Details for: EPAS1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 226.8145
Cell Significance Index: -57.5300 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 111.6534
Cell Significance Index: -45.3600 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 110.7665
Cell Significance Index: -45.6300 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 47.6149
Cell Significance Index: -45.4600 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 46.6116
Cell Significance Index: -57.4700 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 19.6291
Cell Significance Index: -42.9600 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 19.6128
Cell Significance Index: -52.5400 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 14.3840
Cell Significance Index: -56.7600 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 12.7748
Cell Significance Index: 665.4200 - Cell Name: glomerular capillary endothelial cell (CL1001005)
Fold Change: 9.5842
Cell Significance Index: 35.7200 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 7.3026
Cell Significance Index: 105.0300 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 7.2835
Cell Significance Index: 194.4800 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 6.7111
Cell Significance Index: 69.5100 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 4.5905
Cell Significance Index: 81.1200 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 4.1573
Cell Significance Index: 70.0300 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 2.9661
Cell Significance Index: 18.4300 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.7837
Cell Significance Index: 37.9800 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 2.7129
Cell Significance Index: 30.8200 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 2.3404
Cell Significance Index: 14.1400 - Cell Name: perivascular cell (CL4033054)
Fold Change: 2.3044
Cell Significance Index: 10.6400 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 2.1971
Cell Significance Index: 418.1300 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 1.6425
Cell Significance Index: 14.5800 - Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 1.6240
Cell Significance Index: 5.6500 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.4137
Cell Significance Index: 280.5500 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.9061
Cell Significance Index: 163.3400 - Cell Name: pulmonary capillary endothelial cell (CL4028001)
Fold Change: 0.8763
Cell Significance Index: 12.0000 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.8756
Cell Significance Index: 25.1000 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.7982
Cell Significance Index: 98.1500 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.7145
Cell Significance Index: 116.2100 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.6983
Cell Significance Index: 436.0500 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.5984
Cell Significance Index: 4.8800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.5774
Cell Significance Index: 43.0300 - Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.5622
Cell Significance Index: 3.5200 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.5043
Cell Significance Index: 455.3300 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.4965
Cell Significance Index: 29.8100 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.4592
Cell Significance Index: 49.9500 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.4421
Cell Significance Index: 20.0400 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.2568
Cell Significance Index: 32.9200 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2493
Cell Significance Index: 5.4000 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2380
Cell Significance Index: 129.9600 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.2331
Cell Significance Index: 26.6100 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1983
Cell Significance Index: 13.7200 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1757
Cell Significance Index: 17.3800 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.1656
Cell Significance Index: 1.5300 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.1612
Cell Significance Index: 4.0300 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.1569
Cell Significance Index: 1.8700 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1028
Cell Significance Index: 65.2900 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0891
Cell Significance Index: 6.8400 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.0830
Cell Significance Index: 0.6600 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.0671
Cell Significance Index: 0.9900 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0458
Cell Significance Index: 2.8900 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0219
Cell Significance Index: 0.7700 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0086
Cell Significance Index: 1.1900 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0045
Cell Significance Index: 3.3700 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0112
Cell Significance Index: -1.9200 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0118
Cell Significance Index: -5.2000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0126
Cell Significance Index: -17.0700 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0165
Cell Significance Index: -31.0000 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0238
Cell Significance Index: -16.4900 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0245
Cell Significance Index: -18.1300 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0256
Cell Significance Index: -47.1900 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0284
Cell Significance Index: -43.6800 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.0560
Cell Significance Index: -0.4700 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0588
Cell Significance Index: -33.1400 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0602
Cell Significance Index: -27.3300 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0622
Cell Significance Index: -45.6100 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0825
Cell Significance Index: -9.4500 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1270
Cell Significance Index: -26.7600 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1319
Cell Significance Index: -19.1700 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.1456
Cell Significance Index: -52.2400 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1540
Cell Significance Index: -44.3000 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.1936
Cell Significance Index: -38.8400 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1962
Cell Significance Index: -20.0400 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2347
Cell Significance Index: -27.3600 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.2570
Cell Significance Index: -33.2000 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.2897
Cell Significance Index: -15.0500 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.3468
Cell Significance Index: -4.9800 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.3633
Cell Significance Index: -9.8900 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.3991
Cell Significance Index: -18.6100 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.4426
Cell Significance Index: -52.2000 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.4609
Cell Significance Index: -28.2600 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.5029
Cell Significance Index: -7.7800 - Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: -0.5033
Cell Significance Index: -4.7800 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.5321
Cell Significance Index: -55.4000 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.5596
Cell Significance Index: -28.2800 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.5912
Cell Significance Index: -41.8100 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.6051
Cell Significance Index: -47.9200 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.6173
Cell Significance Index: -34.6400 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.6398
Cell Significance Index: -17.8800 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.6443
Cell Significance Index: -30.2800 - Cell Name: embryonic fibroblast (CL2000042)
Fold Change: -0.6648
Cell Significance Index: -3.1800 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.7039
Cell Significance Index: -15.0500 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.7840
Cell Significance Index: -50.5800 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.8084
Cell Significance Index: -54.3600 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.8816
Cell Significance Index: -13.2100 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.8820
Cell Significance Index: -18.7900 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.8969
Cell Significance Index: -55.1300 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.0611
Cell Significance Index: -33.9900 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -1.0637
Cell Significance Index: -55.8500 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -1.0883
Cell Significance Index: -48.1400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1880273405
Symbol: EPAS1_HUMAN
Name: Endothelial PAS domain-containing protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9000051
Title: Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.
PubMed ID: 9000051
DOI: 10.1101/gad.11.1.72
PubMed ID: 9079689
Title: Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway.
PubMed ID: 9079689
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10202154
Title: Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300.
PubMed ID: 10202154
PubMed ID: 19208626
Title: Erythrocytosis-associated HIF-2alpha mutations demonstrate a critical role for residues C-terminal to the hydroxylacceptor proline.
PubMed ID: 19208626
PubMed ID: 16181639
Title: Structural basis of ARNT PAS-B dimerization: use of a common beta-sheet interface for hetero- and homodimerization.
PubMed ID: 16181639
PubMed ID: 18378852
Title: Novel exon 12 mutations in the HIF2A gene associated with erythrocytosis.
PubMed ID: 18378852
PubMed ID: 25043035
Title: Altitude adaptation in Tibetans caused by introgression of Denisovan-like DNA.
PubMed ID: 25043035
DOI: 10.1038/nature13408
PubMed ID: 31189709
Title: The Kaposi's Sarcoma-Associated Herpesvirus ORF34 Protein Interacts and Stabilizes HIF-2alpha via Binding to the HIF-2alpha bHLH and PAS Domains.
PubMed ID: 31189709
DOI: 10.1128/jvi.00764-19
PubMed ID: 34050022
Title: The history and evolution of the Denisovan-EPAS1 haplotype in Tibetans.
PubMed ID: 34050022
PubMed ID: 36417539
Title: A pleiotropic hypoxia-sensitive EPAS1 enhancer is disrupted by adaptive alleles in Tibetans.
PubMed ID: 36417539
PubMed ID: 36930720
Title: Human genetic history on the Tibetan Plateau in the past 5100 years.
PubMed ID: 36930720
PubMed ID: 18184961
Title: A gain-of-function mutation in the HIF2A gene in familial erythrocytosis.
PubMed ID: 18184961
DOI: 10.1056/nejmoa073123
PubMed ID: 22367913
Title: Two new mutations in the HIF2A gene associated with erythrocytosis.
PubMed ID: 22367913
DOI: 10.1002/ajh.23123
Sequence Information:
- Length: 870
- Mass: 96459
- Checksum: 4838989598234FC1
- Sequence:
MTADKEKKRS SSERRKEKSR DAARCRRSKE TEVFYELAHE LPLPHSVSSH LDKASIMRLA ISFLRTHKLL SSVCSENESE AEADQQMDNL YLKALEGFIA VVTQDGDMIF LSENISKFMG LTQVELTGHS IFDFTHPCDH EEIRENLSLK NGSGFGKKSK DMSTERDFFM RMKCTVTNRG RTVNLKSATW KVLHCTGQVK VYNNCPPHNS LCGYKEPLLS CLIIMCEPIQ HPSHMDIPLD SKTFLSRHSM DMKFTYCDDR ITELIGYHPE ELLGRSAYEF YHALDSENMT KSHQNLCTKG QVVSGQYRML AKHGGYVWLE TQGTVIYNPR NLQPQCIMCV NYVLSEIEKN DVVFSMDQTE SLFKPHLMAM NSIFDSSGKG AVSEKSNFLF TKLKEEPEEL AQLAPTPGDA IISLDFGNQN FEESSAYGKA ILPPSQPWAT ELRSHSTQSE AGSLPAFTVP QAAAPGSTTP SATSSSSSCS TPNSPEDYYT SLDNDLKIEV IEKLFAMDTE AKDQCSTQTD FNELDLETLA PYIPMDGEDF QLSPICPEER LLAENPQSTP QHCFSAMTNI FQPLAPVAPH SPFLLDKFQQ QLESKKTEPE HRPMSSIFFD AGSKASLPPC CGQASTPLSS MGGRSNTQWP PDPPLHFGPT KWAVGDQRTE FLGAAPLGPP VSPPHVSTFK TRSAKGFGAR GPDVLSPAMV ALSNKLKLKR QLEYEEQAFQ DLSGGDPPGG STSHLMWKRM KNLRGGSCPL MPDKPLSANV PNDKFTQNPM RGLGHPLRHL PLPQPPSAIS PGENSKSRFP PQCYATQYQD YSLSSAHKVS GMASRLLGPS FESYLLPELT RYDCEVNVPV LGSSTLLQGG DLLRALDQAT
Genular Protein ID: 192220275
Symbol: B3KW07_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
Sequence Information:
- Length: 336
- Mass: 36509
- Checksum: D5C86DD03FDE0B34
- Sequence:
MDGEDFQLSP ICPEERLLAE NPQSTPQHCF SAMTNIFQPL APVAPHSPFL LDKFQQQLES KKTEPEHRPM SSIFFDAGSK ASLPPCCGQA STPLSSMGGR SNTQWPPDPP LHFGPTKWAV GDQRTEFLGA APLGPPVSPP HVSTFKTRSA KGFGARGPDV LSPAMVALSN KLKLKRQLEY EEQAFQDLSG GDPPGGSTSH LMWKRMKNLR GGSCPLMPDK PLSANVPNDK FTQNPMRGLG HPLRHLPLPQ PPSAISPGEN SKSRFPPQCY ATQYQDYSLS SAHKVSGMAS RLLGPSFESY LLPELTRYDC EVNVPVLGSS TLLQGGDLLR ALDQAT
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.