Gene MEGF8 - ENSG00000105429 | NCBI Gene ID: 1954

Details for: MEGF8

Gene ID: 1954

Symbol: MEGF8

Ensembl ID: ENSG00000105429

Description: multiple EGF like domains 8

Associated with

Bmp signaling pathway
(GO:0030509)
Calcium ion binding
(GO:0005509)
Cell migration involved in gastrulation
(GO:0042074)
Coronary vasculature development
(GO:0060976)
Craniofacial suture morphogenesis
(GO:0097094)
Determination of digestive tract left/right asymmetry
(GO:0071907)
Determination of heart left/right asymmetry
(GO:0061371)
Embryonic heart tube left/right pattern formation
(GO:0060971)
Embryonic heart tube morphogenesis
(GO:0003143)
Embryonic limb morphogenesis
(GO:0030326)
Embryonic skeletal system morphogenesis
(GO:0048704)
Epiboly involved in gastrulation with mouth forming second
(GO:0055113)
Extracellular exosome
(GO:0070062)
Fasciculation of sensory neuron axon
(GO:0097155)
Left/right pattern formation
(GO:0060972)
Limb morphogenesis
(GO:0035108)
Membrane
(GO:0016020)
Negative regulation of smoothened signaling pathway
(GO:0045879)
Nucleus
(GO:0005634)
Positive regulation of axon extension involved in axon guidance
(GO:0048842)
Protein binding
(GO:0005515)
Regulation of gene expression
(GO:0010468)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: GABAergic neuron (CL0000617)
Fold Change: 1.61
Marker Score: 6702
Cell Name: neuron (CL0000540)
Fold Change: 1.35
Marker Score: 5478
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.28
Marker Score: 78977
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.28
Marker Score: 13209
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.28
Marker Score: 12001
Cell Name: mesangial cell (CL0000650)
Fold Change: 1.27
Marker Score: 1528
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.26
Marker Score: 47982
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.26
Marker Score: 10833
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.26
Marker Score: 11929
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.25
Marker Score: 46138
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.25
Marker Score: 1930
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.25
Marker Score: 5182
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.18
Marker Score: 4553
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 1.14
Marker Score: 17060
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 1.13
Marker Score: 5239
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.13
Marker Score: 8673
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 1.12
Marker Score: 22273
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.05
Marker Score: 16365
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71788
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48013
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30404
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.95
Marker Score: 491
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2409
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.94
Marker Score: 446
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.94
Marker Score: 1903
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2729
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.89
Marker Score: 5106
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5294
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.87
Marker Score: 314
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.83
Marker Score: 662
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.82
Marker Score: 1337
Cell Name: Leydig cell (CL0000178)
Fold Change: 0.79
Marker Score: 849
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.74
Marker Score: 568
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.74
Marker Score: 383
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.74
Marker Score: 3098
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.73
Marker Score: 236
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.72
Marker Score: 15452
Cell Name: endocrine cell (CL0000163)
Fold Change: 0.72
Marker Score: 374
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.72
Marker Score: 289
Cell Name: brush cell (CL0002204)
Fold Change: 0.69
Marker Score: 628
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.67
Marker Score: 172
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.66
Marker Score: 277
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.63
Marker Score: 656
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.63
Marker Score: 376.5
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.63
Marker Score: 575
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 0.6
Marker Score: 350
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 0.6
Marker Score: 398
Cell Name: stellate neuron (CL0000122)
Fold Change: 0.59
Marker Score: 3176
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.58
Marker Score: 19536
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.58
Marker Score: 1361
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.57
Marker Score: 3446
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 0.57
Marker Score: 318
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.56
Marker Score: 174
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.55
Marker Score: 1481
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.55
Marker Score: 150
Cell Name: ciliated cell (CL0000064)
Fold Change: 0.55
Marker Score: 1886
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 0.54
Marker Score: 914
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.54
Marker Score: 259
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.54
Marker Score: 431
Cell Name: macroglial cell (CL0000126)
Fold Change: 0.54
Marker Score: 1230
Cell Name: taste receptor cell (CL0000209)
Fold Change: 0.53
Marker Score: 462
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.53
Marker Score: 558
Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 0.52
Marker Score: 2735
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 0.52
Marker Score: 2155
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 0.52
Marker Score: 594
Cell Name: granule cell (CL0000120)
Fold Change: 0.51
Marker Score: 3845
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.51
Marker Score: 1877
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 0.5
Marker Score: 566
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.5
Marker Score: 1024
Cell Name: chromaffin cell (CL0000166)
Fold Change: 0.5
Marker Score: 704
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 0.49
Marker Score: 1244
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.48
Marker Score: 309
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.48
Marker Score: 185
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.48
Marker Score: 8470
Cell Name: neuronal brush cell (CL0000555)
Fold Change: 0.46
Marker Score: 1553
Cell Name: glial cell (CL0000125)
Fold Change: 0.46
Marker Score: 502
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.44
Marker Score: 15320
Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 0.44
Marker Score: 254
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.44
Marker Score: 4397
Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.43
Marker Score: 2578.5
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.43
Marker Score: 203
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 0.43
Marker Score: 146
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.43
Marker Score: 214
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.43
Marker Score: 467
Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 0.43
Marker Score: 137
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.43
Marker Score: 101
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.43
Marker Score: 320
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.43
Marker Score: 282
Cell Name: astrocyte (CL0000127)
Fold Change: 0.42
Marker Score: 364
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.42
Marker Score: 1754
Cell Name: acinar cell (CL0000622)
Fold Change: 0.42
Marker Score: 294
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.41
Marker Score: 797
Cell Name: pulmonary ionocyte (CL0017000)
Fold Change: 0.41
Marker Score: 253
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 0.41
Marker Score: 682
Cell Name: germ cell (CL0000586)
Fold Change: 0.41
Marker Score: 714
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.41
Marker Score: 142
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.4
Marker Score: 381
Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: 0.39
Marker Score: 300
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.39
Marker Score: 491
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.39
Marker Score: 892

Hover over a box to see details here...

**Key characteristics:** - Multiple EGF domains: MEGF8 contains eight EGF domains, which are membrane-bound proteins that are involved in cell signaling and growth. - Expression: MEGF8 is highly expressed in neurons, particularly in the cerebral cortex, hippocampus, and cerebellum. - Functions: MEGF8 plays a crucial role in several cellular processes, including cell migration, morphogenesis, and neural tube formation. **Pathways and functions:** - Bmp signaling pathway: MEGF8 is a key regulator of the Bmp signaling pathway, a crucial pathway for cell migration and proliferation. - Calcium ion binding: MEGF8 is a calcium sensor, and its expression is regulated by calcium levels. - Cell migration: MEGF8 is involved in cell migration by promoting the migration of neurons and other cells. - Neural tube formation: MEGF8 plays a critical role in the development of the neural tube by promoting the migration and survival of neural stem cells. **Clinical significance:** - Mutations in the MEGF8 gene have been linked to a number of neurological disorders, including autism, schizophrenia, and epilepsy. - Targeting MEGF8 has emerged as a promising therapeutic strategy for these disorders. - MEGF8 is a potential target for the treatment of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. **Conclusion:** The MEGF8 gene is a key regulator of cell migration, morphogenesis, and neural tube formation. Its mutations have significant implications for human health, and targeting MEGF8 has emerged as a promising therapeutic strategy for neurodegenerative diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Multiple epidermal growth factor-like domains protein 8

Genular Protein ID: 3444886545

Symbol: MEGF8_HUMAN

Name: Multiple epidermal growth factor-like domains protein 8

UniProtKB Accession Codes:

Q7Z7M0 A8KAY0 O75097

Database IDs:

Citations:

PubMed ID: 9693030

Title: Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening.

PubMed ID: 9693030

DOI: 10.1006/geno.1998.5341

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 23063620

Title: Mutations in multidomain protein MEGF8 identify a Carpenter syndrome subtype associated with defective lateralization.

PubMed ID: 23063620

DOI: 10.1016/j.ajhg.2012.08.027

Sequence Information:

Length: 2845
Mass: 303100
Checksum: DDBF0EE07511587D
Sequence:

MALGKVLAMA LVLALAVLGS LSPGARAGDC KGQRQVLREA PGFVTDGAGN YSVNGNCEWL 
IEAPSPQHRI LLDFLFLDTE CTYDYLFVYD GDSPRGPLLA SLSGSTRPPP IEASSGKMLL 
HLFSDANYNL LGFNASFRFS LCPGGCQSHG QCQPPGVCAC EPGWGGPDCG LQECSAYCGS 
HGTCASPLGP CRCEPGFLGR ACDLHLWENQ GAGWWHNVSA RDPAFSARIG AAGAFLSPPG 
LLAVFGGQDL NNALGDLVLY NFSANTWESW DLSPAPAARH SHVAVAWAGS LVLMGGELAD 
GSLTNDVWAF SPLGRGHWEL LAPPASSSSG PPGLAGHAAA LVDDVWLYVS GGRTPHDLFS 
SGLFRFRLDS TSGGYWEQVI PAGGRPPAAT GHSMVFHAPS RALLVHGGHR PSTARFSVRV 
NSTELFHVDR HVWTTLKGRD GLQGPRERAF HTASVLGNYM VVYGGNVHTH YQEEKCYEDG 
IFFYHLGCHQ WVSGAELAPP GTPEGRAAPP SGRYSHVAAV LGGSVLLVAG GYSGRPRGDL 
MAYKVPPFVF QAPAPDYHLD YCSMYTDHSV CSRDPECSWC QGACQAAPPP GTPLGACPAA 
SCLGLGRLLG DCQACLAFSS PTAPPRGPGT LGWCVHNESC LPRPEQARCR GEQISGTVGW 
WGPAPVFVTS LEACVTQSFL PGLHLLTFQQ PPNTSQPDKV SIVRSTTITL TPSAETDVSL 
VYRGFIYPML PGGPGGPGAE DVAVWTRAQR LHVLARMARG PDTENMEEVG RWVAHQEKET 
RRLQRPGSAR LFPLPGRDHK YAVEIQGQLN GSAGPGHSEL TLLWDRTGVP GGSEISFFFL 
EPYRSSSCTS YSSCLGCLAD QGCGWCLTSA TCHLRQGGAH CGDDGAGGSL LVLVPTLCPL 
CEEHRDCHAC TQDPFCEWHQ STSRKGDAAC SRRGRGRGAL KSPEECPPLC SQRLTCEDCL 
ANSSQCAWCQ STHTCFLFAA YLARYPHGGC RGWDDSVHSE PRCRSCDGFL TCHECLQSHE 
CGWCGNEDNP TLGRCLQGDF SGPLGGGNCS LWVGEGLGLP VALPARWAYA RCPDVDECRL 
GLARCHPRAT CLNTPLSYEC HCQRGYQGDG ISHCNRTCLE DCGHGVCSGP PDFTCVCDLG 
WTSDLPPPTP APGPPAPRCS RDCGCSFHSH CRKRGPGFCD ECQDWTWGEH CERCRPGSFG 
NATGSRGCRP CQCNGHGDPR RGHCDNLSGL CFCQDHTEGA HCQLCSPGYY GDPRAGGSCF 
RECGGRALLT NVSSVALGSR RVGGLLPPGG GAARAGPGLS YCVWVVSATE ELQPCAPGTL 
CPPLTLTFSP DSSTPCTLSY VLAFDGFPRF LDTGVVQSDR SLIAAFCGQR RDRPLTVQAL 
SGLLVLHWEA NGSSSWGFNA SVGSARCGSG GPGSCPVPQE CVPQDGAAGA GLCRCPQGWA 
GPHCRMALCP ENCNAHTGAG TCNQSLGVCI CAEGFGGPDC ATKLDGGQLV WETLMDSRLS 
ADTASRFLHR LGHTMVDGPD ATLWMFGGLG LPQGLLGNLY RYSVSERRWT QMLAGAEDGG 
PGPSPRSFHA AAYVPAGRGA MYLLGGLTAG GVTRDFWVLN LTTLQWRQEK APQTVELPAV 
AGHTLTARRG LSLLLVGGYS PENGFNQQLL EYQLATGTWV SGAQSGTPPT GLYGHSAVYH 
EATDSLYVFG GFRFHVELAA PSPELYSLHC PDRTWSLLAP SQGAKRDRMR NVRGSSRGLG 
QVPGEQPGSW GFREVRKKMA LWAALAGTGG FLEEISPHLK EPRPRLFHAS ALLGDTMVVL 
GGRSDPDEFS SDVLLYQVNC NAWLLPDLTR SASVGPPMEE SVAHAVAAVG SRLYISGGFG 
GVALGRLLAL TLPPDPCRLL SSPEACNQSG ACTWCHGACL SGDQAHRLGC GGSPCSPMPR 
SPEECRRLRT CSECLARHPR TLQPGDGEAS TPRCKWCTNC PEGACIGRNG SCTSENDCRI 
NQREVFWAGN CSEAACGAAD CEQCTREGKC MWTRQFKRTG ETRRILSVQP TYDWTCFSHS 
LLNVSPMPVE SSPPLPCPTP CHLLPNCTSC LDSKGADGGW QHCVWSSSLQ QCLSPSYLPL 
RCMAGGCGRL LRGPESCSLG CAQATQCALC LRRPHCGWCA WGGQDGGGRC MEGGLSGPRD 
GLTCGRPGAS WAFLSCPPED ECANGHHDCN ETQNCHDQPH GYECSCKTGY TMDNMTGLCR 
PVCAQGCVNG SCVEPDHCRC HFGFVGRNCS TECRCNRHSE CAGVGARDHC LLCRNHTKGS 
HCEQCLPLFV GSAVGGGTCR PCHAFCRGNS HICISRKELQ MSKGEPKKYS LDPEEIENWV 
TEGPSEDEAV CVNCQNNSYG EKCESCLQGY FLLDGKCTKC QCNGHADTCN EQDGTGCPCQ 
NNTETGTCQG SSPSDRRDCY KYQCAKCRES FHGSPLGGQQ CYRLISVEQE CCLDPTSQTN 
CFHEPKRRAL GPGRTVLFGV QPKFTNVDIR LTLDVTFGAV DLYVSTSYDT FVVRVAPDTG 
VHTVHIQPPP APPPPPPPAD GGPRGAGDPG GAGASSGPGA PAEPRVREVW PRGLITYVTV 
TEPSAVLVVR GVRDRLVITY PHEHHALKSS RFYLLLLGVG DPSGPGANGS ADSQGLLFFR 
QDQAHIDLFV FFSVFFSCFF LFLSLCVLLW KAKQALDQRQ EQRRHLQEMT KMASRPFAKV 
TVCFPPDPTA PASAWKPAGL PPPAFRRSEP FLAPLLLTGA GGPWGPMGGG CCPPAIPATT 
AGLRAGPITL EPTEDGMAGV ATLLLQLPGG PHAPNGACLG SALVTLRHRL HEYCGGGGGA 
GGSGHGTGAG RKGLLSQDNL TSMSL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: MEGF8

Associated with

Cells (max top 100)

Other Information

Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening. PubMed ID: 9693030

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334