Details for: EN1

Gene ID: 2019

Symbol: EN1

Ensembl ID: ENSG00000163064

Description: engrailed homeobox 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 20.4512
    Cell Significance Index: 349.5900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.3355
    Cell Significance Index: 19.3900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.2544
    Cell Significance Index: 30.3900
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.5933
    Cell Significance Index: 1.3700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.4664
    Cell Significance Index: 6.1200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2723
    Cell Significance Index: 2.9600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.2250
    Cell Significance Index: 3.2800
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 0.2011
    Cell Significance Index: 0.1400
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.1169
    Cell Significance Index: 1.2200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1061
    Cell Significance Index: 2.2200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1047
    Cell Significance Index: 1.5000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.0557
    Cell Significance Index: 1.3600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0430
    Cell Significance Index: 2.1700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0402
    Cell Significance Index: 7.9800
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.0264
    Cell Significance Index: 0.2800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0031
    Cell Significance Index: 1.3600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0006
    Cell Significance Index: -0.0100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0013
    Cell Significance Index: -0.1400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0013
    Cell Significance Index: -0.3600
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0023
    Cell Significance Index: -0.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0034
    Cell Significance Index: -0.5800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0099
    Cell Significance Index: -1.2700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0101
    Cell Significance Index: -0.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0121
    Cell Significance Index: -1.3900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0180
    Cell Significance Index: -8.1900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0190
    Cell Significance Index: -0.2600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0245
    Cell Significance Index: -4.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0259
    Cell Significance Index: -3.3500
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: -0.0278
    Cell Significance Index: -0.1900
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0347
    Cell Significance Index: -0.5600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0379
    Cell Significance Index: -0.4900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0426
    Cell Significance Index: -1.2200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0448
    Cell Significance Index: -3.3400
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.0450
    Cell Significance Index: -0.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0461
    Cell Significance Index: -2.1500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0537
    Cell Significance Index: -2.5300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0537
    Cell Significance Index: -0.6800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0594
    Cell Significance Index: -1.4800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0792
    Cell Significance Index: -1.5800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0799
    Cell Significance Index: -4.9100
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0888
    Cell Significance Index: -1.2400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0890
    Cell Significance Index: -1.3500
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.1077
    Cell Significance Index: -1.0300
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1183
    Cell Significance Index: -1.1400
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.1222
    Cell Significance Index: -1.3300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1253
    Cell Significance Index: -3.1300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1269
    Cell Significance Index: -7.1200
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.1277
    Cell Significance Index: -0.2900
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.1279
    Cell Significance Index: -1.4800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1296
    Cell Significance Index: -2.5300
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.1324
    Cell Significance Index: -1.4600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1361
    Cell Significance Index: -2.9800
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.1465
    Cell Significance Index: -1.4400
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.1559
    Cell Significance Index: -1.7800
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.1561
    Cell Significance Index: -1.5100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1582
    Cell Significance Index: -4.0300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1593
    Cell Significance Index: -2.5800
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.1624
    Cell Significance Index: -1.0000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1631
    Cell Significance Index: -4.3700
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.1683
    Cell Significance Index: -2.1200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1684
    Cell Significance Index: -1.1400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1704
    Cell Significance Index: -5.0200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1711
    Cell Significance Index: -4.5000
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.1714
    Cell Significance Index: -1.9400
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1726
    Cell Significance Index: -2.1000
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1736
    Cell Significance Index: -1.8800
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.1855
    Cell Significance Index: -1.8000
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.1867
    Cell Significance Index: -2.1500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1880
    Cell Significance Index: -5.0200
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1955
    Cell Significance Index: -2.9300
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.1960
    Cell Significance Index: -2.5100
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.2046
    Cell Significance Index: -1.2700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2081
    Cell Significance Index: -4.9900
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.2081
    Cell Significance Index: -2.8300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.2110
    Cell Significance Index: -2.7600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2220
    Cell Significance Index: -3.8100
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.2223
    Cell Significance Index: -2.4400
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.2238
    Cell Significance Index: -2.1100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2319
    Cell Significance Index: -5.0100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2342
    Cell Significance Index: -4.9700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2388
    Cell Significance Index: -4.2200
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.2413
    Cell Significance Index: -3.6100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2464
    Cell Significance Index: -4.8500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2478
    Cell Significance Index: -4.9000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2486
    Cell Significance Index: -4.9900
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.2512
    Cell Significance Index: -3.2400
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.2527
    Cell Significance Index: -3.0500
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.2549
    Cell Significance Index: -3.2300
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -0.2562
    Cell Significance Index: -2.0400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2575
    Cell Significance Index: -5.0400
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.2580
    Cell Significance Index: -2.9300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.2591
    Cell Significance Index: -3.4100
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.2766
    Cell Significance Index: -2.1500
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.2781
    Cell Significance Index: -3.7500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2790
    Cell Significance Index: -4.6700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2874
    Cell Significance Index: -4.9700
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2915
    Cell Significance Index: -1.7300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3035
    Cell Significance Index: -4.4800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.3108
    Cell Significance Index: -4.3100
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.3148
    Cell Significance Index: -3.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional regulation:** EN1 acts as a transcriptional repressor or activator, depending on the context, influencing the expression of target genes involved in various biological processes. 2. **Cell-type specificity:** EN1 is highly expressed in hematopoietic cells, suggesting a role in hematopoiesis and blood cell development. 3. **Neuronal differentiation:** EN1 is also expressed in neurons and has been implicated in the regulation of neuronal development and function. 4. **Diverse cellular contexts:** EN1 is expressed in multiple cell types, including endothelial cells, cardiac cells, and immune cells, underscoring its pleiotropic nature. **Pathways and Functions:** 1. **Cerebellum development:** EN1 plays a crucial role in the development of the cerebellum, a region involved in motor coordination and learning. 2. **Hematopoiesis:** EN1 regulates the expression of genes involved in hematopoiesis, influencing the development and function of blood cells. 3. **Neuronal differentiation:** EN1 promotes the differentiation of neurons, particularly in the development of the nervous system. 4. **Pattern formation:** EN1 is involved in the regulation of pattern formation during embryonic development, including the development of the midbrain-hindbrain boundary. **Functions:** 1. **Transcriptional regulation:** EN1 modulates the expression of target genes, influencing cell fate decisions and tissue morphogenesis. 2. **Cell cycle regulation:** EN1 may play a role in regulating the cell cycle, particularly in hematopoietic cells. 3. **Apoptosis regulation:** EN1 negatively regulates apoptosis, a process of programmed cell death, in neurons and other cell types. 4. **Cocaine response:** EN1 is involved in the regulation of the response to cocaine, a psychostimulant that affects the brain's reward system. **Clinical Significance:** 1. **Blood disorders:** Mutations in the EN1 gene have been linked to blood disorders, such as anemia and leukemia. 2. **Neurological disorders:** EN1 dysregulation has been implicated in various neurological disorders, including autism spectrum disorder and schizophrenia. 3. **Cocaine addiction:** EN1 may play a role in the development of cocaine addiction, particularly in the regulation of dopamine release and reward processing. 4. **Cancer:** EN1 has been identified as a potential oncogene, with its expression elevated in certain types of cancer, such as leukemia and lymphoma. In conclusion, the engrailed homeobox 1 (EN1) gene is a multifunctional transcription factor involved in various developmental and physiological processes. Its dysregulation has been implicated in several diseases, highlighting the importance of EN1 in maintaining cellular homeostasis and tissue function. Further research is needed to fully elucidate the mechanisms by which EN1 regulates gene expression and to explore its therapeutic potential in various diseases.

Genular Protein ID: 242091627

Symbol: HME1_HUMAN

Name: Homeobox protein engrailed-1

UniProtKB Accession Codes:

Q05925 Q4ZG44

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 GO 29 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1363401

Title: Cloning and sequence comparison of the mouse, human, and chicken engrailed genes reveal potential functional domains and regulatory regions.

PubMed ID: 1363401

DOI: 10.1002/dvg.1020130505

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 33568816

Title: Non-coding deletions identify Maenli lncRNA as a limb-specific En1 regulator.

PubMed ID: 33568816

DOI: 10.1038/s41586-021-03208-9

Sequence Information:

  • Length: 392
  • Mass: 40115
  • Checksum: BDFE6279E9C27BFD
  • Sequence:
    • MEEQQPEPKS QRDSALGAAA AATPGGLSLS LSPGASGSSG SGSDGDSVPV SPQPAPPSPP 
AAPCLPPLAH HPHLPPHPPP PPPQHLAAPA HQPQPAAQLH RTTNFFIDNI LRPDFGCKKE 
QPPPQLLVAA AARGGAGGGG RVERDRGQTA AGRDPVHPLG TRAPGAASLL CAPDANCGPP 
DGSQPAAAGA GASKAGNPAA AAAAAAAAVA AAAAAAAAKP SDTGGGGSGG GAGSPGAQGT 
KYPEHGNPAI LLMGSANGGP VVKTDSQQPL VWPAWVYCTR YSDRPSSGPR TRKLKKKKNE 
KEDKRPRTAF TAEQLQRLKA EFQANRYITE QRRQTLAQEL SLNESQIKIW FQNKRAKIKK 
ATGIKNGLAL HLMAQGLYNH STTTVQDKDE SE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.