Details for: EMP2

Gene ID: 2013

Symbol: EMP2

Ensembl ID: ENSG00000213853

Description: epithelial membrane protein 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 5.06
    Marker Score: 6098
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 4.33
    Marker Score: 6261
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 4.28
    Marker Score: 10877
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.06
    Marker Score: 49167
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.96
    Marker Score: 15583
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.85
    Marker Score: 2456
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.85
    Marker Score: 3041
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.74
    Marker Score: 21401.5
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.65
    Marker Score: 17249
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.61
    Marker Score: 22512
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 2.54
    Marker Score: 1140
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.54
    Marker Score: 2163
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.47
    Marker Score: 1475
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.44
    Marker Score: 18155
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.41
    Marker Score: 3551
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.35
    Marker Score: 3414
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.35
    Marker Score: 9057
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.34
    Marker Score: 3763
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.14
    Marker Score: 617
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.14
    Marker Score: 1455
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.11
    Marker Score: 4218
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.1
    Marker Score: 18263
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.1
    Marker Score: 5492
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.1
    Marker Score: 2374
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.06
    Marker Score: 1623
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.06
    Marker Score: 8581.5
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2
    Marker Score: 833
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 2
    Marker Score: 566
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.99
    Marker Score: 1784
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.98
    Marker Score: 3618
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.96
    Marker Score: 66537
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.88
    Marker Score: 3179
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.86
    Marker Score: 630
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.85
    Marker Score: 1544.5
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.85
    Marker Score: 2040
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.85
    Marker Score: 688
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.85
    Marker Score: 12009
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.84
    Marker Score: 1937
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.82
    Marker Score: 2128
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.81
    Marker Score: 893
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.81
    Marker Score: 18170
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.8
    Marker Score: 435
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.79
    Marker Score: 413
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.79
    Marker Score: 576
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.79
    Marker Score: 4859
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.73
    Marker Score: 1624
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.72
    Marker Score: 1855
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.71
    Marker Score: 1647
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 1.7
    Marker Score: 467
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.69
    Marker Score: 2181
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.69
    Marker Score: 1616
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.68
    Marker Score: 2097
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.67
    Marker Score: 490
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.65
    Marker Score: 3141.5
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.65
    Marker Score: 22162
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.62
    Marker Score: 2571
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.61
    Marker Score: 456
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.61
    Marker Score: 1719
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.6
    Marker Score: 905
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.6
    Marker Score: 910
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.59
    Marker Score: 1436
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.58
    Marker Score: 368
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.58
    Marker Score: 1364
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.58
    Marker Score: 1038
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.56
    Marker Score: 397
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.54
    Marker Score: 3658
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.54
    Marker Score: 967
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.53
    Marker Score: 1444
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.52
    Marker Score: 1000
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.51
    Marker Score: 376
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.51
    Marker Score: 1600
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.5
    Marker Score: 825
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.5
    Marker Score: 376
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.49
    Marker Score: 998
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.49
    Marker Score: 869
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.49
    Marker Score: 3383
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.47
    Marker Score: 466
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.46
    Marker Score: 50495.5
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.46
    Marker Score: 851
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.45
    Marker Score: 9274
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.45
    Marker Score: 1995
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.43
    Marker Score: 1608
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.43
    Marker Score: 1313
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.42
    Marker Score: 342
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.42
    Marker Score: 1427
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.4
    Marker Score: 1733
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.4
    Marker Score: 283
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.39
    Marker Score: 296
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.39
    Marker Score: 3043.5
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.38
    Marker Score: 655
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.36
    Marker Score: 2547
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.35
    Marker Score: 508
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.34
    Marker Score: 521
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.34
    Marker Score: 625
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.33
    Marker Score: 29789
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.33
    Marker Score: 17504
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.32
    Marker Score: 3225
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.32
    Marker Score: 5170
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.31
    Marker Score: 942
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.31
    Marker Score: 1308

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - EMP2 is a cell surface protein that is expressed on epithelial cells, endothelial cells, and immune cells. - It is a member of the EMP2 family of cell surface proteins. - EMP2 is a transmembrane protein that is composed of 13 transmembrane domains. - It is a key regulator of cell-matrix adhesion, cell migration, and cell population proliferation. **Pathways and functions:** - EMP2 is involved in the regulation of cell-matrix adhesion. It is a key regulator of epithelial cell migration and invasion. - It is also involved in the regulation of endothelial cell migration and survival. - EMP2 is a key regulator of cell population proliferation. It is expressed in high levels in epithelial cells and endothelial cells during development. - It is also expressed in immune cells, where it plays a role in the regulation of immune cell migration and activation. **Clinical significance:** - Mutations in the EMP2 gene have been linked to a number of human diseases, including lung cancer, breast cancer, and prostate cancer. - Studies of EMP2 have also been used to develop new therapies for these diseases. **Additional information:** - The EMP2 gene is located on chromosome 17q21.1. - It is a highly expressed gene in the human lung. - EMP2 is a well-characterized protein that has been extensively studied.

Genular Protein ID: 1269333398

Symbol: EMP2_HUMAN

Name: Epithelial membrane protein 2

UniProtKB Accession Codes:

P54851 B2R7V6 D3DUF8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 GO 47 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8917086

Title: Epithelial membrane protein-2 and epithelial membrane protein-3: two novel members of the peripheral myelin protein 22 gene family.

PubMed ID: 8917086

DOI: 10.1016/0378-1119(96)00134-5

PubMed ID: 8996089

Title: Characterization of a tumor-associated gene, a member of a novel family of genes encoding membrane glycoproteins.

PubMed ID: 8996089

DOI: 10.1016/s0378-1119(96)00475-1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12107182

Title: Epithelial membrane proteins induce membrane blebbing and interact with the P2X7 receptor C terminus.

PubMed ID: 12107182

DOI: 10.1074/jbc.m205120200

PubMed ID: 12710941

Title: Epithelial membrane protein-2 is expressed in discrete anatomical regions of the eye.

PubMed ID: 12710941

DOI: 10.1016/s0014-4800(03)00009-1

PubMed ID: 16216233

Title: Epithelial membrane protein-2 regulates surface expression of alphavbeta3 integrin in the endometrium.

PubMed ID: 16216233

DOI: 10.1016/j.ydbio.2005.09.003

PubMed ID: 16487956

Title: Knockdown of the tetraspan protein epithelial membrane protein-2 inhibits implantation in the mouse.

PubMed ID: 16487956

DOI: 10.1016/j.ydbio.2006.01.015

PubMed ID: 18400107

Title: Steroid hormone regulation of EMP2 expression and localization in the endometrium.

PubMed ID: 18400107

DOI: 10.1186/1477-7827-6-15

PubMed ID: 19494199

Title: Functional consequences of interactions between FAK and epithelial membrane protein 2 (EMP2).

PubMed ID: 19494199

DOI: 10.1167/iovs.08-3315

PubMed ID: 21637765

Title: Epithelial membrane protein-2 promotes endometrial tumor formation through activation of FAK and Src.

PubMed ID: 21637765

DOI: 10.1371/journal.pone.0019945

PubMed ID: 22728127

Title: Anti-EMP2 diabody blocks epithelial membrane protein 2 (EMP2) and FAK mediated collagen gel contraction in ARPE-19 cells.

PubMed ID: 22728127

DOI: 10.1016/j.exer.2012.06.002

PubMed ID: 23439602

Title: Epithelial membrane protein 2 controls VEGF expression in ARPE-19 cells.

PubMed ID: 23439602

DOI: 10.1167/iovs.12-11013

PubMed ID: 23334331

Title: EMP2 regulates angiogenesis in endometrial cancer cells through induction of VEGF.

PubMed ID: 23334331

DOI: 10.1038/onc.2012.622

PubMed ID: 24814193

Title: Mutations in EMP2 cause childhood-onset nephrotic syndrome.

PubMed ID: 24814193

DOI: 10.1016/j.ajhg.2014.04.010

PubMed ID: 28295343

Title: Epithelial membrane protein 2 (EMP2) deficiency alters placental angiogenesis, mimicking features of human placental insufficiency.

PubMed ID: 28295343

DOI: 10.1002/path.4893

Sequence Information:

  • Length: 167
  • Mass: 19199
  • Checksum: 3E341DF3581EBCBF
  • Sequence:
    • MLVLLAFIIA FHITSAALLF IATVDNAWWV GDEFFADVWR ICTNNTNCTV INDSFQEYST 
LQAVQATMIL STILCCIAFF IFVLQLFRLK QGERFVLTSI IQLMSCLCVM IAASIYTDRR 
EDIHDKNAKF YPVTREGSYG YSYILAWVAF ACTFISGMMY LILRKRK

Genular Protein ID: 1615622281

Symbol: Q7Z4B3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q7Z4B3

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GenomeRNAi 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 RefSeq 1

Sequence Information:

  • Length: 103
  • Mass: 11216
  • Checksum: 16740014A154842E
  • Sequence:
    • MLGYQACEDG KVNATPTAGQ NLGLHRHSCL HLGPQNSIPE PCELIDTFRV WGTASFPSYP 
RRPLPSCPAL HATPGWPLTP ISRASEDPST IHSFIHSFIH SST

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.