Details for: ELAVL4

Gene ID: 1996

Symbol: ELAVL4

Ensembl ID: ENSG00000162374

Description: ELAV like RNA binding protein 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 6.02
    Marker Score: 8464.5
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 3.56
    Marker Score: 14858
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.99
    Marker Score: 3358
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 2.79
    Marker Score: 1657
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.69
    Marker Score: 14103
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 2.54
    Marker Score: 855
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 2.54
    Marker Score: 1199
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.5
    Marker Score: 11573
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.3
    Marker Score: 34431
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.24
    Marker Score: 861
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.19
    Marker Score: 1378
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.14
    Marker Score: 78815
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.13
    Marker Score: 20016
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 2.07
    Marker Score: 4294
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.02
    Marker Score: 124527
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.97
    Marker Score: 7606
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.96
    Marker Score: 20277
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.89
    Marker Score: 10145
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.88
    Marker Score: 7798
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.84
    Marker Score: 680
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.82
    Marker Score: 17269
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.81
    Marker Score: 68880
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.8
    Marker Score: 35777
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.8
    Marker Score: 15429
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.75
    Marker Score: 7116
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.68
    Marker Score: 869
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.67
    Marker Score: 701
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.65
    Marker Score: 2542
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.64
    Marker Score: 3102
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.63
    Marker Score: 12515
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1169
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.58
    Marker Score: 521
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.56
    Marker Score: 11776
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.52
    Marker Score: 1629
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.48
    Marker Score: 4977
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.45
    Marker Score: 843
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.41
    Marker Score: 5470
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.41
    Marker Score: 1324
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.33
    Marker Score: 2696
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.32
    Marker Score: 1647
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.31
    Marker Score: 630.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.3
    Marker Score: 2646
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.23
    Marker Score: 691
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.21
    Marker Score: 330
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4813
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.08
    Marker Score: 2471
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.02
    Marker Score: 1719
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71818
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48043
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.99
    Marker Score: 477.5
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.98
    Marker Score: 15323
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.97
    Marker Score: 401
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.96
    Marker Score: 1881
  • Cell Name: visceromotor neuron (CL0005025)
    Fold Change: 0.96
    Marker Score: 279
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5338
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.93
    Marker Score: 1153
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.92
    Marker Score: 421
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5287
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.86
    Marker Score: 262
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.85
    Marker Score: 653
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.85
    Marker Score: 8579
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.82
    Marker Score: 367
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.78
    Marker Score: 471
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.74
    Marker Score: 1546
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.72
    Marker Score: 231
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.68
    Marker Score: 753
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.68
    Marker Score: 235
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.62
    Marker Score: 139
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.61
    Marker Score: 303
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.61
    Marker Score: 390
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.59
    Marker Score: 1027
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.59
    Marker Score: 1674
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.57
    Marker Score: 788
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.55
    Marker Score: 222
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.5
    Marker Score: 240
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.48
    Marker Score: 104
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.47
    Marker Score: 118
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.47
    Marker Score: 242
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.47
    Marker Score: 190
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.46
    Marker Score: 147
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.46
    Marker Score: 198
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.42
    Marker Score: 416
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.42
    Marker Score: 151
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.41
    Marker Score: 409
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.41
    Marker Score: 109
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.4
    Marker Score: 1031
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.38
    Marker Score: 243

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Other Information

**Key characteristics:** * ELAVL4 is a protein of the ELAVL family, which are a group of proteins that are involved in RNA processing. * It is a highly conserved protein, with a sequence that is similar in humans and mice. * ELAVL4 is a multi-functional protein that can interact with a variety of molecules, including RNA, proteins, and lipids. * It is involved in the regulation of neuronal differentiation, survival, and plasticity. **Pathways and functions:** * ELAVL4 is involved in the 3'-utr-mediated regulation of gene expression. * It is a key regulator of dendrite morphogenesis, and it is also involved in the regulation of translation at the post-synapse. * It is involved in the response to nerve growth factor, and it is also involved in the response to endoplasmic reticulum stress. **Clinical significance:** * Mutations in the ELAVL4 gene have been linked to a number of neurological disorders, including autism, schizophrenia, and Parkinson's disease. * ELAVL4 is a promising target for the treatment of these disorders. **Additional information:** * ELAVL4 is a highly conserved protein, with a sequence that is similar in humans and mice. * It is a multi-functional protein that can interact with a variety of molecules, including RNA, proteins, and lipids. * It is involved in the regulation of neuronal differentiation, survival, and plasticity.

Genular Protein ID: 16401805

Symbol: ELAV4_HUMAN

Name: ELAV-like protein 4

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1655278

Title: HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal.

PubMed ID: 1655278

DOI: 10.1016/0092-8674(91)90184-z

PubMed ID: 12209604

Title: Novel products of the HuD, HuC, NNP-1 and alpha-internexin genes identified by autologous antibody screening of a pediatric neuroblastoma library.

PubMed ID: 12209604

DOI: 10.1002/ijc.10550

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7898713

Title: Paraneoplastic encephalomyelitis antigens bind to the AU-rich elements of mRNA.

PubMed ID: 7898713

DOI: 10.1212/wnl.45.3.544

PubMed ID: 10710437

Title: RNA-binding analyses of HuC and HuD with the VEGF and c-myc 3'-untranslated regions using a novel ELISA-based assay.

PubMed ID: 10710437

DOI: 10.1093/nar/28.7.e20

PubMed ID: 12034726

Title: Poly(A) tail length-dependent stabilization of GAP-43 mRNA by the RNA-binding protein HuD.

PubMed ID: 12034726

DOI: 10.1074/jbc.m201982200

PubMed ID: 12468554

Title: Post-transcriptional regulation of acetylcholinesterase mRNAs in nerve growth factor-treated PC12 cells by the RNA-binding protein HuD.

PubMed ID: 12468554

DOI: 10.1074/jbc.m209383200

PubMed ID: 17035636

Title: A nuclear function of Hu proteins as neuron-specific alternative RNA processing regulators.

PubMed ID: 17035636

DOI: 10.1091/mbc.e06-02-0099

PubMed ID: 16508003

Title: CARM1 regulates proliferation of PC12 cells by methylating HuD.

PubMed ID: 16508003

DOI: 10.1128/mcb.26.6.2273-2285.2006

PubMed ID: 17234598

Title: The RNA-binding protein HuD binds acetylcholinesterase mRNA in neurons and regulates its expression after axotomy.

PubMed ID: 17234598

DOI: 10.1523/jneurosci.4626-06.2007

PubMed ID: 18218628

Title: Post-transcriptional regulation of neuro-oncological ventral antigen 1 by the neuronal RNA-binding proteins ELAV.

PubMed ID: 18218628

DOI: 10.1074/jbc.m706082200

PubMed ID: 21088113

Title: HuD interacts with survival motor neuron protein and can rescue spinal muscular atrophy-like neuronal defects.

PubMed ID: 21088113

DOI: 10.1093/hmg/ddq500

PubMed ID: 21389246

Title: The survival of motor neuron (SMN) protein interacts with the mRNA-binding protein HuD and regulates localization of poly(A) mRNA in primary motor neuron axons.

PubMed ID: 21389246

DOI: 10.1523/jneurosci.3631-10.2011

PubMed ID: 22387028

Title: RNA-binding protein HuD controls insulin translation.

PubMed ID: 22387028

DOI: 10.1016/j.molcel.2012.01.016

PubMed ID: 24857657

Title: HuD regulates coding and noncoding RNA to induce APP[?]Abeta processing.

PubMed ID: 24857657

DOI: 10.1016/j.celrep.2014.04.050

PubMed ID: 29061699

Title: HuD and the Survival Motor Neuron Protein Interact in Motoneurons and Are Essential for Motoneuron Development, Function, and mRNA Regulation.

PubMed ID: 29061699

DOI: 10.1523/jneurosci.1528-17.2017

PubMed ID: 11175903

Title: Structural basis for recognition of AU-rich element RNA by the HuD protein.

PubMed ID: 11175903

DOI: 10.1038/84131

Sequence Information:

  • Length: 385
  • Mass: 42398
  • Checksum: A253E05DE653F4EE
  • Sequence:
  • MEWNGLKMII STMEPQVSNG PTSNTSNGPS SNNRNCPSPM QTGATTDDSK TNLIVNYLPQ 
    NMTQEEFRSL FGSIGEIESC KLVRDKITGQ SLGYGFVNYI DPKDAEKAIN TLNGLRLQTK 
    TIKVSYARPS SASIRDANLY VSGLPKTMTQ KELEQLFSQY GRIITSRILV DQVTGVSRGV 
    GFIRFDKRIE AEEAIKGLNG QKPSGATEPI TVKFANNPSQ KSSQALLSQL YQSPNRRYPG 
    PLHHQAQRFR LDNLLNMAYG VKRLMSGPVP PSACPPRFSP ITIDGMTSLV GMNIPGHTGT 
    GWCIFVYNLS PDSDESVLWQ LFGPFGAVNN VKVIRDFNTN KCKGFGFVTM TNYDEAAMAI 
    ASLNGYRLGD RVLQVSFKTN KAHKS

Genular Protein ID: 1731167148

Symbol: A0A0R4J2E6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 402
  • Mass: 44478
  • Checksum: A3E67F6200AD3F26
  • Sequence:
  • MLRYLQPLGC VHGGKGLTDM RLLLLREIVI NESRNCSFMI ISTMEPQVSN GPTSNTSNGP 
    SSNNRNCPSP MQTGATTDDS KTNLIVNYLP QNMTQEEFRS LFGSIGEIES CKLVRDKITG 
    QSLGYGFVNY IDPKDAEKAI NTLNGLRLQT KTIKVSYARP SSASIRDANL YVSGLPKTMT 
    QKELEQLFSQ YGRIITSRIL VDQVTGVSRG VGFIRFDKRI EAEEAIKGLN GQKPSGATEP 
    ITVKFANNPS QKSSQALLSQ LYQSPNRRYP GPLHHQAQRF RLDNLLNMAY GVKRFSPITI 
    DGMTSLVGMN IPGHTGTGWC IFVYNLSPDS DESVLWQLFG PFGAVNNVKV IRDFNTNKCK 
    GFGFVTMTNY DEAAMAIASL NGYRLGDRVL QVSFKTNKAH KS

Genular Protein ID: 2706640727

Symbol: B1APY9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 371
  • Mass: 41008
  • Checksum: 45AD5B5BB04ECC9F
  • Sequence:
  • MEWNGLKMII STMEPQVSNG PTSNTSNGPS SNNRNCPSPM QTGATTDDSK TNLIVNYLPQ 
    NMTQEEFRSL FGSIGEIESC KLVRDKITGQ SLGYGFVNYI DPKDAEKAIN TLNGLRLQTK 
    TIKVSYARPS SASIRDANLY VSGLPKTMTQ KELEQLFSQY GRIITSRILV DQVTGVSRGV 
    GFIRFDKRIE AEEAIKGLNG QKPSGATEPI TVKFANNPSQ KSSQALLSQL YQSPNRRYPG 
    PLHHQAQRFR LDNLLNMAYG VKRFSPITID GMTSLVGMNI PGHTGTGWCI FVYNLSPDSD 
    ESVLWQLFGP FGAVNNVKVI RDFNTNKCKG FGFVTMTNYD EAAMAIASLN GYRLGDRVLQ 
    VSFKTNKAHK S

Genular Protein ID: 1753849961

Symbol: A0A494C147_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 379
  • Mass: 41835
  • Checksum: 347446A9794939EF
  • Sequence:
  • MFEISRTLNA ALLNNEIIST MEPQVSNGPT SNTSNGPSSN NRNCPSPMQT GATTDDSKTN 
    LIVNYLPQNM TQEEFRSLFG SIGEIESCKL VRDKITGQSL GYGFVNYIDP KDAEKAINTL 
    NGLRLQTKTI KVSYARPSSA SIRDANLYVS GLPKTMTQKE LEQLFSQYGR IITSRILVDQ 
    VTGVSRGVGF IRFDKRIEAE EAIKGLNGQK PSGATEPITV KFANNPSQKS SQALLSQLYQ 
    SPNRRYPGPL HHQAQRFRLD NLLNMAYGVK RFSPITIDGM TSLVGMNIPG HTGTGWCIFV 
    YNLSPDSDES VLWQLFGPFG AVNNVKVIRD FNTNKCKGFG FVTMTNYDEA AMAIASLNGY 
    RLGDRVLQVS FKTNKAHKS

Genular Protein ID: 707250198

Symbol: A0A494C0M6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 128
  • Mass: 14017
  • Checksum: E11F4916ED9D79D3
  • Sequence:
  • MVMIISTMEP QVSNGPTSNT SNGPSSNNRN CPSPMQTGAT TDDSKTNLIV NYLPQNMTQE 
    EFRSLFGSIG EIESCKLVRD KITGQSLGYG FVNYIDPKDA EKAINTLNGL RLQTKTIKAT 
    VYLCFSLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.