Details for: EMP2

Gene ID: 2013

Symbol: EMP2

Ensembl ID: ENSG00000213853

Description: epithelial membrane protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 362.3383
    Cell Significance Index: -56.3600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 222.9705
    Cell Significance Index: -56.5600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 142.7851
    Cell Significance Index: -58.8200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 114.6736
    Cell Significance Index: -54.1400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 80.9511
    Cell Significance Index: -54.3200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 45.7600
    Cell Significance Index: -56.4200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.7551
    Cell Significance Index: -55.6000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 16.2205
    Cell Significance Index: -35.5000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.2383
    Cell Significance Index: -56.1900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.5385
    Cell Significance Index: 32.5900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.1744
    Cell Significance Index: 43.3100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.9882
    Cell Significance Index: 52.8100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.9280
    Cell Significance Index: 152.1000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.8489
    Cell Significance Index: 513.5800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.6206
    Cell Significance Index: 322.2300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.3371
    Cell Significance Index: 65.3200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.3254
    Cell Significance Index: 173.3100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.1132
    Cell Significance Index: 57.5200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.0146
    Cell Significance Index: 890.7000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.9807
    Cell Significance Index: 215.4500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.9499
    Cell Significance Index: 12.0000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.8265
    Cell Significance Index: 20.7500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.7267
    Cell Significance Index: 122.1200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.1878
    Cell Significance Index: 34.0500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.1044
    Cell Significance Index: 128.7000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0872
    Cell Significance Index: 981.6300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9486
    Cell Significance Index: 65.6000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9389
    Cell Significance Index: 186.3300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9297
    Cell Significance Index: 151.2000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9262
    Cell Significance Index: 505.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8295
    Cell Significance Index: 37.6000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7461
    Cell Significance Index: 95.6400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7431
    Cell Significance Index: 141.4100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5882
    Cell Significance Index: 80.7700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5708
    Cell Significance Index: 43.8100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.5442
    Cell Significance Index: 6.9700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.5206
    Cell Significance Index: 10.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5111
    Cell Significance Index: 14.7300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.5089
    Cell Significance Index: 7.6300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.3344
    Cell Significance Index: 4.8100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3143
    Cell Significance Index: 10.9200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2579
    Cell Significance Index: 13.0400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2153
    Cell Significance Index: 5.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1954
    Cell Significance Index: 147.8800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1892
    Cell Significance Index: 18.7200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1239
    Cell Significance Index: 233.3500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0676
    Cell Significance Index: 2.1600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0513
    Cell Significance Index: 35.4600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0466
    Cell Significance Index: 63.3100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0463
    Cell Significance Index: 7.9000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0436
    Cell Significance Index: 5.6400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0356
    Cell Significance Index: 54.8300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0336
    Cell Significance Index: 15.2400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0185
    Cell Significance Index: 0.3100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0216
    Cell Significance Index: -39.7700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0238
    Cell Significance Index: -15.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0350
    Cell Significance Index: -25.9600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0405
    Cell Significance Index: -25.3200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0660
    Cell Significance Index: -48.4200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0683
    Cell Significance Index: -38.5300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1266
    Cell Significance Index: -45.4200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1410
    Cell Significance Index: -2.3800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1430
    Cell Significance Index: -30.1200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1640
    Cell Significance Index: -47.2000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1692
    Cell Significance Index: -24.6000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.2305
    Cell Significance Index: -46.2400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2645
    Cell Significance Index: -27.0200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2852
    Cell Significance Index: -5.9700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2900
    Cell Significance Index: -6.7000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3144
    Cell Significance Index: -2.1300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3443
    Cell Significance Index: -16.1800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3682
    Cell Significance Index: -7.8700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.3772
    Cell Significance Index: -5.3700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.3847
    Cell Significance Index: -5.5300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.4017
    Cell Significance Index: -6.4500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4120
    Cell Significance Index: -23.1200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4268
    Cell Significance Index: -19.9000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4293
    Cell Significance Index: -9.3000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4348
    Cell Significance Index: -49.6300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4528
    Cell Significance Index: -6.6800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4607
    Cell Significance Index: -54.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4623
    Cell Significance Index: -48.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4736
    Cell Significance Index: -54.2600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6348
    Cell Significance Index: -50.2800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6696
    Cell Significance Index: -41.0500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.7139
    Cell Significance Index: -15.2100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.8122
    Cell Significance Index: -52.4000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.8424
    Cell Significance Index: -51.7800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.8563
    Cell Significance Index: -57.5800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.8855
    Cell Significance Index: -13.0700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.8872
    Cell Significance Index: -46.5800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.9298
    Cell Significance Index: -7.8100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.9585
    Cell Significance Index: -23.9600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.9616
    Cell Significance Index: -25.7700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.9645
    Cell Significance Index: -60.7900
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.9837
    Cell Significance Index: -10.2700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.0014
    Cell Significance Index: -36.7600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.0777
    Cell Significance Index: -44.1600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.1025
    Cell Significance Index: -28.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EMP2 is a type II transmembrane protein with a short cytoplasmic tail and a long extracellular domain. It belongs to the immunoglobulin superfamily and contains multiple immunoglobulin-like domains, which are essential for its interactions with other proteins and cellular components. EMP2 is highly expressed in epithelial cells, endothelial cells, and stem cells, and its expression is regulated by various signaling pathways. **Pathways and Functions:** EMP2 is involved in various cellular processes, including: 1. **Cell Signaling:** EMP2 interacts with various signaling molecules, such as integrins, kinases, and phosphatases, to regulate cell signaling pathways, including the PI3K/AKT and MAPK/ERK pathways. 2. **Cell Migration:** EMP2 plays a crucial role in cell migration, particularly in endothelial cells, where it regulates the migration of cells during angiogenesis and vasculogenesis. 3. **Cell Adhesion:** EMP2 interacts with integrins and other adhesion molecules to regulate cell adhesion to the extracellular matrix and other cells. 4. **Apoptosis:** EMP2 has been shown to regulate apoptosis in various cell types, including epithelial cells and endothelial cells. 5. **Development:** EMP2 is involved in embryonic development, particularly in the formation of the heart and lungs. **Signaling Pathways:** 1. **Actin-mediated cell contraction:** EMP2 interacts with actin filaments to regulate cell contraction and cytoskeletal organization. 2. **Activation of protein kinase activity:** EMP2 regulates the activity of various protein kinases, including PI3K and MAPK, to modulate cell signaling pathways. 3. **Apoptotic process:** EMP2 interacts with pro-apoptotic and anti-apoptotic proteins to regulate apoptosis in various cell types. 4. **Bleb assembly:** EMP2 regulates the assembly of blebs, which are membrane protrusions that play a crucial role in cell migration and signaling. 5. **Endothelial cell migration:** EMP2 regulates the migration of endothelial cells during angiogenesis and vasculogenesis. **Clinical Significance:** Dysregulation of EMP2 has been implicated in various diseases, including: 1. **Cancer:** EMP2 has been shown to be overexpressed in various types of cancer, including lung, breast, and colon cancer. 2. **Cardiovascular disease:** EMP2 has been implicated in the development of cardiovascular disease, particularly in the context of endothelial dysfunction and angiogenesis. 3. **Neurological disorders:** EMP2 has been shown to be involved in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Autoimmune diseases:** EMP2 has been implicated in the pathogenesis of autoimmune diseases, including rheumatoid arthritis and multiple sclerosis. In conclusion, EMP2 is a multifunctional protein that plays a crucial role in various cellular processes, including cell signaling, migration, and development. Its dysregulation has been implicated in various diseases, highlighting the importance of EMP2 in maintaining tissue homeostasis and preventing disease. Further research is needed to fully elucidate the functions of EMP2 and its role in human disease.

Genular Protein ID: 1269333398

Symbol: EMP2_HUMAN

Name: Epithelial membrane protein 2

UniProtKB Accession Codes:

P54851 B2R7V6 D3DUF8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 GO 46 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8917086

Title: Epithelial membrane protein-2 and epithelial membrane protein-3: two novel members of the peripheral myelin protein 22 gene family.

PubMed ID: 8917086

DOI: 10.1016/0378-1119(96)00134-5

PubMed ID: 8996089

Title: Characterization of a tumor-associated gene, a member of a novel family of genes encoding membrane glycoproteins.

PubMed ID: 8996089

DOI: 10.1016/s0378-1119(96)00475-1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12107182

Title: Epithelial membrane proteins induce membrane blebbing and interact with the P2X7 receptor C terminus.

PubMed ID: 12107182

DOI: 10.1074/jbc.m205120200

PubMed ID: 12710941

Title: Epithelial membrane protein-2 is expressed in discrete anatomical regions of the eye.

PubMed ID: 12710941

DOI: 10.1016/s0014-4800(03)00009-1

PubMed ID: 16216233

Title: Epithelial membrane protein-2 regulates surface expression of alphavbeta3 integrin in the endometrium.

PubMed ID: 16216233

DOI: 10.1016/j.ydbio.2005.09.003

PubMed ID: 16487956

Title: Knockdown of the tetraspan protein epithelial membrane protein-2 inhibits implantation in the mouse.

PubMed ID: 16487956

DOI: 10.1016/j.ydbio.2006.01.015

PubMed ID: 18400107

Title: Steroid hormone regulation of EMP2 expression and localization in the endometrium.

PubMed ID: 18400107

DOI: 10.1186/1477-7827-6-15

PubMed ID: 19494199

Title: Functional consequences of interactions between FAK and epithelial membrane protein 2 (EMP2).

PubMed ID: 19494199

DOI: 10.1167/iovs.08-3315

PubMed ID: 21637765

Title: Epithelial membrane protein-2 promotes endometrial tumor formation through activation of FAK and Src.

PubMed ID: 21637765

DOI: 10.1371/journal.pone.0019945

PubMed ID: 22728127

Title: Anti-EMP2 diabody blocks epithelial membrane protein 2 (EMP2) and FAK mediated collagen gel contraction in ARPE-19 cells.

PubMed ID: 22728127

DOI: 10.1016/j.exer.2012.06.002

PubMed ID: 23439602

Title: Epithelial membrane protein 2 controls VEGF expression in ARPE-19 cells.

PubMed ID: 23439602

DOI: 10.1167/iovs.12-11013

PubMed ID: 23334331

Title: EMP2 regulates angiogenesis in endometrial cancer cells through induction of VEGF.

PubMed ID: 23334331

DOI: 10.1038/onc.2012.622

PubMed ID: 24814193

Title: Mutations in EMP2 cause childhood-onset nephrotic syndrome.

PubMed ID: 24814193

DOI: 10.1016/j.ajhg.2014.04.010

PubMed ID: 28295343

Title: Epithelial membrane protein 2 (EMP2) deficiency alters placental angiogenesis, mimicking features of human placental insufficiency.

PubMed ID: 28295343

DOI: 10.1002/path.4893

Sequence Information:

  • Length: 167
  • Mass: 19199
  • Checksum: 3E341DF3581EBCBF
  • Sequence:
    • MLVLLAFIIA FHITSAALLF IATVDNAWWV GDEFFADVWR ICTNNTNCTV INDSFQEYST 
LQAVQATMIL STILCCIAFF IFVLQLFRLK QGERFVLTSI IQLMSCLCVM IAASIYTDRR 
EDIHDKNAKF YPVTREGSYG YSYILAWVAF ACTFISGMMY LILRKRK

Genular Protein ID: 1615622281

Symbol: Q7Z4B3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q7Z4B3

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 RefSeq 1

Sequence Information:

  • Length: 103
  • Mass: 11216
  • Checksum: 16740014A154842E
  • Sequence:
    • MLGYQACEDG KVNATPTAGQ NLGLHRHSCL HLGPQNSIPE PCELIDTFRV WGTASFPSYP 
RRPLPSCPAL HATPGWPLTP ISRASEDPST IHSFIHSFIH SST

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.