Details for: EN1

Gene ID: 2019

Symbol: EN1

Ensembl ID: ENSG00000163064

Description: engrailed homeobox 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 11.53
    Marker Score: 6390
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 5.77
    Marker Score: 3278.5
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 4.96
    Marker Score: 2614
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 2.28
    Marker Score: 954.5
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.27
    Marker Score: 2283
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 2.19
    Marker Score: 1445
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.95
    Marker Score: 2179
  • Cell Name: T cell (CL0000084)
    Fold Change: 1.91
    Marker Score: 3288
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.39
    Marker Score: 2825
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.28
    Marker Score: 2429
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.2
    Marker Score: 12346.5
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.19
    Marker Score: 1134
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71803.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48030
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.98
    Marker Score: 13143.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5354
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5282
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.86
    Marker Score: 500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.85
    Marker Score: 13330.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.83
    Marker Score: 1345
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 402
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.77
    Marker Score: 1223
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.74
    Marker Score: 1147
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.74
    Marker Score: 1188
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.64
    Marker Score: 509
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.64
    Marker Score: 383
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.61
    Marker Score: 3661
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.52
    Marker Score: 399
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.49
    Marker Score: 518
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 283
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.47
    Marker Score: 225
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.47
    Marker Score: 214.5
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.38
    Marker Score: 795.5
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.38
    Marker Score: 167
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.36
    Marker Score: 213
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.34
    Marker Score: 303
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.3
    Marker Score: 95.5
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.29
    Marker Score: 251
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.28
    Marker Score: 345.5
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.27
    Marker Score: 143
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.25
    Marker Score: 1616
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.25
    Marker Score: 141
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.25
    Marker Score: 164
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.23
    Marker Score: 119
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.22
    Marker Score: 239
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.22
    Marker Score: 57
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.21
    Marker Score: 572
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.2
    Marker Score: 53
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.2
    Marker Score: 74
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.19
    Marker Score: 47.5
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.17
    Marker Score: 50
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.17
    Marker Score: 38.5
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.17
    Marker Score: 47
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.16
    Marker Score: 676.5
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.15
    Marker Score: 118.5
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.15
    Marker Score: 146
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.15
    Marker Score: 37
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.15
    Marker Score: 42.5
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 0.14
    Marker Score: 42.5
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.14
    Marker Score: 44.5
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.13
    Marker Score: 33
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.13
    Marker Score: 45
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.13
    Marker Score: 33.5
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.13
    Marker Score: 55
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.13
    Marker Score: 51
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.12
    Marker Score: 40
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.12
    Marker Score: 37
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.12
    Marker Score: 43
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.12
    Marker Score: 42
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.12
    Marker Score: 139
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.12
    Marker Score: 78
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.12
    Marker Score: 45
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.11
    Marker Score: 46
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.11
    Marker Score: 37
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.11
    Marker Score: 40.5
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.11
    Marker Score: 69
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.11
    Marker Score: 47.5
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.11
    Marker Score: 36.5
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.1
    Marker Score: 106
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.1
    Marker Score: 30.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.1
    Marker Score: 228.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1
    Marker Score: 3233
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.09
    Marker Score: 45
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.09
    Marker Score: 34.5
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.09
    Marker Score: 71
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.09
    Marker Score: 46.5
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.09
    Marker Score: 45
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.09
    Marker Score: 44.5
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.09
    Marker Score: 165
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.09
    Marker Score: 50
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.09
    Marker Score: 205
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.08
    Marker Score: 30
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.08
    Marker Score: 46
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.08
    Marker Score: 47.5

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Other Information

**Key characteristics:** - Ensembl ID: ENSG00000163064 - Protein: HME1_HUMAN (Homeobox protein engrailed-1) - Function: Transcription factor - Expression: Erythrocyte, megakaryocyte, hematopoietic stem cell, megakaryocyte-erythroid progenitor cell, blood vessel endothelial cell, precursor B cell, plasma cell, T cell, immature innate lymphoid cell, cardiac endothelial cell **Pathways and functions:** - Regulation of transcription by rna polymerase ii - Negative regulation of transcription by rna polymerase ii - Control of embryonic forelimb morphogenesis and development - Participation in the development of the cerebellum - Role in the development of the midbrain and hindbrain - Regulation of skeletal system development - Involvement in social behavior **Clinical significance:** - Mutations in EN1 have been linked to various human diseases, including autism, schizophrenia, and cardiovascular disease. - EN1 inhibitors are being investigated as potential therapeutic agents for these diseases. **Additional information:** - EN1 is a highly conserved transcription factor with homologs in other organisms. - It is a key player in human development and disease pathogenesis. - Further research is needed to fully understand the role of EN1 in human health and disease.

Genular Protein ID: 242091627

Symbol: HME1_HUMAN

Name: Homeobox protein engrailed-1

UniProtKB Accession Codes:

Q05925 Q4ZG44

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 GO 29 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1363401

Title: Cloning and sequence comparison of the mouse, human, and chicken engrailed genes reveal potential functional domains and regulatory regions.

PubMed ID: 1363401

DOI: 10.1002/dvg.1020130505

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 33568816

Title: Non-coding deletions identify Maenli lncRNA as a limb-specific En1 regulator.

PubMed ID: 33568816

DOI: 10.1038/s41586-021-03208-9

Sequence Information:

  • Length: 392
  • Mass: 40115
  • Checksum: BDFE6279E9C27BFD
  • Sequence:
    • MEEQQPEPKS QRDSALGAAA AATPGGLSLS LSPGASGSSG SGSDGDSVPV SPQPAPPSPP 
AAPCLPPLAH HPHLPPHPPP PPPQHLAAPA HQPQPAAQLH RTTNFFIDNI LRPDFGCKKE 
QPPPQLLVAA AARGGAGGGG RVERDRGQTA AGRDPVHPLG TRAPGAASLL CAPDANCGPP 
DGSQPAAAGA GASKAGNPAA AAAAAAAAVA AAAAAAAAKP SDTGGGGSGG GAGSPGAQGT 
KYPEHGNPAI LLMGSANGGP VVKTDSQQPL VWPAWVYCTR YSDRPSSGPR TRKLKKKKNE 
KEDKRPRTAF TAEQLQRLKA EFQANRYITE QRRQTLAQEL SLNESQIKIW FQNKRAKIKK 
ATGIKNGLAL HLMAQGLYNH STTTVQDKDE SE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.