significance Index: -9.0700 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0834
Cell Significance Index: -5.3800 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0868
Cell Significance Index: -18.2800 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0881
Cell Significance Index: -1.8700 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0984
Cell Significance Index: -12.7100 - Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: -0.0990
Cell Significance Index: -1.3200 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.1082
Cell Significance Index: -1.5500 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1266
Cell Significance Index: -7.7600 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: -0.1411
Cell Significance Index: -1.1700 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.1469
Cell Significance Index: -2.9500 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1488
Cell Significance Index: -11.0900 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1514
Cell Significance Index: -3.1400 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1555
Cell Significance Index: -16.1900 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1561
Cell Significance Index: -11.0400 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1649
Cell Significance Index: -7.7500 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1733
Cell Significance Index: -5.5500 - Cell Name: decidual cell (CL2000002)
Fold Change: -0.1882
Cell Significance Index: -3.0200 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1906
Cell Significance Index: -4.9000 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1907
Cell Significance Index: -15.1100 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.2094
Cell Significance Index: -4.1400 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.2215
Cell Significance Index: -3.2700 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2424
Cell Significance Index: -7.7200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.2459
Cell Significance Index: -12.8100 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.2628
Cell Significance Index: -2.7200 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.2638
Cell Significance Index: -5.7000 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.2660
Cell Significance Index: -8.7100 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.2694
Cell Significance Index: -9.3600 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.2897
Cell Significance Index: -5.6600 - Cell Name: hippocampal interneuron (CL1001569)
Fold Change: -0.3154
Cell Significance Index: -4.0900 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.3312
Cell Significance Index: -8.8600 - Cell Name: peg cell (CL4033014)
Fold Change: -0.3541
Cell Significance Index: -8.1800
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3444886545
Symbol: MEGF8_HUMAN
Name: Multiple epidermal growth factor-like domains protein 8
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9693030
Title: Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening.
PubMed ID: 9693030
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 16335952
Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
PubMed ID: 16335952
DOI: 10.1021/pr0502065
PubMed ID: 23063620
Title: Mutations in multidomain protein MEGF8 identify a Carpenter syndrome subtype associated with defective lateralization.
PubMed ID: 23063620
Sequence Information:
- Length: 2845
- Mass: 303100
- Checksum: DDBF0EE07511587D
- Sequence:
MALGKVLAMA LVLALAVLGS LSPGARAGDC KGQRQVLREA PGFVTDGAGN YSVNGNCEWL IEAPSPQHRI LLDFLFLDTE CTYDYLFVYD GDSPRGPLLA SLSGSTRPPP IEASSGKMLL HLFSDANYNL LGFNASFRFS LCPGGCQSHG QCQPPGVCAC EPGWGGPDCG LQECSAYCGS HGTCASPLGP CRCEPGFLGR ACDLHLWENQ GAGWWHNVSA RDPAFSARIG AAGAFLSPPG LLAVFGGQDL NNALGDLVLY NFSANTWESW DLSPAPAARH SHVAVAWAGS LVLMGGELAD GSLTNDVWAF SPLGRGHWEL LAPPASSSSG PPGLAGHAAA LVDDVWLYVS GGRTPHDLFS SGLFRFRLDS TSGGYWEQVI PAGGRPPAAT GHSMVFHAPS RALLVHGGHR PSTARFSVRV NSTELFHVDR HVWTTLKGRD GLQGPRERAF HTASVLGNYM VVYGGNVHTH YQEEKCYEDG IFFYHLGCHQ WVSGAELAPP GTPEGRAAPP SGRYSHVAAV LGGSVLLVAG GYSGRPRGDL MAYKVPPFVF QAPAPDYHLD YCSMYTDHSV CSRDPECSWC QGACQAAPPP GTPLGACPAA SCLGLGRLLG DCQACLAFSS PTAPPRGPGT LGWCVHNESC LPRPEQARCR GEQISGTVGW WGPAPVFVTS LEACVTQSFL PGLHLLTFQQ PPNTSQPDKV SIVRSTTITL TPSAETDVSL VYRGFIYPML PGGPGGPGAE DVAVWTRAQR LHVLARMARG PDTENMEEVG RWVAHQEKET RRLQRPGSAR LFPLPGRDHK YAVEIQGQLN GSAGPGHSEL TLLWDRTGVP GGSEISFFFL EPYRSSSCTS YSSCLGCLAD QGCGWCLTSA TCHLRQGGAH CGDDGAGGSL LVLVPTLCPL CEEHRDCHAC TQDPFCEWHQ STSRKGDAAC SRRGRGRGAL KSPEECPPLC SQRLTCEDCL ANSSQCAWCQ STHTCFLFAA YLARYPHGGC RGWDDSVHSE PRCRSCDGFL TCHECLQSHE CGWCGNEDNP TLGRCLQGDF SGPLGGGNCS LWVGEGLGLP VALPARWAYA RCPDVDECRL GLARCHPRAT CLNTPLSYEC HCQRGYQGDG ISHCNRTCLE DCGHGVCSGP PDFTCVCDLG WTSDLPPPTP APGPPAPRCS RDCGCSFHSH CRKRGPGFCD ECQDWTWGEH CERCRPGSFG NATGSRGCRP CQCNGHGDPR RGHCDNLSGL CFCQDHTEGA HCQLCSPGYY GDPRAGGSCF RECGGRALLT NVSSVALGSR RVGGLLPPGG GAARAGPGLS YCVWVVSATE ELQPCAPGTL CPPLTLTFSP DSSTPCTLSY VLAFDGFPRF LDTGVVQSDR SLIAAFCGQR RDRPLTVQAL SGLLVLHWEA NGSSSWGFNA SVGSARCGSG GPGSCPVPQE CVPQDGAAGA GLCRCPQGWA GPHCRMALCP ENCNAHTGAG TCNQSLGVCI CAEGFGGPDC ATKLDGGQLV WETLMDSRLS ADTASRFLHR LGHTMVDGPD ATLWMFGGLG LPQGLLGNLY RYSVSERRWT QMLAGAEDGG PGPSPRSFHA AAYVPAGRGA MYLLGGLTAG GVTRDFWVLN LTTLQWRQEK APQTVELPAV AGHTLTARRG LSLLLVGGYS PENGFNQQLL EYQLATGTWV SGAQSGTPPT GLYGHSAVYH EATDSLYVFG GFRFHVELAA PSPELYSLHC PDRTWSLLAP SQGAKRDRMR NVRGSSRGLG QVPGEQPGSW GFREVRKKMA LWAALAGTGG FLEEISPHLK EPRPRLFHAS ALLGDTMVVL GGRSDPDEFS SDVLLYQVNC NAWLLPDLTR SASVGPPMEE SVAHAVAAVG SRLYISGGFG GVALGRLLAL TLPPDPCRLL SSPEACNQSG ACTWCHGACL SGDQAHRLGC GGSPCSPMPR SPEECRRLRT CSECLARHPR TLQPGDGEAS TPRCKWCTNC PEGACIGRNG SCTSENDCRI NQREVFWAGN CSEAACGAAD CEQCTREGKC MWTRQFKRTG ETRRILSVQP TYDWTCFSHS LLNVSPMPVE SSPPLPCPTP CHLLPNCTSC LDSKGADGGW QHCVWSSSLQ QCLSPSYLPL RCMAGGCGRL LRGPESCSLG CAQATQCALC LRRPHCGWCA WGGQDGGGRC MEGGLSGPRD GLTCGRPGAS WAFLSCPPED ECANGHHDCN ETQNCHDQPH GYECSCKTGY TMDNMTGLCR PVCAQGCVNG SCVEPDHCRC HFGFVGRNCS TECRCNRHSE CAGVGARDHC LLCRNHTKGS HCEQCLPLFV GSAVGGGTCR PCHAFCRGNS HICISRKELQ MSKGEPKKYS LDPEEIENWV TEGPSEDEAV CVNCQNNSYG EKCESCLQGY FLLDGKCTKC QCNGHADTCN EQDGTGCPCQ NNTETGTCQG SSPSDRRDCY KYQCAKCRES FHGSPLGGQQ CYRLISVEQE CCLDPTSQTN CFHEPKRRAL GPGRTVLFGV QPKFTNVDIR LTLDVTFGAV DLYVSTSYDT FVVRVAPDTG VHTVHIQPPP APPPPPPPAD GGPRGAGDPG GAGASSGPGA PAEPRVREVW PRGLITYVTV TEPSAVLVVR GVRDRLVITY PHEHHALKSS RFYLLLLGVG DPSGPGANGS ADSQGLLFFR QDQAHIDLFV FFSVFFSCFF LFLSLCVLLW KAKQALDQRQ EQRRHLQEMT KMASRPFAKV TVCFPPDPTA PASAWKPAGL PPPAFRRSEP FLAPLLLTGA GGPWGPMGGG CCPPAIPATT AGLRAGPITL EPTEDGMAGV ATLLLQLPGG PHAPNGACLG SALVTLRHRL HEYCGGGGGA GGSGHGTGAG RKGLLSQDNL TSMSL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.